90 research outputs found
ΠΡΠ΅Π½ΠΊΠ° Π°ΠΌΠΏΠ»ΠΈΡΡΠ΄ ΠΈ Π²Π΅ΡΠΎΡΡΠ½ΠΎΡΡΠ΅ΠΉ ΠΌΠ½ΠΎΠ³ΠΎΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΡ ΠΏΠ΅ΡΠ΅Ρ ΠΎΠ΄ΠΎΠ² Π² Π°ΡΠΎΠΌΠ°Ρ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΌΠ½ΠΎΠ³ΠΎΡΠ°ΡΡΠΈΡΠ½ΠΎΠΉ ΡΠ΅ΠΎΡΠΈΠΈ Π²ΠΎΠ·ΠΌΡΡΠ΅Π½ΠΈΠΉ
ΠΠ·Π»Π°Π³Π°Π΅ΡΡΡ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ ΠΊ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΠΏΡΠΈΠ±Π»ΠΈΠΆΠ΅Π½Π½ΡΡ
ΡΠΎΡΠΌΡΠ» Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ Π°ΠΌΠΏΠ»ΠΈΡΡΠ΄ ΠΈ Π²Π΅ΡΠΎΡΡΠ½ΠΎΡΡΠ΅ΠΉ ΠΌΠ½ΠΎΠ³ΠΎΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΡ
ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄ΠΎΠ² Π² Π°ΡΠΎΠΌΠ°Ρ
. ΠΡΠΈΠ±Π»ΠΈΠΆΠ΅Π½Π½ΡΠ΅ ΡΠΎΡΠΌΡΠ»Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠΎΡΠ½ΡΡ
, Π² ΡΠ°ΠΌΠΊΠ°Ρ
ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΡΡΠ΄ΠΊΠ° ΡΠ΅ΠΎΡΠΈΠΈ Π²ΠΎΠ·ΠΌΡΡΠ΅Π½ΠΈΠΉ, Π²ΡΡΠ°ΠΆΠ΅Π½ΠΈΠΉ ΠΈ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈ ΠΎΠ±ΠΎΡΠ½ΠΎΠ²ΡΠ²Π°ΡΡΡΡ. ΠΠΎΠ΄Ρ
ΠΎΠ΄ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΏΡΠΎΡΡΠΎ ΠΎΡΠ΅Π½ΠΈΠ²Π°ΡΡ Π²Π΅ΡΠΎΡΡΠ½ΠΎΡΡΠΈ ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄ΠΎΠ² ΠΈ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ², Π½ΠΎ ΠΈ ΠΎΡΠΊΡΡΠ²Π°Π΅Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ Π²ΡΡΠ²Π»ΡΡΡ Π΄ΠΎΠΌΠΈΠ½ΠΈΡΡΡΡΠΈΠ΅ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄ΠΎΠ². Π Π°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΠΏΡΠΈΠ±Π»ΠΈΠΆΠ΅Π½ΠΈΡ Π²ΡΡΡΡΡΠΊΠΈ, ΡΠ΅Π·ΠΎΠ½Π°Π½ΡΠ° Π² Π½Π΅ΠΏΡΠ΅ΡΡΠ²Π½ΠΎΠΌ ΡΠΏΠ΅ΠΊΡΡΠ΅, ΡΠ΅Π·ΠΎΠ½Π°Π½ΡΠ° Π² Π΄ΠΈΡΠΊΡΠ΅ΡΠ½ΠΎΠΌ ΡΠΏΠ΅ΠΊΡΡΠ΅, Π½Π΅ΠΎΡΡΠΎΠ³ΠΎΠ½Π°Π»ΡΠ½ΡΡ
ΠΎΡΠ±ΠΈΡΠ°Π»Π΅ΠΉ
Loss reduΡing in pulse tranformer of betatron injection system
Present betatrons have limited operating frequency, which is no more than 400 Hz. It's caused by thermal operating mode of betatron elements. High voltage injection system is the one of betatron elements. The highest thermal losses is observed in core of impulse transformer. Too high thermal losses in pulse transformer core causes distortion of high voltage injection pulse shape and break the electron capture condition. That's why the betatron dose rate is decreased
Cerebral vein thrombosis: clinical manifestation and diagnosis
BACKGROUND: Cerebral venous thrombosis (CVT) is a disease with a wide spectrum of symptoms and severity. In this study we analysed the predictive value of clinical signs and symptoms and the contribution of D-dimer measurements for diagnosis. METHODS: We evaluated consecutive patients admitted with suspected CVT receiving non-invasive imaging. Symptoms and symptom combination as well as D-dimer levels were evaluated regarding their diagnostic value. RESULTS: 239 patients were included in this study, 170 (71%) were females. In 39 patients (16%) a CVT was found. For identifying a CVT patients underwent either a venous CT-angiography or MR-angiography or both. No combination of symptoms either alone or together with the D-dimer measurements had a sensitivity and positive predictive value as well as negative predictive value and specificity high enough to serve as red flag. D-dimer testing produced rates of 9% false positive and of 24% false negative results. For D-dimer values a Receiver Operating Characteristic curve (ROC) and the area under the curve (AUC = 0.921; CI: 0.864 - 0.977) were calculated. An increase of sensitivity above 0.9 results in a relevant decrease in specificity; a sensitivity of 0.9 matches a specificity value of 0.9. This corresponds to a D-dimer cut-off level of 0.16 ΞΌg/ml. CONCLUSION: Imaging as performed by venous CT-angiography or MR-angiography has a 1 to 2 in 10 chance to detect CVT when typical symptoms are present. D-dimer measurements are of limited clinical value because of false positive and negative results
Evaluation of Medication-Related Osteonecrosis of the Jaw (MRONJ) in Terms of Staging and Treatment Strategies by Dental Students at Different Educational Levels
Background: The role of medication-related osteonecrosis of the jaw (MRONJ) as a dentomaxillo-
facial pathology is becoming increasingly important due to its growing prevalence. The
success of preventive and therapeutic measures relies mainly on the dentistβs ability to correctly
diagnose the disease. Methods: The aim of this study was to evaluate the skills of dental students
of different educational levels in choosing the correct stage, diagnostics, and treatment option for
MRONJ based on clinical and radiographic imaging (panoramic radiograph, CBCT). The study
was designed as a cross-sectional cohort study. Twenty dental students were asked to complete a
questionnaire in their third and fifth year of studies in which they had to correctly stage the disease,
choose the radiological diagnostics and recommend the treatment. The control group contained
experienced oral and maxillofacial surgeons. Results: With an overall performance of 59% (third
year: 145.2/248 points; fifth year: 145.3/248 points), no statistically significant difference between the
educational levels could be observed. The classification based on CBCT imaging was significantly
more often correct compared to panoramic radiographs (p < 0.001). Conclusions: This study highlights
studentsβ lack of knowledge in staging, diagnostics, and treatment of MRONJ, even though the
CBCT positively affected decision-making. No significant increase in knowledge could be confirmed
through clinical education. This study highlights the need for students to catch up on MRONJ
diagnostics and treatment planning. Further expansion of teaching in this diseaseβs context and X-ray
diagnostics is needed
ΠΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ Π±Π°Π³Π°ΡΠΎΡΠ°ΡΠΎΠ²ΠΈΡ Π½Π΅ΠΉΡΠΎΠ½Π½ΠΈΡ ΠΌΠ΅ΡΠ΅ΠΆ Π΄Π»Ρ Π°Π²ΡΠΎΠΌΠ°ΡΠΈΡΠ½ΠΎΠ³ΠΎ Π²ΠΈΠ΄ΡΠ»Π΅Π½Π½Ρ ΠΎΠ·Π½Π°ΠΊ ΠΏΡΠΈ Π²ΠΈΡΡΡΠ΅Π½Π½Ρ Π·Π°Π΄Π°ΡΡ ΡΠΎΠ·ΠΏΡΠ·Π½Π°Π²Π°Π½Π½Ρ ΠΎΠ±ΡΠ°Π·ΡΠ²
Π ΡΠΎΠ±ΠΎΡΡ ΡΠΎΠ·Π³Π»ΡΠ½ΡΡΠΎ ΠΏΡΠ΄Ρ
ΠΎΠ΄ΠΈ Π΄ΠΎ Π²ΠΈΠ΄ΡΠ»Π΅Π½Π½Ρ ΠΎΠ·Π½Π°ΠΊ ΠΏΡΠΈ ΡΠΎΠ·ΠΏΡΠ·Π½Π°Π²Π°Π½Π½Ρ ΠΎΠ±ΡΠ°Π·ΡΠ² Ρ Π·Π°ΡΡΠΎΡΡΠ²Π°Π½Π½Ρ Π±Π°Π³Π°ΡΠΎΡΠ°ΡΠΎΠ²ΠΈΡ
Π½Π΅ΠΉΡΠΎΠ½Π½ΠΈΡ
ΠΌΠ΅ΡΠ΅ΠΆ Π΄Π»Ρ ΡΠΎΠ·Π²'ΡΠ·Π°Π½Π½Ρ ΡΠ°ΠΊΠΈΡ
Π·Π°Π΄Π°Ρ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΏΡΠΎΡΠ΅Ρ ΠΌΠΎΠ΄Π΅Π»ΡΠ²Π°Π½Π½Ρ Π±Π°Π³Π°ΡΠΎΡΠ°ΡΠΎΠ²ΠΎΠ³ΠΎ ΠΏΠ΅ΡΡΠ΅ΠΏΡΡΠΎΠ½Ρ Π΄Π»Ρ Π°Π²ΡΠΎΠΌΠ°ΡΠΈΡΠ½ΠΎΠ³ΠΎ Π²ΠΈΠ΄ΡΠ»Π΅Π½Π½Ρ ΠΎΠ·Π½Π°ΠΊ Π·ΠΎΠ±ΡΠ°ΠΆΠ΅Π½Π½Ρ Ρ ΠΏΠΎΠ΄Π°Π»ΡΡΠΎΡ ΠΊΠ»Π°ΡΠΈΡΡΠΊΠ°ΡΡΡ. ΠΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½ΠΎ Π²ΠΏΠ»ΠΈΠ² Π±Π°Π·ΠΎΠ²ΠΈΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡΠ² Π½Π° ΡΠΊΡΡΡΡ ΡΠΎΠ·ΠΏΡΠ·Π½Π°Π²Π°Π½Π½Ρ.The paper deals with approaches to feature extraction in pattern recognition and application of multilayer neural nets for solving such problems. The modeling process of multilayer perceptron for automatic feature extraction and further classification is described. The basic parameters influence on quality of recognition is researched
The influence of bisphosphonates on human osteoblast migration and integrin aVb3/tenascin C gene expression in vitro
<p>Abstract</p> <p>Background</p> <p>Bisphosphonates are therapeutics of bone diseases, such as Paget's disease, multiple myeloma or osteoclastic metastases. As a severe side effect the bisphosphonate induced osteonecrosis of the jaw (BONJ) often requires surgical treatment and is accompanied with a disturbed wound healing.</p> <p>Therefore, the influence on adhesion and migration of human osteoblasts (hOB) after bisphosphonate therapy has been investigated by morphologic as well as gene expression methods.</p> <p>Methods</p> <p>By a scratch wound experiment, which measures the reduction of defined cell layer gap, the morphology and migration ability of hOB was evaluated. A test group of hOB, which was stimulated by zoledronate 5 Γ 10<sup>-5</sup>M, and a control group of unstimulated hOB were applied. Furthermore the gene expression of integrin aVb3 and tenascin C was quantified by Real-Time rtPCR at 5data points over an experimental period of 14 days. The bisphosphonates zoledronate, ibandronate and clodronate have been compared with an unstimulated hOB control.</p> <p>Results</p> <p>After initially identical migration and adhesion characteristics, zoledronate inhibited hOB migration after 50 h of stimulation. The integrinavb3 and tenascin C gene expression was effected by bisphosphonates in a cell line dependent manner with decreased, respectively inconsistent gene expression levels over time. The non-nitrogen containing bisphosphonates clodronate led to decreased gene expression levels.</p> <p>Conclusion</p> <p>Bisphosphonates seem to inhibit hOB adhesion and migration. The integrin aVb3 and tenascin C gene expression seem to be dependent on the cell line. BONJ could be enhanced by an inhibition of osteoblast adhesion and migration. The gene expression results, however, suggest a cell line dependent effect of bisphosphonates, which could explain the interindividual differences of BONJ incidences.</p
Rheological and flow birefringence studies of rod-shaped pigment nanoparticle dispersions
We study rheological and rheo-optical properties of suspensions of anisometric pigment particles in a non-polar fluid. Different rheological regimes from the dilute regime to an orientationally arrested gel state were characterized and compared with existing theoretical models. We demonstrate the intricate flow behaviour in a wide range of volume fractions. A unique combination of the optical properties of the particles results in a giant rheo-optical effect: an unprecedentedly large shear stress-induced birefringence was found in the isotropic range, exhibiting a sharp pre-transitional behaviour
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