Exclusive surgical treatment for vestibular schwannoma regrowth or recurrence: A meta-analysis of the literature

Vestibular schwannomas can be treated in different ways, but for symptomatic or growing tumors, the gold standard is surgical removal of the lesion. In order to preserve neurovascular structures, partial removal is often performed, leaving a residual that may grow in subsequent years. To date, there is no consensus with regard to surgical treatment of vestibular schwannoma residuals, and so this review focuses on this topic. A structured search was performed on PubMed searching for all articles discussing vestibular schwannoma residuals and recurrences. Only articles discussing surgical treatment were included, focusing on studies which also examined facial nerve outcomes. A total of 51 articles were eligible for review and these included 375 patients. Statistical analysis was performed by correlating the following parameters: patients' gender and age at first surgery, surgical approach adopted at first and subsequent surgeries, tumor and residual size, and extent of resection (gross total, near total, subtotal or others) at first and subsequent surgical procedures. Facial nerve function was also analyzed focusing on its performance when correlated with the different surgical approaches. The data were analyzed by linear regression but there were no correlations between any of the parameters chosen. There was a statistically significant difference between the first approach used (mainly the retrosigmoid route) compared with subsequent approaches (mainly the translabyrinthine route). In total, 8.5 % of patients needed further treatment due to residual regrowth. Facial nerve outcome was independent of the parameters chosen. Exclusive surgical treatment for vestibular schwannoma residuals had a very low failure rate in terms of requiring further treatment. The approach usually chosen for second surgery was the translabyrinthine technique, and this may be explained by the location of the residual, rather than its size. The choice of a particular surgical approach rather than another had no influence on facial nerve function. Complications rates are comparable to Gamma Knife Radiosurgery's as reported in the literature

A Computation Fluid Dynamics Methodology for the Analysis of the Slipper-Swash Plate Dynamic Interaction in Axial Piston Pumps

This paper proposes a CFD methodology for the simulation of the slipper's dynamics of a swash-plate axial piston unit under actual operating conditions. The study considers a typical slipper design, including a vented groove at the swash-plate interface. The dynamic fluid-body interaction (DFBI) model is exploited to find the instantaneous position of the slipper, while the morphing approach is adopted to cope with the corresponding mesh distortion. A modular approach is adopted to ensure high-quality mesh on the entire slipper surface and sliding interfaces provide the fluid dynamic connection between neighboring regions. The external forces acting on the slipper are included by means of user-defined lookup tables with the simulation estimating the lift force induced by fluid compression. Moreover, the force produced by the metal-to-metal contact between the slipper and the swash plate is modeled through a specific tool of the software. The pressure signal over an entire revolution of the pump is taken as an input of the simulation and a variable time step is used to manage the high-pressure gradients occurring in the regions of inner and outer dead points of the piston. The weakly compressible characteristic of the fluid is considered by a specific pressure-dependent density approach, and the two-equation eddy-viscosity k-omega SST (shear stress transport) model is used to assess the turbulent behavior of the flow. Furthermore, the transitional model predicts the onset of transition, thus solving different equations depending on whether the flow enters a laminar or turbulent regime. In conclusion, the proposed methodology investigates the motion of the slipper in response to several external forces acting on the component. The numerical results are discussed in terms of variable clearance height, pressure distribution within the gap, and lift forces acting on the slipper under specific pump operations

Friedrich Nietzsche e la forza retorica

L’articolo ruota attorno ad almeno tre questioni: (1) l’attenzione del giovane Nietzsche per la retorica antica è accidentale e transitoria oppure risponde a motivi essenziali e quindi anche duraturi della sua esperienza filosofica? (2) Incontrando la costitutiva retoricità e metaforicità del linguaggio Nietzsche pone il primo sigillo sulla sua liquidazione della verità come mito insostenibile oppure comincia a cimentarsi con l’idea che la verità non si riduca a verità in sé, univoca e priva di travestimenti? (3) Quali possono essere le ragioni filosofiche per cui Nietzsche pensa alla retorica solo in termini di figure e di stile, lasciando invece cadere ogni rilevanza delle argomentazioni

On the Mechanical Energy Involved in the Catastrophic Rupture of Liquid Hydrogen Tanks

Hydrogen can play a central role in the energy transition thanks to its unique properties. However, its low density is one of the main drawbacks. The liquefaction process can drastically increase its density up to virtually 71 kg m-3 at atmospheric pressure and -253°C (NIST, 2019). The safety knowledge gap on physical explosions is still broad in the case of liquid hydrogen (LH2). For instance, it is unclear what are the consequences yields as well as the probabilities of a catastrophic rupture of an LH2 tank. A boiling liquid expanding vapour explosion (BLEVE) might arise after this top event. In this case, the expansion of the compressed gaseous phase is followed by the flashing of a fraction of the liquid. Moreover, combustion may occur for hydrogen since it is highly flammable. This complex phenomenon was not widely explored for LH2 yet. This study focused on the physical explosion by also considering the combustion process. Many integral models were adopted to estimate the mechanical energy developed by the explosion. The tank pressure prior to the rupture was considered below the critical one (1.298 MPa (NIST, 2019)). It was assumed that both liquid and gaseous phases are present inside the tank. The influences of the filling degree of the tank (liquid level) and the temperatures of the liquid and gaseous phases on the explosion energy were analysed. The results were compared with the ones of a previous study where similar models were employed to estimate the mechanical energy of an LH2 tank with different initial conditions (Ustolin et al., 2020a). In particular, the effect of the combustion process on the explosion energy and shock wave overpressure was not accounted for. The aim of this study is to conduct a comparison between different models and assess which are the most and the least conservative. The outcomes of this work provide critical suggestions on the consequence analysis of cryogenic liquefied gas vessels explosions

Development of a Numerical Approach for the CFD Simulation of a Gear Pump under Actual Operating Conditions

The geometric complexity and high-pressure gradients that characterize the design of the flow field of gear pumps make it very difficult to obtain an accurate CFD simulation of the component. Usually, assumptions are made both in terms of geometrical features and physics being included in the analysis. The contact between the teeth, which is a key factor for the correct functioning of these pumps, represents a critical challenge in 3D CFD simulations, mainly due to the intrinsic limits of the dynamic meshing techniques that can hardly effectively manage a zero or close to zero gap point forming during gear rotation. The geometric complexity and high-pressure gradients that characterize the gear pump flow field make a CFD analysis quite difficult, and the contact between the gear teeth is usually avoided, thus being an extremely important feature. In this paper, a gear pump composed of inlet and outlet pipes was considered, and the contact between the gear's teeth was modeled in two different ways, one where it is effectively implemented and one where it is avoided using distancing and a proper casing modification. Herein, a new methodology is proposed for the application of the dynamic mesh method in the Simcenter STAR-CCM+ environment using an adaptive remeshing technique. The proposed methodology is compared with the alternative overset meshing method available in the software. The new meshing method is implemented using a user-routing that reproduces the real geometry of the gears while rotating during the pump operation, with teeth contact included. The routine is optimized in order to limit the additional computation and time needed for the remeshing process. The results that can be obtained using the two meshing approaches for the gear pump are compared in terms of computational effort and the accuracy of the results. The two methods showed opposite results in almost all the reported results, with the overset being more precise in the radial pressure evaluation and the dynamic being more reliable in the cavitation/aeration extension cloud

ROSAT HRI X-ray Observations of the Open Globular Cluster NGC 288

A ROSAT HRI X-ray image was obtained of the open globular cluster NGC 288, which is located near the South Galactic Pole. This is the first deep X-ray image of this system. We detect a Low Luminosity Globular Cluster X-ray source (LLGCX) RXJ005245.0-263449 with an X-ray luminosity of (5.5+-1.4)x10^32 ergs/s (0.1-2.0 keV), which is located very close to the cluster center. There is evidence for X-ray variability on a time scale of <~ 1 day. The presence of this LLGCX in such an open cluster suggests that dense stellar systems with high interaction rates are not needed to form LLGCXs. We also searched for diffuse X-ray emission from NGC 288. Upper limits on the X-ray luminosities are L_X^h < 9.5x10^32 ergs/s (0.52-2.02 keV) and L_X^s < 9.3x10^32 ergs/s (0.11-0.41 keV). These imply upper limits to the diffuse X-ray to optical light ratios in NGC 288 which are lower than the values observed for X-ray faint early-type galaxies. This indicates that the soft X-ray emission in these galaxies is due either to a component which is not present in globular clusters (e.g., interstellar gas, or a stellar component which is not found in low metallicity Population II systems), or to a relatively small number of bright Low Mass X-ray Binaries (LMXBs).Comment: The Astrophysical Journal in press. Minor revisions to improve presentation. 6 pages with 3 embedded Postscript figures in emulateapj.st

Human reliability analysis: exploring the intellectual structure of a research field

Humans play a crucial role in modern socio-technical systems. Rooted in reliability engineering, the discipline of Human Reliability Analysis (HRA) has been broadly applied in a variety of domains in order to understand, manage and prevent the potential for human errors. This paper investigates the existing literature pertaining to HRA and aims to provide clarity in the research field by synthesizing the literature in a systematic way through systematic bibliometric analyses. The multi-method approach followed in this research combines factor analysis, multi-dimensional scaling, and bibliometric mapping to identify main HRA research areas. This document reviews over 1200 contributions, with the ultimate goal of identifying current research streams and outlining the potential for future research via a large-scale analysis of contributions indexed in Scopus database

Risk Assessment at the Cosmetic Product Manufacturer by Expert Judgment Method

A case study was performed in a cosmetic product manufacturer. We have identified the main risk factors of occupational accidents and their causes. Risk of accidents is assessed by the expert judgment method. Event tree for the most probable accident is built and recommendations on improvement of occupational health and safety protection system at the cosmetic product manufacturer are developed. The results of this paper can be used to develop actions to improve the occupational safety and health system in the chemical industry

Chemically Induced Mismatch of Rings and Stations in [3]Rotaxanes

The mechanical interlocking of molecular components can lead to the appearance of novel and unconventional properties and processes, with potential relevance for applications in nanoscience, sensing, catalysis, and materials science. We describe a [3]rotaxane in which the number of recognition sites available on the axle component can be changed by acid-base inputs, encompassing cases in which this number is larger, equal to, or smaller than the number of interlocked macrocycles. These species exhibit very different properties and give rise to a unique network of acid-base reactions that leads to a fine pKa tuning of chemically equivalent acidic sites. The rotaxane where only one station is available for two rings exhibits a rich coconformational dynamics, unveiled by an integrated experimental and computational approach. In this compound, the two crown ethers compete for the sole recognition site, but can also come together to share it, driven by the need to minimize free energy without evident inter-ring interactions