Orogenic lithosphere and slabs in the greater Alpine area – interpretations based on teleseismic P-wave tomography

Based on recent results of AlpArray, we propose a new model of Alpine collision that involves subduction and detachment of thick (∼ 180 km) European lithosphere. Our approach combines teleseismic P-wave tomography and existing local earthquake tomography (LET), allowing us to image the Alpine slabs and their connections with the overlying orogenic lithosphere at an unprecedented resolution. The images call into question the conventional notion that downward-moving lithosphere and slabs comprise only seismically fast lithosphere. We propose that the European lithosphere is heterogeneous, locally containing layered positive and negative Vp anomalies of up to 5 %–6 %. We attribute this layered heterogeneity to seismic anisotropy and/or compositional differences inherited from the Variscan and pre-Variscan orogenic cycles rather than to thermal anomalies. The lithosphere–asthenosphere boundary (LAB) of the European Plate therefore lies below the conventionally defined seismological LAB. In contrast, the lithosphere of the Adriatic Plate is thinner and has a lower boundary approximately at the base of strong positive Vp anomalies at 100–120 km. Horizontal and vertical tomographic slices reveal that beneath the central and western Alps, the European slab dips steeply to the south and southeast and is only locally still attached to the Alpine lithosphere. However, in the eastern Alps and Carpathians, this slab is completely detached from the orogenic crust and dips steeply to the north to northeast. This along-strike change in attachment coincides with an abrupt decrease in Moho depth below the Tauern Window, the Moho being underlain by a pronounced negative Vp anomaly that reaches eastward into the Pannonian Basin area. This negative Vp anomaly is interpreted as representing hot upwelling asthenosphere that heated the overlying crust, allowing it to accommodate Neogene orogen-parallel lateral extrusion and thinning of the ALCAPA tectonic unit (upper plate crustal edifice of Alps and Carpathians) to the east. A European origin of the northward-dipping, detached slab segment beneath the eastern Alps is likely since its down-dip length matches estimated Tertiary shortening in the eastern Alps accommodated by originally south-dipping subduction of European lithosphere. A slab anomaly beneath the Dinarides is of Adriatic origin and dips to the northeast. There is no evidence that this slab dips beneath the Alps. The slab anomaly beneath the Northern Apennines, also of Adriatic origin, hangs subvertically and is detached from the Apenninic orogenic crust and foreland. Except for its northernmost segment where it locally overlies the southern end of the European slab of the Alps, this slab is clearly separated from the latter by a broad zone of low Vp velocities located south of the Alpine slab beneath the Po Basin. Considered as a whole, the slabs of the Alpine chain are interpreted as highly attenuated, largely detached sheets of continental margin and Alpine Tethyan oceanic lithosphere that locally reach down to a slab graveyard in the mantle transition zone (MTZ)

Imaging structure and geometry of slabs in the greater Alpine area – a P-wave travel-time tomography using AlpArray Seismic Network data

We perform a teleseismic P-wave travel-time tomography to examine the geometry and structure of subducted lithosphere in the upper mantle beneath the Alpine orogen. The tomography is based on waveforms recorded at over 600 temporary and permanent broadband stations of the dense AlpArray Seismic Network deployed by 24 different European institutions in the greater Alpine region, reaching from the Massif Central to the Pannonian Basin and from the Po Plain to the river Main. Teleseismic travel times and travel-time residuals of direct teleseismic P waves from 331 teleseismic events of magnitude 5.5 and higher recorded between 2015 and 2019 by the AlpArray Seismic Network are extracted from the recorded waveforms using a combination of automatic picking, beamforming and cross-correlation. The resulting database contains over 162 000 highly accurate absolute P-wave travel times and travel-time residuals. For tomographic inversion, we define a model domain encompassing the entire Alpine region down to a depth of 600 km. Predictions of travel times are computed in a hybrid way applying a fast TauP method outside the model domain and continuing the wave fronts into the model domain using a fast marching method. We iteratively invert demeaned travel-time residuals for P-wave velocities in the model domain using a regular discretization with an average lateral spacing of about 25 km and a vertical spacing of 15 km. The inversion is regularized towards an initial model constructed from a 3D a priori model of the crust and uppermost mantle and a 1D standard earth model beneath. The resulting model provides a detailed image of slab configuration beneath the Alpine and Apenninic orogens. Major features are a partly overturned Adriatic slab beneath the Apennines reaching down to 400 km depth still attached in its northern part to the crust but exhibiting detachment towards the southeast. A fast anomaly beneath the western Alps indicates a short western Alpine slab whose easternmost end is located at about 100 km depth beneath the Penninic front. Further to the east and following the arcuate shape of the western Periadriatic Fault System, a deep-reaching coherent fast anomaly with complex internal structure generally dipping to the SE down to about 400 km suggests a slab of European origin limited to the east by the Giudicarie fault in the upper 200 km but extending beyond this fault at greater depths. In its eastern part it is detached from overlying lithosphere. Further to the east, well-separated in the upper 200 km from the slab beneath the central Alps but merging with it below, another deep-reaching, nearly vertically dipping high-velocity anomaly suggests the existence of a slab beneath the eastern Alps of presumably the same origin which is completely detached from the orogenic root. Our image of this slab does not require a polarity switch because of its nearly vertical dip and full detachment from the overlying lithosphere. Fast anomalies beneath the Dinarides are weak and concentrated to the northernmost part and shallow depths. Low-velocity regions surrounding the fast anomalies beneath the Alps to the west and northwest follow the same dipping trend as the overlying fast ones, indicating a kinematically coherent thick subducting lithosphere in this region. Alternatively, these regions may signify the presence of seismic anisotropy with a horizontal fast axis parallel to the Alpine belt due to asthenospheric flow around the Alpine slabs. In contrast, low-velocity anomalies to the east suggest asthenospheric upwelling presumably driven by retreat of the Carpathian slab and extrusion of eastern Alpine lithosphere towards the east while low velocities to the south are presumably evidence of asthenospheric upwelling and mantle hydration due to their position above the European slab

The sequential trauma score - a new instrument for the sequential mortality prediction in major trauma*

<p>Abstract</p> <p>Background</p> <p>There are several well established scores for the assessment of the prognosis of major trauma patients that all have in common that they can be calculated at the earliest during intensive care unit stay. We intended to develop a sequential trauma score (STS) that allows prognosis at several early stages based on the information that is available at a particular time.</p> <p>Study design</p> <p>In a retrospective, multicenter study using data derived from the Trauma Registry of the German Trauma Society (2002-2006), we identified the most relevant prognostic factors from the patients basic data (P), prehospital phase (A), early (B1), and late (B2) trauma room phase. Univariate and logistic regression models as well as score quality criteria and the explanatory power have been calculated.</p> <p>Results</p> <p>A total of 2,354 patients with complete data were identified. From the patients basic data (P), logistic regression showed that age was a significant predictor of survival (AUC_{model p}, area under the curve = 0.63). Logistic regression of the prehospital data (A) showed that blood pressure, pulse rate, Glasgow coma scale (GCS), and anisocoria were significant predictors (AUC_{model A}= 0.76; AUC_{model P + A}= 0.82). Logistic regression of the early trauma room phase (B1) showed that peripheral oxygen saturation, GCS, anisocoria, base excess, and thromboplastin time to be significant predictors of survival (AUC_{model B1}= 0.78; AUC_{model P +A + B1}= 0.85). Multivariate analysis of the late trauma room phase (B2) detected cardiac massage, abbreviated injury score (AIS) of the head ≥ 3, the maximum AIS, the need for transfusion or massive blood transfusion, to be the most important predictors (AUCmodel B2 = 0.84; AUCfinal model P + A + B1 + B2 = 0.90). The explanatory power - a tool for the assessment of the relative impact of each segment to mortality - is 25% for P, 7% for A, 17% for B1 and 51% for B2. A spreadsheet for the easy calculation of the sequential trauma score is available at: <url>http://www.sequential-trauma-score.com</url></p> <p>Conclusions</p> <p>This score is the first sequential, dynamic score to provide a prognosis for patients with blunt major trauma at several points in time. With every additional piece of information the precision increases. The medical team has a simple, useful tool to identify patients at high risk and to predict the prognosis of an individual patient with major trauma very early, quickly and precisely.</p

Dissolved Cd, Co, Cu, Fe, Mn, Ni and Zn in the Arctic Ocean

During the Polarstern (PS94) expedition, summer 2015, part of the international GEOTRACES program, sources and sinks of dissolved (D) Cd, Co, Cu, Fe, Mn, Ni and Zn were studied in the central Arctic Ocean. In the Polar Surface Water in which the TransPolar Drift (TPD) is situated, salinity and δ18O derived fractions indicated a distinct riverine source for silicate DCo, DCu, DFe, DMn and DNi. Linear relationships between DMn and the meteoric fraction depended on source distance, likely due to Mn-precipitation during transport. In the upper 50 m of the Makarov Basin, outside the TPD core, DCo, DMn, DNi, DCd and DCu were enriched by Pacific waters, whereas DFe seemed diluted. DCo, DFe, DMn and DZn were relatively high in the Barents Sea and led to enrichment of Atlantic water flowing into the Nansen Basin. Deep concentrations of all metals were significantly lower in the Makarov Basin compared to the Nansen and Amundsen, the Eurasian, Basins. The Gakkel ridge hydrothermal input and higher continental slope convection are explanations for higher metal concentrations in the Eurasian Basins. Although scavenging rates are lower in the Makarov Basin compared to the Eurasian Basins, the residence time is longer and therefore scavenging can decrease the dissolved concentrations with time. This study provides a baseline to assess future change, and additionally identifies processes driving trace metal distributions. Our results underline the importance of fluvial input as well as shelf sources and internal cycling, notably scavenging, for the distribution of bio-active metals in the Arctic Ocean

Papillary Renal Cell Carcinomas Rewire Glutathione Metabolism and Are Deficient in Both Anabolic Glucose Synthesis and Oxidative Phosphorylation

Papillary renal cell carcinoma (pRCC) is a malignant kidney cancer with a prevalence of 7–20% of all renal tumors. Proteome and metabolome profiles of 19 pRCC and patient-matched healthy kidney controls were used to elucidate the regulation of metabolic pathways and the underlying molecular mechanisms. Glutathione (GSH), a main reactive oxygen species (ROS) scavenger, was highly increased and can be regarded as a new hallmark in this malignancy. Isotope tracing of pRCC derived cell lines revealed an increased de novo synthesis rate of GSH, based on glutamine consumption. Furthermore, profound downregulation of gluconeogenesis and oxidative phosphorylation was observed at the protein level. In contrast, analysis of the The Cancer Genome Atlas (TCGA) papillary RCC cohort revealed no significant change in transcripts encoding oxidative phosphorylation compared to normal kidney tissue, highlighting the importance of proteomic profiling. The molecular characteristics of pRCC are increased GSH synthesis to cope with ROS stress, deficient anabolic glucose synthesis, and compromised oxidative phosphorylation, which could potentially be exploited in innovative anti-cancer strategies

The PHENIX Experiment at RHIC

The physics emphases of the PHENIX collaboration and the design and current status of the PHENIX detector are discussed. The plan of the collaboration for making the most effective use of the available luminosity in the first years of RHIC operation is also presented.Comment: 5 pages, 1 figure. Further details of the PHENIX physics program available at http://www.rhic.bnl.gov/phenix

Flow Measurements via Two-particle Azimuthal Correlations in Au + Au Collisions at sqrt(s_NN) = 130 GeV

Two particle azimuthal correlation functions are presented for charged hadrons produced in Au + Au collisions at RHIC sqrt(s_NN) = 130 GeV. The measurements permit determination of elliptic flow without event-by-event estimation of the reaction plane. The extracted elliptic flow values v_2 show significant sensitivity to both the collision centrality and the transverse momenta of emitted hadrons, suggesting rapid thermalization and relatively strong velocity fields. When scaled by the eccentricity of the collision zone, epsilon, the scaled elliptic flow shows little or no dependence on centrality for charged hadrons with relatively low p_T. A breakdown of this epsilon scaling is observed for charged hadrons with p_T > 1.0 GeV/c for the most central collisions.Comment: 6 pages, RevTeX 3, 4 figures, 307 authors, submitted to Phys. Rev. Lett. on 11 April 2002. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (will be made) publicly available at http://www.phenix.bnl.gov/phenix/WWW/run/phenix/papers.htm

Net Charge Fluctuations in Au + Au Interactions at sqrt(s_NN) = 130 GeV

Data from Au + Au interactions at sqrt(s_NN) = 130 GeV, obtained with the PHENIX detector at RHIC, are used to investigate local net charge fluctuations among particles produced near mid-rapidity. According to recent suggestions, such fluctuations may carry information from the Quark Gluon Plasma. This analysis shows that the fluctuations are dominated by a stochastic distribution of particles, but are also sensitive to other effects, like global charge conservation and resonance decays.Comment: 6 pages, RevTeX 3, 3 figures, 307 authors, submitted to Phys. Rev. Lett. on 21 March, 2002. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (will be made) publicly available at http://www.phenix.bnl.gov/phenix/WWW/run/phenix/papers.htm

Event-by-event fluctuations in Mean pTp_T and Mean eTe_T in sqrt(s_NN) = 130 GeV Au+Au Collisions

Distributions of event-by-event fluctuations of the mean transverse momentum and mean transverse energy near mid-rapidity have been measured in Au+Au collisions at sqrt(s_NN) = 130 GeV at RHIC. By comparing the distributions to what is expected for statistically independent particle emission, the magnitude of non-statistical fluctuations in mean transverse momentum is determined to be consistent with zero. Also, no significant non-random fluctuations in mean transverse energy are observed. By constructing a fluctuation model with two event classes that preserve the mean and variance of the semi-inclusive p_T or e_T spectra, we exclude a region of fluctuations in sqrt(s_NN) = 130 GeV Au+Au collisions.Comment: 10 pages, RevTeX 3, 7 figures, 4 tables, 307 authors, submitted to Phys. Rev. C on 22 March 2002. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (will be made) publicly available at http://www.phenix.bnl.gov/phenix/WWW/run/phenix/papers.htm

Centrality Dependence of Charged Particle Multiplicity in Au-Au Collisions at sqrt(s_NN)=130 GeV

We present results for the charged-particle multiplicity distribution at mid-rapidity in Au - Au collisions at sqrt(s_NN)=130 GeV measured with the PHENIX detector at RHIC. For the 5% most central collisions we find $dN_{ch}/d\eta_{|\eta=0} = 622 \pm 1 (stat) \pm 41 (syst)$. The results, analyzed as a function of centrality, show a steady rise of the particle density per participating nucleon with centrality.Comment: 307 authors, 43 institutions, 6 pages, 4 figures, 1 table Minor changes to figure labels and text to meet PRL requirements. One author added: M. Hibino of Waseda Universit