857 research outputs found

    Intertextualidad de arte y vida en obras recientes de Clara Janés: una perspectiva femenina

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    La conocida poeta española Clara Janés, autora de más de 30 libros de poesía, muchos de ellos ya traducidos a varias lenguas, siempre ha cultivado un enfoque estético que cruza fronteras entre arte y vida, integrando una con la otra para crear una totalidad intertextual coherente de múltiples y diversas formas artísticas. Propongo aquí enfocar en tres de sus obras recientes todavía menos conocidas, La indetenible quietud (versión revisada, 2008), Peregrinaje (2010) y, por último, Psi o el jardín de las delicias (2014), en donde Janés entreteje sus meditaciones literarias y filosóficas en armonía con expresiones artísticas variadas. En la primera, pondera sus reflexiones en torno a la obra del famoso escultor vasco Eduardo Chillida, en la segunda se vuelve atrás para examinar un texto original (Toscana) de su musa más importante, Vladimir Holan, a la vez que se basa en imágenes de pintura clásica, y en la más reciente (Psi), explora sus propias experiencias místicas-espirituales en relación con teorías de la física cuántica. También de paso haré referencia a los efectos de la música en Kampa y los de la física en Variables ocultas y Orbes del sueño. En el conjunto de su poesía, crea Janés un solo intertexto enorme sacado de diferentes medios de expresión artística, reflejando su visión poética que todo en la vida es arte y que el arte se convierte en vida, en una forma más típicamente femenina que masculin

    A Priestly Profile of the First Navy Chaplain to Receive the Medal of Honor

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    This tribute to Father Joseph O\u27Callahan, S.J. profiles the family upbringing and religious training of the Jesuit priest who served as a chaplain in the United States Navy and later as a professor at the College of the Holy Cross. It also recounts Fr. O\u27Callahan\u27s heroic efforts in the aftermath of an attack on the USS Franklin during World War II. He was later awarded the Congressional Medal of Honor, the first chaplain of the armed forces to ever receive the nation\u27s highest honor

    Immunoparalysis in Septic Shock Patients

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    In the recent years, it has become clear that septic shock is characterized by the simultaneous production of inflammatory and anti-inflammatory mediators; the primary role of the latter is to counterbalance the former, thus limiting the severity of their systemic effects. However, in a number of patients, the anti-inflammatory substances can cause a downregulation in both the innate and adaptive immune capabilities, leading a second phase characterized to secondary infections caused by opportunist germs and the reactivation of latent viruses, muscle wasting; altogether, these abnormalities set the stage for a chronic critical condition. This condition, whose identification is relatively recent, is called immunoparalysis. Unfortunately, the current approach to septic shock is focused much more on the inflammatory phase than in the ensuing immunoparalysis, whose diagnosis can be challenging. In this chapter, the role played by both classes of mediators, the monitoring of the immune system, and the possible current and not yet available therapeutic strategies of immunoparalysis are reviewed and discussed

    Editor\u27s Introduction

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    The VA Engage Journal is an annually published scholarly journal promoting reflection and dialogue on the topic of civic engagement by undergraduate, graduate, and professional students at Virginia colleges and universities. The journal acts as a forum for discussion to enhance our collective understanding of the purposes and practices of civic engagement. Students may submit critical reflections on engagement, reviews of current literature, and personal quantitative, qualitative, or mixed-methods research studies for publication. In the fifth volume of the VA Engage Journal, four authors reflect on the different limitations in their communities and the potential for growth through engagement that challenges these limits

    Constructing (Dis)ability through participation in early childhood markets: Preschool leaders’ enrolment decision-making

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    This article employs a critical case study (critical disability studies and critical policy analysis) to unpack how leaders in publicly funded private prekindergarten programs invoke conceptions of normality, and subsequently abnormality, during decision-making processes for student (dis)enrolment. More specifically, this research is concerned with ways private preschool leaders’ constructions of disability are implicated in decision-making affecting student enrolment and disenrollment, thereby facilitating constructions of children’s participation in this state-sanctioned early childhood education program. Three leadership teams at private preschools participated in responsive interviews, observations, and provided policy and curricular documents for analysis. Findings reveal how policy, market, and preschool leaders’ conceptions of (ab)normality influenced decision-making rationales and outcomes affecting (dis)enrolled students. Additionally, findings indicated leaders’ sense of identity impacted their interpretation of and reaction to program polices, local market pressures, and their construction of the “good consumer”—a parent/child dyad prepared for rigor with the exhibition of self-control. This research evinces complexities undergirding leaders’ decision-making when choosing to (dis)enrol students in publicly-funded voucher programs on privately-driven markets and how decisions function to (re)shape (dis)ability discourses in early childhood

    EVALUATING SEMANTIC ANALYSIS METHODS FOR SHORT ANSWER GRADING USING LINEAR REGRESSION

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    The assessment of free-text answers may demand significant human effort, especially in scenarios with many students. This paper focuses on the automatic grading of short answer written in Portuguese language using techniques of natural language processing and semantic analysis. A previous study found that a similarity scoring model might be more suitable to a question type than to another. In this study, we combine latent semantic analysis (LSA) and a WordNet path-based similarity method using linear regression to predict scores for 76 short answers to three questions written by high school students. The predicted scores compared well to human scores and the use of combined similarity scores showed an improvement in overall results in relation to a previous study on the same corpus. The presented approach may be used to support the automatic grading of short answer using supervised machine learning to weight different similarity scoring models. &nbsp

    Characterizing the Intracellular Distribution of Mutant Thyroid Hormone Receptor α-1 A382PfsX7

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    Resistance to Thyroid Hormone (RTH) syndrome is a developmental disease characterized by the failure of peripheral tissues to respond to thyroid hormone signaling. A382PfsX7 is a nonfunctional RTH-associated variant of thyroid hormone receptor α1 which fails to bind thyroid hormone and disassociate from corepressors. The mutation also deletes a nuclear export signal (NES) from the C-terminal end of the receptor. This thesis sought to determine whether this NES deletion altered the intracellular distribution of TR in a way which would imply interference with its role in transcriptional activation and repression. Using lipid-based transfection of fluorescently-labeled TR into HeLa (human) cells and fluorescent microscopy, the nuclear-to-cytoplasmic ratio of wild-type (WT) and mutant TR and the presence of TR aggregates was evaluated. Coexpression of WT-TRα1 and A382PfsX7 is associated with a cytosolic shift in localization and an increased frequency of TR aggregation. These data suggest that novel interactions between WT and mutant receptors may increase the aggregation propensity of TR and thereby alter localization
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