Effects of sleep apnoea therapy on blood pressure and metabolism: a CPAP sex gap?

International audienc

Modalités thérapeutiques du syndrome d’apnées-hypopnées obstructives du sommeil de l’adulte en dehors de la pression positive continue

International audienc

Porto-Pulmonary Venous Anastomosis: A Reversible Cause of Chronic Hypoxemia in Portal Hypertension

International audienc

Ticagrelor-Associated Shift From Obstructive to Central Sleep Apnea: A Case Report

International audienc

Circulating microparticles from obstructive sleep apnea syndrome patients induce endothelin-mediated angiogenesis

International audienceMicroparticles are deemed true biomarkers and vectors of biological information between cells. Depending on their origin, the composition of microparticles varies and the subsequent message transported by them, such as proteins, mRNA, or miRNA, can differ. In obstructive sleep apnea syndrome (OSAS), circulating microparticles are associated with endothelial dysfunction by reducing endothelial-derived nitric oxide production. Here, we have analyzed the potential role of circulating microparticles from OSAS patients on the regulation of angiogenesis and the involved pathway. VEGF content carried by circulating microparticles from OSAS patients was increased when compared with microparticles from non-OSAS patients. Circulating microparticles from OSAS patients induced an increase of angiogenesis that was abolished in the presence of the antagonist of endothelin-1 receptor type B. In addition, endothelin-1 secretion was increased in human endothelial cells treated by OSAS microparticles. We highlight that circulating microparticles from OSAS patients can modify the secretome of endothelial cells leading to angiogenesis.</p

A Case of Pulmonary Adenocarcinoma Presenting with Diffuse Cystic Lesions

The main causes of diffuse cystic lung diseases include lymphangioleiomyomatosis, pulmonary Langerhans cell histiocytosis, Birt-Hogg-Dubé syndrome, lymphoid interstitial pneumonia, light chain deposition disease, Pneumocystis jirovecii pneumonia, hypersensitivity pneumonitis, and desquamative interstitial pneumonia. Diffuse cystic lung diseases are rarely caused by a malignant process, which are secondary to metastases from sarcomas and gastrointestinal and gynecologic adenocarcinomas. Here, we present a rare case of invasive pulmonary adenocarcinoma associated with progressive diffusion of cystic lesions, revealed by chronic cough and progressive shortness of breath. It is important for clinicians to be aware of this unusual imaging manifestation of lung cancer, to avoid misdiagnoses

Polyphenols impact on vascular dysfunction associated with obstructive sleep apnea: a randomized controlled trial

International audienc

Polyphenols impact on vascular dysfunction associated with obstructive sleep apnea: a randomized controlled trial

International audienc

Home Non-Invasive Ventilation Fails to Improve Quality of Life in the Elderly: Results from a Multicenter Cohort Study

International audienc

Obstructive sleep apnoea syndrome in patients living with diabetes: which patients should be screened?

International audienceBecause type 2 diabetes (T2D) is related to obesity, it is often associated with obstructive sleep apnoea syndrome (OSAS), although OSAS is also frequently diagnosed in patients with type 1 diabetes (T1D) and may promote gestational diabetes. Thus, this systematic review of the scientific evidence aimed to evaluate the epidemiological association between OSAS and all forms of diabetes, the current understanding of the pathophysiological mechanisms behind these associations, the expected benefits and limitations of OSAS treatment in patients with diabetes and, finally, to propose which patients require screening for OSAS