Agustín Sánchez Rodrigo y la epigrafía en Serradilla, Cáceres, y sus alrededores

Este artículo examina la correspondencia entre Fidel Fita, prestigioso académico de la Historia, y Agustín Sánchez Rodrigo, vecino de Serradilla, Cáceres, cuyo objeto fue la media docena de inscripciones antiguas de cuya existencia en su pueblo y alrededores el segundo había tenido noticias.This paper assesses the epistolar exchange between Fidel Fita, a leading member of the Spanish Real Academía de la Historia, and Agustín Sánchez Rodrigo, the editor of a local newspaper in Serradilla, province of Cáceres, Spain. The motive behind the correspondence was Sánchez’ interest in sharing several ancient inscripcions found in Serradilla and environs

Cuatro altares de La Vera, Cáceres

This paper describes four Roman altars recently found in La Vera, which is the name given to the country lying between Tiétar river and Sierra de Gredos, in the Spanish province of Cáceres. Of the nine inscriptions, three epigraphs are dedications to local deities: Band(-) Vortiacius, a new divine couple, Ulisus and Ulisona; and Quangeius, this one being placed in fano, which is the second occurrence of that word in Spanish epigraphy. The last piece is a tombstone so dilapidated that it is difficult to tell apart even the normal features of an ancient epitaph.Se describen cuatro altares inscritos recientemente descubiertos en La Vera, comarca cacereña situada en la orilla septentrional del río Tiétar. De las nuevas inscripciones, tres son altares dedicados a lo que se han llamado “dioses indígenas”: Band(-) Vortiacius, lo que parece una nueva paredría (Ulisus y Ulisona) y Quangeius; nótese que este se colocó in fano, la segunda mención epigráfica del término aparecida hasta ahora en la Península. La última pieza es un epitafio, pero tan estropeado por la erosión, que apenas se reconocen los elementos característicos de esta clase de epígrafes

Understanding the DayCent model: Calibration, sensitivity, and identifiability through inverse modeling

AbstractThe ability of biogeochemical ecosystem models to represent agro-ecosystems depends on their correct integration with field observations. We report simultaneous calibration of 67 DayCent model parameters using multiple observation types through inverse modeling using the PEST parameter estimation software. Parameter estimation reduced the total sum of weighted squared residuals by 56% and improved model fit to crop productivity, soil carbon, volumetric soil water content, soil temperature, N2O, and soil NO3− compared to the default simulation. Inverse modeling substantially reduced predictive model error relative to the default model for all model predictions, except for soil NO3− and NH4+. Post-processing analyses provided insights into parameter–observation relationships based on parameter correlations, sensitivity and identifiability. Inverse modeling tools are shown to be a powerful way to systematize and accelerate the process of biogeochemical model interrogation, improving our understanding of model function and the underlying ecosystem biogeochemical processes that they represent

Rendimiento y calidad de Avena sativa asociada con Vicia sativa en la región puna del Perú

The study was conducted at the Alpaicayan Experimental Centre, Daniel Alcides Carrión National University, Pasco, Peru, with the objective of determining the forage production and nutritional quality of oats associated with vetch. Forage production was determined in green matter content (GM), dry matter (DM) and percent of dry matter (%DM). For the nutritional value, crude protein (%CP), neutral detergent fibre (%NDF), acid detergent fibre (%ADF), calcium (%Ca) and phosphorus (%P) were determined. The treatments were T-1 (Creole oat, 150 kg/ha), T-2 (Mantaro 15 oat, 110 kg/ha), T-3 (Mantaro 15 oat plus vetch, 110 and 30 kg/ha) and T-4 (creole oat plus vetch, 150 and 30 kg/ha). GM production indicated that T-1 and T-4 were similar but significantly greater than T-2 and T-3 (p<0.05); however, without significant differences in DM production between treatments. T-4 obtained the largest content of %PC, T-2 and T-4 presented greater yields of %NDF and %ADF. T-4 presented the highest content of %P, while there was no difference between treatments for the content of %Ca. It is concluded that the Mantaro 15 + vetch treatment has a better forage production and is of better nutritional quality in relation to the other treatments.El estudio se realizó en el Centro Experimental Alpaicayán, Universidad Nacional Daniel Alcides Carrión, Pasco, Perú, con el objetivo fue determinar la producción forrajera y calidad nutricional de la avena asociada con vicia. Se determinó la producción forrajera en contenidos de materia verde (MV), materia seca (MS) y el porcentaje de materia seca (%MS). Para el valor nutricional se determinaron la proteína cruda (%PC), fibra detergente neutro (%FDN), fibra detergente ácido (%FDA), calcio (%Ca) y fósforo (%P). Los tratamientos fueron T-1 (avena criolla, 150 kg/ha), T-2 (avena Mantaro 15, 110 kg/ha), T- 3 (avena Mantaro 15 más vicia, 110 y 30 kg/ha) y T-4 (avena criolla más vicia, 150 y 30 kg/ha). La producción de MV indicó que T-1 y T-4 fue similar, pero significativamente superior a T-2 y T-3 (p<0.05); sin embargo, sin diferencias significativas en producción de MS entre tratamientos. T-4 obtuvo mayor contenido de %PC, T-2 y T-4 presentaron los mayores rendimientos de %FDN y %FDA. T-4 presentó el mayor contenido de %P, en tanto que no hubo diferencias entre tratamientos para el contenido de %Ca. Se concluye que el tratamiento Mantaro 15 +vicia tiene una mejor producción forrajera y es de mejor calidad nutricional en referencia a los otros tratamientos.

New insights into cancer: MDM2 binds to the citrullinating enzyme PADI4

PADI4 is one of the human isoforms of a family of enzymes implicated in the conversion of arginine to citrulline. MDM2 is an E3 ubiquitin ligase which is crucial for down-regulation of degradation of the tumor suppressor gene p53. Given the relationship between both PADI4 and MDM2 with p53-signaling pathways, we hypothesized they may interact directly, and this interaction could be relevant in the context of cancer. Here, we showed their association in the nucleus and cytosol in several cancer cell lines. Furthermore, binding was hampered in the presence of GSK484, an enzymatic PADI4 inhibitor, suggesting that MDM2 could bind to the active site of PADI4, as confirmed by in silico experiments. In vitro and in silico studies showed that the isolated N-terminal region of MDM2, N-MDM2, interacted with PADI4, and residues Thr26, Val28, Phe91 and Lys98 were more affected by the presence of the enzyme. Moreover, the dissociation constant between N-MDM2 and PADI4 was comparable to the IC50 of GSK484 from in cellulo experiments. The interaction between MDM2 and PADI4 might imply MDM2 citrullination, with potential therapeutic relevance for improving cancer treatment, due to the generation of new antigens

GA design of small thin-wire antennas: comparison with Sierpinski-type prefractal antennas

A new set of genetically generated electrically small thin-wire antennas with a better performance than that of several families of Sierpinsky prefractal monopoles of the same electrical size at resonance is presentedPeer Reviewe

Essential role of the N-terminal region of TFII-I in viability and behavior

<p>Abstract</p> <p>Background</p> <p><it>GTF2I </it>codes for a general intrinsic transcription factor and calcium channel regulator TFII-I, with high and ubiquitous expression, and a strong candidate for involvement in the morphological and neuro-developmental anomalies of the Williams-Beuren syndrome (WBS). WBS is a genetic disorder due to a recurring deletion of about 1,55-1,83 Mb containing 25-28 genes in chromosome band 7q11.23 including <it>GTF2I</it>. Completed homozygous loss of either the <it>Gtf2i </it>or <it>Gtf2ird1 </it>function in mice provided additional evidence for the involvement of both genes in the craniofacial and cognitive phenotype. Unfortunately nothing is now about the behavioral characterization of heterozygous mice.</p> <p>Methods</p> <p>By gene targeting we have generated a mutant mice with a deletion of the first 140 amino-acids of TFII-I. mRNA and protein expression analysis were used to document the effect of the study deletion. We performed behavioral characterization of heterozygous mutant mice to document <it>in vivo </it>implications of TFII-I in the cognitive profile of WBS patients.</p> <p>Results</p> <p>Homozygous and heterozygous mutant mice exhibit craniofacial alterations, most clearly represented in homozygous condition. Behavioral test demonstrate that heterozygous mutant mice exhibit some neurobehavioral alterations and hyperacusis or odynacusis that could be associated with specific features of WBS phenotype. Homozygous mutant mice present highly compromised embryonic viability and fertility. Regarding cellular model, we documented a retarded growth in heterozygous MEFs respect to homozygous or wild-type MEFs.</p> <p>Conclusion</p> <p>Our data confirm that, although additive effects of haploinsufficiency at several genes may contribute to the full craniofacial or neurocognitive features of WBS, correct expression of <it>GTF2I </it>is one of the main players. In addition, these findings show that the deletion of the fist 140 amino-acids of TFII-I altered it correct function leading to a clear phenotype, at both levels, at the cellular model and at the <it>in vivo </it>model.</p