15 research outputs found
QCD and strongly coupled gauge theories : challenges and perspectives
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- T Alho
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- U Aglietti
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- V Baru
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- VA Saleev
- VD Toneev
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- W Altmannshofer
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- WE Caswell
- WE Caswell
- WJ Marciano
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- WT Giele
- WT Giele
- X Feng
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- X Zhao
- X-D Ji
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- X-D Ji
- X-D Ji
- X-F Chen
- X-G He
- X-M Xu
- X-N Wang
- X-N Wang
- X. Garcia i Tormo
- XH Mo
- XL Wang
- Y Akaishi
- Y Aoki
- Y Aoki
- Y Aoki
- Y Aoki
- Y Aoki
- Y Aoki
- Y Aoki
- Y Burnier
- Y Burnier
- Y Burnier
- Y Burnier
- Y Burnier
- Y Chen
- Y Fan
- Y Gabellini
- Y Grossman
- Y He
- Y Ikeda
- Y Ikeda
- Y Jia
- Y Jia
- Y Koma
- Y Koma
- Y Li
- Y Liu
- Y Liu
- Y Nambu
- Y Nambu
- Y Sakaki
- Y Zhu
- Y-J Zhang
- Y-J Zhang
- Y-Q Ma
- Y-Q Ma
- Y-Q Ma
- Y-Q Ma
- Y-Q Ma
- Y-T Chien
- Y-Y Bu
- Y-Y Keum
- YA Karpenko
- YA Simonov
- YL Dokshitzer
- YL Dokshitzer
- YM Antipov
- YM Antipov
- YV Kovchegov
- YV Kovchegov
- YV Kovchegov
- YV Stadnick
- YY Keum
- Z Bern
- Z Bern
- Z Bern
- Z Chacko
- Z Fodor
- Z Fodor
- Z Fodor
- Z Fodor
- Z Fodor
- Z Fodor
- Z Fodor
- Z Fodor
- Z Fu
- Z Fu
- Z Komargodski
- Z Komargodski
- Z Ligeti
- Z Ligeti
- Z-B Kang
- Z-B Kang
- Z-B Kang
- Z-G He
- Z-G He
- Z-H Li
- Z-W Lin
- Z-W Lin
- Z. Fodor
- Publication venue
- Publication date
- 01/01/2014
- Field of study
We highlight the progress, current status, and open challenges of QCD-driven physics, in theory and in experiment. We discuss how the strong interaction is intimately connected to a broad sweep of physical problems, in settings ranging from astrophysics and cosmology to strongly coupled, complex systems in particle and condensed-matter physics, as well as to searches for physics beyond the Standard Model. We also discuss how success in describing the strong interaction impacts other fields, and, in turn, how such subjects can impact studies of the strong interaction. In the course of the work we offer a perspective on the many research streams which flow into and out of QCD, as well as a vision for future developments.Peer reviewe
Expert system approaches to the selection of materials handling and transfer equipment
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1994
- Field of study
RAGE Regulates Immune Cell Infiltration and Angiogenesis in Choroidal Neovascularization
- Author
- A Bierhaus
- A Bierhaus
- A Caicedo
- A Tsuji
- AB Robinson
- Alan W. Stitt
- Angelika Bierhaus
- AZ Kalea
- B Chang
- BeijnumJR Van
- C Combadiere
- C Tsutsumi
- C Tsutsumi-Miyahara
- Carmel McVicar
- CM Mcvicar
- D Frommhold
- E Boulanger
- F Cruz-Guilloty
- Florian Sennlaub
- GR Barile
- H Kettenmann
- H Zong
- H Zong
- HE Grossniklaus
- Heping Xu
- HP Hammes
- J Ambati
- J Roychoudhury
- J Tian
- Josephine V. Glenn
- JR Beattie
- JT Handa
- JV Glenn
- JV Glenn
- K Grote
- KA Howes
- L Perrone
- Liza Colhoun
- M Chen
- M Slevin
- MA Hofmann
- Mei Chen
- MG Rambotti
- Michael Quinn
- Michael Ward
- MJ Mattapallil
- N Taniguchi
- P Jin
- PS Muther
- PT De Jong
- R Bianchi
- R Bianchi
- R Constien
- R Donato
- R Giri
- RS Apte
- SF Yan
- Shilpa Dasari
- T Chavakis
- T Fujimoto
- T Ishibashi
- TS Aleman
- UF Luhmann
- UF Luhmann
- W Ma
- X Chen
- X Ding
- Y Yamada
- Z Yang
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 26/02/2014
- Field of study
Purpose: RAGE regulates pro-inflammatory responses in diverse cells and tissues. This study has investigated if RAGE plays a role in immune cell mobilization and choroidal neovascular pathology that is associated with the neovascular form of agerelated macular degeneration (nvAMD). Methods: RAGE null (RAGE-/-) mice and age-matched wild type (WT) control mice underwent laser photocoagulation to generate choroidal neovascularization (CNV) lesions which were then analyzed for morphology, S100B immunoreactivity and inflammatory cell infiltration. The chemotactic ability of bone marrow derived macrophages (BMDMs) towards S100B was investigated. Results: RAGE expression was significantly increased in the retina during CNV of WT mice (
Down-regulation of microRNA-216a confers protection against yttrium aluminium garnet laser-induced retinal injury via the GDNF-mediated GDNF/GFRα1/RET signalling pathway
- Author
- A Iida
- A Jain
- A Kretz
- AE Autry
- AF Olena
- C Harada
- C Turlea
- DR Senger
- ED Weichel
- F Goto
- G Thumann
- I Jaadane
- J Jakus
- JF Girmens
- JH Stern
- Jian-Zhong He
- JJ Treanor
- K Masuzawa
- K Schulmeister
- K Yoshida
- LF Lin
- M Belokopytov
- M Kasaoka
- MH Chen
- Min Zhong
- N Binz
- PS Muther
- Q Hou
- Qi Luo
- R Chiu
- R Pinter
- RA Fernandes
- RH Masland
- RJ Blanch
- RJ Blanch
- S He
- S Jing
- S Matsuda
- SA Georgi
- SH Chung
- Shu-Hua Fu
- SM Hauck
- TR Sundermeier
- UE Ghitza
- Wei Lai
- Xi-Bin Hu
- Y Hu
- Y Jiang
- Y Shao
- Y Wang
- Y Zhang
- Y Zhang
- Yan-Fei Qiu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Fate mapping reveals that microglia and recruited monocyte-derived macrophages are definitively distinguishable by phenotype in the retina
- Author
- A London
- A London
- A Mildner
- A Mildner
- A Noailles
- A Wenzel
- AM Santos
- B Ajami
- B Ajami
- B Rojas
- C Jakubzick
- CB Toomey
- CL Howe
- CN Parkhurst
- D Song
- DE Wright
- E Zigmond
- ED Ponomarev
- ED Ponomarev
- EL Gautier
- F Ginhoux
- F Sennlaub
- GJ Guillemin
- GX Zhang
- H Kohno
- H Xu
- H Xu
- I Avraham-Davidi
- I Hilgendorf
- JD Sedgwick
- JM Malacara
- K Kierdorf
- K Molawi
- L Zhao
- L Zhao
- LT Remington
- M Chen
- M Greter
- MB Graeber
- MJ Kan
- MM LaVail
- MS Zinkernagel
- N Saederup
- PS Muther
- R Shechter
- R Yamasaki
- S Joly
- S Yona
- T Goldmann
- T Langmann
- TF Ng
- U Lehmann
- V Maneu
- WK Noell
- X Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
What do laboratory-forgetting paradigms tell us about use-inspired forgetting?
- Author
- AA Rizio
- AM Maxcey
- AM Maxcey
- AM Maxcey
- AM Maxcey
- AM Maxcey
- AM Maxcey
- AM Maxcey
- BC Storm
- BH Basden
- BH Basden
- BJ Underwood
- C Wetzel
- CK Quinlan
- CL Rae
- CM MacLeod
- CM MacLeod
- CT Weidemann
- DE Stokes
- DH Tan
- EK Vogel
- F Faul
- GR Wylie
- HL Roediger
- HL Roediger III
- I Reppa
- I Reppa
- JGW Raaijmakers
- JGW Raaijmakers
- JM Golding
- JP Wilson
- K Fukuda
- K-H BĂ€uml
- KA Paller
- KF Rugo
- KM Thompson
- KR Brandt
- KS Button
- L Sahakyan
- LL Jacoby
- MC Anderson
- MC Anderson
- MC Anderson
- MC Anderson
- MD Paz-Caballero
- NL Foster
- P Bekinschtein
- P Vuilleumier
- PS Scotti
- R Russo
- RE Geiselman
- SJ Luck
- T Yang
- W Yang
- WA Bainbridge
- WS Muther
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Using eye-tracking into decision makers evaluation in evolutionary interactive UA-FLP algorithms
- Author
- A Derakhshan Asl
- A Kusiak
- AdoraciĂłn AntolĂ-Cabrera
- B Golany
- Carlos Carmona-Muñoz
- D Rozado
- F Guo
- G Aiello
- G Aiello
- G Yu-Hsin Chen
- GC Armour
- I Basappa Hunagund
- J Burian
- J Guan
- J Liu
- JA Diego-Mas
- JA Tompkins
- JF Gonçalves
- JY Kim
- KY Wong
- L GarcĂa-HernĂĄndez
- L GarcĂa-HernĂĄndez
- L GarcĂa-HernĂĄndez
- L GarcĂa-HernĂĄndez
- L Salas-Morera
- Laura GarcĂa-HernĂĄndez
- Lorenzo Salas-Morera
- M Alonso Dos Santos
- M Causse
- M Gade
- M KrĂłl
- MS Bazaraa
- N Bozorgi
- N Charness
- P Koprinkova-Hristova
- P Kouvelis
- PS Welgama
- PY Yin
- R Kothari
- R Matai
- R Muther
- RC Lee
- S Kulturel-Konak
- S Kulturel-Konak
- S Kulturel-Konak
- S Kulturel-Konak
- SS Heragu
- V Madhusudanan Pillai
- X Wei
- X Zuo
- Y Peng
- Y Zhang
- YA Bozer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Schalen
- Author
- A Aas-Jakobsen
- A Chronowicz
- A Paduart
- A Paduart
- A PflĂŒger
- A Pucher
- A Tedesco
- AA Beles
- AA Beles
- AA Paduart
- ACI
- AM Haas
- AM Haas
- AM Haas
- B Kuyt
- B Nguyen
- B RieĂland
- BN Ghosh
- C Faber
- C Hoffmann
- D Bausch
- D RĂŒdiger
- D Schade
- E Baker
- E DulĂącska
- E Hampe
- E Hampe
- E Hampe
- E Hampe
- F Candela
- F Derflinger
- F Dischinger
- F LâAllemand
- F Otto
- F Otto
- FIP
- G Schaper
- G Worch
- GE Rosemeier
- GK Khaidukov
- GS Ramaswamy
- H Akbar
- H Caminos
- H Duddeck
- H Duddeck
- H Gohle
- H Hossdorf
- H Isler
- H Isler
- H Kraus
- H Lundgren
- H Pucher
- H Rothert
- H RĂŒhle
- H RĂŒhle
- H-W Tietge
- HA Hadid
- HJ Wittneben
- HJ Wittneben
- I Doganoff
- I Doganoff
- IASS
- IASS
- International Symposium on Natural Draft Cooling Towers
- J Form
- J Joedicke
- J Schlaich
- J Schlaich
- J Schlaich
- JA Dumitrescu
- JL Waling
- K Girkmann
- K Hayashi
- K Hirschfeld
- K SchÀfer
- K Szmodits
- K Tompert
- K-H Wölfer
- K-W Bieger
- Kollar. L. Die dehnungslosen FormÀnderungen von Schalen
- L Fischer
- L JankĂł
- L Kollar
- L Kollar
- M Godwin
- M Hentényi
- M Scherberger
- MP Collins
- NR Saeed
- P Ballesteros
- P Csonka
- P Misch
- PBJ Gravina
- PCI (Prestressed Concrete Institute USA)
- PS Chana
- R Krapfenbauer
- R Rabich
- R Rabich
- R Rabich
- R Rabich
- R Rabich
- RL Nicholls
- S Bosniakowski
- S Greiner
- S Poldnyi
- S Schleeh
- S Timoshenko
- Shotcrete and foam insulation shaped over inflated baloon form Concr
- SJ Medwadowski
- Symp. on pipes and tanks. IASS-Bull
- TYW Tsui
- U Muther
- V Giongu
- V Kolar
- W FlĂŒgge
- W FlĂŒgge
- W Fuchssteiner
- W KrÀtzig
- W Olszak
- W Olszak
- W Ringleben
- W Sobek
- W Teepe
- W Zerna
- W Zerna
- WB KrÀtzig
- WB KrÀtzig
- Y Basar
- Y Basar
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1988
- Field of study
Renal Cystic Disease
- Author
- A Biagini
- A Cantani
- A Chagnac
- A Sedman
- A Sholder
- A Telenti
- A Whelton
- A Yoshida
- AB Chapman
- AB Chapman
- AB Chapman
- AB Chapman
- AB Chapman
- AB Chapman
- AH Sklar
- AJ Taylor
- AR Harrison
- AR Mcgregor
- AS Levey
- AS Levey
- AT Evans
- B Salusky
- BG Clarke
- BL Mcclennan
- BR Cole
- BR Gilbert
- BS Kaplan
- BS Kaplan
- BS Kaplan
- BS Kaplan
- BT Steele
- C Antignac
- C Sungur
- CG Iglesias
- CV Leier
- D Churchill
- D Ravine
- DB Finlay
- DC Mendelssohn
- DC Smith
- DG Robins
- DH Pretorius
- DK Boal
- DM Manjoney
- DN Churchill
- DO Wiebers
- DP Link
- DS Keith
- E Higashihara
- E Higashihara
- E Higashihara
- E Kohaut
- E Levine
- E Levine
- E Levine
- E Levine
- E Levine
- E Levine
- E Levine
- E Levine
- E Lieberman
- E Sujansky
- EE Torres
- EG Plas
- ER Yendt
- F Alvares
- F Mainzer
- FE Cuppage
- G Concolino
- G Murphy
- GB Hopkins
- GD Chisholm
- GM Fick
- GM Fick
- GT Everson
- GT Everson
- H Blyth
- H Boichis
- H Goran
- H Kaariainen
- H Vandeursen
- I Ishikawa
- I Ishikawa
- I Ishikawa
- I Ishikawa
- I Ishikawa
- I Ishikawa
- I Ishikawa
- I Ishikawa
- I Ishikawa
- I Ishikawa
- I Ishikawa
- J Bommer
- J Hamberger
- J Huston
- J Kuyper
- J Lucaya
- J Milutinovic
- J Milutinovic
- J Milutinovic
- J Yemasu
- J Yium
- JC Bear
- JC Bear
- JD Harley
- JE Gernert
- JH Parks
- JJ Grantham
- JJ Grantham
- JJ Grantham
- JJ Grantham
- JJ Grantham
- JJJ Gehrig
- JKJ Roth
- JM Cobben
- JM Ginalski
- JM Panisello
- JM Sumfest
- JP Chadarevian
- JR Gregoire
- K Mchugh
- K Shikata
- K Zerres
- K Zerres
- KA Duncan
- KD Gardner
- KD Newman
- KF Hossack
- KR Orton
- KW Florijn
- L Baert
- LA Levine
- LH Phillips
- LW Elzinga
- LW Elzinga
- LW Elzinga
- LW Elzinga
- M Bronshtein
- M Martinez-Maldonado
- M OâNeill
- M Timio
- M Zeier
- M Zeier
- MA Matson
- MA Weiner
- MB Hamida
- MD Hughson
- MF Gagnadoux
- MF Gagnadoux
- MF Gagnadoux
- MI Mcdonald
- ML Macdougall
- MP Bubrick
- N Gretz
- N Gretz
- ND Vaziri
- O Mickisck
- OZ Dalgaard
- P Jungers
- P Landais
- PA Gabow
- PA Gabow
- PA Gabow
- PA Gabow
- PA Gabow
- PA Gabow
- PA Gabow
- PA Gabow
- PA Gabow
- PA Gabow
- PD Wilson
- PE Bell
- PJ Osther
- PL Hilpert
- PM Fitzpatrick
- PNJ Bretan
- PS Avasthi
- PS Chandhoke
- PS Parfrey
- R Huseman
- R Kala
- R Romero
- R Romero
- R Verani
- R Waldherr
- RA Mcdonald
- RA Risdon
- RA Valadez
- RD Seaton
- RE Reid
- RG Notley
- RM Vertel
- RS Muther
- RV Pinnick
- S Klahr
- S Mir
- S Saxena
- S Schwab
- SA Ritter
- Scientific Advisory Board of the National Kidney Foundation
- SG Rockson
- SH Cornell
- SJ Schwab
- SJ Schwab
- SK Anand
- SKS So
- SL Watkins
- SN Yarimizu
- SS Sagel
- ST Reeders
- ST Reeders
- SY Nakada
- The European Polycystic Kidney Disease Consortium
- U Querfeld
- U Zwettler
- UR Limioco
- V Osathanondh
- VE Torres
- VE Torres
- VE Torres
- W Kupin
- W Proesmans
- WD Kaehny
- WD Kaehny
- WE Stamm
- WI Schievink
- WJ Amend
- WJ Kimberling
- WJ Kimberling
- WJ Kimberling
- WL Hellerstedt
- WM Bennett
- WM Bennett
- WM Bennett
- WY Chung
- Y Nakanuma
- YH Lien
- YH Lien
- YM Traub
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1998
- Field of study
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
- Author
- Abecasis GR
- Aben KK
- Absher D
- Absher DM
- Aherrahrou Z
- Ahlqvist E
- Ahmadi K
- Alavere H
- Alibrandi MT
- Allayee H
- Allen HL
- Almgren P
- Almgren P
- Altshuler D
- Altshuler D
- Amin N
- Amin N
- Anand SS
- Andersen K
- Anderson JL
- Ardissino D
- Ardlie K
- Arnold AM
- Aspelund T
- Assimes TL
- Assimes TL
- Atwood LD
- Aulchenko YS
- Balkau B
- Balkau B
- Ball SG
- Balmforth AJ
- Balmforth AJ
- Barbalic M
- Barker A
- Barker DJ
- Barlassina C
- Barnes D
- Barnes TA
- Barrett A
- Barroso H
- Barroso I
- Barroso I
- Barroso I
- Bataille V
- Becker DM
- Becker LC
- Beckmann JS
- Beilby JP
- Bell JT
- Ben-Shlomo Y
- Benediktsson R
- Bengtsson Bostr\uf6m K
- Bennett AJ
- Bennett AJ
- Berger K
- Bergman RN
- Bergman RN
- Bergmann S
- Berndt SI
- Biebermann H
- Bis JC
- Blagieva R
- Blakemore AI
- Blankenberg S
- Boehm BO
- Boehnke M
- Boehnke M
- Boehnke M
- Boeing H
- Boekholdt SM
- Boerwinkle E
- Boerwinkle E
- Boerwinkle E
- Boes T
- Bonnycastle LL
- Bonnycastle LL
- Borecki IB
- Bornstein SR
- Bouatia-Naji N
- Bouatia-Naji N
- Bragi Walters G
- Braund PS
- Bravenboer B
- Brown MJ
- Brown MJ
- Buchanan TA
- Bumpstead S
- Burnett MS
- Burtt P
- Busonero F
- Buysschaert I
- C4D Consortium
- Cambien F
- Campbell H
- Campbell H
- Cappuccio FP
- Cardiogenics
- CARDIoGRAM Consortium
- Carlquist JF
- Cauchi S
- Caulfield MJ
- Cavalcanti-Proen\ue7a C
- Chambers J
- Chanock SJ
- Charpentier G
- Chasman DI
- Chen CM
- Chen H
- Chen L
- Chines PS
- Chines PS
- Cichon S
- Clarke R
- Clarke R
- Codd V
- Coin L
- Collins FS
- Collins FS
- Collins FS
- Connell J
- Cooper CC
- Cooper MN
- Cornelis M
- Couper DJ
- Crawford G
- Cupples LA
- Cupples LA
- Daly MJ
- Danesh J
- Davies RW
- Day IN
- de Faire U
- Dedoussis G
- Dedoussis GV
- Dehghan A
- Deloukas P
- Deloukas P
- Deloukas P
- Deloukas P
- Demissie S
- den Heijer M
- Dennison EM
- Dermitzakis ET
- Dermitzakis ET
- Devaney JM
- di Meglio P
- DIAGRAM Consortium
- Diemert P
- Dimas AS
- Dimas AS
- Dina C
- Dixon AL
- Do R
- Doering A
- Doney AS
- Dorret I B
- Duan J
- Dupuis J
- Durbin R
- Ebrahim S
- Eifert S
- Eiriksdottir G
- El Mokhtari NE
- Elliott AL
- Elliott KS
- Elliott P
- Ellis SG
- Elosua R
- Elosua R
- Engert JC
- Epstein SE
- Erdmann J
- Erdmann J
- Erdos MR
- Erdos MR
- Eric E S
- Eriksson JG
- Eriksson JG
- Eriksson P
- Esko T
- Estrada K
- Eury E
- Facheris MF
- Farooqi IS
- Feitosa MF
- Felix SB
- Ferrannini E
- Ferreira T
- Ferreira T
- Fischer M
- Fischer-Posovszky P
- Fisher E
- Florez JC
- Florez JC. Voight BF
- Folkersen L
- Folsom AR
- Folsom AR
- Forsen TJ
- Fox CS
- Fox CS
- Fox CS
- Franklin CS
- Franzosi MG
- Frayling TM
- Frayling TM
- Freimer NB
- Freyer J
- Friedrich N
- Froguel P
- Froguel P
- Froguel P
- Fu M
- Gaget S
- Gejman PV
- Geus EJ
- GIANT Consortium
- Gieger C
- Gieger C
- Gieger C
- Gigante B
- Girelli D
- Gjesing AP
- Glass D
- Glazer NL
- Gloyn AL
- Gloyn AL
- Goddard ME
- Goel A
- Goel A
- Goodall AH
- Goyette P
- Gr\ue4ssler J
- Gr\uf6nberg H
- Grallert H
- Grallert H
- Grarup N
- Green T
- Greenawalt DM
- Gretarsdottir S
- Griffin S
- Groop L
- Groop L
- Groop LC
- Groves CJ
- Groves CJ
- Grundberg E
- Gu HF
- Gudnason V
- Gudnason V
- Guiducci C
- Guiducci C
- Gulcher JR
- Gustafsson S
- Gustafsson S
- Gyllensten U
- Gyllensten U
- Hadjadj S
- Hall AS
- Hall AS
- Hall P
- Halperin E
- Hammond CJ
- Hammond N
- Hamsten A
- Hansen T
- Hansen T
- Haritunians T
- Harris TB
- Hartikainen AL
- Hassanali N
- Hassanali N
- Hassanali N
- Hattersley AT
- Hattersley AT
- Havulinna AS
- Hayes RB
- Hayward C
- Hazen SL
- Heard-Costa NL
- Heath AC
- Hebebrand J
- Hedman \uc5K
- Heid IM
- Heinrich J
- Hengstenberg C
- Hengstenberg C
- Herder C
- Hicks AA
- Hide WA
- Hinney A
- Hirschhorn JN
- Hitman GA
- Hoesel V
- Hofman A
- Hofman A
- Hofman A
- Hofmann OM
- Holm H
- Homuth G
- Hopewell JC
- Horikoshi M
- Horne BD
- Hottenga JJ
- Hu FB
- Hu FB
- Hui J
- Huikuri HV
- Hunter DJ
- Hunter DJ
- Huth C
- Hveem K
- Hveem K
- Ida Chen YD
- Igl W
- Illig T
- Illig T
- Illig T
- Ingelsson E
- Ingelsson E
- Ingle C
- Iribarren C
- Iribarren C
- Isomaa B
- Isomaa B
- Isomaa B
- J\uf8rgensen T
- J\uf8rgensen T
- Jackson AU
- Jackson AU
- Jackson AU
- Jacobs KB
- James AL
- Jameson KA
- Jansson JO
- Jarick I
- Jarvelin MR
- Jewell E
- Johansson \uc5
- John U
- Johnson P
- Johnson PR
- Johnson T
- Jones GT
- Jousilahti P
- Jukema JW
- Jula A
- K\ue4h\uf6nen M
- K\uf6nig IR
- K\uf6nig IR
- Kaakinen M
- Kaiser MA
- Kajantie E
- Kajantie E
- Kanoni S
- Kao WH
- Kaplan LM
- Kaplan LM
- Kaplan RC
- Kaprio J
- Karpe F
- Kastelein JJ
- Kathiresan S
- Kathiresan S
- Kerr-Conte J
- Ketkar S
- Kettunen J
- Khaw KT
- Khaw KT
- Kiemeney LA
- Kilpel\ue4inen TO
- Kinnunen L
- Klopp N
- Knowles JW
- Knowles JW
- Kolcic I
- Kolovou G
- Kong A
- Kong A
- Kooner J
- Koskinen S
- Kovacs P
- Kraft P
- Kraft P
- Krude H
- Kutalik Z
- Kuulasmaa T
- Kuusisto J
- Kuusisto J
- Kuusisto J
- Kval\uf8y K
- Laakso M
- Laakso M
- Laakso M
- Laaksonen R
- Laitinen J
- Lambrechts D
- Lamina C
- Langenberg C
- Langenberg C
- Lantieri O
- Lanzani C
- Launer LJ
- Lauritzen T
- Lawlor DA
- Lawrence RW
- Leander K
- Lecoeur C
- Lettre G
- Lettre G
- Levinson DF
- Li M
- Li M
- Li S
- Liang L
- Lieb W
- Lieverse A
- Lind L
- Lindgren CM
- Lindgren CM
- Lindgren CM
- Liu J
- Lokki ML
- Loley C
- Loos RJ
- Loos RJ
- Lorentzon M
- Lotery AJ
- Luan J
- Luan J
- Luben RN
- Ludwig B
- Lyssenko V
- Lyssenko V
- M\ue4gi R
- M\ue4larstig A
- M\ue4rz W
- M\ufchleisen TW
- M\ufcnzel T
- Macciardi F
- MAGIC
- Makrilakis K
- Mangino M
- Manning AK
- Mannucci PM
- Manunta P
- Maouche S
- Marek D
- Marre M
- Marre M
- Mart\uednez-Larrad MT
- Martin NG
- Martinelli N
- McArdle WL
- Mccarroll SA
- McCarroll SA
- McCarthy A
- McCarthy MI
- McCarthy MI
- McCarthy MI
- McCarthy MI
- Mcculloch LJ
- McKeown PP
- McKnight B
- McPherson R
- Meigs JB
- Meigs JB
- Meisinger C
- Meitinger T
- Meitinger T
- Meitinger T
- Melander O
- Melander O
- Merlini PA
- Metspalu A
- Meyre D
- Midthjell K
- Midthjell K
- Min JL
- Moffatt MF
- Mohlke KL
- Mohlke KL
- Monda KL
- Montgomery GW
- Montgomery SB
- Mooser V
- Morgan T
- Morken MA
- Morken MA
- Morris AD
- Morris AP
- Morris AP
- Muhlestein JB
- Mulic R
- Munroe PB
- Musunuru K
- MuTHER Consortium
- Myers RH
- N\uf6then MM
- Nahrstaedt J
- Narisu N
- Narisu N
- Narisu N
- Nastase Mannila M
- Navarro P
- Nelis M
- Nelson CP
- Nemesh J
- Nestle FO
- Neville MJ
- Ngwa JS
- Nica A
- Nica AC
- Nieminen MS
- Nilesh J S.
- Nilsson P
- Nisbet J
- North KE
- Nyholt DR
- O'Connell JR
- O'Donnell CJ
- O'Donnell CJ
- O'Rahilly S
- O'Rahilly S
- Ohlsson C
- Ohrvik J
- Olivieri O
- Ong KK
- Ongen H
- Oostra B
- Osmond C
- Ostenson CG
- Ouwehand WH
- Ouwehand WH
- Owen KR
- Palmer CN
- Palmer LJ
- Pankow JS
- Par\ue9 G
- Parish S
- Park JH
- Parker AN
- Parts L
- Pascoe L
- Patel RS
- Patterson CC
- Pattou F
- Payne F
- Payne F
- Peden JF
- Pedersen O
- Pedersen O
- Pellikka N
- Peltonen L
- Penninx BW
- Perola M
- Perry JR
- Perry JR
- Peter M V
- Peters A
- Peters A
- Peters MJ
- Petersen K
- Petrie JR
- Peyvandi F
- Pichler I
- Pietil\ue4inen KH
- Platou C
- Platou CG
- Polasek O
- Potter S
- Pouta A
- Pramstaller PP
- Pramstaller PP
- Preuss M
- Preuss M
- Proen\ue7a C
- Prokopenko I
- Prokopenko I
- Prokopenko I
- Qi L
- Qi L
- Qu L
- Quertermous T
- Quertermous T
- Quyyumi AA
- Rader DJ
- Rafelt S
- Raitakari O
- Rallidis LS
- Randall JC
- Rathmann W
- Raychaudhuri S
- Raychaudhuri S
- Rayner NW
- Reilly MP
- Reinehr T
- Rice C
- Ridderstr\ue5le M
- Ridker PM
- Rief W
- Ripatti S
- Rissanen A
- Rivadeneira F
- Roberts R
- Robertson NR
- Robertson NR
- Rocheleau G
- Roden M
- Rosendaal FR
- Rubin D
- Rudan I
- Rudan I
- Ruokonen A
- Rybin D
- Rzehak P
- Saleheen D
- Salomaa V
- Salomaa V
- Samani NJ
- Sampietro ML
- Sampson MJ
- Sanders AR
- Sandholt C
- Sandhu MS
- Sandhu MS
- Sanna S
- Saramies J
- Savolainen MJ
- Saxena R
- Sayer AA
- Sch\ue4fer A
- Schadt E
- Scherag A
- Scherag S
- Schillert A
- Schipf S
- Schlessinger D
- Schreiber S
- Schreiber S
- Schrezenmeir J
- Schunkert H
- Schunkert H
- Schwartz SM
- Schwarz PE
- Scott LJ
- Scott LJ
- Seedorf U
- Segr\ue8 AV
- Segr\ue8 AV
- Sekowska M
- Sennblad B
- Serrano-R\uedos M
- Shaun P
- Shi J
- Shields BM
- Shrader P
- Shuldiner AR
- Sigurdsson G
- Sijbrands E
- Silander K
- Silveira A
- Sinisalo J
- Siscovick DS
- Siscovick DS
- Sivananthan M
- Sivapalaratnam S
- Sladek R
- Small K
- Smit JH
- Smith A
- Smith AV
- Smith GD
- Smith TB
- Snoep JD
- Soranzo N
- Soranzo N
- Soranzo N
- Sovio U
- Spars\uf8 T
- Spector TD
- Spector TD
- Speliotes EK
- Spertus JA
- Stanc\ue1kov\ue1 A
- Stark K
- Stefansson K
- Stefansson K
- Stefansson K
- Stein LD
- Steinthorsdottir V
- Steinthorsdottir V
- Stephens J
- Stewart AF
- Stirrups K
- Stirrups K
- Stoll M
- Strachan DP
- Strassburger K
- Strawbridge RJ
- Stringham HM
- Stringham HM
- Stumvoll M
- Sun Q
- Surakka I
- Surdulescu G
- Swift AJ
- Swift AJ
- Swift AJ
- Syv\ue4nen AC
- T\uf6njes A
- Tammesoo ML
- Taneera J
- Tang WH
- Tardif JC
- Teder-Laving M
- Tennstedt S
- Terho L
- Teslovich TM
- Thiering E
- Thompson JR
- Thompson JR
- Thomson B
- Thorand B
- Thorgeirsson G
- Thorleifsson G
- Thorleifsson G
- Thorleifsson G
- Thorsteinsdottir U
- Thorsteinsdottir U
- Tichet J
- Timpson NJ
- Tomaszewski M
- Travers M
- Travers ME
- Tuomi T
- Tuomi T
- Tuomi T
- Tuomilehto J
- Tuomilehto J
- Turrini F
- Tyrer JP
- Uda M
- Uitterlinden A
- Uitterlinden A
- Uitterlinden AG
- Valle TT
- van 't Hooft FM
- van Dam RM
- van Duijn CM
- van Haeften TW
- van Herpt T
- van Hoek M
- van Meurs JB
- van Ommen GJ
- van Rij AM
- van Vliet JV
- van Wingerden S
- Vatin V
- Vedantam S
- Viikari J
- Visvikis-Siest S
- Vitart V
- Vogel CI
- Voight BF
- Voight BF
- Voight BF
- Wabitsch M
- Waeber G
- Waite LL
- Walker M
- Walker M
- Wallaschofski H
- Walters GB
- Wareham NJ
- Wareham NJ
- Wareham NJ
- Wareham NJ
- Watanabe RM
- Watanabe RM
- Watanabe RM
- Watkins H
- Watkins H
- Weedon MN
- Weedon MN
- Weedon MN
- Welch R
- Welch RP
- Wells GA
- Weyant RJ
- Wheeler E
- Wheeler E
- White CC
- Wichmann E
- Wichmann HE
- Widen E
- Wiegand S
- Wijmenga C
- Wiklund F
- Wild PS
- Wild SH
- Wilk A
- Willemsen G
- Willenborg C
- Willer CJ
- Willer CJ
- William Rayner N
- Wilson JF
- Winkler TW
- Witte DR
- Witteman J
- Witteman JC
- Witteman JC
- Wood AR
- Workalemahu T
- Wright BJ
- Wu G
- Xie W
- Xu J
- Yang J
- Yang TP
- Ye S
- Zabena C
- Zeggini E
- Zeller T
- Zethelius B
- Zgaga L
- Zhang Q
- Zhao JH
- Ziegler A
- Ziegler A
- Zitting P
- Zondervan KT
- Publication venue
- Publication date
- 01/01/2011
- Field of study
OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired \u3b2-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology.RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of 3c2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates.RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5
7 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7
7 10(-4)), improved \u3b2-cell function (P = 1.1
7 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8
7 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets.CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis