Synthesis and biological evaluation of 1-(5-(2-chloroquinolin-3-yl)-3-phenyl-1H-pyrazol-1-yl)ethanone derivatives as potential antimicrobial agents

A novel series of 2-Chloroquinoline nucleus clubbed with the pyrazole ring has been synthesized and screened for antibacterial and antifungal activity. The results obtained were promising against both bacterial and fungal strains.   Among the series, compound MB-N was found moderately active against Aspergillus fumigatus, Penicillium notatum and Bacillus subtilis having MIC 48, 46 and 44 μg/ml, respectively whereas compound MB-A was found active against P. notatum, B. subtilis and Escherichia coli having MIC 57, 54 and 43 μg/ml, respectively as compared to standard

Triazole hybrids as new type of anti-fungal agents

The present work involves synthesis of novel anti-fungal agents containing triazole scaffold. The newly designed compounds were synthesized on the trails of ketoconazole using the molecular hybridization approach. A series of 10 compounds having (2-((1H-1,2,4-triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl esters (4a–j) were prepared by conventional synthetic approach. The synthesized compounds were subjected for in vitro anti-fungal screening against Aspergillus niger, Aspergillus fumigatus, Candida albicans and Penicillium notatum. Out of 10 newly synthesized compounds, six compounds (4b–f and j) showed remarkable anti-fungal activity (MIC range 6.5–25 μg/ml), whereas compound 4d (MIC 6.5 μg/ml) was more potent than standard drug ketoconazole (MIC 12.5 μg/ml). These triazole hybrids can be considered as potential anti-fungal agents