Chézy-sur-Marne. La crypte de Saint-Pierre au Bourg

Ignorée des sources écrites, la crypte de Chézy a été relevée avant sa quasi destruction en 1910. L’enquête reprise dans le cadre du PCR a permis de dresser un bilan archéologique et historique combinant les sources disponibles dans les diverses archives et un nouvel examen de terrain. Cette enquête permet de restituer une crypte-halle romane d’une ampleur inattendue. Localisation et environnement L’abbaye bénédictine de Saint-Pierre de Chézy-sur-Marne était située à 7 km au sud-ouest de Chât..

Château-Thierry (Aisne). La Charité. Rapport d’évaluation archéologique

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Château-Thierry (Aisne). Collèges Jean Macé. Rapport de fouilles archéologiques

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Cryptes médiévales et culte des saints en Ile-de-France et en Picardie: Chézy-sur-Marne. La crypte de Saint-Pierre au Bourg

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Functional Arterial Spin Labeling during a working memory task MRI at 3T. Comparison with BOLD fMRI

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Functional Arterial Spin Labeling during a working memory task MRI at 3T. Comparison with BOLD fMRI

International audienc

Impact on Renal Resistive Index of Diabetes in Renal Transplant Donors and Recipients: A Retrospective Analysis of 1827 Kidney Transplant Recipients

International audienceHigh renal resistive index (RI) is observed in diabetes and is associated with poor patient survival, but whether it is primarily due to renal vascular resistance or systemic vascular alterations is unclear. The respective impact of kidney transplant from diabetic donors or to diabetic recipients on RI would shed some light on this issue. The objective of the study was to analyze the impact of donor and recipient diabetes on RI in order to understand the respective impact of the kidney and the vascular environment. The authors conducted a retrospective study in 1827 renal transplant recipients who received a kidney between 1985 and 2017, and had Doppler measurements at 3~months after transplant. Donor and recipient characteristics at the time of transplant and at 3~months were reviewed. Both donor diabetes and recipient diabetes were associated with RI in univariate analysis, but only recipient diabetes remained significantly associated in stepwise multivariate analyses (effect estimate on RI: +0.03~±~0.005, P~<~0.001). These findings were confirmed when RI was expressed as a binary variable using a cutoff of 0.75 (OR~=~2.50 [1.77, 3.54], P~<~0.001). Other determinants of RI were recipient characteristics (age, sex, systolic and diastolic blood pressure, and duration of dialysis). Donor characteristics were not associated with RI. Our results suggest that high RI observed in diabetic recipients shortly after transplant is primarily due to the new vascular environment, rather than to characteristics of the transplanted kidney. Therefore, RI reflects systemic rather than intra-renal changes

The Association between Renal Resistive Index and Premature Mortality after Kidney Transplantation Is Modified by Pre-Transplant Diabetes Status: A Cohort Study

International audienceBACKGROUND: Renal resistive index (RI) predicts mortality in renal transplant recipients, but we do not know whether this is true in diabetic patients. The objective of this study was to analyse the long-term predictive value of RI for death with a functioning graft (DWFG) in renal transplant recipients with or without pre-transplant diabetes. METHODS: We conducted a retrospective study in 1800 renal transplant recipients between 1985 and 2017 who were followed for up to 30 years (total observation period: 14\,202 patient years). Donor and recipient characteristics at time of transplantation and at 3\,months were reviewed. The long-term predictive value of RI for DWFG and the age-RI and arterial pressure-RI relationships were assessed. RESULTS: A total of 284/1800 (15.7%) patients had diabetes mellitus before transplantation. RI was <0.75 in 1327/1800 patients (73.7%). High RI was associated with a higher risk of DWFG in non-diabetic patients [hazard ratio (HR)\,=\,3.39, 95% confidence interval 2.50-4.61; P\,<\,0.001], but not in patients with pre-transplant diabetes (HR\,=\,1.25, 0.70-2.19; P\,=\,0.39), even after multiple adjustments. There was no interaction between diabetes and age. In contrast, there was an interaction between RI and pulse pressure. CONCLUSION: Our study indicates that RI is not a predictor of DWFG in diabetic renal transplant recipients, in contrast to non-diabetic recipients. These findings could be due to a different age-RI or pulse pressure-RI relationship

Does Portopulmonary Hypertension Impede Liver Transplantation in Cirrhotic Patients? A French Multicentric Retrospective Study

International audiencePortopulmonary hypertension is defined by the presence of pulmonary arterial hypertension associated with portal hypertension. Its presence is a major stake for cirrhotic patients requiring liver transplantation (LT), with increased postoperative mortality and unpredictable evolution after transplantation. The aim was to study outcomes after liver transplantation in patients with portopulmonary hypertension and to identify factors associated with normalization of pulmonary hypertension. METHODS: Patients with portopulmonary hypertension who underwent LT between 2008 and 2016 in 8 French centers were retrospectively included. Pulmonary artery pressure was established by right heart catheterization before and after LT. Primary endpoint was the normalization of pulmonary artery pressure after LT. RESULTS: Twenty-three patients who received liver transplant between 2008 and 2016 were included. Two (8.7%) patients died in the immediate posttransplant period from right heart failure. With appropriate vasoactive medical treatment and LT, pulmonary arterial pressure was normalized in 14 patients (60.8%), demonstrating recovery from portopulmonary hypertension. In univariate analysis, the use of vasoactive combination therapy was the only prognostic factor for pulmonary arterial hypertension normalization after LT. CONCLUSIONS: Treatment of portopulmonary hypertension with a combination of vasoactive drugs allows LT with acceptable postoperative cardiovascular-related mortality and normalization of pulmonary hypertension in the majority of the patients

High-frequency ultrasound quantification of acute radiation dermatitis: pilot study of patients undergoing radiotherapy for breast cancer

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