Stereoisomeric synthesis of oxazolidinone and fused pyrrolidine derivatives <i>via</i> azomethine ylides and their antimicrobial activity

Abstract

412-415The reaction of isatin with secondary cyclic α-amino acid 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid gives rise to azomethineylide which undergoes [3+2] cycloaddition with various dipolarophiles to afford inseparable stereoisomeric mixture of spiro oxazolidinone and fused pyrrolidine derivatives. The newly synthesized compounds have been screened for their antimicrobial activities