Social Support, Identity Affirmation, and Psychological Well-Being: A Developmental and Intersectional Comparison between Italian Cisgender and Non-Binary People with Bisexual Orientation

Incorporating the perspectives of positive psychology, intersectionality, and life course into minority stress theory, this study aimed to examine the relationships between social support, identity affirmation, and psychological well-being among 483 Italian individuals with bisexual orientation, accounting for differences in gender identity (cisgender vs. non-binary) and age groups (young, early, and middle adult). A mediation model was tested in which identity affirmation served as a presumed mediator between social support and psychological well-being. We also examined whether gender identity and age group moderated the hypothesized associations. Multivariate ANOVA and multigroup mediation analyses were conducted. Results showed that (a) cisgender individuals had higher social support and psychological well-being than non-binary individuals, but not identity affirmation, which was higher in the latter group, (b) psychological well-being, but not social support and identity affirmation, differed between groups, with the youngest cohort reporting worse health than their elders, (c) identity affirmation mediated the relationship between social support and psychological well-being, (d) mediation was significant only in binary individuals (compared to cisgender), whereas no age differences were found. Overall, this study highlights the need to consider bisexual individuals as a nonhomogeneous population living multiple life experiences, especially when minority identities intersect

Circulating anti-Hsp70 levels in nascent metabolic syndrome: the Casale Monferrato Study.

The metabolic syndrome (MetS) confers an increased risk of both type 2 diabetes and cardiovascular diseases (CVD). Heat shock protein 70 (Hsp70), an intracellular polypeptide, can be exposed on the plasma membrane and/or released into the circulation, eliciting both native and immune responses that may contribute to vascular damage. Our aim was to assess if serum anti-Hsp70 antibody levels were cross-sectionally associated with uncomplicated MetS. A cross-sectional case–control study from the nondiabetic cohort of the Casale Monferrato Study was performed. Subjects with established CVD and/or abnormal renal function were excluded. Case subjects (n = 180) were defined as those fulfilling the criteria for the diagnosis of MetS. Control subjects (n = 136) were completely free of any component of the MetS. Serum anti-Hsp70 levels were measured by immunoenzymatic assay. We found that anti-Hsp70 antibody levels were significantly higher in cases than in control subjects [122.6 (89.5–155.6) vs 107.1 (77.3–152.4) μg/ml, p = 0.04], even after age and sex adjustment. In logistic regression analysis, higher levels of log-anti-Hsp70 conferred greater odds ratio (OR) for MetS, independently of age and sex. There was a statistically significant trend of ORs across quartiles of anti-Hsp70 and values greater than 108.0 μg/ml conferred a 77 % increased OR of MetS as compared with values in the lower quartiles. The strength of the association slightly decreased after further adjustment for apolipoprotein B, smoking, and albumin excretion rate. In conclusion, our results show that serum anti-Hsp70 antibody levels are independently associated with nascent MetS

A multicenter study on the diagnostic significance of a single cerebrospinal fluid IgG band

The analysis of paired cerebrospinal fluid (CSF) and serum samples with isolectric focusing (IEF) can yield different patterns which can be of aid in the differential diagnosis of central nervous system (CNS) disorders. Rarely, a single CSF-restricted IgG band, which is not included within these patterns, can be detected in association with inflammatory disorders, multiple sclerosis (MS) above all. However, the diagnostic meaning of this abnormality is still uncertain. The main aim of our multicenter study was to establish the frequency and disease associations of single CSF IgG bands. Differences in the CSF profiles between MS and other diseases, and the follow-up patterns were also evaluated. Medical records of patients who underwent CSF analysis, which included IEF, over a 11.5-year period were retrospectively scrutinized at the participating centers, which used similar IEF techniques. One hundred and fifty-one of 9422 CSF reports (1.6%) showed single CSF-restricted IgG bands. Of the 129 patients with a definite diagnosis, 58.2% had CNS inflammatory-demyelinating diseases (the most frequent being MS: 21.7%), 6.2% tumours, 5.4% inflammatory peripheral nervous system diseases and 30.2% miscellaneous diseases. At follow-up, 3 out of the 10 patients with a repeated CSF analysis had developed an oligoclonal band pattern. Our findings indicate that single CSF IgG bands tend to associate with diseases characterized by the involvement of intrathecal humoral immune responses, and strongly support the notion that this abnormality should be regularly reported, thus alerting clinicians of possible inflammatory disorders of the CNS

The Microcephalin Ancestral Allele in a Neanderthal Individual

Background: The high frequency (around 0.70 worlwide) and the relatively young age (between 14,000 and 62,000 years) of a derived group of haplotypes, haplogroup D, at the microcephalin (MCPH1) locus led to the proposal that haplogroup D originated in a human lineage that separated from modern humans.1 million years ago, evolved under strong positive selection, and passed into the human gene pool by an episode of admixture circa 37,000 years ago. The geographic distribution of haplogroup D, with marked differences between Africa and Eurasia, suggested that the archaic human form admixing with anatomically modern humans might have been Neanderthal. Methodology/Principal Findings: Here we report the first PCR amplification and high- throughput sequencing of nuclear DNA at the microcephalin (MCPH1) locus from Neanderthal individual from Mezzena Rockshelter (Monti Lessini, Italy). We show that a well-preserved Neanderthal fossil dated at approximately 50,000 years B.P., was homozygous for the ancestral, non-D, allele. The high yield of Neanderthal mtDNA sequences of the studied specimen, the pattern of nucleotide misincorporation among sequences consistent with post-mortem DNA damage and an accurate control of the MCPH

Old and new physics interpretations of the NuTeV anomaly

We discuss whether the NuTeV anomaly can be explained, compatibly with all other data, by QCD erects (maybe, if the strange sea is asymmetric, or there is a tiny violation of isospin), new physics in propagators or couplings of the vector bosons (not really), loops of supersymmetric particles (no), dimension six operators (yes, for one specific SU(2)(L)-invariant operator), leptoquarks (not in a minimal way), extra U(1) gauge bosons (maybe: an unmixed Z' coupled to B - 3L(mu) also increases the muon g - 2 by about 10(-9) and gives a 'burst' to cosmic rays above the GZK cutoff)

On Exotic Solutions of the Atmospheric Neutrino Problem

The measurements of the fluxes of atmospheric neutrinos give evidence for the disappearance of muon neutrinos. The determination of the dependence of the disappearance probability on the neutrino energy and trajectory allows in principle to establish unambiguosly the existence of neutrino oscillations. Alternative mechanisms for the disappearance of the neutrinos have been proposed, but do not provide a viable description of the data, if one includes both events where the neutrinos interact in the detector and $\nu$-induced upward going muons. The proposed mechanisms differ in the energy dependence of the disappearance probability and the upward going muon data that are produced by high energy neutrinos give a crucial constraint.Comment: LaTex, 18 pages, 6 figure

Lead isotope systematics in hydrothermal sulphide deposits from the central-eastern Southalpine (northern Italy)

The isotopic compositions of lead in copper-bearing hydrothermal sulphide deposits from the central-eastern Southalpine domain were analysed using a Multi-Collector-ICP-MS. The data were combined with existing lead isotope data (ore lead) for hydrothermal polymetallic deposits from the same area and compared with the isotopic compositions of potential lead sources. Copper and polymetallic pre-Variscan (Late Ordovician\u2013Early Silurian) stratiform, post-Variscan (Permian to Triassic) vein, and stratabound sediment-hosted (Late Permian to Early Triassic) deposits, are characterised by highly variable ratios of radiogenic to non-radiogenic lead, but show very similar, high, time-integrated mu (=238U/204Pb) and W (=232Th/204Pb) values. A progressive relative increase in radiogenic lead is observed from (i) pre-Variscan deposits to (ii) post-Variscan sulphide-rich veins in the Variscan metamorphic basement and in the lower units of the Early Permian volcanic sequence, to (iii) post-Variscan sulphide-rich and fluorite-rich veins in the upper units of the Early Permian volcanic sequence, to (iv) post-Variscan fluorite-rich veins cutting the overlying Late Permian sediments and mid-Triassic mafic dikes. The dominant lead sources for all these deposits were Cambrian\u2013Devonian (meta) sediments of the Variscan basement. Contributions from Permian and Triassic igneous rocks were of minor importance, if any, even for vein deposits which were evidently related to Permian magmatism. The isotopic compositions of some of the Permian vein deposits are consistent with, although they do not unequivocally prove, remobilization of metals from the pre-Variscan stratiform deposits. Stratabound deposits in the Late Permian sandstones and, possibly, those in the Early Triassic carbonates also received a major lead input from the Variscan metasediments, with a variable additional contribution from the host Permian sediments. Deposits in Triassic magmatic rocks are displaced to slightly lower m and W values, suggesting lead contribution from Triassic magmatism. The high m and W values of the deposits studied here are consistent with regional isotopic patterns of Pb\u2013Zn-rich deposits in more northerly and easterly sectors of the Eastern Alps (Austroalpine, eastern Southalpine) and of several circum-Mediterranean Pb\u2013Zn and polymetallic deposits of Paleozoic to Triassic age (Sardinia, Betic Cordillera) or derived from remobilisation of Paleozoic deposits (Tuscany). This isotopic uniformity suggests that an isotopic province characterized by the dominance of old (Early Proterozoic to Archean) detrital source material extended across a relatively wide portion of the former north-Gondwanan margin