1,687 research outputs found
Unique Case of Anca-Negative Pauci-Immune Necrotizing Glomerulonephritis With Diffuse Alveolar Hemorrhage, Potentially Associated With Midostaurin
We present a 61-year-old male with FLT3-mutated acute myeloid leukemia treated with midostaurin who developed acute kidney injury requiring hemodialysis and pulmonary renal syndrome. Antibodies to proteinase-3, myeloperoxidase, and glomerular basement membrane were negative. Renal biopsy confirmed acute pauci-immune focal necrotizing glomerulonephritis (GN) with fibrin crescents indicating rapidly progressing glomerulonephritis. He improved with pulse methylprednisolone, intravenous cyclophosphamide, and plasma exchange with resolution of hemoptysis. This case highlights the importance of prompt renal biopsy to guide early initiation of life-saving therapies. To our knowledge, this is the first reported case of ANCA-negative pauci-immune necrotizing GN likely secondary to midostaurin
Effectiviteit bodembeschermende voorzieningen voor spoelbassins in de bloembollensector; veldonderzoek
Drie principes van bodembeschermende voorzieningen voor spoelbassins zijn in de praktijk onderzocht: remming van infiltratiesnelheid (met klei en folie afdichtingen), hydrologische isolatie (interceptor drains met en zonder afdichtingslaag) en adsorptie. Op zand-, zavel en lössgronden is afdichten met klei of leem nodig wanneer de bodem boven de grondwaterspiegel ligt om recirculatie mogelijk te maken, maar deze maatregel is onvoldoende voor de bescherming van de bodem en zijn aanvullende voorzieningen nodig (bijvoorbeeld hydrologische isolatie). In kwelgebieden en in situaties met een verlaagde bodem is deze variant wel effectief. De effectiviteit van hydrologische isolatie en adsorptielagen lopen uiteen van 90 tot 95%. De investeringen voor bodembeschermende voorzieningen bedragen f 3,00 tot f 13,00 per m3 en de jaarlijkse kosten f 1,70 tot f 2,20 per m3 bassin inhoud. Monitoring dient zich te richten op verspreiding bij hydrologische isolatie en infiltratieremming, aangevuld met monitoring van de kwaliteit van het grondwater. Monitoring van adsorptielagen dient zich te richten op de kwaliteit van de adsorptielaag en de bodem daaronder
E proteins orchestrate dynamic transcriptional cascades implicated in the suppression of the differentiation of group 2 innate lymphoid cells
Group 2 innate lymphoid cells (ILC2s) represent a subset of newly discovered immune cells that are involved in immune reactions against microbial pathogens, host allergic reactions, as well as tissue repair. The basic helix-loop-helix transcription factors collectively called E proteins powerfully suppress the differentiation of ILC2s from bone marrow and thymic progenitors while promoting the development of B and T lymphocytes. How E proteins exert the suppression is not well understood. Here we investigated the underlying molecular mechanisms using inducible gain and loss of function approaches in ILC2s and their precursors, respectively. Cross-examination of RNA-seq and ATAC sequencing data obtained at different time points reveals a set of genes that are likely direct targets of E proteins. Consequently, a widespread down-regulation of chromatin accessibility occurs at a later time point, possibly due to the activation of transcriptional repressor genes such as Cbfa2t3 and Jdp2. The large number of genes repressed by gain of E protein function leads to the down-regulation of a transcriptional network important for ILC2 differentiation
A burst search for gravitational waves from binary black holes
Compact binary coalescence (CBC) is one of the most promising sources of
gravitational waves. These sources are usually searched for with matched
filters which require accurate calculation of the GW waveforms and generation
of large template banks. We present a complementary search technique based on
algorithms used in un-modeled searches. Initially designed for detection of
un-modeled bursts, which can span a very large set of waveform morphologies,
the search algorithm presented here is constrained for targeted detection of
the smaller subset of CBC signals. The constraint is based on the assumption of
elliptical polarisation for signals received at the detector. We expect that
the algorithm is sensitive to CBC signals in a wide range of masses, mass
ratios, and spin parameters. In preparation for the analysis of data from the
fifth LIGO-Virgo science run (S5), we performed preliminary studies of the
algorithm on test data. We present the sensitivity of the search to different
types of simulated CBC waveforms. Also, we discuss how to extend the results of
the test run into a search over all of the current LIGO-Virgo data set.Comment: 12 pages, 4 figures, 2 tables, submitted for publication in CQG in
the special issue for the conference proceedings of GWDAW13; corrected some
typos, addressed some minor reviewer comments one section restructured and
references updated and correcte
Hospitalized Infection as a Trigger for Acute Ischemic Stroke
Acute triggers for ischemic stroke, which may include infection, are understudied, as is whether background cardiovascular disease (CVD) risk modifies such triggering. We hypothesized that infection increases acute stroke risk, especially among those with low CVD risk
Role of BMI in the Association of the TCF7L2 rs7903146 Variant with Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study
We examined the association of variation in the type 2 diabetes risk-conferring TCF7L2 gene with the risk of incident coronary heart disease (CHD) among the lean, overweight, and obese members of the Atherosclerosis Risk in Communities (ARIC) Study cohort. Cox proportional hazard regression analyses were performed using a general model, with the major homozygote as the reference category. For 9,865 whites, a significant increase in the risk of CHD was seen only among lean ( BMI < 25âkg/m2) individuals homozygous for the T allele of the TCF7L2 rs7903146 gene risk variant (hazard ratio 1.42; 95% CI 1.03,1.97; P = .01). No association was found among 3,631 blacks, regardless of BMI status. An attenuated hazard ratio was observed among the nondiabetic ARIC cohort members. This study suggests that body mass modifies the association of the TCF7L2 rs7903146 T allele with CHD risk
The Relationship Between Self-Reported History of Endodontic Therapy and Coronary Heart Disease in the Atherosclerosis Risk in Communities Study
Results from numerous studies have suggested links between periodontal disease and coronary heart disease (CHD), but endodontic disease has not been studied extensively in this regard
Networks of gravitational wave detectors and three figures of merit
This paper develops a general framework for studying the effectiveness of
networks of interferometric gravitational wave detectors and then uses it to
show that enlarging the existing LIGO-VIRGO network with one or more planned or
proposed detectors in Japan (LCGT), Australia, and India brings major benefits,
including much larger detection rate increases than previously thought... I
show that there is a universal probability distribution function (pdf) for
detected SNR values, which implies that the most likely SNR value of the first
detected event will be 1.26 times the search threshold. For binary systems, I
also derive the universal pdf for detected values of the orbital inclination,
taking into account the Malmquist bias; this implies that the number of
gamma-ray bursts associated with detected binary coalescences should be 3.4
times larger than expected from just the beaming fraction of the gamma burst.
Using network antenna patterns, I propose three figures of merit that
characterize the relative performance of different networks... Adding {\em any}
new site to the planned LIGO-VIRGO network can dramatically increase, by
factors of 2 to 4, the detected event rate by allowing coherent data analysis
to reduce the spurious instrumental coincident background. Moving one of the
LIGO detectors to Australia additionally improves direction-finding by a factor
of 4 or more. Adding LCGT to the original LIGO-VIRGO network not only improves
direction-finding but will further increase the detection rate over the
extra-site gain by factors of almost 2, partly by improving the network duty
cycle... Enlarged advanced networks could look forward to detecting three to
four hundred neutron star binary coalescences per year.Comment: 38 pages, 7 figures, 2 tables. Accepted for publication in Classical
and Quantum Gravit
Weak Lensing from Space I: Instrumentation and Survey Strategy
A wide field space-based imaging telescope is necessary to fully exploit the
technique of observing dark matter via weak gravitational lensing. This first
paper in a three part series outlines the survey strategies and relevant
instrumental parameters for such a mission. As a concrete example of hardware
design, we consider the proposed Supernova/Acceleration Probe (SNAP). Using
SNAP engineering models, we quantify the major contributions to this
telescope's Point Spread Function (PSF). These PSF contributions are relevant
to any similar wide field space telescope. We further show that the PSF of SNAP
or a similar telescope will be smaller than current ground-based PSFs, and more
isotropic and stable over time than the PSF of the Hubble Space Telescope. We
outline survey strategies for two different regimes - a ``wide'' 300 square
degree survey and a ``deep'' 15 square degree survey that will accomplish
various weak lensing goals including statistical studies and dark matter
mapping.Comment: 25 pages, 8 figures, 1 table, replaced with Published Versio
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