LAS PLATAFORMAS DIGITALES EN EL DESARROLLO DEL ENOTURISMO EN CASTILLA Y LEÓN: PÁGINAS WEB Y REDES SOCIALES

Wine tourism is a growing economic activity in Castilla y León. More and more people are interested in knowing the ins and outs of the world of wine, so wine is becoming one of the pillars of rural development in the plains of the Duero. In order to achieve this key role in the territory, this activity has had to adapt to changes in the tastes of consumers and, especially, to faster and more direct new forms of communication. This paper aims to outlook the existing situation in the wineries of Castilla y León in the field of new technologies and, especially, of websites and social networks, two key tools for the development of wine tourism.El enoturismo es una actividad económica en crecimiento en Castilla y León. Cada vez son más las personas interesadas en conocer el mundo de la vid y el vino, convirtiéndose en uno de los pilares del desarrollo rural en las llanuras del Duero. Para lograr este papel clave en el territorio, esta actividad ha tenido que adaptarse a los cambios en los gustos de los consumidores y, en especial, a las nuevas formas de comunicación digital, más rápidas y directas. Con este trabajo se pretende ver la situación existente en las bodegas castellano-leonesas en el ámbito de las nuevas tecnologías y, en especial, de las páginas web y redes sociales, dos herramientas claves para el desarrollo del turismo enológico

EL CANAL DE CASTILLA: RECURSO PATRIMONIAL DEL AGUA Y PERSPECTIVAS DE USO E INNOVACIÓN TURÍSTICA

Castile and León has important resources that allow tourism development, such as the Castilla Canal, a hydraulic infrastructure that has become a key element of the Spanish industrial heritage of the 18th-19th centuries. This research analyzes the Castilla Canal as a tourist resource and its level of innovation as a smart tourism destination, where communication technologies play a key role in the management and planning of available resources, in a territory that is in a regression socioeconomic status for decades.Castilla y León cuenta con importantes recursos que permiten el desarrollo turístico, como el Canal de Castilla, una infraestructura hidráulica que se ha convertido en un elemento clave del patrimonio industrial español de los siglos XVIII-XIX. En esta investigación se analiza el Canal de Castilla como recurso turístico y su nivel de innovación como destino de turismo inteligente, donde las tecnologías de la comunicación juegan un papel clave en la gestión y planificación de los recursos disponibles, en un territorio que se encuentra en regresión socioeconómica desde hace décadas

Evaluation of the Nanodomain Structure in In-Zn-O Transparent Conductors

The optimization of novel transparent conductive oxides (TCOs) implies a better understanding of the role that the dopant plays on the optoelectronic properties of these materials. In this work, we perform a systematic study of the homologous series ZnkIn2Ok+3 (IZO) by characterizing the specific location of indium in the structure that leads to a nanodomain framework to release structural strain. Through a systematic study of different terms of the series, we have been able to observe the influence of the k value in the nano-structural features of this homologous series. The stabilization and visualization of the structural modulation as a function of k is discussed, even in the lowest term of the series (k = 3). The strain fields and atomic displacements in the wurtzite structure as a consequence of the introduction of In3+ are evaluated.Depto. de Química InorgánicaFac. de Ciencias QuímicasTRUEMinisterio de Ciencia, Innovación y Tecnología /Ministerio de EconomíaComunidad de Madridpu

A novel mutation, outside of the candidate region for diagnosis, in the inverted formin 2 gene can cause focal segmental glomerulosclerosis

Focal and segmental glomerulosclerosis (FSGS) is a histological pattern that has several etiologies, including genetics. The autosomal dominant form of FSGS is a heterogenic disease caused by mutations within three known genes: alpha-actinin 4 (ACTN4), canonical transient receptor potential 6 (TRPC6), and the inverted formin 2 (INF2) gene. More recently, INF2 mutations have also been attributed to Charcot-Marie-Tooth neuropathy associated with FSGS. Here we performed direct sequencing, histological characterization, and functional studies in a cohort of families with autosomal dominant FSGS. We detected a novel mutation in exon 6 of the INF2 gene outside of the exon 2-4 candidate region used for rapid diagnosis of autosomal dominant FSGS. This new mutation is predicted to alter a highly conserved amino-acid residue within the 17th alpha-helix of the diaphanous inhibitory domain of the protein. A long-term follow-up of this family indicated that all patients were diagnosed in adulthood, as opposed to early childhood, and progression to end-stage renal disease was at different times without clinical or electrodiagnostic evidence of neuropathy. Thus, this novel mutation in INF2 linked to nonsyndromic FSGS indicates the necessity for full gene sequencing if no mutation is found in the current rapid-screen region of the gene. 2012 International Society of Nephrology

A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues

Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. However, testing these mechanical hypotheses on proteins in their natural environment remains inaccesible to conventional tools. To address this limitation, here we demonstrate a mouse model carrying a HaloTag-TEV insertion in the protein titin, the main determinant of myocyte stiffness. Using our system, we specifically sever titin by digestion with TEV protease, and find that the response of muscle fibers to length changes requires mechanical transduction through titin’s intact polypeptide chain. In addition, HaloTag-based covalent tethering enables examination of titin dynamics under force using magnetic tweezers. At pulling forces < 10 pN, titin domains are recruited to the unfolded state, and produce 41.5 zJ mechanical work during refolding. Insertion of the HaloTag-TEV cassette in mechanical proteins opens opportunities to explore the molecular basis of cellular force generation, mechanosensing and mechanotransduction

APLICACIÓN Y AJUSTE EN LA PRÁCTICA DEL NUEVO PROCESO DE MEJORA PARA PROCESOS DE SOFTWARE AGILE SPI PROCESS: CASO DE ESTUDIO REAL EN UNA PYME

RESUMENEl trabajar en el sector de las PyMES (Pequeñas y Medianas Empresas) con un programa SPI (Software Process Improvement - Mejora de Procesos de Software) es un interés que se ha vuelto muy importante en todo el mundo. Algunos estudios han demostrado que la dificultad de aplicación de grandes modelos en un SPI es un problema en PyMEs, fundamentalmente por los grandes costes asociados a su aplicación (tiempo y recursos), especialmente en el seguimiento de los planes de acción e implantación [6]. Otro problema añadido para las PyMEs, es el largo plazo de espera necesario para la obtención de resultados [2], nuevamente demasiado para una PyME. Éste artículo propone un proceso para la Mejora de Procesos de Software para apoyar la gestión y administración de un programa de mejora pero adaptado a las características de las PyMEs, fue desarrollado en el proyecto SIMEP-SW y aplicado a dos PyMES de Software. Este artículo presenta el modelo y la experiencia de su aplicación en unaPyME. La experiencia permitió probar el modelo y evaluar su impacto en el contexto de las PyMES. Algunas lecciones aprendidas fueron recopiladas para refinar y ajustar el modelo. En definitiva, el tamaño de una empresa no limita el éxito de los programas de mejora sino que se ve afectado fundamentalmente por los problemas mencionados anteriormente; el proceso expuesto en este trabajo pretende que sea utilizado en empresas de cualquier tamaño, especialmente las PyMES. PALABRAS CLAVEMejora de Procesos de Software (SPI)CalidadCMMIPequeñas y Medianas Empresas (PyMEs)PyMEÁgilProceso ABSTRACTWorking in the SMEs (Small and Medium Enterprises) sector with an SPI (Software Process Improvement) program is an interest that has become very important anywhere in the world. Some studies have demonstrated that the difficulty of application of large international models in a SPI is a problem in SMEs, basically by the great costs associated to its application (time and resources), specially in the tracking of the action and implantation plans [6]. Another problem for the SMEs is the long waiting time for obtaining results [2], again too much for a SME. This article proposes a process for the Software Process Improvement to support the managementand administration of an improvement program but adapted to the features of the SMEs, it was developed in the SIMEP-SW project and applied to two software SMEs. This article presents the model and the experience of its application in a SME. The experience has allowed to prove the model and to evaluate their impact in the context of the SMEs. Some learned lessons were compiled to refine and to fit the model. After all, the size of an enterprise doesn't limit the success of the improvement programs but it is affected fundamentally by the problems mentioned previously; the process exposed in this work pretends to be used in enterprises of any size, especially the SMEs. KEYWORDS: Software Process Improvement (SPI)QualityCMMISmall and Medium Enterprises (SME's)SMEAgileProces

APLICACIÓN Y AJUSTE EN LA PRÁCTICA DEL NUEVO PROCESO DE MEJORA PARA PROCESOS DE SOFTWARE AGILE SPI PROCESS: CASO DE ESTUDIO REAL EN UNA PYME

RESUMENEl trabajar en el sector de las PyMES (Pequeñas y Medianas Empresas) con un programa SPI (Software Process Improvement - Mejora de Procesos de Software) es un interés que se ha vuelto muy importante en todo el mundo. Algunos estudios han demostrado que la dificultad de aplicación de grandes modelos en un SPI es un problema en PyMEs, fundamentalmente por los grandes costes asociados a su aplicación (tiempo y recursos), especialmente en el seguimiento de los planes de acción e implantación [6]. Otro problema añadido para las PyMEs, es el largo plazo de espera necesario para la obtención de resultados [2], nuevamente demasiado para una PyME. Éste artículo propone un proceso para la Mejora de Procesos de Software para apoyar la gestión y administración de un programa de mejora pero adaptado a las características de las PyMEs, fue desarrollado en el proyecto SIMEP-SW y aplicado a dos PyMES de Software. Este artículo presenta el modelo y la experiencia de su aplicación en unaPyME. La experiencia permitió probar el modelo y evaluar su impacto en el contexto de las PyMES. Algunas lecciones aprendidas fueron recopiladas para refinar y ajustar el modelo. En definitiva, el tamaño de una empresa no limita el éxito de los programas de mejora sino que se ve afectado fundamentalmente por los problemas mencionados anteriormente; el proceso expuesto en este trabajo pretende que sea utilizado en empresas de cualquier tamaño, especialmente las PyMES. PALABRAS CLAVEMejora de Procesos de Software (SPI)CalidadCMMIPequeñas y Medianas Empresas (PyMEs)PyMEÁgilProceso ABSTRACTWorking in the SMEs (Small and Medium Enterprises) sector with an SPI (Software Process Improvement) program is an interest that has become very important anywhere in the world. Some studies have demonstrated that the difficulty of application of large international models in a SPI is a problem in SMEs, basically by the great costs associated to its application (time and resources), specially in the tracking of the action and implantation plans [6]. Another problem for the SMEs is the long waiting time for obtaining results [2], again too much for a SME. This article proposes a process for the Software Process Improvement to support the managementand administration of an improvement program but adapted to the features of the SMEs, it was developed in the SIMEP-SW project and applied to two software SMEs. This article presents the model and the experience of its application in a SME. The experience has allowed to prove the model and to evaluate their impact in the context of the SMEs. Some learned lessons were compiled to refine and to fit the model. After all, the size of an enterprise doesn't limit the success of the improvement programs but it is affected fundamentally by the problems mentioned previously; the process exposed in this work pretends to be used in enterprises of any size, especially the SMEs. KEYWORDS: Software Process Improvement (SPI)QualityCMMISmall and Medium Enterprises (SME's)SMEAgileProces

Inflammatory myopathy in the context of an unusual overlapping laminopathy

Laminopathies are genetic disorders associated with alterations in nuclear envelope proteins, known as lamins. The LMNA gene encodes lamins A and C, and LMNA mutations have been linked to diseases involving fat (type 2 familial partial lipodystrophy [FPLD2]), muscle (type 2 Emery–Dreifuss muscular dystrophy [EDMD2], type 1B limb-girdle muscular dystrophy [LGMD1B], and dilated cardiomyopathy), nerves (type 2B1 Charcot–Marie–Tooth disease), and premature aging syndromes. Moreover, overlapping syndromes have been reported. This study aimed to determine the genetic basis of an overlapping syndrome in a patient with heart disease, myopathy, and features of lipodystrophy, combined with severe metabolic syndrome. We evaluated a 54-year-old woman with rheumatoid arthritis, chronic hypercortisolism (endogenous and exogenous), and a history of cured adrenal Cushing syndrome. The patient presented with a complex disorder, including metabolic syndrome associated with mild partial lipodystrophy (Köbberling-like); mild hypertrophic cardiomyopathy, with Wolff–Parkinson– White syndrome and atrial fibrillation; and limb-girdle inflammatory myopathy. Mutational analysis of the LMNA gene showed a heterozygous c.1634G>A (p.R545H) variant in exon 10 of LMNA. This variant has previously been independently associated with FPLD2, EDMD2, LGMD1B, and heart disease. We describe a new, LMNA-associated, complex overlapping syndrome in which fat, muscle, and cardiac disturbances are related to a p.R545H variant.This work was funded by the Instituto de Salud Carlos III (grant number: PI081449) and the European Regional Development Fund, FEDER. In addition, SRG was awarded a Research Fellowship granted by the Asociación Española de Familiares y Afectados de Lipodistrofias (AELIP)S

La Cueva de la Güelga: (Cangas de Oní­s, Asturias)

Depto. de Prehistoria, Historia Antigua y ArqueologíaFac. de Geografía e HistoriaTRUEpu

Control síncrono de potencia de un D-STATCOMde bajo costo.

This article presents the model and simulation of a D-STATCOM in the Simulink-Matlab tool, the objective is to correct the power factor of an inductive or capacitive load of a distribution system, using a proposed control technique that seeks to make the device raise the power factor of the, through a similar of control of synchronous generators; This will allow to have a low - cost device, since the topology and the control technique used are simple, favoring the reduction of losses that occur in the distribution system with a low software and hardware requirement. To validate the operation, the behavior of the device and the control technique in different load scenarios are analyzed, likewise, a harmonic content analysis is presented together with the most relevant conclusions of the research.Este artículo presenta el modelo y simulación de un D-STATCOM en la herramienta Simulink - Matlab, el objetivo es corregir el factor de potencia de una carga inductiva o capacitiva de un sistema de distribución, utilizando una técnica de control propuesta que busca que el dispositivo eleve el factor de potencia de la carga dentro de los límites permitidos, a través de un control análogo al utilizado en los generadores síncronos; esto permitirá tener un dispositivo de bajo costo, ya que la topología utilizada es simple y el control sencillo, que favorezca la reducción de las pérdidas que se presentan en el sistema de distribución, con un requerimiento bajo de software y hardware. Para validar el funcionamiento se analiza el comportamiento del dispositivo y la técnica de control frente a diferentes escenarios de carga, al igual que se presenta un análisis de contenido armónico junto con las conclusiones más relevantes de la investigación