76 research outputs found

    Robustness of spatial Penning trap modes against environment-assisted entanglement

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    The separability of the spatial modes of a charged particle in a Penning trap in the presence of an environment is studied by means of the positive partial transpose (PPT) criterion. Assuming a weak Markovian environment, described by linear Lindblad operators, our results strongly suggest that the environmental coupling of the axial and cyclotron degrees of freedom does not lead to entanglement at experimentally realistic temperatures. We therefore argue that, apart from unavoidable decoherence, the presence of such an environment does not alter the effectiveness of recently suggested quantum information protocols in Penning traps, which are based on the combination of a spatial mode with the spin of the particle.Comment: 11 pages, 2 figure

    Liga method of forming high-contrast collimators and anti-scatter grids with high aspect ratio

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    The article deals with creation and application of high-contrast anti-scatter X-ray grids for X-ray imaging in the range of 20–200 keV from microfocus X-ray tubes. A prototype high-aspect-ratio nickel grid structure is used to consider the impact of anti-scatter grid on the directional patterns of the IMA-2-150D X-ray tube. The suppression of scattered radiation and narrowing of the directional radiation pattern are demonstrated. The contrast of the nickel prototype is apparently insuffi cient. The article presents LIGA methods for manufacturing anti-scatter X-ray grids made of gold in Siberian Synchrotron and Terahertz Radiation Centre. A method for forming resistive grid structures using deep X-ray lithography is described and test structures are shown. The development of manufacturing technology for anti-scatter X-ray grids is in progress

    Invariant correlational entropy as a signature of quantum phase transitions in nuclei

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    We study phase transformations in finite nuclei as a function of interaction parameters. The signature of a transition is given by invariant correlational entropy that reflects the sensitivity of an individual many-body state to changes of external parameters; peaks in this quantity indicate the critical regions. This approach is able to reveal the pairing phase transition, identify the isovector and isoscalar pairing regions and determine the role of other interactions. We show the examples of the phase diagram in the parameter space.Comment: 6 pages, 6 figure

    Simple relations among E2 matrix elements of low-lying collective states

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    A method is developed to derive simple relations among the reduced matrix elements of the quadrupole operator between low-lying collective states. As an example, the fourth order scalars of Q are considered. The accuracy and validity of the proposed relations is checked for the ECQF Hamiltonian of the IBM-1 in the whole parameter space of the Casten triangle. Furthermore these relations are successfully tested for low-lying collective states in nuclei for which all relevant data is available.Comment: 12 pages, 1 figure, RevTeX preprint-styl

    An Ξ±2(ZΞ±)5m\alpha^{2}(Z \alpha)^{5}m Contribution to the Hydrogen Lamb Shift from Virtual Light by Light Scattering

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    The radiative correction to the Lamb shift of order Ξ±2(ZΞ±)5m\alpha^{2}(Z\alpha)^5m induced by the light by light scattering insertion in external photons is obtained. The new contribution turns out to be equal to βˆ’0.122(2)Ξ±2(ZΞ±)5/(Ο€n3)(mr/m)3m-0.122(2)\alpha^2(Z\alpha)^5/(\pi n^3)(m_r/m)^3m. Combining this contribution with our previous results we obtain the complete correction of order Ξ±2(ZΞ±)5m\alpha^{2}(Z\alpha)^5m induced by all diagrams with closed electron loops. This correction is 37.3(1)37.3(1) kHz and 4.67(1)4.67(1) kHz for the 1S1S- and 2S2S-states in hydrogen, respectively.Comment: pages, Penn State Preprint PSU/TH/142, February 199

    Singular Character of Critical Points in Nuclei

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    The concept of critical points in nuclear phase transitional regions is discussed from the standpoints of Q-invariants, simple observables and wave function entropy. It is shown that these critical points very closely coincide with the turning points of the discussed quantities, establishing the singular character of these points in nuclear phase transition regions between vibrational and rotational nuclei, with a finite number of particles.Comment: 12 pages, 7 figures, elsart, revised version, considerable changes and addition

    Quadrupole shape invariants in the interacting boson model

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    In terms of the Interacting Boson Model, shape invariants for the ground state, formed by quadrupole moments up to sixth order, are studied in the dynamical symmetry limits and, for the first time, over the whole structural range of the IBM-1. The results are related to the effective deformation parameters and their fluctuations in the geometrical model. New signatures that can distinguish vibrator and gamma-soft rotor structures, and one that is related to shape coexistence, are identified.Comment: 10 pages, ReVTeX, epsf, 2 Postscript figures include

    Assessment of The Impact of Road Transport on the Environment and Human Health

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    Π£Π²Π΅Π»ΠΈΡ‡Π΅Π½ΠΈΠ΅ числа автотранспортных срСдств ΠΎΡ‚Ρ€ΠΈΡ†Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎ влияСт Π½Π° качСство ΠΎΠΊΡ€ΡƒΠΆΠ°ΡŽΡ‰Π΅ΠΉ срСды, Π° Ρ‚Π°ΠΊΠΆΠ΅ наносит Π²Ρ€Π΅Π΄ Π·Π΄ΠΎΡ€ΠΎΠ²ΡŒΡŽ насСлСния. НаибольшиС ΠΎΠ±ΡŠΠ΅ΠΌΡ‹ выбросов Π·Π°Π³Ρ€ΡΠ·Π½ΡΡŽΡ‰ΠΈΡ… вСщСств автотранспортом Π½Π°Π±Π»ΡŽΠ΄Π°ΡŽΡ‚ΡΡ Π² Ρ‚Π°ΠΊΠΈΡ… Π³ΠΎΡ€ΠΎΠ΄Π°Ρ… Π£Ρ€Π°Π»ΡŒΡΠΊΠΎΠ³ΠΎ Ρ€Π΅Π³ΠΈΠΎΠ½Π° ΠΊΠ°ΠΊ Π•ΠΊΠ°Ρ‚Π΅Ρ€ΠΈΠ½Π±ΡƒΡ€Π³, ΠŸΠ΅Ρ€Π²ΠΎΡƒΡ€Π°Π»ΡŒΡΠΊ, ВСрхняя ΠŸΡ‹ΡˆΠΌΠ°, ПолСвской. ВслСдствиС этого ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ мСроприятий, Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½Π½Ρ‹Ρ… Π½Π° ΡƒΠΌΠ΅Π½ΡŒΡˆΠ΅Π½ΠΈΠ΅ загрязнСния ΠΎΠΊΡ€ΡƒΠΆΠ°ΡŽΡ‰Π΅ΠΉ срСды автотранспортом, ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ‚ ΡƒΠ»ΡƒΡ‡ΡˆΠΈΡ‚ΡŒ качСство ΠΆΠΈΠ·Π½ΠΈ Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ сохранит ΠΏΡ€ΠΈΡ€ΠΎΠ΄Ρƒ для Π±ΡƒΠ΄ΡƒΡ‰ΠΈΡ… ΠΏΠΎΠΊΠΎΠ»Π΅Π½ΠΈΠΉ. Π’ Π΄Π°Π½Π½ΠΎΠΌ ΠΏΡ€ΠΎΠ΅ΠΊΡ‚Π΅, Π²ΠΎ-ΠΏΠ΅Ρ€Π²Ρ‹Ρ…, исслСдовано ΠΏΠ°Π³ΡƒΠ±Π½ΠΎΠ΅ влияниС автотранспорта Π½Π° качСство ΠΎΠΊΡ€ΡƒΠΆΠ°ΡŽΡ‰Π΅ΠΉ срСды; Π²ΠΎ-Π²Ρ‚ΠΎΡ€Ρ‹Ρ…, ΠΈΠ·ΡƒΡ‡Π΅Π½ химичСский состав Π²Ρ‹Ρ…Π»ΠΎΠΏΠ½Ρ‹Ρ… Π³Π°Π·ΠΎΠ² ΠΈ ΠΈΡ… влияниС Π½Π° Π·Π΄ΠΎΡ€ΠΎΠ²ΡŒΠ΅ Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ°; рассмотрСно государствСнноС Ρ€Π΅Π³ΡƒΠ»ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ экологичСской бСзопасности ΠΏΡ€ΠΈ эксплуатации Π°Π²Ρ‚ΠΎΠΌΠΎΠ±ΠΈΠ»ΡŒΠ½Ρ‹Ρ… срСдств; исслСдован ΡƒΡ€ΠΎΠ²Π΅Π½ΡŒ загрязнСния Π³Π°Π·ΠΎΠ²Ρ‹ΠΌΠΈ выбросами Π°Π²Ρ‚ΠΎΠΌΠΎΠ±ΠΈΠ»ΡŒΠ½ΠΎΠ³ΠΎ транспорта ΠΏΡ€ΠΈΠ·Π΅ΠΌΠ½ΠΎΠ³ΠΎ слоя атмосфСры посёлка АсбСстовский МО Π³. АлапаСвск; ΠΏΡ€ΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Π½Ρ‹ мСроприятия, Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½Π½Ρ‹Π΅ Π½Π° ΡƒΠΌΠ΅Π½ΡŒΡˆΠ΅Π½ΠΈΠ΅ загрязнСния ΠΏΡ€ΠΈΡ€ΠΎΠ΄Π½ΠΎΠΉ срСды автотранспортом. ИсслСдованиС уровня загрязнСния Π³Π°Π·ΠΎΠ²Ρ‹ΠΌΠΈ выбросами Π°Π²Ρ‚ΠΎΠΌΠΎΠ±ΠΈΠ»ΡŒΠ½ΠΎΠ³ΠΎ транспорта ΠΏΡ€ΠΈΠ·Π΅ΠΌΠ½ΠΎΠ³ΠΎ слоя атмосфСры посёлка АсбСстовский МО Π³. АлапаСвск ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ, Ρ‡Ρ‚ΠΎ загрязнСниС ΠΎΠΊΡ€ΡƒΠΆΠ°ΡŽΡ‰Π΅ΠΉ срСды ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚Π°ΠΌΠΈ сгорания Π°Π²Ρ‚ΠΎΠΌΠΎΠ±ΠΈΠ»ΡŒΠ½ΠΎΠ³ΠΎ Ρ‚ΠΎΠΏΠ»ΠΈΠ²Π° ΠΈ ΠΈΡ… Π½Π΅Π³Π°Ρ‚ΠΈΠ²Π½ΠΎΠ΅ влияниС Π½Π° Π·Π΄ΠΎΡ€ΠΎΠ²ΡŒΠ΅ Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° Π΄Π΅ΠΉΡΡ‚Π²ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ ΡΡƒΡ‰Π΅ΡΡ‚Π²ΡƒΡŽΡ‚. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ исслСдования ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΈ ΡΠ΄Π΅Π»Π°Ρ‚ΡŒ Π²Ρ‹Π²ΠΎΠ΄ ΠΎ Ρ‚ΠΎΠΌ, Ρ‡Ρ‚ΠΎ стратСгия развития Π°Π²Ρ‚ΠΎΠΌΠΎΠ±ΠΈΠ»ΡŒΠ½ΠΎΠΉ ΠΏΡ€ΠΎΠΌΡ‹ΡˆΠ»Π΅Π½Π½ΠΎΡΡ‚ΠΈ Π΄ΠΎΠ»ΠΆΠ½Π° Π±Ρ‹Ρ‚ΡŒ Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½Π° Π½Π° ΡΠΎΠ²Π΅Ρ€ΡˆΠ΅Π½ΡΡ‚Π²ΠΎΠ²Π°Π½ΠΈΠ΅ автомобиля, ΡΡ‚Ρ€Π΅ΠΌΡΡΡŒ ΡΠ΄Π΅Π»Π°Ρ‚ΡŒ Π΅Π³ΠΎ Π±ΠΎΠ»Π΅Π΅ экологичным Π½Π° соврСмСнном Ρ€Ρ‹Π½ΠΊΠ΅. Помимо этого, Π°Π²Ρ‚ΠΎΠ»ΡŽΠ±ΠΈΡ‚Π΅Π»ΡΠΌ слСдуСт ΡΠΎΠ±Π»ΡŽΠ΄Π°Ρ‚ΡŒ ΠΏΡ€Π°Π²ΠΈΠ»Π° эксплуатации Π°Π²Ρ‚ΠΎΠΌΠΎΠ±ΠΈΠ»Π΅ΠΉ. Π­Ρ‚ΠΈ ΠΈΠ΄Π΅ΠΈ нашли ΠΎΡ‚Ρ€Π°ΠΆΠ΅Π½ΠΈΠ΅ Π² ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½ΠΎΠΌ Π²ΠΈΠ΄Π΅ΠΎΡ€ΠΎΠ»ΠΈΠΊΠ΅, созданном ΠΏΠΎ ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Π°ΠΌ ΠΏΡ€ΠΎΠ΅ΠΊΡ‚Π°, Β«ΠœΡ‹ Π·Π° экологичный транспорт!Β»An increasing number of motor vehicles negatively affects the quality of the environment, as well as harms the health of the population. The largest volumes of emissions of pollutants by motor transport are observed in such cities of the Ural region as Yekaterinburg, Pervouralsk, Verkhnyaya Pyshma, Polevskoy. As a result, the implementation of measures aimed at reducing environmental pollution by motor transport will improve the quality of human life and preserve nature for future generations. In this project, firstly, the detrimental effect of motor transport on the quality of the environment was investigated; secondly, the chemical composition of exhaust gases and their impact on human health were studied; state regulation of environmental safety during the operation of motor vehicles was considered; the level of pollution by gas emissions of motor transport of the surface layer of the atmosphere of the village of Asbestovsky MO Alapaevsk was investigated; measures aimed at reducing pollution of the environment by motor transport were analyzed. The study of the level of pollution by gas emissions of motor transport of the surface layer of the atmosphere of the village of Asbestovsky MO, Alapaevsk, showed that environmental pollution by combustion products of automobile fuel and their negative impact on human health really exist. The results of the study led to the conclusion that the strategy for the development of the automotive industry should be aimed at improving the car, striving to make it more environmentally friendly in the modern market. In addition, motorists should follow the rules of operation of cars. These ideas are reflected in a social video created based on the materials of the project, "We are for eco-friendly transport!

    Π‘ΠΈΠ½Ρ‚Π΅Π· Ρ‚Π° антивірусна Π°ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŒ ΠΏΠΎΡ…Ρ–Π΄Π½ΠΈΡ… [(9-R1-10-R2-3-R-2-оксо-2H-[1,2,4]-Ρ‚Ρ€ΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-с]Ρ…Ρ–Π½Π°Π·ΠΎΠ»Ρ–Π½-6-Ρ–Π»)Ρ‚Ρ–ΠΎ]Π°Ρ†Π΅Ρ‚Π°ΠΌΡ–Π΄Ρ–Π² Π· Ρ„Ρ€Π°Π³ΠΌΠ΅Π½Ρ‚Π°ΠΌΠΈ каркасних Π°ΠΌΡ–Π½Ρ–Π²

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    Alkylation of potassium 9-R1-10-R2-3-R-2-oxo-2Н-[1,2,4]triazino[2,3 с]quinazolin-6-thiolates by N-cycloalkyl-(cycloalkylaryl-)-2-chloracetamides and interaction of [(9-R1-10-R2-3-R-2-ΠΎxo-2H-[1,2,4]triazino[2,3-с]quinazolin-6-yl) thio]acetiс acids imidazolides and chloranhydrides with carcass amines yielded the corresponding amides. The structures of the compounds synthesized have been confirmed by 1H, 13C NMR, LC–MS and EI-MS analysis.The features of 1H, 13C NMR, LC–MS and EI-MS spectra have been described, and characteristic signals have been identified. The compounds synthesized have been studied for their antiviral activity. The results of the antiviral assay have shown that some compounds exhibit a moderate and high activity against the strains studied.The correlation between the structure and the antiviral action has been also discussed. According to the data obtained the conclusion can be made that the combination of carcass amine moieties with the fragment of little known [(9-R1-10-R2-3-R-2-ΠΎxo-2H-[1,2,4]-triazino[2,3-с]quinazolin-6-yl)thio]асetic acid results in compounds with a high antiviral activity. High indicators of the antiviral activity of compounds 3.2 and 3.14 against Influenza Type A H3N2 allow to suppose the expediency of further chemical modification of [1,2,4]triazino[2,3-с]quinazoline directed to obtaining new antiviral agents.АлкилированиС ΠΊΠ°Π»ΠΈΠΉ 9-R1-10-R2-3-R-2-оксо-2H-[1,2,4]Ρ‚Ρ€ΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-c]Ρ…ΠΈΠ½Π°Π·ΠΎΠ»ΠΈΠ½-6-Ρ‚ΠΈΠΎΠ»Π°Ρ‚ΠΎΠ² N-Ρ†ΠΈΠΊΠ»ΠΎΠ°Π»ΠΊΠΈΠ»-(Ρ†ΠΈΠΊΠ»ΠΎΠ°Π»ΠΊΠΈΠ»Π°Ρ€ΠΈΠ»-)-2-Ρ…Π»ΠΎΡ€Π°Ρ†Π΅Ρ‚Π°ΠΌΠΈΠ΄Π°ΠΌΠΈ ΠΈ взаимодСйствиС ΠΈΠΌΠΈΠ΄Π°Π·ΠΎΠ»ΠΈΠ΄ΠΎΠ² ΠΈ Ρ…Π»ΠΎΡ€Π°Π½Π³ΠΈΠ΄Ρ€ΠΈΠ΄ΠΎΠ² [(9-R1-10-R2-3-R-2-оксо-2H-[1,2,4]Ρ‚Ρ€ΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-c]Ρ…ΠΈΠ½Π°Π·ΠΎΠ»ΠΈΠ½-6-ΠΈΠ»)Ρ‚ΠΈΠΎ]уксусных кислот с каркасными Π°ΠΌΠΈΠ½Π°ΠΌΠΈ Π²Π΅Π΄Π΅Ρ‚ ΠΊ ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Π½ΠΈΡŽ Π°ΠΌΠΈΠ΄ΠΎΠ². Π‘Ρ‚Ρ€ΡƒΠΊΡ‚ΡƒΡ€Ρƒ ΠΈ чистоту синтСзированных соСдинСний установлСно комплСксом Ρ„ΠΈΠ·ΠΈΠΊΠΎ-химичСских ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ², Π² частности, 1H-, 13C-NMR, LC–MS ΠΈ EI-MS Π°Π½Π°Π»ΠΈΠ·ΠΎΠΌ. Π’Π°ΠΊΠΆΠ΅ Π±Ρ‹Π»ΠΈ описаны особСнности 1H-, 13C-NMR, LC–MS ΠΈ EI-MS спСктров ΠΈ ΠΈΠ΄Π΅Π½Ρ‚ΠΈΡ„ΠΈΡ†ΠΈΡ€ΠΎΠ²Π°Π½Ρ‹ характСристичСскиС сигналы. Π‘ΠΈΠ½Ρ‚Π΅Π·ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Π΅ соСдинСния Π±Ρ‹Π»ΠΈ исслСдованы Π½Π° Π½Π°Π»ΠΈΡ‡ΠΈΠ΅ противовирусной активности. УстановлСно, Ρ‡Ρ‚ΠΎ ΠΎΡ‚Π΄Π΅Π»ΡŒΠ½Ρ‹Π΅ прСдставитСли класса синтСзированных соСдинСний ΠΏΡ€ΠΎΡΠ²Π»ΡΡŽΡ‚ ΡƒΠΌΠ΅Ρ€Π΅Π½Π½ΡƒΡŽ ΠΈΠ»ΠΈ Π²Ρ‹ΡΠΎΠΊΡƒΡŽ ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΠ²ΠΈΡ€ΡƒΡΠ½ΡƒΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ΠΏΠΎ ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΡŽ ΠΊ ΠΈΠ·ΡƒΡ‡Π°Π΅ΠΌΡ‹ΠΌ ΡˆΡ‚Π°ΠΌΠΌΠ°ΠΌ. ΠžΠ±ΡΡƒΠΆΠ΄Π΅Π½Π° коррСляция «структура-дСйствиС». Богласно ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹ΠΌ Π΄Π°Π½Π½Ρ‹ΠΌ ΠΌΠΎΠΆΠ½ΠΎ ΡΠ΄Π΅Π»Π°Ρ‚ΡŒ Π²Ρ‹Π²ΠΎΠ΄, Ρ‡Ρ‚ΠΎ комбинация структуры каркасных Π°ΠΌΠΈΠ½ΠΎΠ² с Ρ„Ρ€Π°Π³ΠΌΠ΅Π½Ρ‚ΠΎΠΌ малоизвСстных [(9-R1-10-R2-3-R-2-оксо-2H-[1,2,4]-Ρ‚Ρ€ΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-с]Ρ…ΠΈΠ½Π°Π·ΠΎΠ»ΠΈΠ½-6-ΠΈΠ»)Ρ‚ΠΈΠΎ]уксусных кислот позволяСт ΠΏΠΎΠ»ΡƒΡ‡ΠΈΡ‚ΡŒ вСщСства с высокой противовирусной Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒΡŽ. ВысокиС ΠΈΠ½Π΄ΠΈΠΊΠ°Ρ‚ΠΎΡ€Ρ‹ противовирусной активности ΠΏΠΎ ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΡŽ ΠΊ ΡˆΡ‚Π°ΠΌΠΌΡƒ Influenza Type A H3N2 соСдинСний 3.2 ΠΈ 3.14 Π΄Π°ΡŽΡ‚ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡ‚ΡŒ ΠΏΡ€ΠΎΠ³Π½ΠΎΠ·ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ ΠΏΠ΅Ρ€ΡΠΏΠ΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ дальнСйшСй химичСской ΠΌΠΎΠ΄ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΈ [1,2,4]Ρ‚Ρ€ΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-c]Ρ…ΠΈΠ½Π°Π·ΠΎΠ»ΠΈΠ½Π°, Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½Π½ΠΎΠΉ Π½Π° ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½ΠΈΠ΅ Π½ΠΎΠ²Ρ‹Ρ… противовирусных Π°Π³Π΅Π½Ρ‚ΠΎΠ².Алкілування ΠΊΠ°Π»Ρ–ΠΉ 9-R1-10-R2-3-R-2-оксо-2H-[1,2,4]Ρ‚Ρ€ΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-c]Ρ…Ρ–Π½Π°Π·ΠΎΠ»Ρ–Π½-6-Ρ‚Ρ–ΠΎΠ»Π°Ρ‚Ρ–Π² N-Ρ†ΠΈΠΊΠ»ΠΎΠ°Π»ΠΊΡ–Π»-(Ρ†ΠΈΠΊΠ»ΠΎΠ°Π»ΠΊΡ–Π»Π°Ρ€ΠΈΠ»-)-2-Ρ…Π»ΠΎΡ€Π°Ρ†Π΅Ρ‚Π°ΠΌΡ–Π΄Π°ΠΌΠΈ Ρ‚Π° взаємодія Ρ–ΠΌΡ–Π΄Π°Π·ΠΎΠ»Ρ–Π΄Ρ–Π² Ρ‚Π° Ρ…Π»ΠΎΡ€Π°Π½Π³Ρ–Π΄Ρ€ΠΈΠ΄Ρ–Π² [(9-R1-10-R2-3-R-2-оксо-2H- [1,2,4]Ρ‚Ρ€ΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-c]Ρ…Ρ–Π½Π°Π·ΠΎΠ»Ρ–Π½-6-Ρ–Π»)Ρ‚Ρ–ΠΎ]ΠΎΡ†Ρ‚ΠΎΠ²ΠΈΡ… кислот Π· каркасними Π°ΠΌΡ–Π½Π°ΠΌΠΈ ΠΏΡ€ΠΈΠ·Π²Π΅Π»ΠΈ Π΄ΠΎ утворСння Π²Ρ–Π΄ΠΏΠΎΠ²Ρ–Π΄Π½ΠΈΡ… Π°ΠΌΡ–Π΄Ρ–Π². Π‘Ρ‚Ρ€ΡƒΠΊΡ‚ΡƒΡ€Ρƒ Ρ‚Π° чистоту синтСзованих сполук встановлСно Π·Π° допомогою комплСксу Ρ„Ρ–Π·ΠΈΠΊΠΎ-Ρ…Ρ–ΠΌΡ–Ρ‡Π½ΠΈΡ… ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ–Π², Π·ΠΎΠΊΡ€Π΅ΠΌΠ° 1H, 13C-NMR, LC–MS Ρ‚Π° EI-MS Π°Π½Π°Π»Ρ–Π·ΠΎΠΌ. ΠžΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡ‚Ρ– 1H, 13C NMR, LC–MS Ρ‚Π° EI-MS спСктрів Π±ΡƒΠ»ΠΈ ΠΎΠ±Π³ΠΎΠ²ΠΎΡ€Π΅Π½Ρ–, Ρ‚Π°ΠΊΠΎΠΆ Π±ΡƒΠ»ΠΈ Ρ–Π΄Π΅Π½Ρ‚ΠΈΡ„Ρ–ΠΊΠΎΠ²Π°Π½Ρ– характСристичні сигнали. Π‘ΠΈΠ½Ρ‚Π΅Π·ΠΎΠ²Π°Π½Ρ– сполуки Π±ΡƒΠ»ΠΈ дослідТСні Π½Π° Π½Π°ΡΠ²Π½Ρ–ΡΡ‚ΡŒ антивірусної активності. ВстановлСно, Ρ‰ΠΎ ΠΎΠΊΡ€Π΅ΠΌΡ– прСдставники синтСзованих сполук Π²ΠΈΡΠ²Π»ΡΡŽΡ‚ΡŒ ΠΏΠΎΠΌΡ–Ρ€Π½Ρƒ Ρ‚Π° високу антивірусну Π°ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŒ ΠΏΠΎ Π²Ρ–Π΄Π½ΠΎΡˆΠ΅Π½Π½ΡŽ Π΄ΠΎ ΡˆΡ‚Π°ΠΌΡ–Π², Ρ‰ΠΎ Π΄ΠΎΡΠ»Ρ–Π΄ΠΆΡƒΠ²Π°Π»ΠΈΡΡŒ. ΠšΠΎΡ€Π΅Π»ΡΡ†Ρ–Ρ взаємозв’язків Β«Π±ΡƒΠ΄ΠΎΠ²Π°-дія» Π±ΡƒΠ»Π° ΠΎΠ±Π³ΠΎΠ²ΠΎΡ€Π΅Π½Π°. Π’Ρ–Π΄ΠΏΠΎΠ²Ρ–Π΄Π½ΠΎ Π΄ΠΎ ΠΎΠ΄Π΅Ρ€ΠΆΠ°Π½ΠΈΡ… Π΄Π°Π½ΠΈΡ… ΠΌΠΈ Π·Ρ€ΠΎΠ±ΠΈΠ»ΠΈ висновок, Ρ‰ΠΎ комбінація Π·Π°Π»ΠΈΡˆΠΊΡƒ каркасних Π°ΠΌΡ–Π½Ρ–Π² Π· Ρ„Ρ€Π°Π³ΠΌΠ΅Π½Ρ‚Π°ΠΌΠΈ ΠΌΠ°Π»ΠΎΠ²Ρ–Π΄ΠΎΠΌΠΈΡ… [(9-R1-10-R2-3-R-2-оксо-2H-[1,2,4]-Ρ‚Ρ€ΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-c]Ρ…Ρ–Π½Π°Π·ΠΎΠ»Ρ–Π½-6-Ρ–Π»)Ρ‚Ρ–ΠΎ]ΠΎΡ†Ρ‚ΠΎΠ²ΠΈΡ… кислот дозволяє ΠΎΠ΄Π΅Ρ€ΠΆΠ°Ρ‚ΠΈ сполуки Π·Ρ– Π·Π½Π°Ρ‡Π½ΠΎΡŽ Π°Π½Ρ‚ΠΈΠ²Ρ–Ρ€ΡƒΡΠ½ΠΎΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŽ. Високі Ρ–Π½Π΄ΠΈΠΊΠ°Ρ‚ΠΎΡ€ΠΈ антивірусної активності ΠΏΠΎ Π²Ρ–Π΄Π½ΠΎΡˆΠ΅Π½Π½ΡŽ Π΄ΠΎ ΡˆΡ‚Π°ΠΌΡƒ Influenza Type A H3N2 сполук 3.2 Ρ‚Π° 3.14 Π΄ΠΎΠ·Π²ΠΎΠ»ΡΡŽΡ‚ΡŒ ΠΏΠ΅Ρ€Π΅Π΄Π±Π°Ρ‡ΠΈΡ‚ΠΈ ΠΏΠ΅Ρ€ΡΠΏΠ΅ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŒ ΠΏΠΎΠ΄Π°Π»ΡŒΡˆΠΎΡ— Ρ…Ρ–ΠΌΡ–Ρ‡Π½ΠΎΡ— ΠΌΠΎΠ΄ΠΈΡ„Ρ–ΠΊΠ°Ρ†Ρ–Ρ— [1,2,4]Ρ‚Ρ€ΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-c]Ρ…Ρ–Π½Π°Π·ΠΎΠ»Ρ–Π½Ρƒ Π· ΠΌΠ΅Ρ‚ΠΎΡŽ ΠΏΠΎΡˆΡƒΠΊΡƒ Π½ΠΎΠ²ΠΈΡ… антивірусних Π°Π³Π΅Π½Ρ‚Ρ–Π²
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