7 research outputs found
Combination of a triple alpha-globin gene with beta-thalassemia in a gypsy family: importance of the genetic testing in the diagnosis and search for a donor for bone marrow transplantation for one of their children
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Ruxolitinib in refractory acute and chronic graft-versus-host disease: a multicenter survey study.
- Author
- Caballero Barrigón Dolores
- Caballero-Velázquez Teresa
- Calderón Cabrera Cristina
- De la Cámara LLanzá Rafael
- Díaz Pérez Miguel A
- Escamilla Gómez Virginia
- Espigado Tocino Ildefonso
- Ferra Coll Christelle
- García Cadenas Irene
- García-Gutiérrez Valentín
- González Sierra Pedro A
- González Vicent Marta
- Grupo Español de Trasplante Hematopoyético (GETH)
- João Mende María
- López Corral Lucía
- Martino Bofarull Rodrigo
- Molina Angulo Blanca
- Molés Paula
- Montoro Gómez Juan
- Márquez Malaver Francisco J
- Orti Guillermo
- Parody Porras Rocío
- Parra Salinas Ingrid M
- Poch Marc
- Pérez Martínez Ariadna
- Pérez Estefanía
- Pérez-Simón José A
- Rodríguez Torres Nancy
- Saavedra Gerosa Silvanna
- Sanz Caballer Jaime
- Sierra Jorge
- Sánchez Ortega Isabel
- Valcárcel Ferreiras David
- Velázquez-Kennedy Kyra
- Viguria Alegría María C
- Zudaire Ripa María T
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 07/11/2019
- Field of study
Graft-versus-host disease is the main cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. First-line treatment is based on the use of high doses of corticosteroids. Unfortunately, second-line treatment for both acute and chronic graft-versus-host disease, remains a challenge. Ruxolitinib has been shown as an effective and safe treatment option for these patients. Seventy-nine patients received ruxolitinib and were evaluated in this retrospective and multicenter study. Twenty-three patients received ruxolitinib for refractory acute graft-versus-host disease after a median of 3 (range 1-5) previous lines of therapy. Overall response rate was 69.5% (16/23) which was obtained after a median of 2 weeks of treatment, and 21.7% (5/23) reached complete remission. Fifty-six patients were evaluated for refractory chronic graft-versus-host disease. The median number of previous lines of therapy was 3 (range 1-10). Overall response rate was 57.1% (32/56) with 3.5% (2/56) obtaining complete remission after a median of 4 weeks. Tapering of corticosteroids was possible in both acute (17/23, 73%) and chronic graft-versus-host disease (32/56, 57.1%) groups. Overall survival was 47% (CI: 23-67%) at 6 months for patients with aGVHD (62 vs 28% in responders vs non-responders) and 81% (CI: 63-89%) at 1 year for patients with cGVHD (83 vs 76% in responders vs non-responders). Ruxolitinib in the real life setting is an effective and safe treatment option for GVHD, with an ORR of 69.5% and 57.1% for refractory acute and chronic graft-versus-host disease, respectively, in heavily pretreated patients
A saturated map of common genetic variants associated with human height
- Author
- Abecasis Goncalo R.
- Adair Linda S.
- Adams Hieab H. H.
- Aguilar-Salinas Carlos A.
- Ahluwalia Tarunveer S.
- Akiyama Masato
- Al-Mulla Fahd
- Allison Matthew A.
- Alvarez Marcus
- Andersen Mette K.
- Ani Alireza
- Appadurai Vivek
- Arbeeva Liubov
- Arias Joshua D.
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles L.
- Attia John
- Auton Adam
- Banas Bernhard
- Bandinelli Stefania
- Bartell Eric
- Bennett David A.
- Bergler Tobias
- Berndt Sonja I.
- Bharadwaj Dwaipayan
- Bhaskar Seema
- Bielak Lawrence F.
- Biino Ginevra
- Bin Wei Wen
- Bisgaard Hans
- Boehnke Michael
- Boerwinkle Eric
- Bollepalli Sailalitha
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borja Judith B.
- Bork-Jensen Jette
- Bouchard Claude
- Bowden Donald W.
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Brody Jennifer A.
- Brumpton Ben Michael
- Burgdorf Kristoffer S.
- Buring Julie E.
- Böger Carsten A.
- Bønnelykke Klaus
- Børglum Anders D.
- Cade Brian E.
- Cai Hui
- Cai Qiuyin
- Campbell Archie
- Catamo Eulalia
- Caulfield Mark J.
- Cañadas-Garre Marisa
- Chai Jin-Fang
- Chai Xiaoran
- Chambers John C.
- Chandak Giriraj R.
- Chang Li-Ching
- Chang Yi-Cheng
- Chanock Stephen
- Chanock Stephen J.
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Chien-Hsiun
- Chen Shyh-Huei
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chesi Alessandra
- Cho Yoon Shin
- Choi Seung Hoan
- Christofidou Paraskevi
- Christophersen Ingrid E.
- Chung Ren-Hua
- Ciullo Marina
- Cocca Massimiliano
- Cole John W.
- Collins Francis S.
- Concas Maria Pina
- Cooper Richard S.
- Couture Christian
- Croteau-Chonka Damien
- Cruz Miguel
- Cucca Francesco
- Cuellar-Partida Gabriel
- Cupples L. Adrienne
- Cutler Michael J.
- Damrauer Scott M.
- Danning Rebecca
- Dantoft Thomas M.
- Daw E. Warwick
- de Borst Gert J.
- de Groot Lisette C. P. G. M.
- De Jager Philip L.
- de Kleijn Dominique P. V.
- Dedoussis George V.
- Degenhard Frauke
- Delgado Graciela E.
- Delitala Alessandro
- Deloukas Panos
- Demirkan Ayse
- den Hollander Anneke I.
- Deng Xuan
- Devineni Poornima
- Dietl Alexander
- Dimitriou Maria
- Dimitrov Latchezar
- Dorajoo Rajkumar
- Du Shufa
- Easton Douglas F.
- Ekici Arif B.
- Elders Petra J. M.
- Eliasen Anders U.
- Eliassen A. Heather
- Ellinor Patrick T.
- Elmståhl Sölve
- Engmann Jorgen E.
- Erdmann Jeanette
- Esko Tõnu
- Evans Michele K.
- Fairhurst-Hunter Zammy
- Farmaki Aliki-Eleni
- Fatkin Diane
- Faul Jessica D.
- Feenstra Bjarke
- Feitosa Mary F.
- Fernandez-Lopez Juan-Carlos
- Ferreira Teresa
- Ferrucci Luigi
- Ford Ian
- Forer Lukas
- Fornage Myriam
- Francescatto Margherita
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Freedman Barry I.
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E.
- Gao Yan
- Gao Zishan
- Gasparini Paolo
- Geller Frank
- Giannakopoulou Olga
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Gjesing Anette P.
- Goddard Michael E.
- Goel Anuj
- Golightly Yvonne M.
- Gonzalez-Villalpando Clicerio
- Gordon Scott D.
- Gordon-Larsen Penny
- Gorski Mathias
- Graff Marielisa
- Graham Sarah E.
- Grallert Harald
- Grant Struan F. A.
- Grarup Niels
- Griffiths Lyn
- Grove Jakob
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Haiman Christopher
- Hakonarson Hakon
- Hansen Thomas
- Hansen Torben
- Hartman Catharina A.
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon J.
- Hayward Caroline
- He Jing
- Heard-Costa Nancy
- Hebbar Prashantha
- Heckbert Susan R.
- Heid Iris M.
- Heng Chew-Kiat
- Hengstenberg Christian
- Hewitt Alex W.
- Highland Heather H.
- Hindy George
- Hirschhorn Joel N.
- Hishigaki Haretsugu
- Ho Yuk-Lam A.
- Hofer Edith
- Holliday Elizabeth
- Horn Katrin
- Hornsby Whitney E.
- Hottenga Jouke-Jan
- Hoyng Carel B.
- Huang Hongyan
- Huang Jie
- Huang Paul L.
- Huang Wei
- Huerta-Chagoya Alicia
- Huffman Jennifer E.
- Hung Yi-Jen
- Hunt Steven C.
- Huo Shaofeng
- Hveem Kristian
- Hwang Mi Yeong
- Hyppönen Elina
- Iacono William G.
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D.
- Ikram M. Arfan
- Isasi Carmen R.
- Isono Masato
- Jackson Anne U.
- Jackson Rebecca D.
- Janaka de Silva de
- Jansen Iris E.
- Jarvelin Marjo-Riitta
- Ji Yingjie
- Jiang Yunxuan
- Jin Zi-Bing
- Johansson Ingegerd
- Jonas Jost B.
- Jonsson Anna
- Joshi Peter K.
- Jousilahti Pekka
- Jukema J. Wouter
- Justice Anne E.
- Jäger Susanne
- Jöckel Karl-Heinz
- Jørgensen Torben
- Kalafati Ioanna-Panagiota
- Kamatani Yoichiro
- Kanai Masahiro
- Kang Kui Dong
- Kanoni Stavroula
- Kaprio Jaakko
- Karaderi Tugce
- Kardia Sharon L. R.
- Karpe Fredrik
- Kasturiratne Anuradhani
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kember Rachel L.
- Kentistou Katherine A.
- Kessler Thorsten
- Khera Amit V.
- Khor Chiea Chuen
- Kiemeney Lambertus A. L. M.
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kirchhof Paulus
- Kivimaki Mika
- Kleber Marcus E.
- Knol Maria J.
- Koh Woon-Puay
- Koistinen Heikki A.
- Kolovou Genovefa D.
- Kooner Jaspal S.
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan
- Kraft Peter
- Krauss Ronald M.
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kähönen Mika
- Kårhus Line L.
- Köttgen Anna
- Laakso Markku
- Lange Leslie A.
- Langenberg Claudia
- Launer Lenore J.
- Lauzon Marie
- Le Marchand Loic
- Le Marchand Loic
- Le Phuong
- Lea Rodney
- Lee Hyejin
- Lee Jong-Young
- Lee Nanette R.
- Lehtimäki Terho
- Leonard Hampton L.
- Lettre Guillaume
- Li Huaixing
- Li Liming
- Li Shengchao A.
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Honghuang
- Lin Kuang
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lindgren Cecilia M.
- Linneberg Allan
- Liu Ching-Ti
- Liu Jianjun
- Liu Jun
- Liu Xueping
- Lo Ken Sin
- Locke Adam E.
- Loeffler Markus
- Loh Po-Ru
- London Barry
- Long Jirong
- Loos Ruth J. F.
- Lores-Motta Laura
- Luan Jian’an
- Lubitz Steven A.
- Lye Stephen J.
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Lüll Kreete
- Machado Moara
- Mackey David A.
- Magnusson Patrik K. E.
- Mahajan Anubha
- Malden Deborah E.
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marcus Gregory M.
- Marouli Eirini
- Marten Jonathan
- Martin Nicholas G.
- Matsuda Fumihiko
- Mattheisen Manuel
- Mavarani Laven
- McCarthy Mark I.
- McDaid Aaron F.
- McGarrah Robert W.
- McGue Matt
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Medland Sarah E.
- Meidtner Karina
- Melendez Tori L.
- Mellström Dan
- Mercader Josep M.
- Metspalu Andres
- Miao Jenkai
- Milaneschi Yuri
- Miller Jason E.
- Millwood Iona Y.
- Mishra Pashupati P.
- Mitchell Braxton D.
- Mitchell Paul
- Mitchell Ruth E.
- Mohlke Karen L.
- Mook-Kanamori Dennis O.
- Moore Amy
- Morgan Anna
- Morris Andrew D.
- Mucci Lorelei A.
- Mucha Soeren
- Mukamel Ronen E.
- Munroe Patricia B.
- Munz Matthias
- Mägi Reedik
- März Winfried
- Møllehave Line T.
- Nakatochi Masahiro
- Nalls Mike A.
- Nazarian Saman
- Nelson Amanda E.
- Nelson Christopher P.
- Nethander Maria
- Neville Matt J.
- Newton-Cheh Christopher
- Ng Maggie C. Y.
- Nho Chu Won
- Nielsen Aneta A.
- Nielsen Christopher Sivert
- Nolte Ilja M.
- Nongmaithem Suraj S.
- Noordam Raymond
- North Kari E.
- Ntalla Ioanna
- Nutile Teresa
- Nöthen Markus M.
- Ohlsson Claes
- Okada Yukinori
- Oldehinkel Albertine J.
- Orozco Lorena
- O’Donnell Christopher J.
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N. A.
- Pandit Anita
- Parra Esteban J.
- Partida Gabriel Cuellar
- Pattaro Cristian
- Pauper Marc
- Pedersen Oluf
- Pennell Craig E.
- Penninx Brenda W. J. H.
- Perusse Louis
- Peters Annette
- Petersen Eva R. B.
- Petersen Liselotte V.
- Peyser Patricia A.
- Pitkänen Niina
- Polašek Ozren
- Porteous David J.
- Posthuma Danielle
- Poveda Alaitz
- Power Chris
- Pramstaller Peter P.
- Preuss Michael H.
- Province Michael A.
- Pyarajan Saiju
- Pärna Katri
- Qi Qibin
- Qu Jia
- Rader Daniel J.
- Raffield Laura M.
- Raghavan Sridharan
- Raitakari Olli T.
- Rakugi Hiromi
- Ralhan Sarju
- Rallidis Loukianos S.
- Ramirez Julia
- Rao Dabeeru C.
- Rasheed Asif
- Raven Dennis
- Rayner Nigel W.
- Redline Susan
- Reilly Dermot F.
- Reiner Alexander P.
- Rhee Sang Youl
- Ridker Paul M.
- Rienstra Michiel
- Ripatti Samuli
- Ritchie Marylyn D.
- Rivadeneira Fernando
- Riveros Carlos
- Roden Dan M.
- Rohde Rebecca
- Rosendaal Frits Richard
- Rotter Jerome I.
- Rudan Igor
- Ruggiero Daniela
- Ruotsalainen Sanni E.
- Rutters Femke
- Ryan Kathleen A.
- Rüeger Sina
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Sanghera Dharambir K.
- Sattar Naveed
- Saxena Richa
- Schmidt Börge
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B.
- Schunkert Heribert
- Scott Laura J.
- Scott Rodney J.
- Sendamarai Anoop
- Sever Peter
- Shen Botong
- Shi Jingchunzi
- Shin Jae Hun
- Shiroma Eric J.
- Shoemaker M. Benjamin
- Shu Xiao-Ou
- Sidore Carlo
- Sidorenko Julia
- Sim Xueling
- Simonsick Eleanor M.
- Sims Mario
- Singh Jai Rup
- Singleton Andrew B.
- Sinner Moritz F.
- Sitlani Colleen M.
- Slieker Roderick C.
- Smit Roelof A. J.
- Smith Albert V.
- Smith J. Gustav
- Smith Jennifer A.
- Smyth Laura J.
- Snieder Harold
- Southam Lorraine
- Spector Tim D.
- Spracklen Cassandra N.
- Stampfer Meir J.
- Stark Klaus J.
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Strachan David P.
- Sun Liang
- Sun Yan
- Sun Yan V.
- Tabara Yasuharu
- Tai E. Shyong
- Takeuchi Fumihiko
- Tallapragada Divya Sri Priyanka
- Tang Hua
- Tardif Jean-Claude
- Taylor Kent D.
- Tayo Bamidele O.
- Tcheandjieu Catherine
- Terzikhan Natalie
- Tesolin Paola
- Teumer Alexander
- Thanaraj Thangavel A.
- Theusch Elizabeth
- Thompson Deborah J.
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R. H. J.
- Timpson Nicholas J.
- Tremblay Angelo
- Trompet Stella
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Turman Constance
- Tusié-Luna Maria-Teresa
- Tönjes Anke
- Uitterlinden Andre G.
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W.
- van der Most Peter J.
- Van der Velde Nathalie
- van Duijn Cornelia M.
- van Klinken Jan B.
- van Schoor Natasja M.
- van Setten Jessica
- Vedantam Sailaja
- Verma Shefali S.
- Verweij Niek
- Veturi Yogasudha
- Vidal Pedro Marques
- Visscher Peter M.
- Vitart Veronique
- Vollenweider Peter
- Vonk Judith M.
- Vrieze Scott
- Völker Uwe
- Völzke Henry
- Wacher-Rodarte Niels H.
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Lihua
- Wang Ya Xing
- Wang Zhe
- Wareham Nicholas J.
- Warren Helen R.
- Watanabe Richard M.
- Watkins Hugh
- Weir David R.
- Werge Thomas M.
- Wickremasinghe Ananda R.
- Widen Elisabeth
- Wielscher Matthias
- Wiggins Kerri L.
- Wilkens Lynne R.
- Willemsen Gonneke
- Willer Cristen J.
- Willett Walter C.
- Wilson James F.
- Winkler Thomas W.
- Winsvold Bendik K S
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wright Alan F.
- Wu Jer-Yuarn
- Wu Yang
- Wuttke Matthias
- Xia Rui
- Xie Tian
- Xu Huichun
- Yajnik Chittaranjan S.
- Yamamoto Ken
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yengo Loïc
- Yin Xianyong
- Yokota Mitsuhiro
- Young Hannah
- Young Kristin L.
- Yousri Noha A.
- Yu Lei
- Yuan Jian-Min
- Zeggini Eleftheria
- Zemel Babette S.
- Zeng Lingyao
- Zhang Weihua
- Zhang Xinyuan
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiaofeng
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zoledziewska Magdalena
- Zonderman Alan B.
- Zwart John Anker Henrik
- Åsvold Bjørn Olav
- ‘t Hart Leen M.
- Publication venue
- Publication date
- 01/01/2022
- Field of study
A saturated map of common genetic variants associated with human height
- Author
- Abecasis Goncalo R.
- Adair Linda S.
- Adams Hieab H. H.
- Aguilar-Salinas Carlos A.
- Ahluwalia Tarunveer S.
- Akiyama Masato
- Al-Mulla Fahd
- Allison Matthew A.
- Alvarez Marcus
- Andersen Mette K.
- Ani Alireza
- Appadurai Vivek
- Arbeeva Liubov
- Arias Joshua D.
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles L.
- Attia John
- Auton Adam
- Banas Bernhard
- Bandinelli Stefania
- Bartell Eric
- Bennett David A.
- Bergler Tobias
- Berndt Sonja I.
- Bharadwaj Dwaipayan
- Bhaskar Seema
- Bielak Lawrence F.
- Biino Ginevra
- Bin Wei Wen
- Bisgaard Hans
- Boehnke Michael
- Boerwinkle Eric
- Bollepalli Sailalitha
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borja Judith B.
- Bork-Jensen Jette
- Bouchard Claude
- Bowden Donald W.
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Brody Jennifer A.
- Brumpton Ben Michael
- Burgdorf Kristoffer S.
- Buring Julie E.
- Böger Carsten A.
- Bønnelykke Klaus
- Børglum Anders D.
- Cade Brian E.
- Cai Hui
- Cai Qiuyin
- Campbell Archie
- Catamo Eulalia
- Caulfield Mark J.
- Cañadas-Garre Marisa
- Chai Jin-Fang
- Chai Xiaoran
- Chambers John C.
- Chandak Giriraj R.
- Chang Li-Ching
- Chang Yi-Cheng
- Chanock Stephen
- Chanock Stephen J.
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Chien-Hsiun
- Chen Shyh-Huei
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chesi Alessandra
- Cho Yoon Shin
- Choi Seung Hoan
- Christofidou Paraskevi
- Christophersen Ingrid E.
- Chung Ren-Hua
- Ciullo Marina
- Cocca Massimiliano
- Cole John W.
- Collins Francis S.
- Concas Maria Pina
- Cooper Richard S.
- Couture Christian
- Croteau-Chonka Damien
- Cruz Miguel
- Cucca Francesco
- Cuellar-Partida Gabriel
- Cupples L. Adrienne
- Cutler Michael J.
- Damrauer Scott M.
- Danning Rebecca
- Dantoft Thomas M.
- Daw E. Warwick
- de Borst Gert J.
- de Groot Lisette C. P. G. M.
- De Jager Philip L.
- de Kleijn Dominique P. V.
- Dedoussis George V.
- Degenhard Frauke
- Delgado Graciela E.
- Delitala Alessandro
- Deloukas Panos
- Demirkan Ayse
- den Hollander Anneke I.
- Deng Xuan
- Devineni Poornima
- Dietl Alexander
- Dimitriou Maria
- Dimitrov Latchezar
- Dorajoo Rajkumar
- Du Shufa
- Easton Douglas F.
- Ekici Arif B.
- Elders Petra J. M.
- Eliasen Anders U.
- Eliassen A. Heather
- Ellinor Patrick T.
- Elmståhl Sölve
- Engmann Jorgen E.
- Erdmann Jeanette
- Esko Tõnu
- Evans Michele K.
- Fairhurst-Hunter Zammy
- Farmaki Aliki-Eleni
- Fatkin Diane
- Faul Jessica D.
- Feenstra Bjarke
- Feitosa Mary F.
- Fernandez-Lopez Juan-Carlos
- Ferreira Teresa
- Ferrucci Luigi
- Ford Ian
- Forer Lukas
- Fornage Myriam
- Francescatto Margherita
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Freedman Barry I.
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E.
- Gao Yan
- Gao Zishan
- Gasparini Paolo
- Geller Frank
- Giannakopoulou Olga
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Gjesing Anette P.
- Goddard Michael E.
- Goel Anuj
- Golightly Yvonne M.
- Gonzalez-Villalpando Clicerio
- Gordon Scott D.
- Gordon-Larsen Penny
- Gorski Mathias
- Graff Marielisa
- Graham Sarah E.
- Grallert Harald
- Grant Struan F. A.
- Grarup Niels
- Griffiths Lyn
- Grove Jakob
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Haiman Christopher
- Hakonarson Hakon
- Hansen Thomas
- Hansen Torben
- Hartman Catharina A.
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon J.
- Hayward Caroline
- He Jing
- Heard-Costa Nancy
- Hebbar Prashantha
- Heckbert Susan R.
- Heid Iris M.
- Heng Chew-Kiat
- Hengstenberg Christian
- Hewitt Alex W.
- Highland Heather H.
- Hindy George
- Hirschhorn Joel N.
- Hishigaki Haretsugu
- Ho Yuk-Lam A.
- Hofer Edith
- Holliday Elizabeth
- Horn Katrin
- Hornsby Whitney E.
- Hottenga Jouke-Jan
- Hoyng Carel B.
- Huang Hongyan
- Huang Jie
- Huang Paul L.
- Huang Wei
- Huerta-Chagoya Alicia
- Huffman Jennifer E.
- Hung Yi-Jen
- Hunt Steven C.
- Huo Shaofeng
- Hveem Kristian
- Hwang Mi Yeong
- Hyppönen Elina
- Iacono William G.
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D.
- Ikram M. Arfan
- Isasi Carmen R.
- Isono Masato
- Jackson Anne U.
- Jackson Rebecca D.
- Janaka de Silva de
- Jansen Iris E.
- Jarvelin Marjo-Riitta
- Ji Yingjie
- Jiang Yunxuan
- Jin Zi-Bing
- Johansson Ingegerd
- Jonas Jost B.
- Jonsson Anna
- Joshi Peter K.
- Jousilahti Pekka
- Jukema J. Wouter
- Justice Anne E.
- Jäger Susanne
- Jöckel Karl-Heinz
- Jørgensen Torben
- Kalafati Ioanna-Panagiota
- Kamatani Yoichiro
- Kanai Masahiro
- Kang Kui Dong
- Kanoni Stavroula
- Kaprio Jaakko
- Karaderi Tugce
- Kardia Sharon L. R.
- Karpe Fredrik
- Kasturiratne Anuradhani
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kember Rachel L.
- Kentistou Katherine A.
- Kessler Thorsten
- Khera Amit V.
- Khor Chiea Chuen
- Kiemeney Lambertus A. L. M.
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kirchhof Paulus
- Kivimaki Mika
- Kleber Marcus E.
- Knol Maria J.
- Koh Woon-Puay
- Koistinen Heikki A.
- Kolovou Genovefa D.
- Kooner Jaspal S.
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan
- Kraft Peter
- Krauss Ronald M.
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kähönen Mika
- Kårhus Line L.
- Köttgen Anna
- Laakso Markku
- Lange Leslie A.
- Langenberg Claudia
- Launer Lenore J.
- Lauzon Marie
- Le Marchand Loic
- Le Marchand Loic
- Le Phuong
- Lea Rodney
- Lee Hyejin
- Lee Jong-Young
- Lee Nanette R.
- Lehtimäki Terho
- Leonard Hampton L.
- Lettre Guillaume
- Li Huaixing
- Li Liming
- Li Shengchao A.
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Honghuang
- Lin Kuang
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lindgren Cecilia M.
- Linneberg Allan
- Liu Ching-Ti
- Liu Jianjun
- Liu Jun
- Liu Xueping
- Lo Ken Sin
- Locke Adam E.
- Loeffler Markus
- Loh Po-Ru
- London Barry
- Long Jirong
- Loos Ruth J. F.
- Lores-Motta Laura
- Luan Jian’an
- Lubitz Steven A.
- Lye Stephen J.
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Lüll Kreete
- Machado Moara
- Mackey David A.
- Magnusson Patrik K. E.
- Mahajan Anubha
- Malden Deborah E.
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marcus Gregory M.
- Marouli Eirini
- Marten Jonathan
- Martin Nicholas G.
- Matsuda Fumihiko
- Mattheisen Manuel
- Mavarani Laven
- McCarthy Mark I.
- McDaid Aaron F.
- McGarrah Robert W.
- McGue Matt
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Medland Sarah E.
- Meidtner Karina
- Melendez Tori L.
- Mellström Dan
- Mercader Josep M.
- Metspalu Andres
- Miao Jenkai
- Milaneschi Yuri
- Miller Jason E.
- Millwood Iona Y.
- Mishra Pashupati P.
- Mitchell Braxton D.
- Mitchell Paul
- Mitchell Ruth E.
- Mohlke Karen L.
- Mook-Kanamori Dennis O.
- Moore Amy
- Morgan Anna
- Morris Andrew D.
- Mucci Lorelei A.
- Mucha Soeren
- Mukamel Ronen E.
- Munroe Patricia B.
- Munz Matthias
- Mägi Reedik
- März Winfried
- Møllehave Line T.
- Nakatochi Masahiro
- Nalls Mike A.
- Nazarian Saman
- Nelson Amanda E.
- Nelson Christopher P.
- Nethander Maria
- Neville Matt J.
- Newton-Cheh Christopher
- Ng Maggie C. Y.
- Nho Chu Won
- Nielsen Aneta A.
- Nielsen Christopher Sivert
- Nolte Ilja M.
- Nongmaithem Suraj S.
- Noordam Raymond
- North Kari E.
- Ntalla Ioanna
- Nutile Teresa
- Nöthen Markus M.
- Ohlsson Claes
- Okada Yukinori
- Oldehinkel Albertine J.
- Orozco Lorena
- O’Donnell Christopher J.
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N. A.
- Pandit Anita
- Parra Esteban J.
- Partida Gabriel Cuellar
- Pattaro Cristian
- Pauper Marc
- Pedersen Oluf
- Pennell Craig E.
- Penninx Brenda W. J. H.
- Perusse Louis
- Peters Annette
- Petersen Eva R. B.
- Petersen Liselotte V.
- Peyser Patricia A.
- Pitkänen Niina
- Polašek Ozren
- Porteous David J.
- Posthuma Danielle
- Poveda Alaitz
- Power Chris
- Pramstaller Peter P.
- Preuss Michael H.
- Province Michael A.
- Pyarajan Saiju
- Pärna Katri
- Qi Qibin
- Qu Jia
- Rader Daniel J.
- Raffield Laura M.
- Raghavan Sridharan
- Raitakari Olli T.
- Rakugi Hiromi
- Ralhan Sarju
- Rallidis Loukianos S.
- Ramirez Julia
- Rao Dabeeru C.
- Rasheed Asif
- Raven Dennis
- Rayner Nigel W.
- Redline Susan
- Reilly Dermot F.
- Reiner Alexander P.
- Rhee Sang Youl
- Ridker Paul M.
- Rienstra Michiel
- Ripatti Samuli
- Ritchie Marylyn D.
- Rivadeneira Fernando
- Riveros Carlos
- Roden Dan M.
- Rohde Rebecca
- Rosendaal Frits Richard
- Rotter Jerome I.
- Rudan Igor
- Ruggiero Daniela
- Ruotsalainen Sanni E.
- Rutters Femke
- Ryan Kathleen A.
- Rüeger Sina
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Sanghera Dharambir K.
- Sattar Naveed
- Saxena Richa
- Schmidt Börge
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B.
- Schunkert Heribert
- Scott Laura J.
- Scott Rodney J.
- Sendamarai Anoop
- Sever Peter
- Shen Botong
- Shi Jingchunzi
- Shin Jae Hun
- Shiroma Eric J.
- Shoemaker M. Benjamin
- Shu Xiao-Ou
- Sidore Carlo
- Sidorenko Julia
- Sim Xueling
- Simonsick Eleanor M.
- Sims Mario
- Singh Jai Rup
- Singleton Andrew B.
- Sinner Moritz F.
- Sitlani Colleen M.
- Slieker Roderick C.
- Smit Roelof A. J.
- Smith Albert V.
- Smith J. Gustav
- Smith Jennifer A.
- Smyth Laura J.
- Snieder Harold
- Southam Lorraine
- Spector Tim D.
- Spracklen Cassandra N.
- Stampfer Meir J.
- Stark Klaus J.
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Strachan David P.
- Sun Liang
- Sun Yan
- Sun Yan V.
- Tabara Yasuharu
- Tai E. Shyong
- Takeuchi Fumihiko
- Tallapragada Divya Sri Priyanka
- Tang Hua
- Tardif Jean-Claude
- Taylor Kent D.
- Tayo Bamidele O.
- Tcheandjieu Catherine
- Terzikhan Natalie
- Tesolin Paola
- Teumer Alexander
- Thanaraj Thangavel A.
- Theusch Elizabeth
- Thompson Deborah J.
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R. H. J.
- Timpson Nicholas J.
- Tremblay Angelo
- Trompet Stella
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Turman Constance
- Tusié-Luna Maria-Teresa
- Tönjes Anke
- Uitterlinden Andre G.
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W.
- van der Most Peter J.
- Van der Velde Nathalie
- van Duijn Cornelia M.
- van Klinken Jan B.
- van Schoor Natasja M.
- van Setten Jessica
- Vedantam Sailaja
- Verma Shefali S.
- Verweij Niek
- Veturi Yogasudha
- Vidal Pedro Marques
- Visscher Peter M.
- Vitart Veronique
- Vollenweider Peter
- Vonk Judith M.
- Vrieze Scott
- Völker Uwe
- Völzke Henry
- Wacher-Rodarte Niels H.
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Lihua
- Wang Ya Xing
- Wang Zhe
- Wareham Nicholas J.
- Warren Helen R.
- Watanabe Richard M.
- Watkins Hugh
- Weir David R.
- Werge Thomas M.
- Wickremasinghe Ananda R.
- Widen Elisabeth
- Wielscher Matthias
- Wiggins Kerri L.
- Wilkens Lynne R.
- Willemsen Gonneke
- Willer Cristen J.
- Willett Walter C.
- Wilson James F.
- Winkler Thomas W.
- Winsvold Bendik K S
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wright Alan F.
- Wu Jer-Yuarn
- Wu Yang
- Wuttke Matthias
- Xia Rui
- Xie Tian
- Xu Huichun
- Yajnik Chittaranjan S.
- Yamamoto Ken
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yengo Loïc
- Yin Xianyong
- Yokota Mitsuhiro
- Young Hannah
- Young Kristin L.
- Yousri Noha A.
- Yu Lei
- Yuan Jian-Min
- Zeggini Eleftheria
- Zemel Babette S.
- Zeng Lingyao
- Zhang Weihua
- Zhang Xinyuan
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiaofeng
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zoledziewska Magdalena
- Zonderman Alan B.
- Zwart John Anker Henrik
- Åsvold Bjørn Olav
- ‘t Hart Leen M.
- Publication venue
- 'The Nature Conservancy'
- Publication date
- 01/01/2022
- Field of study
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel2) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10–20% (14–24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries
A saturated map of common genetic variants associated with human height.
- Author
- 't Hart Leen M
- 23andMe Research Team
- Abecasis Goncalo R
- Adair Linda S
- Adams Hieab HH
- Aguilar-Salinas Carlos A
- Ahluwalia Tarunveer S
- Akiyama Masato
- Al-Mulla Fahd
- Allison Matthew A
- Alvarez Marcus
- Andersen Mette K
- Ani Alireza
- Appadurai Vivek
- Arbeeva Liubov
- Arias Joshua D
- Arnett Donna K
- Asselbergs Folkert W
- Assimes Themistocles L
- Attia John
- Auton Adam
- Banas Bernhard
- Bandinelli Stefania
- Bartell Eric
- Bennett David A
- Bergler Tobias
- Berndt Sonja I
- Bharadwaj Dwaipayan
- Bhaskar Seema
- Bielak Lawrence F
- Biino Ginevra
- Bin Wei Wen
- Bisgaard Hans
- Boehnke Michael
- Boerwinkle Eric
- Bollepalli Sailalitha
- Bonnycastle Lori L
- Boomsma Dorret I
- Borja Judith B
- Bork-Jensen Jette
- Bouchard Claude
- Bowden Donald W
- Bradfield Jonathan P
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S
- Brody Jennifer A
- Brumpton Ben
- Burgdorf Kristoffer S
- Buring Julie E
- Böger Carsten A
- Bønnelykke Klaus
- Børglum Anders D
- Cade Brian E
- Cai Hui
- Cai Qiuyin
- Campbell Archie
- Catamo Eulalia
- Caulfield Mark J
- Cañadas-Garre Marisa
- Chai Jin-Fang
- Chai Xiaoran
- Chambers John C
- Chandak Giriraj R
- Chang Li-Ching
- Chang Yi-Cheng
- Chanock Stephen J
- Chasman Daniel I
- Chaturvedi Nish
- Chen Chien-Hsiun
- Chen Shyh-Huei
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chesi Alessandra
- Cho Yoon Shin
- Choi Seung Hoan
- Christofidou Paraskevi
- Christophersen Ingrid E
- Chung Ren-Hua
- Ciullo Marina
- Cocca Massimiliano
- Cole John W
- Collins Francis S
- Concas Maria Pina
- Cooper Richard S
- Couture Christian
- Cruz Miguel
- Cucca Francesco
- Cuellar-Partida Gabriel
- Cupples L Adrienne
- Cutler Michael J
- Damrauer Scott M
- Danning Rebecca
- Dantoft Thomas M
- Daw E Warwick
- de Borst Gert J
- de Groot Lisette CPGM
- De Jager Philip L
- de Kleijn Dominique PV
- Dedoussis George V
- Degenhard Frauke
- Delgado Graciela E
- Delitala Alessandro
- Deloukas Panos
- Demirkan Ayse
- den Hollander Anneke I
- Deng Xuan
- Devineni Poornima
- Dietl Alexander
- Dimitriou Maria
- Dimitrov Latchezar
- DiscovEHR (DiscovEHR and MyCode Community Health Initiative)
- Dorajoo Rajkumar
- Du Shufa
- Easton Douglas F
- Ekici Arif B
- Elders Petra JM
- Eliasen Anders U
- Eliassen A Heather
- Ellinor Patrick T
- Elmståhl Sölve
- eMERGE (Electronic Medical Records and Genomics Network)
- Engmann Jorgen E
- Erdmann Jeanette
- Esko Tõnu
- Evans Michele K
- Fairhurst-Hunter Zammy
- Farmaki Aliki-Eleni
- Fatkin Diane
- Faul Jessica D
- Feenstra Bjarke
- Feitosa Mary F
- Fernandez-Lopez Juan-Carlos
- Ferreira Teresa
- Ferrucci Luigi
- Ford Ian
- Forer Lukas
- Fornage Myriam
- Francescatto Margherita
- Franke Andre
- Franks Paul W
- Frayling Timothy M
- Freedman Barry I
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E
- Gao Yan
- Gao Zishan
- Gasparini Paolo
- Geller Frank
- Giannakopoulou Olga
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Gjesing Anette P
- Goddard Michael E
- Goel Anuj
- Golightly Yvonne M
- Gonzalez-Villalpando Clicerio
- Gordon Scott D
- Gordon-Larsen Penny
- Gorski Mathias
- Graff Marielisa
- Graham Sarah E
- Grallert Harald
- Grant Struan FA
- Grarup Niels
- Griffiths Lyn
- Grove Jakob
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Haiman Christopher
- Hakonarson Hakon
- Hansen Thomas F
- Hansen Torben
- Hartman Catharina A
- Hattersley Andrew T
- Havulinna Aki S
- Haworth Simon J
- Hayward Caroline
- He Jing
- Heard-Costa Nancy
- Hebbar Prashantha
- Heckbert Susan R
- Heid Iris M
- Heng Chew-Kiat
- Hengstenberg Christian
- Hewitt Alex W
- Highland Heather H
- Hindy George
- Hirschhorn Joel N
- Hishigaki Haretsugu
- Ho Yuk-Lam A
- Hofer Edith
- Holliday Elizabeth
- Horn Katrin
- Hornsby Whitney E
- Hottenga Jouke-Jan
- Hoyng Carel B
- Huang Hongyan
- Huang Jie
- Huang Paul L
- Huang Wei
- Huerta-Chagoya Alicia
- Huffman Jennifer E
- Hung Yi-Jen
- Hunt Steven C
- Huo Shaofeng
- Hveem Kristian
- Hwang Mi Yeong
- Hyppönen Elina
- Iacono William G
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D
- Ikram M Arfan
- Isasi Carmen R
- Isono Masato
- Jackson Anne U
- Jackson Rebecca D
- Janaka de Silva H
- Jansen Iris E
- Jarvelin Marjo-Riitta
- Ji Yingjie
- Jiang Yunxuan
- Jin Zi-Bing
- Johansson Ingegerd
- Jonas Jost B
- Jonsson Anna
- Joshi Peter K
- Jousilahti Pekka
- Jukema J Wouter
- Justice Anne E
- Jäger Susanne
- Jöckel Karl-Heinz
- Jørgensen Torben
- Kalafati Ioanna-Panagiota
- Kamatani Yoichiro
- Kanai Masahiro
- Kang Kui Dong
- Kanoni Stavroula
- Kaprio Jaakko
- Karaderi Tugce
- Kardia Sharon LR
- Karpe Fredrik
- Kasturiratne Anuradhani
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kember Rachel L
- Kentistou Katherine A
- Kessler Thorsten
- Khera Amit V
- Khor Chiea Chuen
- Kiemeney Lambertus ALM
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kirchhof Paulus
- Kivimaki Mika
- Kleber Marcus E
- Knol Maria J
- Koh Woon-Puay
- Koistinen Heikki A
- Kolovou Genovefa D
- Kooner Jaspal S
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan
- Kraft Peter
- Krauss Ronald M
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kähönen Mika
- Kårhus Line L
- Köttgen Anna
- Laakso Markku
- Lange Leslie A
- Langenberg Claudia
- Launer Lenore J
- Lauzon Marie
- Le Marchand Loic
- Le Phuong
- Lea Rodney
- Lee Hyejin
- Lee Jong-Young
- Lee Nanette R
- Lehtimäki Terho
- Leonard Hampton L
- Lettre Guillaume
- Li Huaixing
- Li Liming
- Li Shengchao A
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lifelines Cohort Study
- Lin Honghuang
- Lin Kuang
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lindgren Cecilia M
- Linneberg Allan
- Liu Ching-Ti
- Liu Jianjun
- Liu Jun
- Liu Xueping
- Lo Ken Sin
- Locke Adam E
- Loeffler Markus
- Loh Po-Ru
- London Barry
- Long Jirong
- Loos Ruth JF
- Lores-Motta Laura
- Luan Jian'an
- Lubitz Steven A
- Lye Stephen J
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Lüll Kreete
- Machado Moara
- Mackey David A
- Magnusson Patrik KE
- Mahajan Anubha
- Malden Deborah E
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marcus Gregory M
- Marouli Eirini
- Marten Jonathan
- Martin Nicholas G
- Matsuda Fumihiko
- Mattheisen Manuel
- Mavarani Laven
- McCarthy Mark I
- McDaid Aaron F
- McGarrah Robert W
- McGue Matt
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Medland Sarah E
- Meidtner Karina
- Melendez Tori L
- Mellström Dan
- Mercader Josep M
- Metspalu Andres
- Miao Jenkai
- Milaneschi Yuri
- Miller Jason E
- Millwood Iona Y
- Mishra Pashupati P
- Mitchell Braxton D
- Mitchell Paul
- Mitchell Ruth E
- Mohlke Karen L
- Mook-Kanamori Dennis O
- Moore Amy
- Morgan Anna
- Morris Andrew D
- Mucci Lorelei A
- Mucha Soeren
- Mukamel Ronen E
- Munroe Patricia B
- Munz Matthias
- Mägi Reedik
- März Winfried
- Møllehave Line T
- Nakatochi Masahiro
- Nalls Mike A
- Nazarian Saman
- Nelson Amanda E
- Nelson Christopher P
- Nethander Maria
- Neville Matt J
- Newton-Cheh Christopher
- Ng Maggie CY
- Nho Chu Won
- Nielsen Aneta A
- Nielsen Christopher S
- Nolte Ilja M
- Nongmaithem Suraj S
- Noordam Raymond
- North Kari E
- Ntalla Ioanna
- Nutile Teresa
- Nöthen Markus M
- O'Donnell Christopher J
- Ohlsson Claes
- Okada Yukinori
- Oldehinkel Albertine J
- Orozco Lorena
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin NA
- Pandit Anita
- Parra Esteban J
- Pattaro Cristian
- Pauper Marc
- Pedersen Oluf
- Pennell Craig E
- Penninx Brenda WJH
- Perusse Louis
- Peters Annette
- Petersen Eva RB
- Petersen Liselotte V
- Peyser Patricia A
- Pitkänen Niina
- Polašek Ozren
- Porteous David J
- Posthuma Danielle
- Poveda Alaitz
- Power Chris
- PRACTICAL Consortium
- Pramstaller Peter P
- Preuss Michael H
- Province Michael A
- Pyarajan Saiju
- Pärna Katri
- Qi Qibin
- Qu Jia
- Rader Daniel J
- Raffield Laura M
- Raghavan Sridharan
- Raitakari Olli T
- Rakugi Hiromi
- Ralhan Sarju
- Rallidis Loukianos S
- Ramirez Julia
- Rao Dabeeru C
- Rasheed Asif
- Raven Dennis
- Rayner Nigel W
- Redline Susan
- Reilly Dermot F
- Reiner Alexander P
- Rhee Sang Youl
- Ridker Paul M
- Rienstra Michiel
- Ripatti Samuli
- Ritchie Marylyn D
- Rivadeneira Fernando
- Riveros Carlos
- Roden Dan M
- Rohde Rebecca
- Rosendaal Frits R
- Rotter Jerome I
- Rudan Igor
- Ruggiero Daniela
- Ruotsalainen Sanni E
- Rutters Femke
- Ryan Kathleen A
- Rüeger Sina
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J
- Sanghera Dharambir K
- Sattar Naveed
- Saxena Richa
- Schmidt Börge
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B
- Schunkert Heribert
- Scott Laura J
- Scott Rodney J
- Sendamarai Anoop
- Sever Peter
- Shen Botong
- Shi Jingchunzi
- Shin Jae Hun
- Shiroma Eric J
- Shoemaker M Benjamin
- Shu Xiao-Ou
- Sidore Carlo
- Sidorenko Julia
- Sim Xueling
- Simonsick Eleanor M
- Sims Mario
- Singh Jai Rup
- Singleton Andrew B
- Sinner Moritz F
- Sitlani Colleen M
- Slieker Roderick C
- Smit Roelof AJ
- Smith Albert V
- Smith J Gustav
- Smith Jennifer A
- Smyth Laura J
- Snieder Harold
- Southam Lorraine
- Spector Tim D
- Spracklen Cassandra N
- Stampfer Meir J
- Stark Klaus J
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Strachan David P
- Sun Liang
- Sun Yan V
- Tabara Yasuharu
- Tai E Shyong
- Takeuchi Fumihiko
- Tallapragada Divya Sri Priyanka
- Tang Hua
- Tardif Jean-Claude
- Taylor Kent D
- Tayo Bamidele O
- Tcheandjieu Catherine
- Terzikhan Natalie
- Tesolin Paola
- Teumer Alexander
- Thanaraj Thangavel A
- Theusch Elizabeth
- Thompson Deborah J
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul RHJ
- Timpson Nicholas J
- Tremblay Angelo
- Trompet Stella
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Turman Constance
- Tusié-Luna Maria-Teresa
- Tönjes Anke
- Uitterlinden Andre G
- Understanding Society Scientific Group
- VA Million Veteran Program
- Vaccargiu Simona
- van Dam Rob M
- van der Harst Pim
- van der Laan Sander W
- van der Most Peter J
- Van der Velde Nathalie
- van Duijn Cornelia M
- van Klinken Jan B
- van Schoor Natasja M
- van Setten Jessica
- Vedantam Sailaja
- Verma Shefali S
- Verweij Niek
- Veturi Yogasudha
- Vidal Pedro Marques
- Visscher Peter M
- Vitart Veronique
- Vollenweider Peter
- Vrieze Scott
- Völker Uwe
- Völzke Henry
- Wacher-Rodarte Niels H
- Walker Mark
- Walters Robin G
- Wang Carol A
- Wang Chaolong
- Wang Lihua
- Wang Ya Xing
- Wang Zhe
- Wareham Nicholas J
- Warren Helen R
- Watanabe Richard M
- Watkins Hugh
- Weir David R
- Werge Thomas M
- Wickremasinghe Ananda R
- Widen Elisabeth
- Wielscher Matthias
- Wiggins Kerri L
- Wilkens Lynne R
- Willemsen Gonneke
- Willer Cristen J
- Willett Walter C
- Wilson James F
- Winkler Thomas W
- Winsvold Bendik S
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R
- Wright Alan F
- Wu Jer-Yuarn
- Wu Yang
- Wuttke Matthias
- Xia Rui
- Xie Tian
- Xu Huichun
- Yajnik Chittaranjan S
- Yamamoto Ken
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yengo Loïc
- Yin Xianyong
- Yokota Mitsuhiro
- Young Hannah
- Young Kristin L
- Yousri Noha A
- Yu Lei
- Yuan Jian-Min
- Zeggini Eleftheria
- Zemel Babette S
- Zeng Lingyao
- Zhang Weihua
- Zhang Xinyuan
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiaofeng
- Zimmermann Martina E
- Zmuda Joseph M
- Zoledziewska Magdalena
- Zonderman Alan B
- Zwart John-Anker
- Åsvold Bjørn Olav
- Publication venue
- Nature
- Publication date
- 01/01/2022
- Field of study
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel2) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries
Evolution over Time of Ventilatory Management and Outcome of Patients with Neurologic Disease∗
- Author
- Abderrahim Azzouzi
- Abroug F.
- Achille Kouatchet
- Achim Lunkeit
- Adam Mikstacki
- Aguilera García
- Ahmed Sbihi
- Ai-Chin Cheng
- Ainhoa Rosselló
- Alain Mercat
- Alan Javier Zazu
- Alberto Belenguer
- Alberto Deicas
- Alberto Marino
- Alberto Soler
- Alejandro Algora
- Alejandro Arroliga
- Alejandro de la Serna
- Alejandro Gómez
- Alejandro Raimondi
- Alejandro Risso
- Alfonso Moreno
- Alfonso Muñoz
- Alfredo Padrón
- Alfredo Vasquez-Sandoval
- Ali Aydım Altunkan
- Ali Zeggwagh A.
- Aline Camile Yehia
- Alistair Nichol
- Allan Walkey
- Allison Bone
- Aloísio Marques do Nascimento
- Alvaro van Bommel
- Amalia Martínez de la Gandara
- Amber Monson
- Ambrogio Sansone
- Amee Patrawalla
- Amin P.
- Amine Ali Zeggwagh
- Amparo Ferrandiz
- Amy Waters
- Ana Carolina Caballero
- Ana Esther Trujillo
- Ana Villagrá
- Anders Aneman
- Andrea Gimenez
- Andrea Matte
- Andrea Neville Cracchiolo
- Andreas Schwartz
- Andreas Viehöfer
- Andrei Piontek
- Andrew Bersten
- Andrew Davies
- Andrew Davies
- Andrew Davies
- Andrew Steel
- Andrey Yaroshetskiy
- Anette Mortensen
- Anitha Shenoy
- Ankur Devendra Bhavsar
- Annunziata Mattei
- Anthony Saleh
- Antonina Pigna
- Antonino Giarratano
- Antonio Anzueto
- Antonio Braschi
- Antonio Corcione
- Antonio García-Jiménez
- Antonio Maestre
- Antonio Pesenti
- Antonio Raso
- Antonio Reyes
- Antonio Villa Delgado
- Antonio Viñuales
- Anzueto A.
- Arianna Boggero
- Ariel Chena
- Armando Pedulla'
- Arnaud W Thille
- Ashley Ellis
- Ashley Ellis
- Asisclo J Villagómez Ortiz
- Auke Reidinga
- Ayed Samia
- Barbara Tamowicz
- Barrios D.
- Bas M Kors
- Begoña Balerdi
- Benoit Veber
- Bernabé Álvarez
- Bersten A.
- Bert Beishuizen
- Besbes Mohamed
- Bilge Çetin
- Bin Du
- Bin Du
- Bin Yu
- Bing Sun
- Birgitte Viebaek
- Bladimir Alejandro Gil
- Bo Broberg
- Bo Wang
- Boris Villamagua
- Brian Sherman
- Bruno Bonaccorsi Fernandino
- Bruno do Valle Pinheiro
- Bryan Beatty
- C Canevet
- Cakar N.
- Cameron Knott
- Camilo Pizarro
- Carlo Alberto Acosta
- Carlos Alberto Studart Gomes
- Carlos André Correia Casado
- Carlos Andrés Díaz
- Carlos Gallego
- Carlos Marian Crespo
- Carlos Robles-Arias
- Carmelo Dueñas
- Carmen Campos
- Carolina Gímenez-Esparza
- Carolina Lorencio
- Cartan Costello
- Catherine Simmonds
- Cayce Strength
- Cayetano Galetti
- Cecilia Carbayo
- Cecilia Hermosa
- Cecilia Pereyra
- Cesar Enciso
- Cezar Mihailescu
- Chabu Coronado
- Chafrina Marie Olay
- Chang Liu
- Chantal Hogan
- Charki Haimeur
- Chau Chin Man
- Chen Chin-Ming
- Chengmin Yu
- Cheromi Sittambalam
- Cheryl Cuzner
- Cheryl Ethier
- Chiara Verga
- Christian Frenkel
- Christian Putensen
- Christopher MacIsaac
- Christopher Spradley
- Chuanyun Qian
- Claire Cattigan
- Claire Reynolds
- Clara Laplaza Eva Regidor
- Clara Pacheco
- Claudia Diaz
- Claudia Olvera-Guzman
- Craig A Piquette
- Craig Cernosek
- Crissie De Spirito
- Crissie Despirito
- Cristian Casabella
- Cristian Cevallos
- Cristina Orlandi
- Cristina Santos
- César Antonio Maquilon
- César Aragón
- César Cruz Lozano
- César Pérez-Calvo
- Damian Violi
- Dana K Soetaert
- Daniel Duarte
- Daniel Fontaneda
- Daniel Vargas
- Daniel Weiss
- David Freire
- David Milliss
- Davide Chiumello
- Daxing Yu
- Debiao Song
- Deborah Barge
- Deborah Cook
- Deepak Govil
- Del-Sorbo L.
- Denice Wells
- Dennis Bergmans
- Dhruva Chaudhry
- Di Russo
- Diane Mackle
- Dianne Hill
- Dianne Stephens
- Dietrich Henzler
- Dimitros Matamis
- Dimple Tejwani
- Dinalva Aparecida Gomes
- Do Danh Quynh
- Dolores Vila
- Dongpo Jiang
- Dorothée Carpentier
- Du B.
- Edgard Luna
- Edgardo E Tabhan
- Edgardo Nuñez
- Edoardo De Robertis
- Eduard Bootsma
- Eduardo Almeida
- Eduardo Fonseca Sad
- Edward Nicolayenko
- Eileen Gilder
- Elena Gallego
- Elena Parreño
- Eleni Antoniadou
- Elias Caragna
- Elisa Estenssoro
- Elisha Fulton
- Elisha Matheson
- Ellen Kinkel
- Emily Stern
- Enrique Maraví
- Enrique Piacentini
- Erika Mannelli
- Erin Braden
- Erna Alberts
- Erwin J Oei
- Esteban A
- Eugenio Palazón
- Eva Benveniste
- Eva Manteiga
- Fabien Grelon
- Fabien Soulis
- Fabricio Picoita
- Fachun Zhou
- Falk Hildebrandt
- Fang Xu
- Farhad N Kapadia
- Fausto Fialho Moura
- Federica Antonicelli
- Federica Tallarini
- Federico Gordo
- Fekri Abroug
- Feng Li
- Fernando Antônio Botoni
- Fernando Fernández
- Fernando Lambert
- Fernando Lipovestky
- Fernando Pérez
- Fernando Ríos
- Fernando Saldarini
- Fernando Sánchez
- Fernando Villarejo
- Fernando Villarejo
- Filomena Faria
- Forbes McGain
- Francesca Frigieri
- Francesco Idone
- Francesco Mojoli
- Francisco Criado
- Francisco Guerrero
- Francisco Lucena
- Francisco Manzano
- Francisco Molina
- Francisco Ortuño
- Frank Torres
- Franklin Villegas
- François Collet
- Freddy Sandy
- Freddy Sánchez
- Frederico Costa Val Barros
- Frederico Rodrigues Anselmo
- Frutos-Vivar F.
- Frédéric Bellec
- Félix Lacoma
- Gabriel D Empaire
- Gaetano Perchiazzi
- Gang Li
- Gary Kinasewitz
- Gary Kinasewitz
- Gastón Pittini
- Gaëtan Bedunaeu
- Gee Young Suh
- Gemma Rialp
- Geneva Tatem
- Geng Zhang
- Genis Carrasco
- George Liziamma
- George Lukas
- Gerardo Filippa
- Gilda Diaz-Fuentes
- Gina Quinde
- Giorgia Citterio
- Giorgio Tulli
- Gonzalez M.
- Gonzalo Javier Ríos
- Graciela Elizabeth
- Graciela Franca
- Graeme Duke
- Gregory A Schmidt
- Guillaume Marcotte
- Guillermo Chiappero
- Guillermo Cueto Robledo
- Guillermo Falconí
- Guillermo Muñiz
- Guillermo Ortiz
- Gustavo Badariotti
- Gustavo Jannello
- Gustavo Morales Muñoz
- Gustavo Paredes
- Géraldine Dessertaine
- Haibo Qiu
- Hannah Mathers
- Hans-Henrik Bülow
- Harald Fritz
- Harry P P M Gelissen
- Heinrich Paulus
- Heinz Kerger
- Helen Rodgers
- Helen Wong
- Heloisa Castro
- Henry Caballero
- Hergen Buscher
- Hernan Nunia
- Hernán Nuñez
- Hong Pu
- Hongyang Xu
- Hongyuan Lin
- Howard Connor
- Hugo Capponcelli
- Hugo Urbano
- Hye Sook Choi
- Ian Carrasco
- Ian Moore
- Ian Seppelt
- Ilaria Curro'
- Ilaria Maria Mastromauro
- Imed Chouchene
- Imogen Mitchell
- Ingrid van den Hul
- Ingrid Von der Osten
- Inmaculada Vallverdú
- Irene Aragão
- Irene Dot
- Irene Watpool
- Islem Ouanes
- Ismail Kati
- Itziar Mintegui
- Ivano Aprile
- Jacinto Baena
- Jackeline Coello
- Jan Dittmann
- Jan Friedrich
- Jan Mehrtens
- Jane Thomas
- Janine Dias Alves
- Jasmin Board
- Jasmin Board
- Jasmin Board
- Jason Fletcher
- Javier Blanco
- Javier Castañeda
- Javier Cebrián
- Javier Díaz Domínguez
- Javier García-Alonso
- Javier González-Robledo
- Javier Horacio Álvarez
- Javier Hurtado
- Javier Ladape Martinez
- Javier Ruiz
- Je Hyeong Kim
- Jean-Christophe M Richard
- Jeff Presneill
- Jeffrey Singh
- Jennifer Germain
- Jennifer Goodson
- Jennifer Holmes
- Jennifer Twombley
- Jenny Dennett
- Jens Brushoj
- Jens Buettner
- Jesús Sánchez
- Jesús Sánchez-Ruiz
- Jian Huang
- Jianbiao Meng
- Jianguo Li
- Jianhong Fu
- Jianying Guo
- Jiaqiong Li
- Jibaja M.
- Jin Hwa Lee
- Jin Young An
- Jinghua Wang
- Jiuzhi Zhang
- Joachim Hartung
- Joan Maria Raurich
- Joana Silvestre
- Joanne Sutton
- Jodi Brown
- Johannes Busch
- John Durning
- John Myburgh
- John Oropell
- John Santamaria
- Jorge Arroyo
- Jorge Gerez
- Jorge Vidal Hernández
- Jorgelina Guyon
- Jose Angel Baltazar Torres
- Josep Maria Sirvent
- José Carlos Versiani
- José Claudio Leo
- José Elizalde
- José Francisco López Baca
- José J Blanco
- José Luis Scapellato
- José Manuel Serrano
- José María Gutiérrez
- José María Montón
- José María Nicolás
- José María Quiroga
- José Miguel Guerrero
- José Salinas
- José Salvador Martínez Cano
- Joyce Okahashi
- Juan Carlos
- Juan Carlos Maurelia
- Juan David Uribe
- Juan Diego Jiménez
- Juan Domingo Fernández
- Juan Guerra
- Juan Pablo Sedano
- Juan Ramón Cortés
- Juanxian Gu
- Judi Tai
- Judith Sagardía
- Julia López-Díaz
- Julian Strati
- Julie Smith
- Julio Osorio
- Julio Pontet
- Julián Hernández
- Jun Jin
- Jörg Haberkorn
- Jörn Schlechtweg
- Karina Bonasegla
- Katherine Davidson
- Kathleen Lilli
- Katty Trelles
- Kelly Choy
- Kerry Canady
- Ki-Suck Jung
- Kim Heus
- Konstantinos Raymondos
- Kwan Ming Chit
- Kyung Chan Kim
- Larry Welder
- Laura Jones
- Laura Sayagues
- Laura Wilson
- Laura Álvarez-Montero
- Lauralyn McIntryre
- Laurent Brochard
- Leanne Boehm
- Lei Chen
- Leila Eckholt
- Leonardo Pazmiño
- Leonie Weisbrodt
- Leticia Rapetti
- Liang Pan
- Lidón Mateu
- Liliana Caipe
- Lisa Julien
- Lisandro Betttini
- Loredana Pitagora
- Lori-Ann Kozikowski
- Lucas Vallejo
- Lucia Capilla
- Luis Fernando Castro Castro
- Luis Gonzalez Mosquera
- Luis González Zambrano
- Luis Marina
- Luis Pablo Cardonnet
- Luis Soto-Germani
- Luis Soto-Román
- Luis Williams
- Lutz Pfeiffer
- Lynette Newby
- M Eugenia
- Madhav Gudi
- Madison Dennis
- Maggiore S. M.
- Manoj K Saxena
- Manuel Jibaja
- Manuel Valledor
- Maoqin Li
- Mar Gobernado
- Marc Fabra
- Marc Lipkus
- Marcela Canola-Mazo
- Marcela Granados
- Marcelo Alcântara Holanda
- Marcelo Choque
- Marcelo Ochoa
- Marcelo Palavecino
- Marco Adversi
- Marco Antônio Ribeiro Leão
- Marco Antônio Soares Reis
- Marco Bezzi
- Marco Escobar
- Marco Gonzalez
- Marco González
- Marco Montes De Oca
- Marcos Delgado
- Marcos Juan Zec
- Marcus Ruecker
- Maria Aparecida Braga
- Maria Del Mar Torres-Perez
- Maria Giannakou
- Maria Wussow
- Mariana Monllau
- Marianna Esposito
- Marin M. D. C.
- Marina Busico
- Mario Acosta
- Mario Alonso Treviño Salinas
- Mario Cancela
- Mario Gómez
- Mario Villabon
- Marisol Rodríguez-Goñi
- Mark Bailey
- Mark Tidswell
- Markus Schappacher
- Marta Beron
- Marta Ferrari
- Marta Ugalde
- Martin Deheza
- Martín Lugaro
- Mary La Pine
- María Belén Yapur
- María Del Carmen de la Torre
- María Elena Pérez-Losada
- María Eugenia González
- María Fernanda García
- María Garitacelaya
- María Isabel Ruiz
- María José Tolón
- María Luisa Navarrete
- María Victoria de la Torre
- María Ángeles Alonso
- María Ángeles Pena
- Matamis D.
- Matthew Kirchner
- Matty Koopmans
- Matías Brizuela
- Mauricio Vinzio
- Maurizio Bottiroli
- Maurizio Raineri Santi
- Maurício Meireles Góes
- Maximillian Ragaller
- Mayur Patel
- Medhat Soliman
- Mehar-Un-Nisa Raja
- Mian Chen
- Michael A Kuiper
- Michael Miletin
- Michael Quintel
- Michela Bombino
- Michele Iannuzzi
- Miguel Fernández-Vivas
- Miguel Lazcano
- Miguel León
- Miguel Llano
- Miguel Ángel González-Gallego
- Mijail Játiva
- Mikhail Kirov
- Mikkel Præst
- Minka Springham
- Miquel Ferrer
- Mirko Belliato
- Mohamed A Saad
- Mohammed Al-Jagbeer
- Monica Rocco
- Monika Holler
- Moo Suk Park
- Mounir Bouaziz
- Mourad Amor
- Muriel A.
- Myriam Montalvo
- Myung-Goo Lee
- Nagarajan Ramakrishnan
- Nahit Cakar
- Neill Adhikari
- Nelson Barros
- Nelson Fonseca
- Nelson Medina
- Nghuyen Ba Tuan
- Nguyen Huu Hoang
- Niall Ferguson
- Nicolas Nin
- Nicole Marinoff
- Nicolás Zamboschi
- Nieves Franco
- Nils Marquardt
- Nin N.
- Norberto Tiribelli
- Norberto Tiribelli
- Norma Beatriz Márquez
- Nuria Alonso
- Oliver Franke
- Olivia Dulfo
- Orla Smith
- Oscar Cluzet
- P Kruska
- P Samaddar
- Pablo Desmery
- Pablo Gómez
- Pang Wing Yan
- Paolo Navalesi
- Pascal Beuret
- Pascual Valdez
- Patricia Albert
- Patricia Jimeno
- Patricia Leung
- Patricia Vogl
- Paul Goldrick
- Paul J Dennesen
- Paul Young
- Paulo Marcal
- Pedro Alzugaray
- Pedro Galdos
- Pedro Jesús Domínguez
- Pedro Rosa
- Pelosi P.
- Penuelas O.
- Pertsas Evangelos
- Peter van der Voort
- Pham Thi Van Anh
- Phil Alkana
- Philippe Berger
- Pierre-Gildas Guitard
- Prachee Sathe
- Pravin Amin
- Priya Nair
- Qing Song
- Qingyuan Zhan
- Qunmei Yao
- Rachael Parke
- Rachel Whyte
- Rafael Blancas
- Rafael Morales
- Rahul Nanchal
- Raju Pusapati
- Ramiro Puetate
- Raquel Manzanedo
- Raquel Montoiro
- Raquel Yano
- Raymondos K.
- Raúl de Pablo
- Raúl González
- Raúl Lombardi
- Remzi Iscimen
- Ricardo Buitrago
- Ricardo Martinez Zubieta
- Ricardo Matos
- Rick McAllister
- Rios F.
- Robba C.
- Robert Fowler
- Robyn Klages
- Rodrigo E Gómez-Paz
- Roger Lamoglie
- Rogério de Castro Pereira
- Roland Schneider
- Rolf Dembinski
- Rolf Rossaint
- Rollin Roldán Mori
- Romano Tetamo
- Román Garrido
- Ronald Pairumani
- Ronnie Mantilla
- Rosa Luz López Martínez
- Rosa Sebastián
- Rosa Álvaro
- Rosalba Tufano
- Rosanna Del Giudice
- Rosanna Vaschetto
- Rosario Urbino
- Rovílson Lara
- Rovílson Lara
- Rubens Altair Amaral de Pádua
- Rubén Camargo
- Rui Moreno
- Rupesh Vakil
- Ryan Albert
- Sabriye Guvenc
- Salem Ould Zein
- Salvatore Maurizio Maggiore
- Samer Haj-Bakri
- Samir Abdelhadi
- Samir Sahu
- Samir Vermani
- Sando Chavarria
- Sangeeta Mehta
- Sanjay Dhanuka
- Santiago Ilutovich
- Sara Cabañes
- Schimdt Alejandra
- Sebastian Circo
- Sebastián E Mare
- Serena Azzari
- Serge Heines
- Sergio Cáceres
- Sergio Lasdica
- Seton Henderson
- Shawna Reddie
- Sheila Nainan Myatra
- Shelby Sutton
- Sheree Gare
- Shirley Nelson
- Shouhong Wang
- Silke Frenzel
- Silvia Mareque
- Silvina Borello
- Silvio A Ñamendys-Silva
- Simon J G Hockley
- Simona Beniczky
- Sindhaghatta Venkatram
- Sine Wichman
- Smyth Smith
- Soares M. A.
- Sofía García
- Soraya Puertas
- Srinivas Samavedam
- Stambouli Neji
- Steffen Appel
- Steffen Weber-Carstens
- Stephanie Lubchansky
- Stephen Lapinsky
- Steven Y Chang
- Stevens Salva
- Subhash Kumar Todi
- Sujoy Mukherjee
- Susan Gillen
- Susana Alves Ferreira
- Susana Moradillo
- Susana Temprano
- Susanne Andi Iversen
- Sutherasan Y.
- Sutrisno Gunawan
- Sylvia den Boer
- Tania Caf
- Tarek Dendane
- Tayfun Adanir
- Tejerina E. E.
- Teresa Mut
- Teresa Sánchez de Dios
- Thille A. W.
- Thomas Bein
- Thomas Lipp
- Thomas Moellhoff
- Thomas Steinke
- Thoralf Kerner
- Tiehe Qin
- Tim Coles
- Tim Houlihan
- Timothy D Girard
- Tom Cowlam
- Tony Sutherland
- Tony Williams
- Travis Parry
- Troy Browne
- Tumbass Volker
- Uli Strauch
- Umesh G
- Unase Büyükkoçak
- V J Cardenas Jr
- Valentín Parra
- Valerio Mangani
- Valery Subbotin
- Valle Pinheiro B.
- Valéria de Carvalho Magela
- Vanesa Ramírez
- Vicente Arraez
- Victoria Goñi
- Vincent John Scott
- Vito Marco Ranieri
- Vivek Joshi
- Wajdi Maazouzi
- Walter Brandt
- Walter Seyde
- Wanxia Li
- Wei He
- Wei Yu
- Wei Zhang
- Weihai Yao
- William Rodriguez-Cintron
- Winfried Schubert
- Wolfgang Baier
- Won-Yeon Lee
- Xi Zhu
- Xianyao Wan
- Xiaobo Huang
- Xue Wang
- Yalin Liu
- Yan Kang
- Yangong Chao
- Yaseen Arabi
- Yi Li
- Yi Yang
- Yogeet Kaur
- Yongjie Yin
- Young Suh G.
- Younsuck Koh
- Yu Bai
- Yuan Xu
- Yuhong Guo
- Yun Seong Kim
- Yunxuan Yue
- Zafer Dogan
- Zalatiel Maycotte Luna
- Zaza Cohen
- Zhengxuan Lv
- Zhenjie Hu
- Zhenyang He
- Zhicheng Zhang
- Zhihua Hu
- Zhixiang Li
- Zoltan Szentkereszty
- Zoraida Parra
- Zsolt Molnar
- Ángela Alonso
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/11/2021
- Field of study
OBJECTIVES: To describe the changes in ventilator management over time in patients with neurologic disease at ICU admission and to estimate factors associated with 28-day hospital mortality. DESIGN: Secondary analysis of three prospective, observational, multicenter studies. SETTING: Cohort studies conducted in 2004, 2010, and 2016. PATIENTS: Adult patients who received mechanical ventilation for more than 12 hours. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Among the 20,929 patients enrolled, we included 4,152 (20%) mechanically ventilated patients due to different neurologic diseases. Hemorrhagic stroke and brain trauma were the most common pathologies associated with the need for mechanical ventilation. Although volume-cycled ventilation remained the preferred ventilation mode, there was a significant (p < 0.001) increment in the use of pressure support ventilation. The proportion of patients receiving a protective lung ventilation strategy was increased over time: 47% in 2004, 63% in 2010, and 65% in 2016 (p < 0.001), as well as the duration of protective ventilation strategies: 406 days per 1,000 mechanical ventilation days in 2004, 523 days per 1,000 mechanical ventilation days in 2010, and 585 days per 1,000 mechanical ventilation days in 2016 (p < 0.001). There were no differences in the length of stay in the ICU, mortality in the ICU, and mortality in hospital from 2004 to 2016. Independent risk factors for 28-day mortality were age greater than 75 years, Simplified Acute Physiology Score II greater than 50, the occurrence of organ dysfunction within first 48 hours after brain injury, and specific neurologic diseases such as hemorrhagic stroke, ischemic stroke, and brain trauma. CONCLUSIONS: More lung-protective ventilatory strategies have been implemented over years in neurologic patients with no effect on pulmonary complications or on survival. We found several prognostic factors on mortality such as advanced age, the severity of the disease, organ dysfunctions, and the etiology of neurologic disease
A saturated map of common genetic variants associated with human height
- Author
- Abecasis Goncalo R.
- Adair Linda S.
- Adams Hieab H. H.
- Aguilar-Salinas Carlos A.
- Ahluwalia Tarunveer S.
- Akiyama Masato
- Al-Mulla Fahd
- Allison Matthew A.
- Alvarez Marcus
- Andersen Mette K.
- Ani Alireza
- Appadurai Vivek
- Arbeeva Liubov
- Arias Joshua D.
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles L.
- Asvold Bjorn Olav
- Attia John
- Auton Adam
- Banas Bernhard
- Bandinelli Stefania
- Bartell Eric
- Bennett David A.
- Bergler Tobias
- Berndt Sonja, I
- Bharadwaj Dwaipayan
- Bhaskar Seema
- Bielak Lawrence F.
- Biino Ginevra
- Bisgaard Hans
- Boehnke Michael
- Boerwinkle Eric
- Boger Carsten A.
- Bollepalli Sailalitha
- Bonnelykke Klaus
- Bonnycastle Lori L.
- Boomsma Dorret, I
- Borglum Anders D.
- Borja Judith B.
- Bork-Jensen Jette
- Bouchard Claude
- Bowden Donald W.
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
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- Cai Hui
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- Catamo Eulalia
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- Chasman Daniel, I
- Chaturvedi Nish
- Chen Chien-Hsiun
- Chen Shyh-Huei
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chesi Alessandra
- Cho Yoon Shin
- Choi Seung Hoan
- Christofidou Paraskevi
- Christophersen Ingrid E.
- Chung Ren-Hua
- Ciullo Marina
- Cocca Massimiliano
- Cole John W.
- Collins Francis S.
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- de Groot Lisette C. P. G. M.
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- de Kleijn Dominique P., V
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- Dedoussis George, V
- Degenhard Frauke
- Delgado Graciela E.
- Delitala Alessandro
- Deloukas Panos
- Demirkan Ayse
- den Hollander Anneke, I
- Deng Xuan
- Devineni Poornima
- Dietl Alexander
- Dimitriou Maria
- Dimitrov Latchezar
- Dorajoo Rajkumar
- Du Shufa
- Easton Douglas F.
- Ekici Arif B.
- Elders Petra J. M.
- Eliasen Anders U.
- Eliassen A. Heather
- Ellinor Patrick T.
- Elmstahl Solve
- Engmann Jorgen E.
- Erdmann Jeanette
- Esko Tonu
- Evans Michele K.
- Fairhurst-Hunter Zammy
- Farmaki Aliki-Eleni
- Fatkin Diane
- Faul Jessica D.
- Feenstra Bjarke
- Feitosa Mary F.
- Fernandez-Lopez Juan-Carlos
- Ferreira Teresa
- Ferrucci Luigi
- Ford Ian
- Forer Lukas
- Fornage Myriam
- Francescatto Margherita
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Freedman Barry, I
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E.
- Gao Yan
- Gao Zishan
- Gasparini Paolo
- Geller Frank
- Giannakopoulou Olga
- Gieger Christian
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- Goddard Michael E.
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- Gonzalez-Villalpando Clicerio
- Gordon Scott D.
- Gordon-Larsen Penny
- Gorski Mathias
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- Graham Sarah E.
- Grallert Harald
- Grant Struan F. A.
- Grarup Niels
- Griffiths Lyn
- Grove Jakob
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Haiman Christopher
- Hakonarson Hakon
- Hansen Thomas F.
- Hansen Torben
- Hartman Catharina A.
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon J.
- Hayward Caroline
- He Jing
- Heard-Costa Nancy
- Hebbar Prashantha
- Heckbert Susan R.
- Heid Iris M.
- Heng Chew-Kiat
- Hengstenberg Christian
- Hewitt Alex W.
- Highland Heather H.
- Hindy George
- Hirschhorn Joel N.
- Hishigaki Haretsugu
- Ho Yuk-Lam A.
- Hofer Edith
- Holliday Elizabeth
- Horn Katrin
- Hornsby Whitney E.
- Hottenga Jouke-Jan
- Hoyng Carel B.
- Huang Hongyan
- Huang Jie
- Huang Paul L.
- Huang Wei
- Huerta-Chagoya Alicia
- Huffman Jennifer E.
- Hung Yi-Jen
- Hunt Steven C.
- Huo Shaofeng
- Hveem Kristian
- Hwang Mi Yeong
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- Iacono William G.
- Ichihara Sahoko
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- Ikeda Daisuke D.
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- Jackson Anne U.
- Jackson Rebecca D.
- Jager Susanne
- Jansen Iris E.
- Jarvelin Marjo-Riitta
- Ji Yingjie
- Jiang Yunxuan
- Jin Zi-Bing
- Jockel Karl-Heinz
- Johansson Ingegerd
- Jonas Jost B.
- Jonsson Anna
- Jorgensen Torben
- Joshi Peter K.
- Jousilahti Pekka
- Jukema J. Wouter
- Justice Anne E.
- Kahonen Mika
- Kalafati Ioanna-Panagiota
- Kamatani Yoichiro
- Kanai Masahiro
- Kang Kui Dong
- Kanoni Stavroula
- Kaprio Jaakko
- Karaderi Tugce
- Kardia Sharon L. R.
- Karhus Line L.
- Karpe Fredrik
- Kasturiratne Anuradhani
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kember Rachel L.
- Kentistou Katherine A.
- Kessler Thorsten
- Khera Amit, V
- Khor Chiea Chuen
- Kiemeney Lambertus A. L. M.
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kirchhof Paulus
- Kivimaki Mika
- Kleber Marcus E.
- Knol Maria J.
- Koh Woon-Puay
- Koistinen Heikki A.
- Kolovou Genovefa D.
- Kooner Jaspal S.
- Kooperberg Charles
- Kottgen Anna
- Kovacs Peter
- Kraaijeveld Adriaan
- Kraft Peter
- Krauss Ronald M.
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Laakso Markku
- Lange Leslie A.
- Langenberg Claudia
- Launer Lenore J.
- Lauzon Marie
- Le Marchand Loic
- Le Phuong
- Lea Rodney
- Lee Hyejin
- Lee Jong-Young
- Lee Nanette R.
- Lehtimaki Terho
- Leonard Hampton L.
- Lettre Guillaume
- Li Huaixing
- Li Liming
- Li Shengchao A.
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Honghuang
- Lin Kuang
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lindgren Cecilia M.
- Linneberg Allan
- Liu Ching-Ti
- Liu Jianjun
- Liu Jun
- Liu Xueping
- Lo Ken Sin
- Locke Adam E.
- Loeffler Markus
- Loh Po-Ru
- London Barry
- Long Jirong
- Loos Ruth J. F.
- Lores-Motta Laura
- Luan Jian'an
- Lubitz Steven A.
- Lull Kreete
- Lye Stephen J.
- Lyssenko Valeriya
- Lyytikainen Leo-Pekka
- Machado Moara
- Mackey David A.
- Magi Reedik
- Magnusson Patrik K. E.
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- Malden Deborah E.
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marcus Gregory M.
- Marouli Eirini
- Marten Jonathan
- Martin Nicholas G.
- Marz Winfried
- Matsuda Fumihiko
- Mattheisen Manuel
- Mavarani Laven
- McCarthy Mark, I
- McDaid Aaron F.
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- McKnight Amy Jayne
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- Meidtner Karina
- Melendez Tori L.
- Mellstrom Dan
- Mercader Josep M.
- Metspalu Andres
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- Milaneschi Yuri
- Miller Jason E.
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- Mishra Pashupati P.
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- Mucci Lorelei A.
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- Mukamel Ronen E.
- Munroe Patricia B.
- Munz Matthias
- Nakatochi Masahiro
- Nalls Mike A.
- Nazarian Saman
- Nelson Amanda E.
- Nelson Christopher P.
- Nethander Maria
- Neville Matt J.
- Newton-Cheh Christopher
- Ng Maggie C. Y.
- Nho Chu Won
- Nielsen Aneta A.
- Nielsen Christopher S.
- Nolte Ilja M.
- Nongmaithem Suraj S.
- Noordam Raymond
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- Nothen Markus M.
- Ntalla Ioanna
- Nutile Teresa
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- Ohlsson Claes
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- Oldehinkel Albertine J.
- Orozco Lorena
- Pahkala Katja
- Pajukanta Paivi
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- Pandit Anita
- Parna Katri
- Parra Esteban J.
- Pattaro Cristian
- Pauper Marc
- Pedersen Oluf
- Pennell Craig E.
- Penninx Brenda W. J. H.
- Perusse Louis
- Peters Annette
- Petersen Eva R. B.
- Petersen Liselotte, V
- Peyser Patricia A.
- Pitkanen Niina
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- Porteous David J.
- Posthuma Danielle
- Poveda Alaitz
- Power Chris
- Pramstaller Peter P.
- Preuss Michael H.
- Province Michael A.
- Pyarajan Saiju
- Qi Qibin
- Qu Jia
- Rader Daniel J.
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- Redline Susan
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- Ripatti Samuli
- Ritchie Marylyn D.
- Rivadeneira Fernando
- Riveros Carlos
- Roden Dan M.
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- Rotter Jerome, I
- Rudan Igor
- Rueger Sina
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- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
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- Sattar Naveed
- Saxena Richa
- Schmidt Borge
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B.
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- Scott Laura J.
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- Sendamarai Anoop
- Sever Peter
- Shen Botong
- Shi Jingchunzi
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- Sidore Carlo
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- Stefansson Kari
- Steinthorsdottir Valgerdur
- Strachan David P.
- Sun Liang
- Sun Yan, V
- t' Hart Leen M.
- Tabara Yasuharu
- Tai E. Shyong
- Takeuchi Fumihiko
- Tallapragada Divyasripriyanka
- Tang Hua
- Tardif Jean-Claude
- Taylor Kent D.
- Tayo Bamidele O.
- Tcheandjieu Catherine
- Terzikhan Natalie
- Tesolin Paola
- Teumer Alexander
- Thanaraj Thangavel A.
- Theusch Elizabeth
- Thompson Deborah J.
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R. H. J.
- Timpson Nicholas J.
- Tonjes Anke
- Tremblay Angelo
- Trompet Stella
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Turman Constance
- Tusie-Luna Maria-Teresa
- Uitterlinden Andre G.
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W.
- van der Most Peter J.
- Van der Velde Nathalie
- van Duijn Cornelia M.
- van Klinken Jan B.
- van Schoor Natasja M.
- van Setten Jessica
- Vedantam Sailaja
- Verma Shefali S.
- Verweij Niek
- Veturi Yogasudha
- Vidal Pedro Marques
- Visscher Peter M.
- Vitart Veronique
- Volker Uwe
- Vollenweider Peter
- Volzke Henry
- Vrieze Scott
- Wacher-Rodarte Niels H.
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Lihua
- Wang Ya Xing
- Wang Zhe
- Wareham Nicholas J.
- Warren Helen R.
- Watanabe Richard M.
- Watkins Hugh
- Wei Wen Bin
- Weir David R.
- Werge Thomas M.
- Wickremasinghe Ananda R.
- Widen Elisabeth
- Wielscher Matthias
- Wiggins Kerri L.
- Wilkens Lynne R.
- Willemsen Gonneke
- Willer Cristen J.
- Willett Walter C.
- Wilson James F.
- Winkler Thomas W.
- Winsvold Bendik S.
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wright Alan F.
- Wu Jer-Yuarn
- Wu Yang
- Wuttke Matthias
- Xia Rui
- Xie Tian
- Xu Huichun
- Yajnik Chittaranjan S.
- Yamamoto Ken
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yengo Loic
- Yin Xianyong
- Yokota Mitsuhiro
- Young Hannah
- Young Kristin L.
- Yousri Noha A.
- Yu Lei
- Yuan Jian-Min
- Zeggini Eleftheria
- Zemel Babette S.
- Zeng Lingyao
- Zhang Weihua
- Zhang Xinyuan
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiaofeng
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zoledziewska Magdalena
- Zonderman Alan B.
- Zwart John-Anker
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