27 research outputs found

    The global burden of cancer attributable to risk factors, 2010-19 : a systematic analysis for the Global Burden of Disease Study 2019

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    Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe

    The effect of morning exercise on mental health of female police employees

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    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Background &amp; Aims of the Study: According to the report of world health, organization mental disorder is one of the important causes of disability in the world and it can result in decrease in the success and advancement of employees. Thus, the purpose of this research is evaluation and comparison of mental health status and its related factors in female employees who take part in morning exercise and who are exempt in one of the police units. This is a descriptive-analytic and cross sectional study. Materials &amp; Methods: The population of this research included 85 female employees who took part in morning exercise as one group and the other group included 65 inactive people who were ill and exempt from exercise. The measurement tool in the research was the Goldberg and Hiller questionnaire of mental health that was consisted of 28 questions. Various studies in the world and in Iran suggest the high validity and reliability of the GHQ-28 questionnaire. The validity of the questionnaire has been approved in more than 70 countries and its reliability has been estimated to be between 82% and 92% in different researches and in different social groups. The data were analyzed using the descriptive statistics (frequency, mean and standard of deviation) and deduction statistics (independent t-test) in SPSS 16 software. Results: Analysis of the research hypotheses at significant level (p<0.05) showed that morning exercise had significant effect on mental health and its subscales such as physical complaint, anxiety, social dysfunction and depression in employees. Moreover, a significant difference was observed by comparing the active and inactive groups in relation to mental health and its subscales. Conclusions: The results of the research show that the effect of exercise and physical activities on mental health can&#039;t be denied. According to the researches that have been done, exercise is effective in two aspects of physical and mental. &nbsp; &nbsp; &nbsp;

    Bilateral Laparoscopic Anatrophic Nephrolithotomy for Managing Staghorn Renal Calculi

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    Measurement, Modeling, And Optimization Of Sound Absorption Performance Of Kenaf Fibers For Building Applications

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    The use of natural fibers in the buildings and construction industries as a sustainable and biodegradable product with the aim of noise pollution control has attracted the attention of many researchers. This work aims to study the acoustic behavior of porous absorbers made of natural Kenaf fibers. To this end, samples of sound absorber were fabricated with thicknesses of 10–40 mm at two different bulk densities of 150 and 200 kg/m3, and their sound absorption coefficient (SAC) was determined by standing wave sound impedance tube at different air gap cavities. A hybrid numerical-mathematical model was also proposed to investigate the acoustic behavior of the samples. To this end, a code was developed to simulate the 3D virtual structure of samples, and flow resistivity was calculated by numerically solving the flow of air in the structures. Tortuosity and two characteristic lengths were obtained using an inverse method programmed in MATLAB®. These parameters were then imported into the Johnson-Champoux-Allard (JCA) model to predict SACs at different frequencies. Afterward, considering the cost and sound absorption average (SAA), samples were optimized using factorial design. Consequently, the acoustic behavior of the optimized acoustic panels was investigated in the reverberation room in terms of reverberation time and random absorption coefficient. Moreover, in order to provide aesthetically and artistically pleasing appearance, the samples were covered with spacer fabrics, and their sound absorption behavior was also studied. The results revealed the promising sound absorption performance of Kenaf fibers. It was found that the SAC at low, mid, and high frequencies increases significantly with increasing the bulk density. The average of SACs for frequencies above 1250 Hz for samples of 40 mm thickness was found to be 0.95, while these values for samples of 30 and 20 mm thickness were respectively 0.85 and 0.7. The introduction of the air gap was found to improve the SAC at low-frequency bands and shift the peak of absorption toward low frequencies. Very good consistency was observed between the predicted and experimental data. The results of the statistical analysis suggested a thickness of 33 mm and a bulk density of 150 kg/m3 for the optimized panels. The results showed that the mean of SAC increased from 0.68 to 0.72 after covering the optimized panels with spacer fabrics

    In-silico investigations of haemodynamic parameters for a blunt thoracic aortic injury case

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    Abstract Accounting for 1.5% of thoracic trauma, blunt thoracic aortic injury (BTAI) is a rare disease with a high mortality rate that nowadays is treated mostly via thoracic endovascular aortic repair (TEVAR). Personalised computational models based on fluid–solid interaction (FSI) principals not only support clinical researchers in studying virtual therapy response, but also are capable of predicting eventual outcomes. The present work studies the variation of key haemodynamic parameters in a clinical case of BTAI after successful TEVAR, using a two-way FSI model. The three-dimensional (3D) patient-specific geometries of the patient were coupled with three-element Windkessel model for both prior and post intervention cases, forcing a correct prediction of blood flow over each section. Results showed significant improvement in velocity and pressure distribution after stenting. High oscillatory, low magnitude shear (HOLMES) regions require careful examination in future follow-ups, since thrombus formation was confirmed in some previously clinically reported cases of BTAI treated with TEVAR. The strength of swirling flows along aorta was also damped after stent deployment. Highlighting the importance of haemodynamic parameters in case-specific therapies. In future studies, compromising motion of aortic wall due to excessive cost of FSI simulations can be considered and should be based on the objectives of studies to achieve a more clinical-friendly patient-specific CFD mode
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