18,985 research outputs found
A Sino-German 6cm polarisation survey of the Galactic plane IX. HII regions
Large-scale radio continuum surveys provide data to get insights into the
physical properties of radio sources. HII regions are prominent radio sources
produced by thermal emission of ionised gas around young massive stars. We
identify and analyse HII regions in the Sino-German 6cm polarisation survey of
the Galactic plane. Objects with flat radio continuum spectra together with
infrared and/or Halpha emission were identified as HII regions. For HII regions
with small apparent sizes, we cross-matched the 6cm small-diameter source
catalogue with the radio HII region catalogue compiled by Paladini and the
infrared HII region catalogue based on the WISE data. Extended HII regions were
identified by eye by overlaying the Paladini and the WISE HII regions onto the
6cm survey images for coincidences. The TT-plot method was employed for
spectral index verification. A total of 401 HII regions were identified and
their flux densities were determined with the Sino-German 6cm survey data. In
the surveyed area, 76 pairs of sources are found to be duplicated in the
Paladini HII region catalogue, mainly due to the non-distinction of previous
observations with different angular resolutions, and 78 objects in their
catalogue are misclassified as HII regions, being actually planetary nebulae,
supernova remnants or extragalactic sources that have steep spectra. More than
30 HII regions and HII region candidates from our 6cm survey data, especially
extended ones, do not have counterparts in the WISE HII region catalogue, of
which 9 are identified for the first time. Based on the newly derived radio
continuum spectra and the evidence of infrared emission, the previously
identified SNRs G11.1-1.0, G20.4+0.1 and G16.4-0.5 are believed to be HII
regions.Comment: version after some minor corrections and language editing, full Table
2 - 5 will appear in CDS, accepted for publication in A&
The VLTI/MIDI view on the inner mass loss of evolved stars from the Herschel MESS sample
The mass-loss process from evolved stars is a key ingredient for our
understanding of many fields of astrophysics, including stellar evolution and
the chemical enrichment of the interstellar medium via stellar yields. One the
main unsolved questions is the geometry of the mass-loss process. Taking
advantage of the results from the Herschel Mass loss of Evolved StarS (MESS)
programme, we initiated a coordinated effort to characterise the geometry of
mass loss from evolved red giants at various spatial scales. For this purpose
we used the MID-infrared interferometric Instrument (MIDI) to resolve the inner
envelope of 14 asymptotic giant branch stars (AGBs) in the MESS sample. In this
contribution we present an overview of the interferometric data collected
within the frame of our Large Programme, and we also add archive data for
completeness. We studied the geometry of the inner atmosphere by comparing the
observations with predictions from different geometric models. Asymmetries are
detected for five O-rich and S-type, suggesting that asymmetries in the N band
are more common among stars with such chemistry. We speculate that this fact is
related to the characteristics of the dust grains. Except for one star, no
interferometric variability is detected, i.e. the changes in size of the shells
of non-mira stars correspond to changes of the visibility of less than 10%. The
observed spectral variability confirms previous findings from the literature.
The detection of dust in our sample follows the location of the AGBs in the
IRAS colour-colour diagram: more dust is detected around oxygen-rich stars in
region II and in the carbon stars in region VII. The SiC dust feature does not
appear in the visibility spectrum of UAnt and SSct, which are two carbon stars
with detached shells. This finding has implications for the theory of SiC dust
formation.Comment: 43 pages, 31 figures; accepted for publication in Astronomy &
Astrophysics. Abstract shortened for compilation reasons. Metadata correcte
Ankylosing Spondylitis: a trade Off of HLA-B27, ERAP, and pathogen interconnections? Focus on Sardinia
The frequency of HLA-B27 in patients with Ankylosing Spondylitis (AS) is over 85%. There are more than 170 recognized HLA-B27 alleles but the majority of them is not sufficiently represented for genetic association studies. So far only two alleles, the HLA-B*2706 in Asia and the HLA-B*2709 in Sardinia, have not been found to be associated with AS. The highly homogenous genetic structure of the Sardinian population has favored the search of relevant variants for disease-association studies. Moreover, malaria, once endemic in the island, has been shown to have contributed to shape the native population genome affecting the relative allele frequency of relevant genes. In Sardinia, the prevalence of HLA-B*2709, which differs from the strongly AS-associated B*2705 prototype for one amino acid (His/Asp116) in the F pocket of the peptide binding groove, is around 20% of all HLA-B27 alleles. We have previously hypothesized that malaria could have contributed to the establishment of this allele in Sardinia. Based on our recent findings, in this perspective article we speculate that the Endoplasmic Reticulum Amino Peptidases, ERAP1 and 2, associated with AS and involved in antigen presentation, underwent co-selection by malaria. These genes, besides shaping the immunopeptidome of HLA-class I molecules, have other biological functions that could also be involved in the immunosurveillance against malaria
Human Frataxin Folds Via an Intermediate State. Role of the C-Terminal Region
The aim of this study is to investigate the folding reaction of human frataxin, whose deficiency causes the neurodegenerative disease Friedreich’s Ataxia (FRDA). The characterization of different conformational states would provide knowledge about how frataxin can be stabilized without altering its functionality. Wild-type human frataxin and a set of mutants, including two highly destabilized FRDA-associated variants were studied by urea-induced folding/unfolding in a rapid mixing device and followed by circular dichroism. The analysis clearly indicates the existence of an intermediate state (I) in the folding route with significant secondary structure content but relatively low compactness, compared with the native ensemble. However, at high NaCl concentrations I-state gains substantial compaction, and the unfolding barrier is strongly affected, revealing the importance of electrostatics in the folding mechanism. The role of the C-terminal region (CTR), the key determinant of frataxin stability, was also studied. Simulations consistently with experiments revealed that this stretch is essentially unstructured, in the most compact transition state ensemble (TSE2). The complete truncation of the CTR drastically destabilizes the native state without altering TSE2. Results presented here shed light on the folding mechanism of frataxin, opening the possibility of mutating it to generate hyperstable variants without altering their folding kinetics.Fil: Faraj, Santiago Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Gonzalez-Lebrero, Rodolfo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Roman, Ernesto Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Santos, Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentin
Sphingomyelin metabolism is involved in the differentiation of MDCK cells induced by environmental hypertonicity
Sphingolipids (SLs) are relevant lipid components of eukaryotic cells. Besides regulating various cellular processes, SLs provide the structural framework for plasma membrane organization. Particularly, SM is associated with detergent-resistant microdomains. We have previously shown that the adherens junction (AJ) complex, the relevant cell-cell adhesion structure involved in cell differentiation and tissue organization, is located in an SM-rich membrane lipid domain. We have also demonstrated that under hypertonic conditions, Madin-Darby canine kidney (MDCK) cells acquire a differentiated phenotype with changes in SL metabolism. For these reasons, we decided to evaluate whether SM metabolism is involved in the acquisition of the differentiated phenotype of MDCK cells. We found that SM synthesis mediated by SM synthase 1 is involved in hypertonicity-induced formation of mature AJs, necessary for correct epithelial cell differentiation. Inhibition of SM synthesis impaired the acquisition of mature AJs, evoking a disintegration-like process reflected by the dissipation of E-cadherin and β- and α-catenins from the AJ complex. As a consequence, MDCK cells did not develop the hypertonicity-induced differentiated epithelial cell phenotype.Fil: Favale, Nicolas Octavio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Santacreu, Bruno Jaime. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Pescio, Lucila Gisele. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Marquez, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Rioja. Departamento de Ciencias de la Salud y Educación; ArgentinaFil: Sterin, Norma Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentin
Re-analysis of the radio luminosity function of Galactic HII regions
We have re-analyzed continuum and recombination lines radio data available in
the literature in order to derive the luminosity function (LF) of Galactic HII
regions. The study is performed by considering the first and fourth Galactic
quadrants independently. We estimate the completeness level of the sample in
the fourth quadrant at 5 Jy, and the one in the first quadrant at 2 Jy. We show
that the two samples (fourth or first quadrant) include, as well as giant and
super-giant HII regions, a significant number of sub-giant sources. The LF is
obtained, in each Galactic quadrant, with a generalized Schmidt's estimator
using an effective volume derived from the observed spatial distribution of the
considered HII regions. The re-analysis also takes advantage of recently
published ancillary absorption data allowing to solve the distance ambiguity
for several objects. A single power-law fit to the LFs retrieves a slope equal
to -2.23+/-0.07 (fourth quadrant) and to -1.85+/-0.11 (first quadrant). We also
find marginal evidence of a luminosity break at L_knee = 10^23.45 erg s^(-1)
Hz^(-1) for the LF in the fourth quadrant. We convert radio luminosities into
equivalent H_alpha and Lyman continuum luminosities to facilitate comparisons
with extra-galactic studies. We obtain an average total HII regions Lyman
continuum luminosity of 0.89 +/- 0.23 * 10^(53) sec^(-1), corresponding to 30%
of the total ionizing luminosity of the Galaxy.Comment: accepted for publication in Ap
- …