Fluorescent Discrimination between Traces of Chemical Warfare Agents and Their Mimics

An array of fluorogenic probes is able to discriminate between nerve agents, sarin, soman, tabun, VX and their mimics, in water or organic solvent, by qualitative fluorescence patterns and quantitative multivariate analysis, thus making the system suitable for the inthe- field detection of traces of chemical warfare agents as well as to differentiate between the real nerve agents and other related compounds.Ministerio de Economía y Competitividad, Spain (Project CTQ2012- 31611), Junta de Castilla y León, Consejería de Educación y Cultura y Fondo Social Europeo (Project BU246A12-1), the European Commission, Seventh Framework Programme (Project SNIFFER FP7-SEC-2012-312411) and the Swedish Ministry of Defence (no. A403913

Biological therapies in the systemic management of psoriasis: International Consensus Conference

Psoriasis is a chronic, immune-mediated disorder that usually requires long-term treatment for control. Approximately 25% of patients have moderate to severe disease and require phototherapy, systemic therapy or both. Despite the availability of numerous therapeutic options, the long-term management of psoriasis can be complicated by treatment-related limitations. With advances in molecular research and technology, several biological therapies are in various stages of development and approval for psoriasis. Biological therapies are designed to modulate key steps in the pathogenesis of psoriasis. Collectively, biologicals have been evaluated in thousands of patients with psoriasis and have demonstrated significant benefit with favourable safety and tolerability profiles. The limitations of current psoriasis therapies, the value of biological therapies for psoriasis, and guidance regarding the incorporation of biological therapies into clinical practice are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72815/1/j.1365-2133.2004.06070.x.pd

MAPLE and object technology evolution

Peer reviewed: YesNRC publication: Ye

Productivity through CIS/2 electronic data exchange format for steel structures - Invited Presentation

Electronic Data Interchange (EDI) helps reduce errors by providing an accurate transfer of member sizes and locations.CIM Steel Integration Standards version 2 (CIS/2) format enables the EDI amongst all parties of the steel supply chain for the steel-framed structures. CIS/2 has now been implemented as a file import or export module by many steel design, analysis, engineering, and fabrication software packages. There are potential cost savings in using the CIS/2 over the paper based transfer of design documents. The major benefit of data transfer through CIS/2 is that the hours normally required for detailing and checking for errors are greatly reduced resulting in cost savings throughout the project since erection could begin sooner and occupancy could occur earlier. Apart from enabling the exchange of data between software applications, CIS/2 can also be used in construction applications, for example tracking of structural steel elements. The presentation provides an overview of economic benefits using CIS/2 and the business challenges that prevent its widespread usage.?L?\ue9change de donn\ue9es informatis\ue9 (EDI) aide \ue0 r\ue9duire les erreurs en procurant un transfert pr\ue9cis des dimensions et des emplacements des \ue9l\ue9ments. Le format d\ue9sign\ue9 CIMSteel Integration Standards, version 2 (CIS/2), autorise l?EDI parmi toutes les parties de la cha\ueene d?approvisionnement en acier pour les structures \ue0 ossature d?acier. CIS/2 est d\ue9sormais appliqu\ue9 comme module d?importation/d?exportation de fichiers par de nombreux progiciels de conception, d?analyse, d?ing\ue9nierie et de fabrication de l?acier. L?utilisation de CIS/2 pr\ue9sente des \ue9conomies potentielles par rapport au transfert sur support papier des documents relatifs \ue0 la conception. Le principal avantage du transfert des donn\ue9es via CIS/2 est une r\ue9duction appr\ue9ciable du nombre d?heures normalement consacr\ue9es \ue0 d\ue9tailler et \ue0 d\ue9pister les erreurs. Il en r\ue9sulte ainsi des \ue9conomies tout au long du projet, l?\ue9dification pouvant commencer plus t\uf4t, de m\ueame que l?occupation des lieux. Outre aux fins de l?\ue9change de donn\ue9es entre les applications logicielles, on peut \ue9galement employer CIS/2 dans les applications de construction, par exemple pour retracer les \ue9l\ue9ments d?acier de structures. Cette pr\ue9sentation fournit une vue d?ensemble des avantages \ue9conomiques de l?utilisation de CIS/2 et des d\ue9fis relatifs aux activit\ue9s qui en restreignent l?usage.Peer reviewed: NoNRC publication: Ye

Stereoselective synthesis and semiempirical studies of spiro bridgehead bicyclic N-heterocycles <i style="">via</i> 1,3-dipolar cycloaddition reactions of azomethine ylides

1204-1209The reaction of acenaphthylene-1,2-dione with chiral cyclic secondary a-amino acids viz. l-proline gives rise to the intermediate azomethine ylide which has been trapped by acetylenic and ethylenic dipolarophiles to produce bridgehead bicyclic cycloadducts. The stereoselectivity of these cycloadditions have been ascertained by semiempirical calculations. The newly synthesized spiroazabicyclic compounds have been characterized by elemental analyses and spectral techniques (IR, 1H NMR, 13C NMR and Mass)

Stereoisomeric synthesis of oxazolidinone and fused pyrrolidine derivatives <i>via</i> azomethine ylides and their antimicrobial activity

412-415The reaction of isatin with secondary cyclic α-amino acid 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid gives rise to azomethineylide which undergoes [3+2] cycloaddition with various dipolarophiles to afford inseparable stereoisomeric mixture of spiro oxazolidinone and fused pyrrolidine derivatives. The newly synthesized compounds have been screened for their antimicrobial activities

RFID-based life cycle tracking of precast concrete units

Aussi disponible en fran\ue7ais: Suivi du cycle de vie d'\ue9l\ue9ments de b\ue9ton pr\ue9fabriqu\ue9s au moyen d'\ue9tiquettes IRFPeer reviewed: NoNRC publication: Ye

Virtual industrial enterprises and enterprise modeling

Peer reviewed: YesNRC publication: Ye

Synthesis and semiempirical calculations of imidazolidine, isoxazolone and thiazoline thiol derivatives of acenaphthylene-1 ,2-dione

3075-3080A convenient synthesis of acenaphthylidene derivatives involving Knovenaegel type condensation of imidazolidine, oxazolidine and thiazolidine derivatives with acenaphth ylene-1,2-dione has been described. The structures of newly synthesized products have been established by spectral technique. Exclusive formation of anti-mono condensation products has been explained on the basis of semi empirical calculations