BlockChain Platforms in Financial Services: Current Perspective

Background: BlockChain technology was invented to support bitcoin, currently the most popular virtual currency. Objectives: The purpose of this paper is to investigate contemporary BlockChain platforms in financial services. Methods/Approach: An unstructured literature review has been used. Results: BlockChain in financial services is mostly associated with bitcoin exchange. However, this is a partial view of both BlockChain technology and its possible adoption for financial services: in fact, many BlockChain platforms are now available and many different financial services can be effectively supported by BlockChain platforms, even though they are not based on virtual-money exchange. Furthermore, people are attracted by the concept of smart contract, i.e., a contract that is automatically executed by computer technology, without human intervention. Conclusions: The contribution of this paper is twofold: first of all, we introduce the four BlockChain platforms that are now most popular, discussing how they support the smart contract concept; second, we identify some typical categories of financial services, matching each of them with the platform that provides the best support for each category

Begini Cara Merawat Kain Sutra yang Baik dan Benar

Kain sutra yang halus dan lembut ternyata tidak bisa dicuci sembarangan, perlu penanganan ekstra. Begini lho cara perawatannya:Kain sutra merupakan komoditas berharga mahal yang dibuat oleh bangsa China. Dari sejak zaman Jalur Sutra, kain ini harganya sudah mahal.Selain mahal, kain sutra perlu diberikan perawatan ekstra. Tidak boleh sembarangan dalam mencuci kain halus nan lembut ini

Use of a truncated conical tank to improve underwater acoustic experiments

Peer Reviewe

Facility ownership and mortality among older adults residing in care homes

BACKGROUND AND OBJECTIVES: Nursing or care home characteristics may have a long-term impact on the residents' mortality risks that has not been studied previously. The study's main objective was to assess the association between facility ownership and long-term, all-cause mortality. RESEARCH DESIGN AND METHODS: We conducted a mortality follow-up study on a cohort of 611 nursing-home residents in the city Madrid, Spain, from their 1998-1999 baseline interviews up to September 2013. Residents lived in three types of facilities: public, subsidized and private, which were also sub-classified according to size (number of beds). Residents' information was collected by interviewing the residents themselves, their caregivers and facility physicians. We used time-to-event multivariable models and inverse probability weighting to estimate standardized mortality risk differences. RESULTS: After a 3728 person-year follow-up (median/maximum of 4.8/15.2 years), 519 participants had died. In fully-adjusted models, the standardized mortality risk difference at 5 years of follow-up between medium-sized private facilities and large-sized public facilities was -18.9% (95% confidence interval [CI]: -33.4 to -4.5%), with a median survival (95% CI) of 3.6 (0.5 to 6.8) additional years. The fully-standardized 5-year mortality difference (95% CIs) between for-profit private facilities and not-for-profit public institutions was -15.1% (-31.1% to 0.9%), and the fully-standardized median survival difference (95% CIs) was 3.0 (-1.7 to 7.7) years. DISCUSSION AND IMPLICATIONS: These results are compatible with an association between factors related with the ownership of facilities and the long-term mortality risk of their residents. One of these factors, the facility size, could partly explain this association.This work was supported by the Carlos III Institute of Health [PI15CIII00037] to JD. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.S

Facility ownership and mortality among older adults residing in care homes

http://hdl.handle.net/20.500.12105/7003 [Dataset]BACKGROUND AND OBJECTIVES: Nursing or care home characteristics may have a long-term impact on the residents' mortality risks that has not been studied previously. The study's main objective was to assess the association between facility ownership and long-term, all-cause mortality. RESEARCH DESIGN AND METHODS: We conducted a mortality follow-up study on a cohort of 611 nursing-home residents in the city Madrid, Spain, from their 1998-1999 baseline interviews up to September 2013. Residents lived in three types of facilities: public, subsidized and private, which were also sub-classified according to size (number of beds). Residents' information was collected by interviewing the residents themselves, their caregivers and facility physicians. We used time-to-event multivariable models and inverse probability weighting to estimate standardized mortality risk differences. RESULTS: After a 3728 person-year follow-up (median/maximum of 4.8/15.2 years), 519 participants had died. In fully-adjusted models, the standardized mortality risk difference at 5 years of follow-up between medium-sized private facilities and large-sized public facilities was -18.9% (95% confidence interval [CI]: -33.4 to -4.5%), with a median survival (95% CI) of 3.6 (0.5 to 6.8) additional years. The fully-standardized 5-year mortality difference (95% CIs) between for-profit private facilities and not-for-profit public institutions was -15.1% (-31.1% to 0.9%), and the fully-standardized median survival difference (95% CIs) was 3.0 (-1.7 to 7.7) years. DISCUSSION AND IMPLICATIONS: These results are compatible with an association between factors related with the ownership of facilities and the long-term mortality risk of their residents. One of these factors, the facility size, could partly explain this association.This work was supported by the Carlos III Institute of Health [PI15CIII00037] to JD. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.S

Effects of petrosaspongiolide M, a novel phospholipase A2 inhibitor, on acute and chronic inflammation

ABSTRACT The marine product petrosaspongiolide M is a novel inhibitor of phospholipase A 2 (PLA 2 ), showing selectivity for secretory PLA 2 versus cytosolic PLA 2 , with a potency on the human synovial enzyme (group II) similar to that of manoalide. This compound was more potent than manoalide on bee venom PLA 2 (group III) and had no effect on group I enzymes (Naja naja and porcine pancreatic PLA 2 ). Inhibition of PLA 2 was also observed in vivo in the zymosan-injected rat air pouch, on the secretory enzyme accumulated in the pouch exudate. Petrosaspongiolide M decreased carrageenan paw edema in mice after the oral administration of 5, 10, or 20 mg/kg. This marine metabolite (0.01-1.0 mol/pouch) induced a dose-dependent reduction in the levels of prostaglandin (PG)E 2 , leukotriene B 4 , and tumor necrosis factor-␣ in the mouse air pouch injected with zymosan 4 h after the stimulus. It also had a weaker effect on cell migration. The inflammatory response of adjuvant arthritis was reduced by petrosaspongiolide M, which also inhibited leukotriene B 4 levels in serum and PGE 2 levels in paw homogenates. In contrast with indomethacin, this marine compound did not reduce PGE 2 levels in stomach homogenates. Petrosaspongiolide M is a new inhibitor of secretory PLA 2 in vitro and in vivo, with anti-inflammatory properties in acute and chronic inflammation

Hardware design of a small UAS helicopter for remote sensing operations

This paper presents the hardware design and integration process employed to develop an Unmanned Aircraft System (UAS) helicopter. The design process evolves from the bare airframe (without any electronics), to become a complete and advanced UAS platform for remote sensing applications. The improvements, design decisions and justifications are described throughout the paper. Two airframes have been used during the design and integration process: the AF25B model and the more advanced AF30 model, from the Copterworks company. The airframe engine reliability and fuel economy have been improved by adding an Electronic Fuel Injection (EFI) and Capacitor Discharge Ignition (CDI), both managed by an Engine Control Unit (ECU). On-board power supply generation and regulation have also been designed and validated. Finally, the integration process incorporates on-board mission computation to improve the concept of operation in remote sensing applications. Several flight tests have been performed to verify the reliability of the whole system. The flight test results demonstrate the correct process of integration and the feasibility of the UAS.Peer ReviewedPostprint (published version

Safety and Efficacy of an Oncolytic Adenovirus as an Immunotherapy for Canine Cancer Patients

The use of oncolytic virus is an innovative approach that has shown promising results as a treatment in oncology. Epithelial-derived tumors are the most frequent neoplasms in dogs, but gold standard therapies can be highly invasive procedures. Due to the accessible localization of these tumors, the intratumoral administration is feasible. Therefore, we propose to determine the safety and efficacy of intratumoral administration of oncolytic adenovirus ICOCAV15, in canine patients with epithelial-derived tumors. Eight dogs with carcinoma/adenocarcinoma were intratumorally treated with ICOCAV15. No clinically relevant changes were observed in the blood count, biochemistry and coagulation test analyzed during follow-up. The survival time of the 6/8 dogs exceeded the median survival time with chemotherapy, showing a partial response rate of 25% and 75% of stable disease. ICOCAV15 was detected in the target lesion by qPCR and immunohistochemistry. Also, some of the non-treated metastasis showed an infiltration of ICOCAV15 by immunohistochemistry. The immune populations were evaluated, and an increase of CD8+, MAC387+, CD3+ and CD20+ cells was reported in some of the patients after the inoculation. These results show that intratumoral ICOCAV15 is safe and well tolerated by dogs. Also, they suggest ICOCAV15 could be a new tool in veterinary oncology for accessible carcinomas/adenocarcinomas. The use of oncolytic viruses is an innovative approach to lyse tumor cells and induce antitumor immune responses. Eight dogs diagnosed with carcinoma/adenocarcinoma were intratumorally treated with ICOCAV15, an oncolytic canine adenovirus (CAV). To evaluate the treatment's safety, a blood count, biochemistry, and coagulation test were performed before treatment and during follow-up. Immune populations were analyzed by flow cytometry. Anti-adenovirus antibodies were also determined. The immune infiltration, vascularization, and viral presence in the tumor were determined by CD3, CD4, CD20, CD31 and CAV by immunohistochemistry. All the dogs maintained a good quality of life during follow-up, and some had increased median survival time when compared with dogs treated with chemotherapy. No treatment-related adverse effects were detected. The Response Evaluation Criteria In Solid Tumors criteria were also assessed: two patients showed a partial response and the rest showed stable disease at various times during the study. ICOCAV15 was detected inside the tumor during follow-up, and antiviral antibodies were detected in all patients. Furthermore, the tumor-infiltrating immune cells increased after viral administration. Therefore, we suggest that intratumorally administered ICOCAV15 could represent as a new tool for the treatment of canine carcinoma because it is safe, well-tolerated by dogs, and shows promising results

ICF-Based Disability Survey in a Rural Population of Adults and Older Adults Living in Cinco Villas, Northeastern Spain: Design, Methods and Population Characteristics

Background: This article describes the methods of a door-to-door screening survey exploring the distribution of disability and its major determinants in northeastern Spain. This study will set the basis for the development of disability-related services for the rural elderly in northeastern Spain. Methods: The probabilistic sample was composed of 1,354 de facto residents from a population of 12,784 Social Security card holders (age: 6 50 years). Cognitive and disability screenings were conducted (period: June 2008-June 2009). Screening instruments were the MMSE and the World Health Organization Disability Assessment Schedule. Participants screened positive for disability underwent an assessment protocol focusing on primary care diagnoses, disability, lifestyle, and social and health service usage. Participants screened positive for cognitive functioning went through in-depth neurological evaluation. Results: The study sample is described. Usable data were available for 1,216 participants. A total of 625 individuals (51.4%) scored within the positive range in the disability screening, while 135 (11.1%) scored within the positive range of the cognitive screening. The proportion of positively screened individuals was higher for women and increased with age. Conclusions: Screening surveys represent a feasible design for examining the distribution of disability and its determinants among the elderly. Data quality may benefit from methodological developments tailored to rural populations with a low education level. Copyright (C) 2010 S. Karger AG, Base

Substance P autocrine signaling contributes to persistent HER2 activation that drives malignant progression and drug resistance in breast cancer.

ERBB receptor transmodulation by heterologous G-protein-coupled receptors (GPCR) generates functional diversity in signal transduction. Tachykinins are neuropeptides and proinflammatory cytokines that promote cell survival and cancer progression by activating several GPCRs. In this work, we found that the pain-associated tachykinin Substance P (SP) contributes to persistent transmodulation of the ERBB receptors, EGFR and HER2, in breast cancer, acting to enhance malignancy and therapeutic resistance. SP and its high-affinity receptor NK-1R were highly expressed in HER2(+) primary breast tumors (relative to the luminal and triple-negative subtypes) and were overall correlated with poor prognosis factors. In breast cancer cell lines and primary cultures derived from breast cancer samples, we found that SP could activate HER2. Conversely, RNA interference-mediated attenuation of NK-1R, or its chemical inhibition, or suppression of overall GPCR-mediated signaling, all strongly decreased steady-state expression of EGFR and HER2, establishing that their basal activity relied upon transdirectional activation by GPCR. Thus, SP exposure affected cellular responses to anti-ERBB therapies. Our work reveals an important oncogenic cooperation between NK-1R and HER2, thereby adding a novel link between inflammation and cancer progression that may be targetable by SP antagonists that have been clinically explored