The effect of internal gravity waves on cloud evolution in sub-stellar atmospheres

Context. Sub-stellar objects exhibit photometric variability which is believed to be caused by a number of processes such as magnetically-driven spots or inhomogeneous cloud coverage. Recent sub-stellar models have shown that turbulent flows and waves, including internal gravity waves, may play an important role in cloud evolution.Aims. The aim of this paper is to investigate the effect of internal gravity waves on dust cloud nucleation and dust growth, and whether observations of the resulting cloud structures could be used to recover atmospheric density information.Methods. For a simplified atmosphere in two dimensions, we numerically solve the governing fluid equations to simulate the effect on dust nucleation and mantle growth as a result of the passage of an internal gravity wave. Furthermore, we derive an expression that relates the properties of the wave-induced cloud structures to observable parameters in order to deduce the atmospheric density.Results. Numerical simulations show that the density, pressure and temperature variations caused by gravity waves lead to an increase of dust nucleation by up to a factor 20, and dust mantle growth rate by up to a factor 1:6, compared to their equilibrium values. Through an exploration of the wider sub-stellar parameter space, we show that in absolute terms, the increase in dust nucleation due to internal gravity waves is stronger in cooler (T dwarfs) and TiO2-rich sub-stellar atmospheres. The relative increase however is greater in warm(L dwarf) and TiO2-poor atmospheres due to conditions less suited for efficient nucleation at equilibrium. These variations lead to banded areas in which dust formation is much more pronounced, and lead to banded cloud structures similar to those observed on Earth. Conclusions. Using the proposed method, potential observations of banded clouds could be used to estimate the atmospheric density of sub-stellar objects

Notre-Dame de Paris as a validation case to improve fire safety modelling in historic buildings

The analysis of the thermal damages in Notre-Dame de Paris is necessary to estimate the impact of the dramatic 2019 fire on the remaining structure prior to reconstruction. In doing so, the large amount of data being generated creates a benchmark environment to test the relevance of numerical fire models in the unconventional configuration of a medieval roof. While being an uncontrolled and complex configuration, it can provide insights regarding the relevance of numerical tools for fire risk assessment in historic buildings. Analysing the thermal degradation of the Lutetian limestone in a vault of the choir, experimental techniques are developed to track the in-depth maximum temperature profile reached during the fire. Numerical simulations of the fire development in the roof space then aim at replicating the observations through the evaluation of the heat flux impinging the vaults during the fire. These simulations are carried out using Fire Dynamic Simulator, which requires a large range of assumptions prior to any simulation regarding materials, geometry, meshing and scale. These assumptions are described and pave the way to a future sensitivity analysis to confront the upcoming outcomes of the simulations with the experimental observations

Tailoring temporal description logics for reasoning over temporal conceptual models

Temporal data models have been used to describe how data can evolve in the context of temporal databases. Both the Extended Entity-Relationship (EER) model and the Unified Modelling Language (UML) have been temporally extended to design temporal databases. To automatically check quality properties of conceptual schemas various encoding to Description Logics (DLs) have been proposed in the literature. On the other hand, reasoning on temporally extended DLs turn out to be too complex for effective reasoning ranging from 2ExpTime up to undecidable languages. We propose here to temporalize the ‘light-weight’ DL-Lite logics obtaining nice computational results while still being able to represent various constraints of temporal conceptual models. In particular, we consider temporal extensions of DL-Lite^N_bool, which was shown to be adequate for capturing non-temporal conceptual models without relationship inclusion, and its fragment DL-Lite^N_core with most primitive concept inclusions, which are nevertheless enough to represent almost all types of atemporal constraints (apart from covering)

Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics

We revisit the dynamics of a gene repressed by its own protein in the case where the transcription rate does not adapt instantaneously to protein concentration but is a dynamical variable. We derive analytical criteria for the appearance of sustained oscillations and find that they require degradation mechanisms much less nonlinear than for infinitely fast regulation. Deterministic predictions are also compared with stochastic simulations of this minimal genetic oscillator

Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics

We revisit the dynamics of a gene repressed by its own protein in the case where the transcription rate does not adapt instantaneously to protein concentration but is a dynamical variable. We derive analytical criteria for the appearance of sustained oscillations and find that they require degradation mechanisms much less nonlinear than for infinitely fast regulation. Deterministic predictions are also compared with stochastic simulations of this minimal genetic oscillator

Optical microscopy via spectral modifications of a nano-antenna

The existing optical microscopes form an image by collecting photons emitted from an object. Here we report on the experimental realization of microscopy without the need for direct optical communication with the sample. To achieve this, we have scanned a single gold nanoparticle acting as a nano-antenna in the near field of a sample and have studied the modification of its intrinsic radiative properties by monitoring its plasmon spectrum.Comment: 6 pages, 4 figures (color

Relativistic effects in a mildly recycled pulsar binary: PSR J1952+2630

We report the results of timing observations of PSR J1952+2630, a 20.7 ms pulsar in orbit with a massive white dwarf companion. With the increased timing baseline, we obtain improved estimates for astrometric, spin, and binary parameters for this system. We get an improvement of an order of magnitude on the proper motion, and, for the first time, we detect three post-Keplerian parameters in this system: the advance of periastron, the orbital decay, and the Shapiro delay. We constrain the pulsar mass to 1.20$^{+0.28}_{-0.29}\rm M_{\odot}$ and the mass of its companion to 0.97$^{+0.16}_{-0.13}\rm M_{\odot}$. The current value of $\dot{P}_{\rm b}$ is consistent with GR expectation for the masses obtained using $\dot{\omega}$ and $h_3$. The excess represents a limit on the emission of dipolar GWs from this system. This results in a limit on the difference in effective scalar couplings for the pulsar and companion (predicted by scalar-tensor theories of gravity; STTs) of $|\alpha_{\rm p}-\alpha_{\rm c}| < 4.8 \times 10^{-3}$, which does not yield a competitive test for STTs. However, our simulations of future campaigns of this system show that by 2032, the precision of $\dot{P}_{\rm b}$ and $\dot{\omega}$ will allow for much more precise masses and much tighter constraints on the orbital decay contribution from dipolar GWs, resulting in $|\alpha_{\rm p}-\alpha_{\rm c}|<1.3 \times 10^{-3}$. We also present the constraints this system will place on the $\{\alpha_0,\beta_0\}$ parameters of DEF gravity by 2032. They are comparable to those of PSR J1738+0333. Unlike PSR J1738+0333, PSR J1952+2630 will not be limited in its mass measurement and has the potential to place even more restrictive limits on DEF gravity in the future. Further improvements to this test will likely be limited by uncertainties in the kinematic contributions to $\dot{P}_{\rm b}$ due to lack of precise distance measurements.Comment: 14 pages, 9 figures, 4 tables. Accepted for publication in Astronomy & Astrophysic

Echocardiographic Guidance During Neonatal and Pediatric Jugular Cannulation for ECMO

Background Internal jugular vein extracorporeal membrane oxygenation (ECMO) cannula position is traditionally confirmed via plain film. Misplaced cannulae can result in need for repositioning and increased morbidity. Echocardiography (ECHO) may be used during cannulation as a more accurate means of guiding cannula position. This study reviews the effect of a protocol encouraging the use of ECHO at cannulation. Methods and materials Single institution retrospective review of patients who received ECMO support using jugular venous cannulation. We compared those who underwent ECHO (ECHO+) at the time of cannulation with those who did not (ECHO−). Results Eighty-nine patients were included: 26 ECHO+, 63 ECHO−. Most ECHO+ patients underwent dual-lumen veno-venous (VV) cannulation (65%); 32% of ECHO− patients had VV support (P = 0.003). There was no difference in the rate of cannula repositioning between the two groups: 8% ECHO+ and 10% ECHO−, P = 0.78. In the VV ECMO subgroup, ECHO+ patients required no repositioning (0/17), while 20% (4/20) of ECHO− VV patients did (P = 0.10). After cannulation, there were 0.58 ECHO studies per patient to verify cannula position in the ECHO+ group compared with 0.22 in the ECHO− group (P = 0.02). Each group had a major mechanical complication: atrial perforation from a guidewire during cannulation in ECHO+ and late atrial perforation from a loose cannula in ECHO−, and there was no difference in minor complications. Conclusions ECHO guidance during neonatal and pediatric jugular cannulation for ECMO did not decrease morbidity or reduce the need for cannula repositioning. ECHO may still be a useful adjunct for precise placement of a dual-lumen VV cannula and during difficult cannulations

Collective cell migration requires vesicular trafficking for chemoattractant delivery at the trailing edge

Chemoattractant signaling induces the polarization and directed movement of cells secondary to the activation of multiple effector pathways. In addition, chemotactic signals can be amplified and relayed to proximal cells via the synthesis and secretion of additional chemoattractant. The mechanisms underlying such remarkable features remain ill defined. We show that the asymmetrical distribution of adenylyl cyclase (ACA) at the back of Dictyostelium discoideum cells, an essential determinant of their ability to migrate in a head-to-tail fashion, requires vesicular trafficking. This trafficking results in a local accumulation of ACA-containing intracellular vesicles and involves intact actin, microtubule networks, and de novo protein synthesis. We also show that migrating cells leave behind ACA-containing vesicles, likely secreted as multivesicular bodies and presumably involved in the formation of head-to-tail arrays of migrating cells. We propose that similar compartmentalization and shedding mechanisms exist in mammalian cells during embryogenesis, wound healing, neuron growth, and metastasis