91 research outputs found
Phosphorylated α-synuclein in Parkinsonâs disease: correlation depends on disease severity
INTRODUCTION: α-Synuclein (α-syn) is a key protein in Parkinsonâs disease (PD), and one of its phosphorylated forms, pS129, is higher in PD patients than healthy controls. However, few studies have examined its levels in longitudinally collected cerebrospinal fluid (CSF) or in preclinical cases. In this study, CSF and clinical data were contributed by >300 subjects from three cohorts (the longitudinal DATATOP cohort, a large cross-sectional cohort, and a cohort of LRRK2 mutation carriers). RESULTS: Consistent with our previous observation that CSF pS129 positively correlated with Unified Parkinsonâs Disease Rating Scale (UPDRS) scores, CSF pS129 in the DATATOP cohort increased over approximately two years of disease progression (mean change 5.60 pg/ml, pâ=â0.050). Intriguingly, in the DATATOP cohort, pS129 negatively correlated with UPDRS scores at the baseline (Râ=ââ0.244, pâ=â0.017), but not final point, suggesting that this association may depend on disease stage. Reanalysis of our previous cohort with stratification by PD stage, and addition of a cohort of LRRK2 mutation carriers with very early/preclinical PD, supported the idea that the relationship between CSF pS129 and disease severity over a wider range of PD stages might be represented with a U-shaped curve, in which lower pS129 levels correlated with worse clinical condition at early stages, but better condition at later stages. CONCLUSION: The observation of a negative-to-positive transition of correlation of pS129 to disease severity as PD progresses could have profound impact on how pS129 is used as a biomarker clinically as well as in modeling PD experimentally
A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein
TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies
Observation of Two New Excited Îb0 States Decaying to Îb0 K-Ï+
Two narrow resonant states are observed in the Îb0K-Ï+ mass spectrum using a data sample of proton-proton collisions at a center-of-mass energy of 13 TeV, collected by the LHCb experiment and corresponding to an integrated luminosity of 6 fb-1. The minimal quark content of the Îb0K-Ï+ system indicates that these are excited Îb0 baryons. The masses of the Îb(6327)0 and Îb(6333)0 states are m[Îb(6327)0]=6327.28-0.21+0.23±0.12±0.24 and m[Îb(6333)0]=6332.69-0.18+0.17±0.03±0.22 MeV, respectively, with a mass splitting of Îm=5.41-0.27+0.26±0.12 MeV, where the uncertainties are statistical, systematic, and due to the Îb0 mass measurement. The measured natural widths of these states are consistent with zero, with upper limits of Î[Îb(6327)0]<2.20(2.56) and Î[Îb(6333)0]<1.60(1.92) MeV at a 90% (95%) credibility level. The significance of the two-peak hypothesis is larger than nine (five) Gaussian standard deviations compared to the no-peak (one-peak) hypothesis. The masses, widths, and resonant structure of the new states are in good agreement with the expectations for a doublet of 1D Îb0 resonances
A Review of Flood-Related Storage and Remobilization of Heavy Metal Pollutants in River Systems
Direct CP violation in charmless three-body decays of B± mesons
Measurements of
C
P
asymmetries in charmless three-body decays of
B
±
mesons are reported using proton-proton collision data collected by the LHCb detector, corresponding to an integrated luminosity of
5.9
â
â
fb
â
1
. The previously observed
C
P
asymmetry in
B
±
â
Ï
±
K
+
K
â
decays is confirmed, and
C
P
asymmetries are observed with a significance of more than five standard deviations in the
B
±
â
Ï
±
Ï
+
Ï
â
and
B
±
â
K
±
K
+
K
â
decays, while the
C
P
asymmetry of
B
±
â
K
±
Ï
+
Ï
â
decays is confirmed to be compatible with zero. The distributions of these asymmetries are also studied as a function of the three-body phase space and suggest contributions from rescattering and resonance interference processes. An indication of the presence of the decays
B
±
â
Ï
±
Ï
c
0
(
1
P
)
in both
B
±
â
Ï
±
Ï
+
Ï
â
and
B
±
â
Ï
±
K
+
K
â
decays is observed, as is
C
P
violation involving these amplitudes
Measurement of antiproton production from antihyperon decays in p He collisions at âsNN = 110 GeV
The interpretation of cosmic antiproton flux measurements from space-borne experiments is currently limited by the knowledge of the antiproton production cross-section in collisions between primary cosmic rays and the interstellar medium. Using collisions of protons with an energy of 6.5TeV incident on helium nuclei at rest in the proximity of the interaction region of the LHCb experiment, the ratio of antiprotons originating from antihyperon decays to prompt production is measured for antiproton momenta between 12 and 110GeV. The dominant antihyperon contribution, namely ÎÂŻâpÂŻÏ+ decays from promptly produced ÎÂŻ particles, is also exclusively measured. The results complement the measurement of prompt antiproton production obtained from the same data sample. At the energy scale of this measurement, the antihyperon contributions to antiproton production are observed to be significantly larger than predictions of commonly used hadronic production models
Measurement of J/Ï -pair production in pp collisions at âs = 13 TeV and study of gluon transverse-momentum dependent PDFs
The production cross-section of J/Ï pairs in proton-proton collisions at a centre-of-mass energy of âs = 13 TeV is measured using a data sample corresponding to an integrated luminosity of 4.2 fbâ1 collected by the LHCb experiment. The measurement is performed with both J/Ï mesons in the transverse momentum range 0 < pT< 14 GeV/c and rapidity range 2.0 < y < 4.5. The cross-section of this process is measured to be 16.36 ± 0.28 (stat) ± 0.88 (syst) nb. The contributions from single-parton scattering and double-parton scattering are separated based on the dependence of the cross-section on the absolute rapidity difference ây between the two J/Ï mesons. The effective cross-section of double-parton scattering is measured to be Ïeff = 13.1 ± 1.8 (stat) ± 2.3 (syst) mb. The distribution of the azimuthal angle ÏCS of one of the J/Ï mesons in the Collins-Soper frame and the pT-spectrum of the J/Ï pairs are also measured for the study of the gluon transverse-momentum dependent distributions inside protons. The extracted values of âšcos 2ÏCSâ© and âšcos 4ÏCSâ© are consistent with zero, but the presence of azimuthal asymmetry at a few percent level is allowed
Nicotinic acetylcholine receptors in attention circuitry: the role of layer VI neurons of prefrontal cortex
TDP-43 plasma levels do not differentiate sporadic inclusion body myositis from other inflammatory myopathies.
Contains fulltext :
89099.pdf (publisher's version ) (Closed access)1 december 201
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