Model for Research into the Factors Influencing the Effective Planning and Management of Production Capacity

In today's dynamic business environment, the success and competitiveness of any production organization is ensured by continuous improvement, sustainable development, effective planning and management. There is a growing scientific interest in the importance and relevance of production management in view of the strong need to redefine the policies and priorities within the respective strategic plan for business development - with increased focus on capacity planning in order for the industrial enterprises to adapt successfully to the dynamically changing conditions of the global environment and intense competition. Accordingly, full advantage is taken from the ample opportunities to study the impact of a number of factors on capacity planning and management. Based on an in-depth literature analysis, interviews and surveys, selected were 18 key factors  that have a profound influence on the effective planning and capacity management of the production organization. Using  the relationship between each of these factors and the capacity management is closely examined by applying the method of Interpretive Structural Modeling (ISM). Additionally, the interrelationships between the key factors under study are further analyzed by means of a Structural self-interaction matrix (SSIM)

Manageable droplet infections in the Dobrich region - past, present and future

Въведение: В края на ХІХ и началото на ХХ век главната причина за смъртността в света са инфекциозните болести. Научните постижения в борбата с инфекциозните заболявания доведоха до ликвидиране на вариолата през 1980 година и изпълнение на международни програми за ликвидиране на други - морбили, епидемичен паротит, вродена рубеола и други. Това са ваксино-предотвратими инфекции, наречени управляеми, за които са въвеждани обективни критерии за епидемиологичен надзор, които дават възможност за своевременни корекции в имунизационните програми и повлияване на заболеваемостта от тях.Цел и задачи: Проучване на регистрираната обща инфекциозна и управляемата въздушно капкова заболяемост в Добричка област за периода 1995- 2012 год.Материали и методи: Отчети, анализи на РЗИ, МЗ, НЦЗПБ, епидемиологично проучване, епидемиологичен анализ, статистически методи.Резултати: Основните показатели на епидемиологичния анализ, които включват заболяемост, смъртност, леталитет, заболяемост по възрастови групи, разглеждаме за продължителен период (1995-2012 г.), тъй като влиянието на имунопрофилактиката при въздушно-капковите инфекции е бавен процес, свързан както с възрастта, така и с държавната политика в областта на имунизационното дело.Изводи: Общата заразна заболяемост в област Добрич за проучвания 18-годишен период (1995- 2012 г.) е около или под средните стойности за страната с изключение на няколко години (1996 г., 2001 г., 2002 г., 2003 г., 2004 г.). Управляемите въздушно-капкови инфекции - морбили, епидемичен паротит, и рубеола са с ниска заболяемост до липсваща такава.Introduction: In the late nineteenth and early twentieth century the main cause of mortality in the world was infectious diseases. Scientific advances in the fight against infectious diseases led to the eradication of smallpox in 1980 and implementation of international programs for the eradication of others - measles, mumps, congenital rubella and others. These are vaccine-preventable infections (the socalled manageable infections), for which objective criteria for epidemiological surveillance have been introduced, that allow for timely adjustments in immunization programs and to influence their morbidity.Purpose and tasks: To investigate the registered total infectious and manageable droplet morbidity in the Dobrich region for the 1995-2012 period.Materials and Methods: Reports, analysis of RHI (Regional Health Inspectorate), MH (Ministry of Health), NCIPD (National Center of Infectious and Parasitic Diseases), epidemiological study, epidemiological analysis, statistical methods.Results: We observed the main indicators of epidemiological analysis, which include morbidity, mortality, lethality and incidence by age groups, for a long period (years 1995-2012), since the impact of immunotherapy in droplet infections is a slow process, related to age as well as to government immunization policies.Conclusions: The total infectious morbidity in Dobrich for the studied 18 years period (1995- 2012) was around or below the national average with exception of a few years (1996, 2001, 2002, 2003 and 2004). The manageable droplet infections - measles, mumps, and rubella have low or no morbidit

NOTES ON THE ROLE PLAYED BY MICROBIOLOGICAL FACTORS IN THE OCCURRENCE AND COURSE OF SCHIZOPHRENIA

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Imprinting: nature and manifestations in humans

Imprinting (filial and sexual) is a process of learning a key stimulus or complex stimuli during early critical periods of development, further determining the implementation of innate forms of behavior. The present literature review summarizes earlier and current data regarding the neurophysiology and neurochemistry of imprinting, and its potential benefits. Although, according to the classic views, imprinting is inherent in birds and some mammals, there are reasons to assume that imprinting or similar forms of learning also exist in humans. In the context of this assumption, the mechanisms of newborn-mother bonding and of assortative mate choice in humans are discussed

UPON THE ETIOLOGICAL TREATMENT OF BACTERIAL NONGONOCOCCAL URETHRITIS

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Histone deacetylase inhibitors induce apoptosis in myeloid leukemia by suppressing autophagy

Histone deacetylase (HDAC)-inhibitors (HDACis) are well characterized anti-cancer agents with promising results in clinical trials. However, mechanistically little is known regarding their selectivity in killing malignant cells while sparing normal cells. Gene expression-based chemical genomics identified HDACis as being particularly potent against Down syndrome associated myeloid leukemia (DS-AMKL) blasts. Investigating the anti-leukemic function of HDACis revealed their transcriptional and posttranslational regulation of key autophagic proteins, including ATG7. This leads to suppression of autophagy, a lysosomal degradation process that can protect cells against damaged or unnecessary organelles and protein aggregates. DS-AMKL cells exhibit low baseline autophagy due to mTOR activation. Consequently, HDAC inhibition repressed autophagy below a critical threshold, which resulted in accumulation of mitochondria, production of reactive oxygen species, DNA-damage and apoptosis. Those HDACi-mediated effects could be reverted upon autophagy activation or aggravated upon further pharmacological or genetic inhibition. Our findings were further extended to other major acute myeloid leukemia subgroups with low basal level autophagy. The constitutive suppression of autophagy due to mTOR activation represents an inherent difference between cancer and normal cells. Thus, via autophagy suppression, HDACis deprive cells of an essential pro-survival mechanism, which translates into an attractive strategy to specifically target cancer cells