4,931 research outputs found
Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review
Objective and design The current study aimed to summarize the evidence of compounds contained in plant species with the ability to block the angiotensin-converting enzyme 2 (ACE-II), through a scoping review. Methods PubMed and Scopus electronic databases were used for the systematic search and a manual search was performed Results Studies included were characterized as in silico. Among the 200 studies retrieved, 139 studies listed after the exclusion of duplicates and 74 were included for the full read. Among them, 32 studies were considered eligible for the qualitative synthesis. The most evaluated class of secondary metabolites was flavonoids with quercetin and curcumin as most actives substances and terpenes (isothymol, limonin, curcumenol, anabsinthin, and artemisinin). Other classes that were also evaluated were alkaloid, saponin, quinone, substances found in essential oils, and primary metabolites as the aminoacid l-tyrosine and the lipidic compound 2-monolinolenin. Conclusion This review suggests the most active substance from each class of metabolites, which presented the strongest affinity to the ACE-II receptor, what contributes as a basis for choosing compounds and directing the further experimental and clinical investigation on the applications these compounds in biotechnological and health processes as in COVID-19 pandemic
Radiative Corrections to the Aharonov-Bohm Scattering
We consider the scattering of relativistic electrons from a thin magnetic
flux tube and perturbatively calculate the order , radiative
correction, to the first order Born approximation. We show also that the second
order Born amplitude vanishes, and obtain a finite inclusive cross section for
the one-body scattering which incorporates soft photon bremsstrahlung effects.
Moreover, we determine the radiatively corrected Aharonov-Bohm potential and,
in particular, verify that an induced magnetic field is generated outside of
the flux tube.Comment: 14 pages, revtex, 3 figure
Connecting RS OPh to [some] Type Ia Supernovae
Aims: Recurrent nova systems like RS Oph have been proposed as a possible
channel to Type Ia Supernova explosions, based on the high mass of the
accreting white dwarf. Additional support to this hypothesis has been recently
provided by the detection of circumstellar material around SN2006X and
SN2007le, showing a structure compatible with that expected for recurrent nova
outbursts.In this paper we investigate the circumstellar environment of RS Oph
and its structure, with the aim of establishing a firmer and independent link
between this class of objects and Type Ia SN progenitors.
Methods: We study the time evolution of CaII, NaI and KI absorption features
in RS Oph, before, during, and after the last outburst, using multi-epoch,
high-resolution spectroscopy, and applying the same method adopted for SN2006X
and SN2007le.
Results: A number of components, blue-shifted with respect to the systemic
velocity of RS Oph, are detected. In particular, one feature strongly weakens
in the first two weeks after the outburst, simultaneously with the
disappearance of very narrow P-Cyg profiles overimposed on the much wider nova
emission lines of H, He, FeII and other elements.
Conclusions: We interpret these facts as the signature of density
enhancements in the circumstellar material, suggesting that the recurrent
eruptions might indeed create complex structures within the material lost by
the donor star. This establishes a strong link between RS Oph and the
progenitor system of the Type Ia SN2006X, for which similar features have been
detected.Comment: 8 pages, 10 figures. Accepted for publication in Astronomy and
Astrophysic
On the Nonabelian Aharonov Bohm Scattering of Spinless Particles
The Aharonov Bohm scattering for spinless, isospin 1/2, particles interacting
through a nonabelian Chern-Simons field is studied. Starting from the
relativistic quantum field theory and using a Coulomb gauge formulation, the
one loop renormalization program is implemented. Through the introduction of an
intermediary cutoff, separating the regions of high and low integration
momentum, the nonrelativistic limit is derived. The next to leading
relativistic approximation is also determined. In this approach quantum field
theory vacuum polarization effects are automatically incorporated.Comment: 20 pages, 8 figures, revtex. Misspelled reference corrected and new
references adde
Incidence, Risk Factors, and Impact of Severe Neutropenia After Hyperthermic Intraperitoneal Mitomycin C
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are considered the standard of care for patients with peritoneal dissemination of appendiceal cancer and are increasingly being evaluated for use in patients with carcinomatosis from colon cancer. Mitomycin C (MMC) is one of the most frequently used HIPEC agents in the management of peritoneal-based gastrointestinal malignancies. This study analyzes the incidence and risk factors for developing neutropenia following MMC-HIPEC combined with CRS.
All patients undergoing CRS and MMC-HIPEC for appendiceal cancer between January 1993 and October 2006 were retrospectively reviewed. Logistic regression was used to identify risk factors for the development of neutropenia, defined as an absolute neutrophil count (ANC) <1,000/mm3.
One hundred and twenty MMC-HIPEC were performed in 117 patients with appendiceal cancer. The incidence of neutropenia was 39%. Neutropenia occurred in 57.6% of female and 21.3% of male patients (p < 0.0001). Female gender and MMC dose per body surface area (BSA) were independent risk factors for neutropenia on multivariable logistic regression [odds ratio (OR) of neutropenia in females = 3.58 (95% confidence interval, CI: 1.52, 8.43); OR for 5 unit (mg/m2) increase in MMC dose per BSA = 3.37 (95% CI: 1.72, 6.63)]. Neutropenia did not increase the risk of mortality, postoperative infection or length of hospital stay.
Neutropenia is a frequent complication associated with MMC-HIPEC. Female sex and MMC dose per BSA are independent risk factors for neutropenia. These differences must be considered in the management of patients undergoing MMC-HIPEC to minimize the toxicity of the procedure
Human bone marrow mesenchymal stem cells : a systematic reappraisal via the genostem experience
Genostem (acronym for “Adult mesenchymal stem cells engineering for connective tissue disorders. From the bench to the bed side”) has been an European consortium of 30 teams working together on human bone marrow Mesenchymal Stem Cell (MSC) biological properties and repair capacity. Part of Genostem activity has been dedicated to the study of basic issues on undifferentiated MSCs properties and on signalling pathways leading to the differentiation into 3 of the connective tissue lineages, osteoblastic, chondrocytic and tenocytic. We have evidenced that native bone marrow MSCs and stromal cells, forming the niche of hematopoietic stem cells, were the same cellular entity located abluminally from marrow sinus endothelial cells. We have also shown that culture-amplified, clonogenic and highly-proliferative MSCs were bona fide stem cells, sharing with other stem cell types the major attributes of self-renewal and of multipotential priming to the lineages to which they can differentiate (osteoblasts, chondrocytes, adipocytes and vascular smooth muscle cells/pericytes). Extensive transcription profiling and in vitro and in vivo assays were applied to identify genes involved in differentiation. Thus we have described novel factors implicated in osteogenesis (FHL2, ITGA5, Fgf18), chondrogenesis (FOXO1A) and tenogenesis (Smad8). Another part of Genostem activity has been devoted to studies of the repair capacity of MSCs in animal models, a prerequisite for future clinical trials. We have developed novel scaffolds (chitosan, pharmacologically active microcarriers) useful for the repair of both bone and cartilage. Finally and most importantly, we have shown that locally implanted MSCs effectively repair bone, cartilage and tendonWork supported by the European Community (Key action 1.2.4-3 Integrated Project Genostem, contract No 503161)
Study of Inclusive J/psi Production in Two-Photon Collisions at LEP II with the DELPHI Detector
Inclusive J/psi production in photon-photon collisions has been observed at
LEP II beam energies. A clear signal from the reaction gamma gamma -> J/psi+X
is seen. The number of observed N(J/psi -> mu+mu-) events is 36 +/- 7 for an
integrated luminosity of 617 pb^{-1}, yielding a cross-section of
sigma(J/psi+X) = 45 +/- 9 (stat) +/- 17 (syst) pb. Based on a study of the
event shapes of different types of gamma gamma processes in the PYTHIA program,
we conclude that (74 +/- 22)% of the observed J/psi events are due to
`resolved' photons, the dominant contribution of which is most probably due to
the gluon content of the photon.Comment: 13 pages, 8 figures, Accepted by Phys. Lett.
Study of Tau-pair Production in Photon-Photon Collisions at LEP and Limits on the Anomalous Electromagnetic Moments of the Tau Lepton
Tau-pair production in the process e+e- -> e+e-tau+tau- was studied using
data collected by the DELPHI experiment at LEP2 during the years 1997 - 2000.
The corresponding integrated luminosity is 650 pb^{-1}. The values of the
cross-section obtained are found to be in agreement with QED predictions.
Limits on the anomalous magnetic and electric dipole moments of the tau lepton
are deduced.Comment: 20 pages, 9 figures, Accepted by Eur. Phys. J.
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