76 research outputs found
Robustness of spatial Penning trap modes against environment-assisted entanglement
The separability of the spatial modes of a charged particle in a Penning trap
in the presence of an environment is studied by means of the positive partial
transpose (PPT) criterion. Assuming a weak Markovian environment, described by
linear Lindblad operators, our results strongly suggest that the environmental
coupling of the axial and cyclotron degrees of freedom does not lead to
entanglement at experimentally realistic temperatures. We therefore argue that,
apart from unavoidable decoherence, the presence of such an environment does
not alter the effectiveness of recently suggested quantum information protocols
in Penning traps, which are based on the combination of a spatial mode with the
spin of the particle.Comment: 11 pages, 2 figure
Liga method of forming high-contrast collimators and anti-scatter grids with high aspect ratio
The article deals with creation and application of high-contrast anti-scatter X-ray grids for X-ray imaging in the range of 20β200 keV from microfocus X-ray tubes. A prototype high-aspect-ratio nickel grid structure is used to consider the impact of anti-scatter grid on the directional patterns of the IMA-2-150D X-ray tube. The suppression of scattered radiation and narrowing of the directional radiation pattern are demonstrated. The contrast of the nickel prototype is apparently insuffi cient. The article presents LIGA methods for manufacturing anti-scatter X-ray grids made of gold in Siberian Synchrotron and Terahertz Radiation Centre. A method for forming resistive grid structures using deep X-ray lithography is described and test structures are shown. The development of manufacturing technology for anti-scatter X-ray grids is in progress
Invariant correlational entropy as a signature of quantum phase transitions in nuclei
We study phase transformations in finite nuclei as a function of interaction
parameters. The signature of a transition is given by invariant correlational
entropy that reflects the sensitivity of an individual many-body state to
changes of external parameters; peaks in this quantity indicate the critical
regions. This approach is able to reveal the pairing phase transition, identify
the isovector and isoscalar pairing regions and determine the role of other
interactions. We show the examples of the phase diagram in the parameter space.Comment: 6 pages, 6 figure
Simple relations among E2 matrix elements of low-lying collective states
A method is developed to derive simple relations among the reduced matrix
elements of the quadrupole operator between low-lying collective states. As an
example, the fourth order scalars of Q are considered. The accuracy and
validity of the proposed relations is checked for the ECQF Hamiltonian of the
IBM-1 in the whole parameter space of the Casten triangle. Furthermore these
relations are successfully tested for low-lying collective states in nuclei for
which all relevant data is available.Comment: 12 pages, 1 figure, RevTeX preprint-styl
An Contribution to the Hydrogen Lamb Shift from Virtual Light by Light Scattering
The radiative correction to the Lamb shift of order
induced by the light by light scattering insertion in external photons is
obtained. The new contribution turns out to be equal to
. Combining this contribution
with our previous results we obtain the complete correction of order
induced by all diagrams with closed electron loops.
This correction is kHz and kHz for the - and
-states in hydrogen, respectively.Comment: pages, Penn State Preprint PSU/TH/142, February 199
Singular Character of Critical Points in Nuclei
The concept of critical points in nuclear phase transitional regions is
discussed from the standpoints of Q-invariants, simple observables and wave
function entropy. It is shown that these critical points very closely coincide
with the turning points of the discussed quantities, establishing the singular
character of these points in nuclear phase transition regions between
vibrational and rotational nuclei, with a finite number of particles.Comment: 12 pages, 7 figures, elsart, revised version, considerable changes
and addition
Quadrupole shape invariants in the interacting boson model
In terms of the Interacting Boson Model, shape invariants for the ground
state, formed by quadrupole moments up to sixth order, are studied in the
dynamical symmetry limits and, for the first time, over the whole structural
range of the IBM-1. The results are related to the effective deformation
parameters and their fluctuations in the geometrical model. New signatures that
can distinguish vibrator and gamma-soft rotor structures, and one that is
related to shape coexistence, are identified.Comment: 10 pages, ReVTeX, epsf, 2 Postscript figures include
Assessment of The Impact of Road Transport on the Environment and Human Health
Π£Π²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΡΠΈΡΠ»Π° Π°Π²ΡΠΎΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΡΡ
ΡΡΠ΅Π΄ΡΡΠ² ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎ Π²Π»ΠΈΡΠ΅Ρ Π½Π° ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎ ΠΎΠΊΡΡΠΆΠ°ΡΡΠ΅ΠΉ ΡΡΠ΅Π΄Ρ, Π° ΡΠ°ΠΊΠΆΠ΅ Π½Π°Π½ΠΎΡΠΈΡ Π²ΡΠ΅Π΄ Π·Π΄ΠΎΡΠΎΠ²ΡΡ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ. ΠΠ°ΠΈΠ±ΠΎΠ»ΡΡΠΈΠ΅ ΠΎΠ±ΡΠ΅ΠΌΡ Π²ΡΠ±ΡΠΎΡΠΎΠ² Π·Π°Π³ΡΡΠ·Π½ΡΡΡΠΈΡ
Π²Π΅ΡΠ΅ΡΡΠ² Π°Π²ΡΠΎΡΡΠ°Π½ΡΠΏΠΎΡΡΠΎΠΌ Π½Π°Π±Π»ΡΠ΄Π°ΡΡΡΡ Π² ΡΠ°ΠΊΠΈΡ
Π³ΠΎΡΠΎΠ΄Π°Ρ
Π£ΡΠ°Π»ΡΡΠΊΠΎΠ³ΠΎ ΡΠ΅Π³ΠΈΠΎΠ½Π° ΠΊΠ°ΠΊ ΠΠΊΠ°ΡΠ΅ΡΠΈΠ½Π±ΡΡΠ³, ΠΠ΅ΡΠ²ΠΎΡΡΠ°Π»ΡΡΠΊ, ΠΠ΅ΡΡ
Π½ΡΡ ΠΡΡΠΌΠ°, ΠΠΎΠ»Π΅Π²ΡΠΊΠΎΠΉ. ΠΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ ΡΡΠΎΠ³ΠΎ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΌΠ΅ΡΠΎΠΏΡΠΈΡΡΠΈΠΉ, Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΡ
Π½Π° ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ Π·Π°Π³ΡΡΠ·Π½Π΅Π½ΠΈΡ ΠΎΠΊΡΡΠΆΠ°ΡΡΠ΅ΠΉ ΡΡΠ΅Π΄Ρ Π°Π²ΡΠΎΡΡΠ°Π½ΡΠΏΠΎΡΡΠΎΠΌ, ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ ΡΠ»ΡΡΡΠΈΡΡ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎ ΠΆΠΈΠ·Π½ΠΈ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΡΠΎΡ
ΡΠ°Π½ΠΈΡ ΠΏΡΠΈΡΠΎΠ΄Ρ Π΄Π»Ρ Π±ΡΠ΄ΡΡΠΈΡ
ΠΏΠΎΠΊΠΎΠ»Π΅Π½ΠΈΠΉ. Π Π΄Π°Π½Π½ΠΎΠΌ ΠΏΡΠΎΠ΅ΠΊΡΠ΅, Π²ΠΎ-ΠΏΠ΅ΡΠ²ΡΡ
, ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ ΠΏΠ°Π³ΡΠ±Π½ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π°Π²ΡΠΎΡΡΠ°Π½ΡΠΏΠΎΡΡΠ° Π½Π° ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎ ΠΎΠΊΡΡΠΆΠ°ΡΡΠ΅ΠΉ ΡΡΠ΅Π΄Ρ; Π²ΠΎ-Π²ΡΠΎΡΡΡ
, ΠΈΠ·ΡΡΠ΅Π½ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΎΡΡΠ°Π² Π²ΡΡ
Π»ΠΎΠΏΠ½ΡΡ
Π³Π°Π·ΠΎΠ² ΠΈ ΠΈΡ
Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° Π·Π΄ΠΎΡΠΎΠ²ΡΠ΅ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°; ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½ΠΎ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΠΎΠ΅ ΡΠ΅Π³ΡΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ ΠΏΡΠΈ ΡΠΊΡΠΏΠ»ΡΠ°ΡΠ°ΡΠΈΠΈ Π°Π²ΡΠΎΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΡΡ
ΡΡΠ΅Π΄ΡΡΠ²; ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ ΡΡΠΎΠ²Π΅Π½Ρ Π·Π°Π³ΡΡΠ·Π½Π΅Π½ΠΈΡ Π³Π°Π·ΠΎΠ²ΡΠΌΠΈ Π²ΡΠ±ΡΠΎΡΠ°ΠΌΠΈ Π°Π²ΡΠΎΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ° ΠΏΡΠΈΠ·Π΅ΠΌΠ½ΠΎΠ³ΠΎ ΡΠ»ΠΎΡ Π°ΡΠΌΠΎΡΡΠ΅ΡΡ ΠΏΠΎΡΡΠ»ΠΊΠ° ΠΡΠ±Π΅ΡΡΠΎΠ²ΡΠΊΠΈΠΉ ΠΠ Π³. ΠΠ»Π°ΠΏΠ°Π΅Π²ΡΠΊ; ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΌΠ΅ΡΠΎΠΏΡΠΈΡΡΠΈΡ, Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΠ΅ Π½Π° ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ Π·Π°Π³ΡΡΠ·Π½Π΅Π½ΠΈΡ ΠΏΡΠΈΡΠΎΠ΄Π½ΠΎΠΉ ΡΡΠ΅Π΄Ρ Π°Π²ΡΠΎΡΡΠ°Π½ΡΠΏΠΎΡΡΠΎΠΌ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ Π·Π°Π³ΡΡΠ·Π½Π΅Π½ΠΈΡ Π³Π°Π·ΠΎΠ²ΡΠΌΠΈ Π²ΡΠ±ΡΠΎΡΠ°ΠΌΠΈ Π°Π²ΡΠΎΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ° ΠΏΡΠΈΠ·Π΅ΠΌΠ½ΠΎΠ³ΠΎ ΡΠ»ΠΎΡ Π°ΡΠΌΠΎΡΡΠ΅ΡΡ ΠΏΠΎΡΡΠ»ΠΊΠ° ΠΡΠ±Π΅ΡΡΠΎΠ²ΡΠΊΠΈΠΉ ΠΠ Π³. ΠΠ»Π°ΠΏΠ°Π΅Π²ΡΠΊ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ, ΡΡΠΎ Π·Π°Π³ΡΡΠ·Π½Π΅Π½ΠΈΠ΅ ΠΎΠΊΡΡΠΆΠ°ΡΡΠ΅ΠΉ ΡΡΠ΅Π΄Ρ ΠΏΡΠΎΠ΄ΡΠΊΡΠ°ΠΌΠΈ ΡΠ³ΠΎΡΠ°Π½ΠΈΡ Π°Π²ΡΠΎΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΠΏΠ»ΠΈΠ²Π° ΠΈ ΠΈΡ
Π½Π΅Π³Π°ΡΠΈΠ²Π½ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° Π·Π΄ΠΎΡΠΎΠ²ΡΠ΅ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π΄Π΅ΠΉΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΡΡΠ΅ΡΡΠ²ΡΡΡ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΈ ΡΠ΄Π΅Π»Π°ΡΡ Π²ΡΠ²ΠΎΠ΄ ΠΎ ΡΠΎΠΌ, ΡΡΠΎ ΡΡΡΠ°ΡΠ΅Π³ΠΈΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π°Π²ΡΠΎΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΠΉ ΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΠΎΡΡΠΈ Π΄ΠΎΠ»ΠΆΠ½Π° Π±ΡΡΡ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π° Π½Π° ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠ΅ Π°Π²ΡΠΎΠΌΠΎΠ±ΠΈΠ»Ρ, ΡΡΡΠ΅ΠΌΡΡΡ ΡΠ΄Π΅Π»Π°ΡΡ Π΅Π³ΠΎ Π±ΠΎΠ»Π΅Π΅ ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ½ΡΠΌ Π½Π° ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΌ ΡΡΠ½ΠΊΠ΅. ΠΠΎΠΌΠΈΠΌΠΎ ΡΡΠΎΠ³ΠΎ, Π°Π²ΡΠΎΠ»ΡΠ±ΠΈΡΠ΅Π»ΡΠΌ ΡΠ»Π΅Π΄ΡΠ΅Ρ ΡΠΎΠ±Π»ΡΠ΄Π°ΡΡ ΠΏΡΠ°Π²ΠΈΠ»Π° ΡΠΊΡΠΏΠ»ΡΠ°ΡΠ°ΡΠΈΠΈ Π°Π²ΡΠΎΠΌΠΎΠ±ΠΈΠ»Π΅ΠΉ. ΠΡΠΈ ΠΈΠ΄Π΅ΠΈ Π½Π°ΡΠ»ΠΈ ΠΎΡΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ Π² ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠΌ Π²ΠΈΠ΄Π΅ΠΎΡΠΎΠ»ΠΈΠΊΠ΅, ΡΠΎΠ·Π΄Π°Π½Π½ΠΎΠΌ ΠΏΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π°ΠΌ ΠΏΡΠΎΠ΅ΠΊΡΠ°, Β«ΠΡ Π·Π° ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ½ΡΠΉ ΡΡΠ°Π½ΡΠΏΠΎΡΡ!Β»An increasing number of motor vehicles negatively affects the quality of the environment, as well as harms the health of the population. The largest volumes of emissions of pollutants by motor transport are observed in such cities of the Ural region as Yekaterinburg, Pervouralsk, Verkhnyaya Pyshma, Polevskoy. As a result, the implementation of measures aimed at reducing environmental pollution by motor transport will improve the quality of human life and preserve nature for future generations. In this project, firstly, the detrimental effect of motor transport on the quality of the environment was investigated; secondly, the chemical composition of exhaust gases and their impact on human health were studied; state regulation of environmental safety during the operation of motor vehicles was considered; the level of pollution by gas emissions of motor transport of the surface layer of the atmosphere of the village of Asbestovsky MO Alapaevsk was investigated; measures aimed at reducing pollution of the environment by motor transport were analyzed. The study of the level of pollution by gas emissions of motor transport of the surface layer of the atmosphere of the village of Asbestovsky MO, Alapaevsk, showed that environmental pollution by combustion products of automobile fuel and their negative impact on human health really exist. The results of the study led to the conclusion that the strategy for the development of the automotive industry should be aimed at improving the car, striving to make it more environmentally friendly in the modern market. In addition, motorists should follow the rules of operation of cars. These ideas are reflected in a social video created based on the materials of the project, "We are for eco-friendly transport!
Π‘ΠΈΠ½ΡΠ΅Π· ΡΠ° Π°Π½ΡΠΈΠ²ΡΡΡΡΠ½Π° Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ ΠΏΠΎΡ ΡΠ΄Π½ΠΈΡ [(9-R1-10-R2-3-R-2-ΠΎΠΊΡΠΎ-2H-[1,2,4]-ΡΡΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-Ρ]Ρ ΡΠ½Π°Π·ΠΎΠ»ΡΠ½-6-ΡΠ»)ΡΡΠΎ]Π°ΡΠ΅ΡΠ°ΠΌΡΠ΄ΡΠ² Π· ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ°ΠΌΠΈ ΠΊΠ°ΡΠΊΠ°ΡΠ½ΠΈΡ Π°ΠΌΡΠ½ΡΠ²
Alkylation of potassium 9-R1-10-R2-3-R-2-oxo-2Π-[1,2,4]triazino[2,3 Ρ]quinazolin-6-thiolates by N-cycloalkyl-(cycloalkylaryl-)-2-chloracetamides and interaction of [(9-R1-10-R2-3-R-2-ΠΎxo-2H-[1,2,4]triazino[2,3-Ρ]quinazolin-6-yl) thio]acetiΡ acids imidazolides and chloranhydrides with carcass amines yielded the corresponding amides. The structures of the compounds synthesized have been confirmed by 1H, 13C NMR, LCβMS and EI-MS analysis.The features of 1H, 13C NMR, LCβMS and EI-MS spectra have been described, and characteristic signals have been identified. The compounds synthesized have been studied for their antiviral activity. The results of the antiviral assay have shown that some compounds exhibit a moderate and high activity against the strains studied.The correlation between the structure and the antiviral action has been also discussed. According to the data obtained the conclusion can be made that the combination of carcass amine moieties with the fragment of little known [(9-R1-10-R2-3-R-2-ΠΎxo-2H-[1,2,4]-triazino[2,3-Ρ]quinazolin-6-yl)thio]Π°Ρetic acid results in compounds with a high antiviral activity. High indicators of the antiviral activity of compounds 3.2 and 3.14 against Influenza Type A H3N2 allow to suppose the expediency of further chemical modification of [1,2,4]triazino[2,3-Ρ]quinazoline directed to obtaining new antiviral agents.ΠΠ»ΠΊΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ°Π»ΠΈΠΉ 9-R1-10-R2-3-R-2-ΠΎΠΊΡΠΎ-2H-[1,2,4]ΡΡΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-c]Ρ
ΠΈΠ½Π°Π·ΠΎΠ»ΠΈΠ½-6-ΡΠΈΠΎΠ»Π°ΡΠΎΠ² N-ΡΠΈΠΊΠ»ΠΎΠ°Π»ΠΊΠΈΠ»-(ΡΠΈΠΊΠ»ΠΎΠ°Π»ΠΊΠΈΠ»Π°ΡΠΈΠ»-)-2-Ρ
Π»ΠΎΡΠ°ΡΠ΅ΡΠ°ΠΌΠΈΠ΄Π°ΠΌΠΈ ΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΈΠΌΠΈΠ΄Π°Π·ΠΎΠ»ΠΈΠ΄ΠΎΠ² ΠΈ Ρ
Π»ΠΎΡΠ°Π½Π³ΠΈΠ΄ΡΠΈΠ΄ΠΎΠ² [(9-R1-10-R2-3-R-2-ΠΎΠΊΡΠΎ-2H-[1,2,4]ΡΡΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-c]Ρ
ΠΈΠ½Π°Π·ΠΎΠ»ΠΈΠ½-6-ΠΈΠ»)ΡΠΈΠΎ]ΡΠΊΡΡΡΠ½ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ Ρ ΠΊΠ°ΡΠΊΠ°ΡΠ½ΡΠΌΠΈ Π°ΠΌΠΈΠ½Π°ΠΌΠΈ Π²Π΅Π΄Π΅Ρ ΠΊ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π°ΠΌΠΈΠ΄ΠΎΠ². Π‘ΡΡΡΠΊΡΡΡΡ ΠΈ ΡΠΈΡΡΠΎΡΡ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠΌ ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ², Π² ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ, 1H-, 13C-NMR, LCβMS ΠΈ EI-MS Π°Π½Π°Π»ΠΈΠ·ΠΎΠΌ. Π’Π°ΠΊΠΆΠ΅ Π±ΡΠ»ΠΈ ΠΎΠΏΠΈΡΠ°Π½Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ 1H-, 13C-NMR, LCβMS ΠΈ EI-MS ΡΠΏΠ΅ΠΊΡΡΠΎΠ² ΠΈ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Ρ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΈΠ³Π½Π°Π»Ρ. Π‘ΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ Π±ΡΠ»ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ Π½Π° Π½Π°Π»ΠΈΡΠΈΠ΅ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²ΠΈΡΠ΅Π»ΠΈ ΠΊΠ»Π°ΡΡΠ° ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΠΏΡΠΎΡΠ²Π»ΡΡΡ ΡΠΌΠ΅ΡΠ΅Π½Π½ΡΡ ΠΈΠ»ΠΈ Π²ΡΡΠΎΠΊΡΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΈΡΡΡΠ½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΠΎ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΊ ΠΈΠ·ΡΡΠ°Π΅ΠΌΡΠΌ ΡΡΠ°ΠΌΠΌΠ°ΠΌ. ΠΠ±ΡΡΠΆΠ΄Π΅Π½Π° ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΡ Β«ΡΡΡΡΠΊΡΡΡΠ°-Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅Β». Π‘ΠΎΠ³Π»Π°ΡΠ½ΠΎ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΠΌ Π΄Π°Π½Π½ΡΠΌ ΠΌΠΎΠΆΠ½ΠΎ ΡΠ΄Π΅Π»Π°ΡΡ Π²ΡΠ²ΠΎΠ΄, ΡΡΠΎ ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΡ ΡΡΡΡΠΊΡΡΡΡ ΠΊΠ°ΡΠΊΠ°ΡΠ½ΡΡ
Π°ΠΌΠΈΠ½ΠΎΠ² Ρ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠΌ ΠΌΠ°Π»ΠΎΠΈΠ·Π²Π΅ΡΡΠ½ΡΡ
[(9-R1-10-R2-3-R-2-ΠΎΠΊΡΠΎ-2H-[1,2,4]-ΡΡΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-Ρ]Ρ
ΠΈΠ½Π°Π·ΠΎΠ»ΠΈΠ½-6-ΠΈΠ»)ΡΠΈΠΎ]ΡΠΊΡΡΡΠ½ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΏΠΎΠ»ΡΡΠΈΡΡ Π²Π΅ΡΠ΅ΡΡΠ²Π° Ρ Π²ΡΡΠΎΠΊΠΎΠΉ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ. ΠΡΡΠΎΠΊΠΈΠ΅ ΠΈΠ½Π΄ΠΈΠΊΠ°ΡΠΎΡΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΠΎ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΊ ΡΡΠ°ΠΌΠΌΡ Influenza Type A H3N2 ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ 3.2 ΠΈ 3.14 Π΄Π°ΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅ΠΉ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ [1,2,4]ΡΡΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-c]Ρ
ΠΈΠ½Π°Π·ΠΎΠ»ΠΈΠ½Π°, Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΠΎΠΉ Π½Π° ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π½ΠΎΠ²ΡΡ
ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΈΡΡΡΠ½ΡΡ
Π°Π³Π΅Π½ΡΠΎΠ².ΠΠ»ΠΊΡΠ»ΡΠ²Π°Π½Π½Ρ ΠΊΠ°Π»ΡΠΉ 9-R1-10-R2-3-R-2-ΠΎΠΊΡΠΎ-2H-[1,2,4]ΡΡΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-c]Ρ
ΡΠ½Π°Π·ΠΎΠ»ΡΠ½-6-ΡΡΠΎΠ»Π°ΡΡΠ² N-ΡΠΈΠΊΠ»ΠΎΠ°Π»ΠΊΡΠ»-(ΡΠΈΠΊΠ»ΠΎΠ°Π»ΠΊΡΠ»Π°ΡΠΈΠ»-)-2-Ρ
Π»ΠΎΡΠ°ΡΠ΅ΡΠ°ΠΌΡΠ΄Π°ΠΌΠΈ ΡΠ° Π²Π·Π°ΡΠΌΠΎΠ΄ΡΡ ΡΠΌΡΠ΄Π°Π·ΠΎΠ»ΡΠ΄ΡΠ² ΡΠ° Ρ
Π»ΠΎΡΠ°Π½Π³ΡΠ΄ΡΠΈΠ΄ΡΠ² [(9-R1-10-R2-3-R-2-ΠΎΠΊΡΠΎ-2H- [1,2,4]ΡΡΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-c]Ρ
ΡΠ½Π°Π·ΠΎΠ»ΡΠ½-6-ΡΠ»)ΡΡΠΎ]ΠΎΡΡΠΎΠ²ΠΈΡ
ΠΊΠΈΡΠ»ΠΎΡ Π· ΠΊΠ°ΡΠΊΠ°ΡΠ½ΠΈΠΌΠΈ Π°ΠΌΡΠ½Π°ΠΌΠΈ ΠΏΡΠΈΠ·Π²Π΅Π»ΠΈ Π΄ΠΎ ΡΡΠ²ΠΎΡΠ΅Π½Π½Ρ Π²ΡΠ΄ΠΏΠΎΠ²ΡΠ΄Π½ΠΈΡ
Π°ΠΌΡΠ΄ΡΠ². Π‘ΡΡΡΠΊΡΡΡΡ ΡΠ° ΡΠΈΡΡΠΎΡΡ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ Π²ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ Π·Π° Π΄ΠΎΠΏΠΎΠΌΠΎΠ³ΠΎΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΡ ΡΡΠ·ΠΈΠΊΠΎ-Ρ
ΡΠΌΡΡΠ½ΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΡΠ², Π·ΠΎΠΊΡΠ΅ΠΌΠ° 1H, 13C-NMR, LCβMS ΡΠ° EI-MS Π°Π½Π°Π»ΡΠ·ΠΎΠΌ. ΠΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡΡ 1H, 13C NMR, LCβMS ΡΠ° EI-MS ΡΠΏΠ΅ΠΊΡΡΡΠ² Π±ΡΠ»ΠΈ ΠΎΠ±Π³ΠΎΠ²ΠΎΡΠ΅Π½Ρ, ΡΠ°ΠΊΠΎΠΆ Π±ΡΠ»ΠΈ ΡΠ΄Π΅Π½ΡΠΈΡΡΠΊΠΎΠ²Π°Π½Ρ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΡΠ½Ρ ΡΠΈΠ³Π½Π°Π»ΠΈ. Π‘ΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½Ρ ΡΠΏΠΎΠ»ΡΠΊΠΈ Π±ΡΠ»ΠΈ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Ρ Π½Π° Π½Π°ΡΠ²Π½ΡΡΡΡ Π°Π½ΡΠΈΠ²ΡΡΡΡΠ½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ. ΠΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΠΎ ΠΎΠΊΡΠ΅ΠΌΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π½ΠΈΠΊΠΈ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ Π²ΠΈΡΠ²Π»ΡΡΡΡ ΠΏΠΎΠΌΡΡΠ½Ρ ΡΠ° Π²ΠΈΡΠΎΠΊΡ Π°Π½ΡΠΈΠ²ΡΡΡΡΠ½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ ΠΏΠΎ Π²ΡΠ΄Π½ΠΎΡΠ΅Π½Π½Ρ Π΄ΠΎ ΡΡΠ°ΠΌΡΠ², ΡΠΎ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΡΠ²Π°Π»ΠΈΡΡ. ΠΠΎΡΠ΅Π»ΡΡΡΡ Π²Π·Π°ΡΠΌΠΎΠ·Π²βΡΠ·ΠΊΡΠ² Β«Π±ΡΠ΄ΠΎΠ²Π°-Π΄ΡΡΒ» Π±ΡΠ»Π° ΠΎΠ±Π³ΠΎΠ²ΠΎΡΠ΅Π½Π°. ΠΡΠ΄ΠΏΠΎΠ²ΡΠ΄Π½ΠΎ Π΄ΠΎ ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ
Π΄Π°Π½ΠΈΡ
ΠΌΠΈ Π·ΡΠΎΠ±ΠΈΠ»ΠΈ Π²ΠΈΡΠ½ΠΎΠ²ΠΎΠΊ, ΡΠΎ ΠΊΠΎΠΌΠ±ΡΠ½Π°ΡΡΡ Π·Π°Π»ΠΈΡΠΊΡ ΠΊΠ°ΡΠΊΠ°ΡΠ½ΠΈΡ
Π°ΠΌΡΠ½ΡΠ² Π· ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ°ΠΌΠΈ ΠΌΠ°Π»ΠΎΠ²ΡΠ΄ΠΎΠΌΠΈΡ
[(9-R1-10-R2-3-R-2-ΠΎΠΊΡΠΎ-2H-[1,2,4]-ΡΡΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-c]Ρ
ΡΠ½Π°Π·ΠΎΠ»ΡΠ½-6-ΡΠ»)ΡΡΠΎ]ΠΎΡΡΠΎΠ²ΠΈΡ
ΠΊΠΈΡΠ»ΠΎΡ Π΄ΠΎΠ·Π²ΠΎΠ»ΡΡ ΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈ ΡΠΏΠΎΠ»ΡΠΊΠΈ Π·Ρ Π·Π½Π°ΡΠ½ΠΎΡ Π°Π½ΡΠΈΠ²ΡΡΡΡΠ½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ. ΠΠΈΡΠΎΠΊΡ ΡΠ½Π΄ΠΈΠΊΠ°ΡΠΎΡΠΈ Π°Π½ΡΠΈΠ²ΡΡΡΡΠ½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΠΎ Π²ΡΠ΄Π½ΠΎΡΠ΅Π½Π½Ρ Π΄ΠΎ ΡΡΠ°ΠΌΡ Influenza Type A H3N2 ΡΠΏΠΎΠ»ΡΠΊ 3.2 ΡΠ° 3.14 Π΄ΠΎΠ·Π²ΠΎΠ»ΡΡΡΡ ΠΏΠ΅ΡΠ΅Π΄Π±Π°ΡΠΈΡΠΈ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΡΡΡ ΠΏΠΎΠ΄Π°Π»ΡΡΠΎΡ Ρ
ΡΠΌΡΡΠ½ΠΎΡ ΠΌΠΎΠ΄ΠΈΡΡΠΊΠ°ΡΡΡ [1,2,4]ΡΡΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-c]Ρ
ΡΠ½Π°Π·ΠΎΠ»ΡΠ½Ρ Π· ΠΌΠ΅ΡΠΎΡ ΠΏΠΎΡΡΠΊΡ Π½ΠΎΠ²ΠΈΡ
Π°Π½ΡΠΈΠ²ΡΡΡΡΠ½ΠΈΡ
Π°Π³Π΅Π½ΡΡΠ²
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