Electron transfer study on newly synthesized Ti(IV)/Zr(IV) complexes of amide and oxime functionality: A pulse radiolytic and theoretical revelation

361-369Complexes of the general formula Cp2Ti(IV)L, Cp2Zr(IV)L, Cp2Ti(IV)L1 and Cp2Zr(IV)L1 have been synthesized with N,N’-bis(2-pyridyl)pyridine-2,6-dicarboxamide (H2L) and 9,10-phenanthrenequinone dioxime (H2L1). The complexes have been characterized by different spectral techniques and their reduction reactions have been carried out with hydrated electron as reducing radical, mechanism which has been explored pulse radiolytically. Theoretical calculations have been performed to understand the effect of chelation and electron transfer processes in complexes

Biological therapies in the systemic management of psoriasis: International Consensus Conference

Psoriasis is a chronic, immune-mediated disorder that usually requires long-term treatment for control. Approximately 25% of patients have moderate to severe disease and require phototherapy, systemic therapy or both. Despite the availability of numerous therapeutic options, the long-term management of psoriasis can be complicated by treatment-related limitations. With advances in molecular research and technology, several biological therapies are in various stages of development and approval for psoriasis. Biological therapies are designed to modulate key steps in the pathogenesis of psoriasis. Collectively, biologicals have been evaluated in thousands of patients with psoriasis and have demonstrated significant benefit with favourable safety and tolerability profiles. The limitations of current psoriasis therapies, the value of biological therapies for psoriasis, and guidance regarding the incorporation of biological therapies into clinical practice are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72815/1/j.1365-2133.2004.06070.x.pd

Fluorescent Discrimination between Traces of Chemical Warfare Agents and Their Mimics

An array of fluorogenic probes is able to discriminate between nerve agents, sarin, soman, tabun, VX and their mimics, in water or organic solvent, by qualitative fluorescence patterns and quantitative multivariate analysis, thus making the system suitable for the inthe- field detection of traces of chemical warfare agents as well as to differentiate between the real nerve agents and other related compounds.Ministerio de Economía y Competitividad, Spain (Project CTQ2012- 31611), Junta de Castilla y León, Consejería de Educación y Cultura y Fondo Social Europeo (Project BU246A12-1), the European Commission, Seventh Framework Programme (Project SNIFFER FP7-SEC-2012-312411) and the Swedish Ministry of Defence (no. A403913

Stereoselective synthesis and semiempirical studies of spiro bridgehead bicyclic N-heterocycles <i style="">via</i> 1,3-dipolar cycloaddition reactions of azomethine ylides

1204-1209The reaction of acenaphthylene-1,2-dione with chiral cyclic secondary a-amino acids viz. l-proline gives rise to the intermediate azomethine ylide which has been trapped by acetylenic and ethylenic dipolarophiles to produce bridgehead bicyclic cycloadducts. The stereoselectivity of these cycloadditions have been ascertained by semiempirical calculations. The newly synthesized spiroazabicyclic compounds have been characterized by elemental analyses and spectral techniques (IR, 1H NMR, 13C NMR and Mass)

Synthetic and antibacterial studies of rhodanine derivatives with indol-2,3-diones

1275-1278A facile synthesis of new isatylidene and quinoline derivatives is described by treatment of rhodanine with indol-2,3-diones via Knoevenagel condensation and Pfitzinger reaction respectively. The reaction of indol-2,3-dione derivatives with five membered heterocycles, viz rhodanine under normal and basic conditions is described. While refluxing with ethanol it afford 3,4-dihydro-3-[2-thioxo-4 –thiazolidinone]indol-2-one 3, under basic conditions l-methyl-2-thio-4-thiazolidino[5,4-b] quinoline-4-carboxylic acid 4 is obtained. The compounds 3 and 4 have been characterized by spectral studies and elemental analyses and screened for antibacterial activity

Modelling chemical reactivity in Diels-Alder cycloaddition reactions of heteroacyl- 1,4-benzoquinones-A semiempirical (AM1) computational study

518-521A semiempirical (AM1) computational study on the modelling of a number of model heteroacyl-1,4-benzoquinones with a selected set of dienes, viz. Electron-rich dienes like isoprene and 2,3-dimethyl-1 ,3-butadiene and electron-deficient diene, like perchloro-1,3-butadiene is described

Stereoisomeric synthesis of oxazolidinone and fused pyrrolidine derivatives <i>via</i> azomethine ylides and their antimicrobial activity

412-415The reaction of isatin with secondary cyclic α-amino acid 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid gives rise to azomethineylide which undergoes [3+2] cycloaddition with various dipolarophiles to afford inseparable stereoisomeric mixture of spiro oxazolidinone and fused pyrrolidine derivatives. The newly synthesized compounds have been screened for their antimicrobial activities

Synthesis, configurational analysis and antimicrobial activity of imidazolidinone, thiazolidinone and isoxazolone derivatives of 9,10-phenanthrenequinone

83-88The Knoevenagel type condensation reactions of phenanthrenequinone with imidazolidinone, thiazolidinone and isoxazolone derivatives have been described. The newly synthesized products have been characterized by spectral data. The exclusive formation of anti-configuration of monocondensation product has been explained on the basis of AM1 calculations. Some of the products have been screened for antimicrobial activity