Molecular Quantum Computing by an Optimal Control Algorithm for Unitary Transformations

Quantum computation is based on implementing selected unitary transformations which represent algorithms. A generalized optimal control theory is used to find the driving field that generates a prespecified unitary transformation. The approach is illustrated in the implementation of one and two qubits gates in model molecular systems.Comment: 10 pages, 2 figure

Internal dissipation and heat leaks in quantum thermodynamic cycles

This is the final version. Available from American Physical Society via the DOI in this recordThe direction of the steady-state heat currents across a generic quantum system connected to multiple baths may be engineered to realize virtually any thermodynamic cycle. In spite of their versatility, such continuous energy-conversion systems are generally unable to operate at maximum efficiency due to non-negligible sources of irreversible entropy production. In this paper we introduce a minimal model of irreversible absorption chiller. We identify and characterize the different mechanisms responsible for its irreversibility, namely heat leaks and internal dissipation, and gauge their relative impact in the overall cooling performance. We also propose reservoir engineering techniques to minimize these detrimental effects. Finally, by looking into a known three-qubit embodiment of the absorption cooling cycle, we illustrate how our simple model may help to pinpoint the different sources of irreversibility naturally arising in more complex practical heat devices.European UnionSpanish MINECOCOST Actio

A HEV-restricted sulfotransferase is expressed in rheumatoid arthritis synovium and is induced by lymphotoxin-alpha/beta and TNF-alpha in cultured endothelial cells.

BackgroundThe recruitment of lymphocytes to secondary lymphoid organs relies on interactions of circulating cells with high endothelial venules (HEV). HEV are exclusive to these organs under physiological conditions, but they can develop in chronically-inflamed tissues. The interaction of L-selectin on lymphocytes with sulfated glycoprotein ligands on HEV results in lymphocyte rolling, which represents the initial step in lymphocyte homing. HEV expression of GlcNAc6ST-2 (also known as HEC-GlcNAc6ST, GST-3, LSST or CHST4), an HEV-restricted sulfotransferase, is essential for the elaboration of L-selectin functional ligands as well as a critical epitope recognized by MECA-79 mAb.ResultsWe examined the expression of GlcNAc6ST-2 in relationship to the MECA-79 epitope in rheumatoid arthritis (RA) synovial vessels. Expression of GlcNAc6ST-2 was specific to RA synovial tissues as compared to osteoarthritis synovial tissues and localized to endothelial cells of HEV-like vessels and small flat-walled vessels. Double MECA-79 and GlcNAc6ST-2 staining showed colocalization of the MECA-79 epitope and GlcNAc6ST-2. We further found that both TNF-alpha and lymphotoxin-alphabeta induced GlcNAc6ST-2 mRNA and protein in cultured human umbilical vein endothelial cells.ConclusionThese observations demonstrate that GlcNAc6ST-2 is induced in RA vessels and provide potential cytokine pathways for its induction. GlcNAc6ST-2 is a novel marker of activated vessels within RA ectopic lymphoid aggregates. This enzyme represents a potential therapeutic target for RA

Performance bound for quantum absorption refrigerators

This is the final version. Available from American Physical Society via the DOI in this recordAn implementation of quantum absorption chillers with three qubits has been recently proposed that is ideally able to reach the Carnot performance regime. Here we study the working efficiency of such self-contained refrigerators, adopting a consistent treatment of dissipation effects. We demonstrate that the coefficient of performance at maximum cooling power is upper bounded by 3/4 of the Carnot performance. The result is independent of the details of the system and the equilibrium temperatures of the external baths. We provide design prescriptions that saturate the bound in the limit of a large difference between the operating temperatures. Our study suggests that delocalized dissipation, which must be taken into account for a proper modeling of the machine-baths interaction, is a fundamental source of irreversibility which prevents the refrigerator from approaching the Carnot performance arbitrarily closely in practice. The potential role of quantum correlations in the operation of these machines is also investigated.Spanish MICINNEuropean UnionCanary Islands GovernmentUniversity of Nottingha

K^0-\bar{K}^0 mixing in the Standard Model from Nf=2+1+1 Twisted Mass Lattice QCD

We present preliminary results at {\beta} = 1.95 (a = 0.077 fm) on the first unquenched N_f=2+1+1 lattice computation of the B_K parameter which controls the neutral kaon oscillations in the Standard Model. Using N_f=2+1+1 maximally twisted sea quarks and Osterwalder-Seiler valence quarks we achieve O(a) improvement and a continuum-like renormalization pattern for the four-fermion operator. Our results are extrapolated/interpolated to the physical light/strange quark mass but not yet to the continuum limit. The computation of the relevant renormalization constants is performed non perturbatively in the RI'-MOM scheme using dedicated simulations with N_f=4 degenerate sea quark flavours produced by the ETM collaboration. We get B_K^{RGI} (a = 0.077) = 0.747(18), which when compared to our previous unquenched N_f=2 determination and most of the existing results, suggests a rather weak B_K^{RGI} dependence on the number of dynamical flavours. We are at the moment analysing lattice data at two additional {\beta} values which will allow us to perform an extrapolation to the continuum limit.Comment: 7 pages, 8 figures, Proceedings of Lattice 2011, XXIX International Symposium on Lattice Field Theory, Squaw Valley, Lake Tahoe, Californi

Kaon oscillations in the Standard Model and Beyond using Nf=2 dynamical quarks

We compute non-perturbatively the B-parameters of the complete basis of four-fermion operators needed to study the Kaon oscillations in the SM and in its supersymmetric extension. We perform numerical simulations with two dynamical maximally twisted sea quarks at three values of the lattice spacing on configurations generated by the ETMC. Unwanted operator mixings and O(a) discretization effects are removed by discretizing the valence quarks with a suitable Osterwalder-Seiler variant of the Twisted Mass action. Operators are renormalized non-perturbatively in the RI/MOM scheme. Our preliminary result for BK(RGI) is 0.73(3)(3).Comment: 7 pages, 3 figures, 1 table, proceedings of the XXVII Int'l Symposyum on Lattice Field Theory (LAT2009), July 26-31 2009, Peking University, Beijing (China

A determination of the average up-down, strange and charm quark masses from Nf=2+1+1N_f=2+1+1

We present a lattice QCD determination of the average up-down, strange and charm quark masses based on simulations performed by the European Twisted Mass Collaboration with $N_f = 2 + 1 + 1$ dynamical fermions. We simulated at three different values of the lattice spacing, the smallest being approximately $0.06fm$, and with pion masses as small as $210 \text{MeV}$. Our results are: $m_{ud}(2\text{GeV})=3.70(17)\text{MeV}$, $m_s(2\text{GeV})=99.2(3.9)\text{MeV}$, $m_c(m_c)=1.350(49)\text{GeV}$, $m_s/m_{ud}=26.64(30)$ and $m_c/m_s=11.65(12)$

Changing the paradigm in postherpetic neuralgia treatment: lidocaine 700 mg medicated plaster

OBJECTIVE: Chronic pain is currently considered a disease state with biopsychosocial consequences and a negative impact on patients' quality of life (QoL). Pain from postherpetic neuralgia (PHN) can persist for months or years and is a prototypical example of chronic pain. We analyzed PHN as a model of chronic pain. including its effects on QoL and clinical aspects. We explored treatment options, focusing on the topical treatment with lidocaine 700 mg medicated plaster (LMP) and how this impacts PHN management.MATERIALS AND METHODS: This article is a narrative review of published studies. Preclinical and clinical studies were retrieved from literature through a search performed in PubMed/MEDLINE.RESULTS: To choose the appropriate treatment for chronic pains, such as PHN, not only efficacy but also tolerability, manageability, practicality, and compliance are important factors. especially in the long term. It is also important to set treatment expectations with the patients as total suppression of pain may be unrealistic. and a balance needs to be found between pain control and the minimization of adverse events. In this respect, LMP may be the best currently available treatment: it is easy to use, has low systemic absorption and thus a low risk for pharmacological interactions. Therefore, treatments can be personalized, and concomitant medications can be added, if needed. Recent data from a real-world study support this view by showing that LMP has superior effectiveness in reducing pain and improving the QoL compared to other commonly used systemic treatments and confirming its good tolerability profile that is mainly characterized by localized skin reactions.CONCLUSIONS: LMP is one of the best currently available treatment options for PHN patients balancing good efficacy with an excellent tolerability profile and can therefore be considered for use as a first-line treatment for PHN

Reduced graphene oxide improves the performance of a methanogenic biocathode

.Microbial electrosynthesis (MES), a sub-branch of bioelectrochemical processes, takes advantage of a certain type of electroactive microorganism to produce added value products (such as methane) from carbon dioxide (CO2). The aim of this study is to quantify the benefits of using a carbon felt electrode modified with reduced graphene-oxide (rgoCF) as a methanogenic biocathode. The current density generated by the rgoCF was almost 30% higher than in the control carbon felt electrode (CF). In addition, charge transfer and ohmic resistances were, on average, 50% lower in the rgoCF electrode. These improvements were accompanied by a larger presence of bacteria (31% larger) and archaea (18% larger) in the rgoCF electrode. The microbial communities were dominated by hydrogenotrophic methanogenic archaea (Methanobacterium) and, to a lesser extent, by a low-diversity group of bacteria in both biocathodes. Finally, it was estimated that for a CO2 feeding rate in the range 15–30 g CO2 per m2 of electrode per day, it is possible to produce a high-quality biogas (>95% methane concentrationS

Diferencias en los indicadores de rendimiento técnico-tácticos entre ganadores y perdedores en la Women Rugby World Cup 2010

El objetivo del presente estudio fue conocer las diferencias en acciones técnico - tácticas entre equipos ganadores y perdedores en equipos de rugby femenino de alto rendimiento. Se analizaron 30 partidos disputados entre 12 equipos nacionales de la Women Rugby World Cup 2010. Las variablesde estudio fueron las conductas relativas a la obtención del balón, el desarrollo del juego, a los reagrupa mientos, los puntos marcados, y las faltas reglamentarias. Se realizó un análisis descriptivo e inferencial de los datos (prueba T de Student y análisis discriminate). Los equipos ganadores realizan más ensayos, transformaciones de ensayos, y pierden menos rucks y touches que los perdedores. Estos resultados pueden usarse como valores de referencia para el entrenamiento y el análisis del rendimiento en competición