1,582 research outputs found

    Transcendent Formation for Agents of Grace: Non-Catholic Teachers for Mission in Catholic Secondary Schools

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    As non-Catholic teachers are being hired into Catholic high schools, they are inducted into the school mission that participates in the Catholic Church’s mission for evangelization. The research on the non-Catholic teachers’ perspectives and experiences of this mission formation is underdeveloped. This study explores the process of Catholic school mission formation conducted by school leaders for non-Catholic teachers in the region of Southern California. Specifically, it examined the perception of non-Catholic teachers’ experience about their mission formation at the Catholic high schools. Simultaneously, it investigated the perception of school leaders in their practice of mission formation for non-Catholic teachers. Drawing upon the phenomenological school of thought, this study uses the method of narrative inquiry. Through semi-structured interviews of non-Catholic teachers and school leaders, this study collected data through their stories of mission formation in the Catholic high school system. The participants for this study were selected through purposeful and convenience sampling. According to the findings, the study demonstrates a relationship of the participants’ conceptual framework of evangelization and their self-understanding of participating in mission, as well as to how effective the school leadership supports them in school mission. Corresponding to Shields’ (2008) study, the study concludes that any induction program will have to admit the limits it can offer but consider the critical starting point: the story that brought them to the school. The findings also demonstrate an opportunity for school leaders to reconsider their practice

    Magnetic anisotropy in Shiba bound states across a quantum phase transition

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    The exchange coupling between magnetic adsorbates and a superconducting substrate leads to Shiba states inside the superconducting energy gap and a Kondo resonance outside the gap. The exchange coupling strength determines whether the quantum many-body ground state is a Kondo singlet or a singlet of the paired superconducting quasiparticles. Here, we use scanning tunneling spectroscopy to identify the different quantum ground states of Manganese phthalocyanine on Pb(111). We observe Shiba states, which are split into triplets by magnetocrystalline anisotropy. Their characteristic spectral weight yields an unambiguous proof of the nature of the quantum ground state.Comment: 6 pages, 4 figure

    Flexible statistical construction of bilingual dictionaries

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    La mayoría de los sistemas previos para construir un diccionario bilingüe a partir de un corpus paralelo dependen de un algoritmo iterativo, usando probabilidades de traducción de palabras para alinear palabras en el corpus y sus alineamientos para estimar probabilidades de traducción, repitiendo hasta la convergencia. Si bien este enfoque produce resultados razonables, es computacionalmente lento, limitando el tamaño del corpus que se puede analizar y el del diccionario producido. Nosotros proponemos una aproximación no iterativa para producir un diccionario bilingüe unidireccional que, si bien menos precisa que las aproximaciones iterativas, es mucho más rápida, permitiendo procesar córpora mayores en un tiempo razonable. Asimismo, permite una estimación en tiempo real de la probabilidad de traducción de un par de términos, lo que significa que permite obtener un diccionario de traducción con los n términos más frecuentes, y calcular las probabilidades de traducción de términos infrecuentes cuando se encuentren en documentos reales.Most previous systems for constructing a bilingual dictionary from a parallel corpus have depended on an iterative algorithm, using word translation probabilities to align words in the corpus, and using word alignments to estimate word translation probabilities, and repeating until convergence. While this approach produces reasonable results, it is computationally slow, limiting the size of the corpus that can be analysed and the size of the dictionary produced. We propose a non-iterative approach for producing a uni-directional bilingual dictionary which, while less accurate than iterative approaches, is far quicker, allowing larger corpora to be processed in reasonable time. The approach also allows on-the-fly estimation of translation likelihoods between a pair of terms, meaning that a translation dictionary can be generated with the n most frequent terms in an initial pass, and the translation likelihood of infrequent terms can be calculated as encountered in real documents

    Revisiting blood-brain barrier: a chromatographic approach

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    Drugs designed to reach a pharmacological CNS target must be effectively transported across the blood-brain barrier (BBB), a thin monolayer of endothelial cells tightly attached together between the blood and the brain parenchyma. Because of the lipidic nature of the BBB, several physicochemical partition models have been studied as surrogates for the passive permeation of potential drug candidates across the BBB (octanol-water, alkane-water, PAMPA...). In the last years, biopartition chromatography is gaining importance as a noncellular system for the estimation of biological properties in early stages of drug development. Microemulsions (ME) are suitable mobile phases, because of their ease of formulation, stability and adjustability to a large number of compositions mimicking biological structures. In the present work, several microemulsion liquid chromatographic (MELC) systems have been characterized by means of the Abraham's solvation parameter model, in order to assess their suitability as BBB distribution or permeability surrogates. In terms of similarity between BBB and MELC systems (dispersion forces arising from solute non-bonded electrons, dipolarity/polarizability, hydrogen-bond acidity and basicity, and molecular volume), the passive permeability surface area product (log PS) for neutral (including zwitterions), fully and partially ionized drugs was found to be well correlated with the ME made of 3.3% SDS (w/v; surfactant) 0.8% heptane (w/v; oil phase) and 6.6% 1-butanol (w/v; co-surfactant) in 50 mM aqueous phosphate buffer, pH 7.4

    Archipelagic Memory: Reading US Filipino Literature and Visual Art Beside US Imperial Archives

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    Archipelagic Memory examines US Filipino cultural productions–including poetry, documentary film, fiction, and museum curation–and narratives of Filipino belonging outside the imperial archive of US-Philippine relations. Through my close-readings of Marlon Fuentes’ film Bontoc Eulogy (1995), Aimee Suzara’s poetry in Souvenir (2014), Gina Apostol’s novel, Insurrecto (2018), and Lysley Tenorio’s short story, “Save the I-Hotel” (2012) I argue that US Filipino literature and visual art undermines dominant narratives of US-Philippine relations and American exceptionalism preserved in the imperial archive by asserting an “archipelagic memory.” My conception of archipelagic memory describes a practice of memory that betrays enduring structures of US state-violence by representing its appearance in the everyday and as a constitutive element of diasporic conviviality. Through aesthetic interventions, diasporic Filipino cultural production expands our understandings of US belonging and history by showing how grief, friendship, care, and family challenge American exceptionalism and suggest alternative modes of political collectivity and community.PHDAmerican CultureUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/169836/1/pascualm_1.pd

    Multidisciplinary Approach of Malignant Tumors of the Biliary Tree

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    Biliary tract carcinomas are aggressive tumors that arise from epithelial cells of bile ducts. They present several difficulties in their clinical management. A late initial diagnosis (frequently in the form of locally advanced disease), jaundice, cholangitis, or poor performance status of patients are some of the medical issues that arise in this setting. Another clinical limitation is the lack of robust evidence for many of the standard procedures in this particular scenario. Biliary tumors are lethal tumors, and most of them present in the form of advanced disease or during late evolution. However, we are witnessing some exciting changes in clinical management of tumors of the biliary tract, such as the development of new radiological techniques and novel interventional radiology procedures, the emergence of new radiotherapy modalities, the establishment of standardized chemotherapy regimens, the advance in molecular knowledge, and the development of new treatments directed against therapeutic targets. On the other hand, the most important step for advancing the treatment of these complex diseases is the appearance of multidisciplinary management teams integrating qualified specialists to resolve appropriate treatment challenges. In this chapter, we summarize the most relevant advances in clinical management and new oncologic treatment in biliary tract carcinomas

    Characterization of hydrophilic interaction liquid chromatography retention by a linear free energy relationship. Comparison to reversed- and normal-phase retentions.

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    The Abraham solvation parameter model, a linear free energy relationship (LFER) approach, has been used to characterize a polymeric zwitterionic (sulfobetaine) column in HILIC mode. When acetonitrile (MeCN) is used in the preparation of mobile phases the main solute characteristics affecting the chromatographic behavior of analytes are the molecular size and the hydrogen-bonding (both acidity and basicity) interactions. The former property is more favorable in the acetonitrile-rich mobile phase, reducing thus the retention, but the latter reveals a higher affinity for the water layer adsorbed on the stationary phase, enhancing retention. However, if the aprotic acetonitrile is replaced by methanol, a hydrogen-bond acidic solvent, solute hydrogen-bond basicity does not contribute any more to retention, quite the opposite. Thus, a slightly different selectivity is observed in methanol/water than in acetonitrile/water. Normal-phase mode and HILIC-MeCN share the same main factors affecting retention. For reversed-phase and immobilized artificial membrane (IAM) chromatography, the solute molecular size increase retention because of the lower amount of energy required in the formation of a cavity in the solvated stationary phase. On the contrary, the analyte hydrogen-bond basicity favors interactions with the hydroorganic mobile phase and reduces retention. The determined parameters justify the reversed selectivity commonly observed in HILIC in reference to reversed-phase. In most instances, the least retained solutes in reversed-phase are the most retained in HILIC

    Evolutionary dynamics of molecular markers during local adaptation: a case study in Drosophila subobscura

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    Here we present a correction to our article "Evolutionary dynamics of molecular markers during local adaptation: a case study in Drosophila subobscura". We have recently detected an error concerning the application of the Ln RH formula – a test to detect positive selection – to our microsatellite data. Here we provide the corrected data and discuss its implications for our overall findings. The corrections presented here have produced some changes relative to our previous results, namely in a locus (dsub14) that presents indications of being affected by positive selection. In general, our populations present less consistent indications of positive selection for this particular locus in both periods studied – between generations 3 and 14 and between generation 14 and 40 of laboratory adaptation. Despite this, the main findings of our study regarding the possibility of positive selection acting on that particular microsatellite still hold. As previously concluded in our article, further studies should be performed on this specific microsatellite locus (and neighboring areas) to elucidate in greater detail the evolutionary forces acting on this specific region of the O chromosome of Drosophila subobscura

    Modeling aquatic toxicity through chromatographic systems

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    Environmental risk assessment requires information about the toxicity of the growing number of chemical products coming from different origins that can contaminate water and become toxicants to aquatic species or other living beings via the trophic chain. Direct toxicity measurements using sensitive aquatic species can be carried out but they may become expensive and ethically questionable. Literature refers to the use of chromatographic measurements that correlate to the toxic effect of a compound over a specific aquatic species as an alternative to get toxicity information. In this work, we have studied the similarity in the response of the toxicity to different species and we have selected eight representative aquatic species (including tadpoles, fish, water fleas, protozoan, and bacteria) with known nonspecific toxicity to chemical substances. Next, we have selected four chromatographic systems offering good perspectives for surrogation of the eight selected aquatic systems, and thus prediction of toxicity from the chromatographic measurement. Then toxicity has been correlated to the chromatographic retention factor. Satisfactory correlation results have been obtained to emulate toxicity in five of the selected aquatic species through some of the chromatographic systems. Other aquatic species with similar characteristics to these five representative ones could also be emulated by using the same chromatographic systems. The final aim of this study is to model chemical products toxicity to aquatic species by means of chromatographic systems to reduce in vivo testing
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