Hadron and Quark Form Factors in the Relativistic Harmonic Oscillator Model

Nucleon, pion and quark form factors are studied within the relativistic harmonic oscillator model including the quark spin. It is shown that the nucleon charge, magnetic and axial form factors and the pion charge form factor can be explained with one oscillator parameter if one accounts for the scaling rule and the size of the constituent quarks.Comment: 9 pages, Latex, 3 postscript figures, DFTT 8/9

Glitches in Southern Pulsars

Timing observations of 40 mostly young pulsars using the ATNF Parkes radio telescope between 1990 January and 1998 December are reported. In total, 20 previously unreported glitches and ten other glitches were detected in 11 pulsars. These included 12 glitches in PSR J1341$-$6220, corresponding to a glitch rate of 1.5 glitches per year. We also detected the largest known glitch, in PSR J1614$-$5047, with $\Delta\nu_g/\nu \approx 6.5 \times 10^{-6}$ where $\nu = 1/P$ is the pulse frequency. Glitch parameters were determined both by extrapolating timing solutions to inter-glitch intervals and by phase-coherent timing fits across the glitch(es). Analysis of glitch parameters, both from this work and from previously published results, shows that most glitches have a fractional amplitude $\Delta\nu_g/\nu$ of between $10^{-8}$ and $10^{-6}$. There is no consistent relationship between glitch amplitude and the time since the previous glitch or the time to the following glitch, either for the ensemble or for individual pulsars. As previously recognised, the largest glitch activity is seen in pulsars with ages of order 10$^4$ years, but for about 30 per cent of such pulsars, no glitches were detected in the 8-year data span. There is some evidence for a new type of timing irregularity in which there is a significant increase in pulse frequency over a few days, accompanied by a decrease in the magnitude of the slowdown rate. Fits of an exponential recovery to post-glitch data show that for most older pulsars, only a small fraction of the glitch decays. In some younger pulsars, a large fraction of the glitch decays, but in others, there is very little decay.Comment: 19 pages, 20 figures. Accepted for publication in MNRA

Deuteron Magnetic and Quadrupole Moments with a Poincar\'e Covariant Current Operator in the Front-Form Dynamics

The deuteron magnetic and quadrupole moments are unambiguosly determined within the front-form Hamiltonian dynamics, by using a new current operator which fulfills Poincar\'e, parity and time reversal covariance, together with hermiticity and the continuity equation. For both quantities the usual disagreement between theoretical and experimental results is largely removed.Comment: To appear in Phys. Rev. Let

Electroexcitation of the P33(1232), P11(1440), D13(1520), S11(1535) at Q^2=0.4 and 0.65(GeV/c)^2

Using two approaches: dispersion relations and isobar model, we have analyzed recent high precision CLAS data on cross sections of \pi^0, \pi^+, and \eta electroproduction on protons, and the longitudinally polarized electron beam asymmetry for p(\vec{e},e'p)\pi^0 and p(\vec{e},e'n)\pi^+. The contributions of the resonances P33(1232), P11(1440), D13(1520), S11(1535) to \pi electroproduction and S11(1535) to \eta electroproduction are found. The results obtained in the two approaches are in good agreement with each other. There is also good agreement between amplitudes of the \gamma^* N \to S11(1535) transition found in \pi and \eta electroproduction. For the first time accurate results are obtained for the longitudinal amplitudes of the P11(1440), D13(1520) and S11(1535) electroexcitation on protons.Comment: 9 pages, 9 figure

Budesonide increases TLR4 and TLR2 expression in Treg lymphocytes of allergic asthmatics

Background: Reduced innate immunity responses as well as reduced T regulatory activities characterise bronchial asthma. Objectives: In this study the effect of budesonide on the expression of TLR4 and TLR2 in T regulatory lymphocyte sub-population was assessed. Methods: TLR4 and TLR2 expression in total peripheral blood mononuclear cells (PBMC), in CD4+/CD25+ and in CD4+/CD25- was evaluated, by flow cytometric analysis, in mild intermittent asthmatics (n = 14) and in controls (n = 11). The in vitro effects of budesonide in modulating: TLR4 and TLR2 expression in controls and in asthmatics; IL-10 expression and cytokine release (IL-6 and TNF-\u3b1 selected by a multiplex assay) in asthmatics were also explored. Results: TLR4 and TLR2 were reduced in total PBMC from asthmatics in comparison to PBMC from controls. CD4+CD25+ cells expressed at higher extent TLR2 and TLR4 in comparison to CD4+CD25- cells. Budesonide was able to increase the expression of TLR4, TLR2 and IL-10 in CD4+/CD25highly+ cells from asthmatics. TLR4 ligand, LPS induced Foxp3 expression. Budesonide was also able to reduce the release of IL-6 and TNF-\u3b1 by PBMC of asthmatics. Conclusions: Budesonide potentiates the activity of Treg by increasing TLR4, TLR2 and IL-10 expression. This event is associated to the decreased release of IL-6 and TNF-\u3b1 in PBMC treated with budesonide. These findings shed light on new mechanisms by which corticosteroids, drugs widely used for the clinical management of bronchial asthma, control T lymphocyte activation

Transition form factors of the N*(1535) as a dynamically generated resonance

We discuss how electromagnetic properties provide useful tests of the nature of resonances, and we study these properties for the N*(1535) which appears dynamically generated from the strong interaction of mesons and baryons. Within this coupled channel chiral unitary approach, we evaluate the A_1/2 and S_1/2 helicity amplitudes as a function of Q^2 for the electromagnetic N*(1535) to gamma* N transition. Within the same formalism we evaluate the cross section for the reactions gamma N to eta N. We find a fair agreement for the absolute values of the transition amplitudes, as well as for the Q^2 dependence of the amplitudes, within theoretical and experimental uncertainties discussed in the paper. The ratios obtained between the S_1/2 and A_1/2 for the neutron or proton states of the N*(1535) are in qualitative agreement with experiment and there is agreement on the signs. The same occurs for the ratio of cross sections for the eta photoproduction on neutron and proton targets in the vicinity of the N*(1535) energy. The global results support the idea of this resonance as being dynamically generated, hence, largely built up from meson baryon components. However, the details of the model indicate that an admixture with a genuine quark state is also demanded that could help obtain a better agreement with experimental data.Comment: 19 pages, 16 figures, REVTe

Beta defensin-2 is reduced in central but not in distal airways of smoker COPD patients

Background: Altered pulmonary defenses in chronic obstructive pulmonary disease (COPD) may promote distal airways bacterial colonization. The expression/activation of Toll Like receptors (TLR) and beta 2 defensin (HBD2) release by epithelial cells crucially affect pulmonary defence mechanisms. Methods: The epithelial expression of TLR4 and of HBD2 was assessed in surgical specimens from current smokers COPD (s-COPD; n = 17), ex-smokers COPD (ex-s-COPD; n = 8), smokers without COPD (S; n = 12), and from non-smoker non-COPD subjects (C; n = 13). Results: In distal airways, s-COPD highly expressed TLR4 and HBD2. In central airways, S and s-COPD showed increased TLR4 expression. Lower HBD2 expression was observed in central airways of s-COPD when compared to S and to ex-s-COPD. s-COPD had a reduced HBD2 gene expression as demonstrated by real-time PCR on micro-dissected bronchial epithelial cells. Furthermore, HBD2 expression positively correlated with FEV1/FVC ratio and inversely correlated with the cigarette smoke exposure. In a bronchial epithelial cell line (16 HBE) IL-1β significantly induced the HBD2 mRNA expression and cigarette smoke extracts significantly counteracted this IL-1 mediated effect reducing both the activation of NFkB pathway and the interaction between NFkB and HBD2 promoter. Conclusions: This study provides new insights on the possible mechanisms involved in the alteration of innate immunity mechanisms in COPD. © 2012 Pace et al

Carcass Lesion Severity and Pre-Slaughter Conditions in Heavy Pigs: A Prospective Study at a Commercial Abattoir in Northern Italy

Pre-slaughter conditions and their effects on carcass quality have been largely addressed for pigs of 90–100 kg live weight, while few studies consider the effects of pre-slaughter conditions on the quality of the carcasses obtained from heavy pigs intended for Protected Designation of Origin (PDO) production. A total of 1680 heavy pigs were transported in 72 batches from a farm to a commercial abattoir on 16 different days, avoiding mixing unfamiliar animals. Slaughterhouse conditions, animal behaviors, and human–animal interactions were annotated at unloading and during the race toward the stunning cage. Carcass lesions on the rear, middle, and shoulder parts of the carcasses were scored. The prevalence of carcasses with severe lesions was 6.92%, 11.87%, and 6.83%, for the rear, middle, and shoulder parts, respectively. Among the pre-slaughter events, waiting before unloading and improper handling practices at the abattoir were the major factors affecting carcass lesion severity. Lairage pen space allowance was also found to affect severe rear and shoulder lesions, and the batches that were transported in the trailer had an increased prevalence of severe shoulder lesions. Our results suggest waiting time before unloading should be shortened as much as possible, and educational programs to train operators for more careful management of animals in the abattoir are greatly required to avoid improper animal handling practices