Análisis de la estabilidad de un buque durante la operación de descarga de una carga pesada

El objetivo del presente trabajo es el de analizar el comportamiento de un buque y su carga en relación con la estabilidad de ambos. Puesto que la estabilidad de un buque está expuesta a numerosos factores que pueden tener una influencia sobre la misma y considerando la complejidad analítica vinculada al análisis de estabilidad, el trabajo se centrará en una circunstancia concreta: la operación de descarga de una carga pesada. El análisis se centrará en los cálculos y consideraciones necesarios para garantizar la seguridad tanto para las personas como para las cosas. La primera parte del trabajo se centra en el estudio analítico teórico de la estabilidad del buque y su carga para la operación de descarga, considerando las características especiales del buque y de la carga, así como la propia operación de descarga. La segunda parte consiste en la aplicación práctica de los resultados obtenidos en la primera mediante la utilización de datos reales, es decir, datos relativos a las características del buque y de la carga, vinculando así el estudio teórico con su aplicación práctica. Esta segunda parte se completa con la exposición de las circunstancias reales acaecidas en la operación de descarga objeto de análisis. Las conclusiones que se alcanzan confirman la complejidad analítica vinculada al análisis de estabilidad en las circunstancias particulares objeto del estudio, identificando los aspectos críticos que deben tomarse en consideración para garantizar la seguridad y éxito de la operación. El uso de datos reales aporta una visión concreta de los parámetros analizados que permite entender mejor el impacto de los mismos, permitiendo de este modo una toma de decisiones más ajustada. Finalmente, la situación real expuesta aporta una visión entendedora de las consecuencias de una deficiente planificación o una ejecución incorrecta de una operación de estas características.The objective of this project is to analyze the behavior of a ship and her cargo in connection with the stability of both. Considering that ship stability is subject to many factors that would impact in the same and considering the analytical complexity of the ship’s stability, the project will focus on a particular circumstance: the unloading operation of a heavy lift. The analysis will review the calculations and considerations to be taken into account with the objective to guarantee the security for both the persons and the properties. The first part of the project will focus on the theoretical analytical study of the ship’s stability and her cargo for the unloading operation, considering the special characteristics of the ship and the cargo, as well as the unloading operation itself. The second part is the practical application of the results that have been obtained in the first part by means of the use of real data, that is, data related to the ship and her cargo characteristics, thus linking the theoretical study with its practical application. This second part is complemented with the description of the real circumstances that happened during the unloading operation which is object of our analysis. The conclusions that are reached confirm the analytical complexity of the stability analysis for the particular circumstances that have been the object of analysis, identifying the critical aspects that have to be considered in order to guarantee the security and success of the operation. The use of real data brings the vision of the parameters that have been analyzed, thus understanding better their impact, leading to a more accurate decision making. Finally, the outcomes arisen from the real unloading operation brings a comprehensive vision of the consequences of a poor planning and incorrect execution of an operation of such characteristics

EL MODELO EDUCATIVO DEL INSTITUTO CIENTÍFICO Y LITERARIO AUTÓNOMO Y SU TRÁNSITO A UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MÉXICO

La inquietud que existe por hacer esta investigación histórica-educativa sobre los inicios de la UAEMex nace a partir desde el momento en que fui parte de la misma, existieron infinidad de cuestionamientos para la elaboración de este proyecto, que sin duda permitieron clarificar la dirección del presente trabajo. Por ejemplo, ¿por qué se funda la máxima casa de estudios en 1828?, ¿en qué circunstancias se encontraba el país?, ¿quienes formaron parte de la historia del ICLA?, ¿la intervención del positivismo en México que tanto benefició o afectó en el modelo educativo que se venía manejando? , ¿en qué momento se encontraba la Universidad al otorgar la autonomía? , ¿por qué se decido otorgarla?, ¿el modelo educativo que actualmente se maneja en México, es el adecuado para la sociedad?. Considero que para todos los estudiantes de la máxima casa de estudios del Estado de México debe ser muy importante conocer la historia de la UAEMex, porque es un orgullo ser parte de la misma y de la transformación a la que pertenecemos como años atrás lo fueron los institutenses y ahora nosotros en la era digital. Es una investigación hecha para toda la población universitaria con la intención de aportar información de gran utilidad para estudiar su identidad universitaria.En el presente trabajo se realizó una investigación sobre los inicios históricos-educativos de la máxima casa de estudios de la Universidad Autónoma del Estado de México; los eventos que repercutieron en las modificaciones de los modelos educativos que se manejaron dentro de la misma. Hablamos de la época post-independentista; los acontecimientos históricos, políticos y económicos que orillaron al antiguo Instituto Científico y Literario Autónomo a aprender a ajustarse a las necesidades sociales que se exigían en aquellos años y al mismo tiempo formar profesionales calificados para atender a las exigencias que el Estado requería.Universidad Autónoma del Estado de Méxic

Therapeutic management of allergic rhinitis: a survey of otolaryngology and allergology specialists

Purpose: To describe the current management of allergic rhinitis (AR) in Spain's specialized care according to the next-generation ARIA guidelines. Methods: An ad hoc online survey was distributed to AR specialists to appraise their perceptions of pathology management, knowledge of next-generation ARIA guidelines (including four case clinics), and their views on the principal barriers and the actions to proper AR management. Results: one hundred nine specialists (38.5% allergists and 61.5% otolaryngologists) completed the study survey. Most respondents (87.2%) had read all or part of the Next-Generation ARIA Guidelines, and 81.6% stated that they considered the patient’s treatment choice preferences. However, only 20.2% of specialists answered according to the recommendations in at least three of the four case clinics. Most participants failed to fulfill the treatment duration according to the guidelines. They regarded the lack of multidisciplinary teams (21.7%) and the lack of patients’ AR treatment adherence (30.6%) as the most critical healthcare system- and patient-related barriers to the correct management of AR, respectively. Promoting patients’ education was considered the most crucial action to improve it. Conclusion: Despite specialists’ awareness, there is a gap between the evidence-based guidelines’ recommendations and their implementation in clinical practice

Draft Genome Sequence of the First NDM-1-ProducingProvidencia stuartiiStrain Isolated in Portugal

We report here the draft genome sequence of the first NDM-1-producing Providencia stuartii strain isolated in Portugal. Sequence analyses revealed the presence of an incompatibility group A/C2 (IncA/C2) plasmid and of diverse acquired genes conferring resistance to β-lactams, aminoglycosides, tetracycline, macrolides, chloramphenicol, and sulfonamides. This sequence contributes to the evaluation of the spread of NDM-1 producers.V. Manageiro was supported by grant SFRH/BPD/77486/2011 from the Fundação para a Ciência e a Tecnologia (FCT), Lisbon, Portugal

Up-scaling validation of a dummy regression approach for predictive modelling the fillet fatty acid composition of cultured European sea bass (Dicentrarchus labrax)

The aim of the study was to validate a dummy regression approach for predictive modelling the fillet fatty acid (FA) composition of cultured European sea bass with dietary FA composition and lipid fillet content as independent variables. The model used our own data on gilthead sea bream as reference subgroup dataset and data from turbot, sole and European sea bass as dummy variables. Most of the observed variance within and among species was explained by the regression model without statistical significant interactions on blocks between diet composition and fish species subgroups. For the validation of European sea bass FA descriptors, predictive values derived from data on fish reared at laboratory scale were plotted against those obtained in farmed fish harvested at commercial size. A close linear association near to equality was found for 12 representative FAs, including saturated FAs, monoenenes and polyunsaturated FAs. This finding reinforces the possibility to produce tailored and healthy seafood products according to the guidelines of essential FA requirements in humans. FA algorithms for all the species in the model are hosted at www.nutrigroup-iats.org/aquafat as a multispecies tool to interrogate the nutritionally regulated FA composition of four cultured marine fish species of a high added value.This study was founded by Spanish (AQUAFAT, AGL2009-07797, Predictive modelling of flesh fatty acid composition in cultured fish species with different muscle lipid content) and EU (ARRAINA, KBBE-2011-5-288925, Advanced research initiatives for nutrition and aquaculture) projects. Additional founding was obtained from the “Generalitat Valenciana” (research grant PROMETEO 2010/006). GFB-L was recipient of a Spanish PhD fellowship from the Diputación Provincial de Castellón.Peer Reviewe

PARAGANGLIOMA E ANGIOEDEMA

Paragangliomas or extra-adrenal pheochromocytomas are rare tumors that arise from chromaffin tissues and tend to occur either sporadically or in the context of complex genetic disorders. They are clinically heterogeneous in nature - symptoms deriving either from the secretory profile of the tumor or from the mass effect of the neoplasm. Dermatologic symptoms are quite seldom described in the literature and have been classified in acute or chronic. The case of a 40 YO Caucasian female that had been enduring for the last 2 years recurring self-limited episodes of angioedema, diarrhoea, chest pain, hypertension or hypotension, dyspnoea and anxiety is reported. Biochemical studies and further imagiologic work up and, later on, pathologic exam allowed to identify a paraganglioma that drained to the left renal artery. Upon surgery, during tumor manipulation, the patient developed an additional systemic crisis that required active life support. Recovery was regular, with a quick and sustained normalization of lab results as well as on the clinical side, with no further episode for the last 17 years.Paragangliomas ou Feocromocitomas extra-suprarrenais são tumores raros derivados do tecido cromafim que tendem a ocorrer esporadicamente ou no contexto de doenças genéticas complexas. São tumores com apresentação clínica variada, dependente do seu perfil secretório ou do efeito de massa determinado pela neoplasia. Sintomas dermatológicos são raros, tendo sido classificados como agudos/paroxísticos ou crónicos. É apresentado caso de uma Eurocaucasiana de 40 anos de idade que referia, nos últimos 2 anos, episódios auto-limitados de angioedema, diarreia, toracalgia, hiper ou hipotensão arterial, dispneia e ansiedade. Estudos laboratoriais e, posteriormente, avaliação imagiológica e exame patológico permitiram identificar um paraganglioma drenante para a veia renal esquerda, o qual foi extirpado com sucesso. Durante a cirurgia, a manipulação do tumor desencadeou uma nova crise grave, a qual exigiu, com carácter de emergência, a instituição de medidas de suporte avançado de vida. A recuperação decorreu sem incidentes, tendo-se verificado uma rápida regularização dos valores laboratoriais a par de uma remissão clínica completa, sem novos episódios verificados durante 17 anos

Dummy regression analysis for modelling the nutritionally tailored fillet fatty acid composition of turbot and sole using gilthead sea bream as a reference subgroup category

Farmed turbot and sole were sampled at different stages of the production cycle for analysis of fillet lipid content and fatty acid (FA) composition. The entire data set along with our own published data on gilthead sea bream were fitted to dummy regression equations with turbot and sole as dummy variables, gilthead sea bream as a reference subgroup category, and diet FA composition and fillet lipid content as independent variables. The relative contribution of each independent variable to the total variance was found to vary within and among FAs and fish species, but strong correlation coefficients (0.76 0.99) were found for almost all of the FA equations, including saturated FAs, monoenes and long-chain polyunsaturated fatty acids (PUFA) of n-3 and n-6 series. Given the differences in lipogenic activities of the fish species, major interaction effects between fillet lipid content and dummy variables were found for monoenes and saturated FAs. The proposed equations (hosted at www.nutrigroup-iats.org/aquafat) were able to fit different proportions of EPA, DPA and DHA underlying the fish species differences in FA desaturation/elongation pathways. The robustness of the model was proven with extra data from the three fish species, allowing a close linear association near to equality for the scatter plot of observed and predicted values. © 2014 John Wiley & Sons Ltd.This study was funded by Spanish (AQUAFAT, AGL2009-07797, Predictive modelling of flesh fatty acid composition in cultured fish species with different muscle lipid content; AQUAGENOMICS, CSD2007-00002, Improvement of aquaculture production by the use of biotechnological tools) and EU (ARRAINA, KBBE-2011-5-288925, Advanced research initiatives for nutrition and aquaculture) projects. Additional funding was obtained from the ‘Generalitat Valenciana’ (research grant PROMETEO 2010/006). GFB-L was recipient of a Spanish PhD fellowship from the Diputación Provincial de Castellón.Peer Reviewe

Ana Manrique de Lara y Piñeiro, condesa de Puñonrostro. Entre la corte de los Austrias y Zaragoza.

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NDM-1-producing Providencia stuartii isolates in a Portuguese Hospital

Objective: Providencia stuartii is an opportunistic pathogen typically associated with urinary infections, and is intrinsically resistance to a wide range of antibiotics. The main aim of this study was to characterize five carbapenemase (CA) NDM-1-producing P. stuartii isolates obtained during an outbreak detected in a Hospital. Methods: MICs were obtained by the reference microdilution broth method, according to EUCAST guidelines. PCR amplification and DNA sequencing were applied to identify the presence of CA genes from class A, B and D. Direct transfer of the CA resistance phenotype was attempted by mating-out assays. Genetic relatedness was examined by PFGE. One isolate, INSRA21868, recovered from the urine of an 88-year-old male patient admitted to the intensive care unit, was selected for genetic characterization using whole-genome sequencing (WGS), performed using 150 bp paired-end reads on a MiSeq (Illumina). A set of bioinformatic web tools were used to estimate the presence of pathogenicity determinants, antibiotic resistance (AR) genes, and clinically relevant mobile genetic elements. Results: All isolates, genetically indistinguishable by PFGE, presented multidrug-resistance with non-susceptibility to all carbapenems tested. Transconjugants had AR profiles similar to those of their parental clinical isolates. All NDM-1 determinants tested were found to be carried on conjugative plasmids. In silico AR analyses using ResFinder-v2.1 revealed genes conferring resistance to β-lactams [blaNDM-1, blaCMY-4 and ΔblaDHA-1), aminoglycosides (aac(2’)-Ia, armA), tetracycline (tetB), macrolides (mphE and msrE), chloramphenicol (catB3), and sulfonamides (sul1). PlasmidFinder-v1.2 analyses revealed the presence of an IncA/C2, which has been associated with wide dissemination of blaNDM-1. In the 3’ region, the blaNDM-1 gene was adjacent to a bleomycin resistance-encoding gene (bleMBL), followed by a trpF and part of the blaDHA-1-ampR region. The ISAba125 element upstream of blaNDM-1 was interrupted by an IS26 element. Conclusion: This study emphasizes the elements involved in dissemination of nosocomial infections and the potential of WGS in epidemiological investigations in the prevention of CA dissemination among hospitals as well as to other bacterial genera.info:eu-repo/semantics/acceptedVersio