Tailoring Phase Space : A Way to Control Hamiltonian Transport

We present a method to control transport in Hamiltonian systems. We provide an algorithm - based on a perturbation of the original Hamiltonian localized in phase space - to design small control terms that are able to create isolated barriers of transport without modifying other parts of phase space. We apply this method of localized control to a forced pendulum model and to a system describing the motion of charged particles in a model of turbulent electric field

Optical Line Width Broadening Mechanisms at the 10 kHz Level in Eu3+:Y2O3 Nanoparticles

We identify the physical mechanisms responsible for the optical homogeneous broadening in Eu3+:Y2O3 nanoparticles to determine whether rare-earth crystals can be miniaturized to volumes less than λ3 whilst preserving their appeal for quantum technology hardware. By studying how the homogeneous line width depends on temperature, applied magnetic field, and measurement time scale the dominant broadening interactions for various temperature ranges above 3 K were characterized. Below 3 K the homogeneous line width is dominated by an interaction not observed in bulk crystal studies. These measurements demonstrate that broadening due to size-dependent phonon interactions is not a significant contributor to the homogeneous line width, which contrasts previous studies in rare-earth ion nanocrystals. Importantly, the results provide strong evidence that for the 400 nm diameter nanoparticles under study the minimum line width achieved (45±1 kHz at 1.3 K) is not fundamentally limited. In addition, we highlight that the expected broadening caused by electric field fluctuations arising from surface charges is comparable to the observed broadening. Under the assumption that such Stark broadening is a significant contribution to the homogeneous line width, several strategies for reducing this line width to below 10 kHz are discussed. Furthermore, it is demonstrated that the Eu3+ hyperfine state lifetime is sufficiently long to preserve spectral features for timescales up to 1 s. These results allow integrated rare-earth ion quantum optics to be pursued at a sub-micron scale and hence, open up directions for greater scaling of rare-earth quantum technology

Targeting the Src Pathway Enhances the Efficacy of Selective FGFR Inhibitors in Urothelial Cancers with FGFR3 Alterations.

Selective FGFR inhibitors such as infigratinib (BGJ398) and erdafitinib (JNJ-42756493) have been evaluated in clinical trials for cancers with FGFR3 molecular alterations, particularly in urothelial carcinoma patients. However, a substantial proportion of these patients (up to 50%) display intrinsic resistance to these drugs and receive minimal clinical benefit. There is thus an unmet need for alternative therapeutic strategies to overcome primary resistance to selective FGFR inhibitors. In this study, we demonstrate that cells expressing cancer-associated activating FGFR3 mutants and the FGFR3-TACC3 fusion showed primary resistance to infigratinib in long-term colony formation assays in both NIH-3T3 and urothelial carcinoma models. We find that expression of these FGFR3 molecular alterations resulted in elevated constitutive Src activation compared to wildtype FGFR3 and that cells co-opted this pathway as a means to achieve intrinsic resistance to infigratinib. Targeting the Src pathway with low doses of the kinase inhibitor dasatinib synergistically sensitized multiple urothelial carcinoma lines harbouring endogenous FGFR3 alterations to infigratinib. Our data provide preclinical rationale that supports the use of dasatinib in combination with selective FGFR inhibitors as a means to overcome intrinsic drug resistance in the salvage therapy setting in urothelial cancer patients with FGFR3 molecular alterations

Analysis of Boltzmann-Langevin Dynamics in Nuclear Matter

The Boltzmann-Langevin dynamics of harmonic modes in nuclear matter is analyzed within linear-response theory, both with an elementary treatment and by using the frequency-dependent response function. It is shown how the source terms agitating the modes can be obtained from the basic BL correlation kernel by a simple projection onto the associated dual basis states, which are proportional to the RPA amplitudes and can be expressed explicitly. The source terms for the correlated agitation of any two such modes can then be extracted directly, without consideration of the other modes. This facilitates the analysis of collective modes in unstable matter and makes it possible to asses the accuracy of an approximate projection technique employed previously.Comment: 13 latex pages, 4 PS figure

Control of test particle transport in a turbulent electrostatic model of the Scrape Off Layer

The ${\bm E}\times{\bm B}$ drift motion of charged test particle dynamics in the Scrape Off Layer (SOL)is analyzed to investigate a transport control strategy based on Hamiltonian dynamics. We model SOL turbulence using a 2D non-linear fluid code based on interchange instability which was found to exhibit intermittent dynamics of the particle flux. The effect of a small and appropriate modification of the turbulent electric potential is studied with respect to the chaotic diffusion of test particle dynamics. Over a significant range in the magnitude of the turbulent electrostatic field, a three-fold reduction of the test particle diffusion coefficient is achieved

Controlling chaotic transport in a Hamiltonian model of interest to magnetized plasmas

We present a technique to control chaos in Hamiltonian systems which are close to integrable. By adding a small and simple control term to the perturbation, the system becomes more regular than the original one. We apply this technique to a model that reproduces turbulent ExB drift and show numerically that the control is able to drastically reduce chaotic transport

Nuclear break-up of 11Be

The break-up of 11Be was studied at 41AMeV using a secondary beam of 11Be from the GANIL facility on a 48Ti target by measuring correlations between the 10Be core, the emitted neutrons and gamma rays. The nuclear break-up leading to the emission of a neutron at large angle in the laboratory frame is identified with the towing mode through its characteristic n-fragment correlation. The experimental spectra are compared with a model where the time dependent Schrodinger equation (TDSE) is solved for the neutron initially in the 11 Be. A good agreement is found between experiment and theory for the shapes of neutron experimental energies and angular distributions. The spectroscopic factor of the 2s orbital is tentatively extracted to be 0.46+-0.15. The neutron emission from the 1p and 1d orbitals is also studied

Elevated arousal at time of decision-making is not the arbiter of risk avoidance in chickens

The somatic marker hypothesis proposes that humans recall previously experienced physiological responses to aid decision-making under uncertainty. However, little is known about the mechanisms used by non-human animals to integrate risk perception with predicted gains and losses. We monitored the behaviour and physiology of chickens when the choice between a high-gain (large food quantity), high-risk (1 in 4 probability of receiving an air-puff) option (HGRAP) or a low-gain (small food quantity), no-risk (of an air-puff) (LGNAP) option. We assessed when arousal increased by considering different stages of the decision-making process (baseline, viewing, anticipation, reward periods) and investigated whether autonomic responses influenced choice outcome both immediately and in the subsequent trial. Chickens were faster to choose and their heart-rate significantly increased between the viewing and anticipation (post-decision, pre-outcome) periods when selecting the HGRAP option. This suggests that they responded physiologically to the impending risk. Additionally, arousal was greater following a HGRAP choice that resulted in an air-puff, but this did not deter chickens from subsequently choosing HGRAP. In contrast to human studies, we did not find evidence that somatic markers were activated during the viewing period, suggesting that arousal is not a good measure of avoidance in non-human animals

Double butterfly spectrum for two interacting particles in the Harper model

We study the effect of interparticle interaction $U$ on the spectrum of the Harper model and show that it leads to a pure-point component arising from the multifractal spectrum of non interacting problem. Our numerical studies allow to understand the global structure of the spectrum. Analytical approach developed permits to understand the origin of localized states in the limit of strong interaction $U$ and fine spectral structure for small $U$.Comment: revtex, 4 pages, 5 figure

Spatial localisation of Discoidin Domain Receptor 2 (DDR2) signalling is dependent on its collagen binding and kinase activity.

Discoidin Domain Receptor 2 (DDR2) is a collagen-binding receptor tyrosine kinase that initiates delayed and sustained tyrosine phosphorylation signalling. To understand the molecular basis of this unique phosphorylation profile, here we utilise fluorescence microscopy to map the spatiotemporal localisation of DDR2 and tyrosine phosphorylated proteins upon stimulation with collagen. We show that cellular phosphorylated proteins are localised to the interface where DDR2 is in contact with collagen and not in the early endosomes or lysosomes. We find that DDR2 localisation is independent of integrin activation and the key DDR2 signalling effector SHC1. Structure-function analysis reveals that DDR2 mutants defective for collagen binding or kinase activity are unable to localise to the cell surface, demonstrating for the first time that both collagen binding and kinase functions are required for spatial localisation of DDR2. This study provides new insights into the underlying structural features that control DDR2 activation in space and time