2,054 research outputs found
Controlling mode orientations and frequencies in levitated cavity optomechanics
Cavity optomechanics offers quantum cooling, quantum control and measurement
of small mechanical oscillators. However the optical backactions that underpin
quantum control can significantly disturb the oscillator modes: mechanical
frequencies are shifted by the optical spring effect and light-matter
hybridisation in strong coupling regimes; mechanical modes hybridise with each
other via the cavity mode. This is even more pertinent in the field of
levitated optomechanics, where optical trapping fully determines the mechanical
modes and their frequencies. Here, using the coherent-scattering (CS) set-up
that allowed quantum ground state cooling of a levitated nanoparticle, we show
that -- when trapping away from a node of the cavity standing wave -- the CS
field opposes optical spring shifts and mechanical mode hybridisation. At an
optimal cancellation point, independent of most experimental parameters, we
demonstrate experimentally that it is possible to strongly cavity cool and
control the {\em unperturbed} modes. Suppression of the cavity-induced mode
hybridisation in the plane is quantified by measuring the
correlation spectra which are seen to always be
anti-correlated except at the cancellation point where they become
uncorrelated. The findings have implications for directional force sensing
using CS set-ups
DeltaPhish: Detecting Phishing Webpages in Compromised Websites
The large-scale deployment of modern phishing attacks relies on the automatic
exploitation of vulnerable websites in the wild, to maximize profit while
hindering attack traceability, detection and blacklisting. To the best of our
knowledge, this is the first work that specifically leverages this adversarial
behavior for detection purposes. We show that phishing webpages can be
accurately detected by highlighting HTML code and visual differences with
respect to other (legitimate) pages hosted within a compromised website. Our
system, named DeltaPhish, can be installed as part of a web application
firewall, to detect the presence of anomalous content on a website after
compromise, and eventually prevent access to it. DeltaPhish is also robust
against adversarial attempts in which the HTML code of the phishing page is
carefully manipulated to evade detection. We empirically evaluate it on more
than 5,500 webpages collected in the wild from compromised websites, showing
that it is capable of detecting more than 99% of phishing webpages, while only
misclassifying less than 1% of legitimate pages. We further show that the
detection rate remains higher than 70% even under very sophisticated attacks
carefully designed to evade our system.Comment: Preprint version of the work accepted at ESORICS 201
Free-hand sketch synthesis with deformable stroke models
We present a generative model which can automatically summarize the stroke
composition of free-hand sketches of a given category. When our model is fit to
a collection of sketches with similar poses, it discovers and learns the
structure and appearance of a set of coherent parts, with each part represented
by a group of strokes. It represents both consistent (topology) as well as
diverse aspects (structure and appearance variations) of each sketch category.
Key to the success of our model are important insights learned from a
comprehensive study performed on human stroke data. By fitting this model to
images, we are able to synthesize visually similar and pleasant free-hand
sketches
A population of luminous accreting black holes with hidden mergers
Major galaxy mergers are thought to play an important part in fuelling the
growth of supermassive black holes. However, observational support for this
hypothesis is mixed, with some studies showing a correlation between merging
galaxies and luminous quasars and others showing no such association. Recent
observations have shown that a black hole is likely to become heavily obscured
behind merger-driven gas and dust, even in the early stages of the merger, when
the galaxies are well separated (5 to 40 kiloparsecs). Merger simulations
further suggest that such obscuration and black-hole accretion peaks in the
final merger stage, when the two galactic nuclei are closely separated (less
than 3 kiloparsecs). Resolving this final stage requires a combination of
high-spatial-resolution infrared imaging and high-sensitivity hard-X-ray
observations to detect highly obscured sources. However, large numbers of
obscured luminous accreting supermassive black holes have been recently
detected nearby (distances below 250 megaparsecs) in X-ray observations. Here
we report high-resolution infrared observations of hard-X-ray-selected black
holes and the discovery of obscured nuclear mergers, the parent populations of
supermassive-black-hole mergers. We find that obscured luminous black holes
(bolometric luminosity higher than 2x10^44 ergs per second) show a significant
(P<0.001) excess of late-stage nuclear mergers (17.6 per cent) compared to a
sample of inactive galaxies with matching stellar masses and star formation
rates (1.1 per cent), in agreement with theoretical predictions. Using
hydrodynamic simulations, we confirm that the excess of nuclear mergers is
indeed strongest for gas-rich major-merger hosts of obscured luminous black
holes in this final stage.Comment: To appear in the 8 November 2018 issue of Nature. This is the
authors' version of the wor
DSCo-NG: A Practical Language Modeling Approach for Time Series Classification
The abundance of time series data in various domains and their high dimensionality characteristic are challenging for harvesting useful information from them. To tackle storage and processing challenges, compression-based techniques have been proposed. Our previous work, Domain Series Corpus (DSCo), compresses time series into symbolic strings and takes advantage of language modeling techniques to extract from the training set knowledge about different classes. However, this approach was flawed in practice due to its excessive memory usage and the need for a priori knowledge about the dataset. In this paper we propose DSCo-NG, which reduces DSCo’s complexity and offers an efficient (linear time complexity and low memory footprint), accurate (performance comparable to approaches working on uncompressed data) and generic (so that it can be applied to various domains) approach for time series classification. Our confidence is backed with extensive experimental evaluation against publicly accessible datasets, which also offers insights on when DSCo-NG can be a better choice than others
MSH3 polymorphisms and protein levels affect CAG repeat instability in huntington's disease mice
Expansions of trinucleotide CAG/CTG repeats in somatic tissues are thought to contribute to ongoing disease progression through an affected individual's life with Huntington's disease or myotonic dystrophy. Broad ranges of repeat instability arise between individuals with expanded repeats, suggesting the existence of modifiers of repeat instability. Mice with expanded CAG/CTG repeats show variable levels of instability depending upon mouse strain. However, to date the genetic modifiers underlying these differences have not been identified. We show that in liver and striatum the R6/1 Huntington's disease (HD) (CAG)~100 transgene, when present in a congenic C57BL/6J (B6) background, incurred expansion-biased repeat mutations, whereas the repeat was stable in a congenic BALB/cByJ (CBy) background. Reciprocal congenic mice revealed the Msh3 gene as the determinant for the differences in repeat instability. Expansion bias was observed in congenic mice homozygous for the B6 Msh3 gene on a CBy background, while the CAG tract was stabilized in congenics homozygous for the CBy Msh3 gene on a B6 background. The CAG stabilization was as dramatic as genetic deficiency of Msh2. The B6 and CBy Msh3 genes had identical promoters but differed in coding regions and showed strikingly different protein levels. B6 MSH3 variant protein is highly expressed and associated with CAG expansions, while the CBy MSH3 variant protein is expressed at barely detectable levels, associating with CAG stability. The DHFR protein, which is divergently transcribed from a promoter shared by the Msh3 gene, did not show varied levels between mouse strains. Thus, naturally occurring MSH3 protein polymorphisms are modifiers of CAG repeat instability, likely through variable MSH3 protein stability. Since evidence supports that somatic CAG instability is a modifier and predictor of disease, our data are consistent with the hypothesis that variable levels of CAG instability associated with polymorphisms of DNA repair genes may have prognostic implications for various repeat-associated diseases
Two loop electroweak corrections to and in the B-LSSM
The rare decays and are important to research new physics beyond standard model. In
this work, we investigate two loop electroweak corrections to and in the minimal
supersymmetric extension of the SM with local gauge symmetry (B-LSSM),
under a minimal flavor violating assumption for the soft breaking terms. In
this framework, new particles and new definition of squarks can affect the
theoretical predictions of these two processes, with respect to the MSSM.
Considering the constraints from updated experimental data, the numerical
results show that the B-LSSM can fit the experimental data for the branching
ratios of and . The
results of the rare decays also further constrain the parameter space of the
B-LSSM.Comment: 33 pages, 9 figures, Published in EPJ
Epigenetic Silencing of Spermatocyte-Specific and Neuronal Genes by SUMO Modification of the Transcription Factor Sp3
SUMO modification of transcription factors is linked to repression of transcription. The physiological significance of SUMO attachment to a particular transcriptional regulator, however, is largely unknown. We have employed the ubiquitously expressed murine transcription factor Sp3 to analyze the role of SUMOylation in vivo. We generated mice and mouse embryonic fibroblasts (MEFs) carrying a subtle point mutation in the SUMO attachment sequence of Sp3 (IKEE553D mutation). The E553D mutation impedes SUMOylation of Sp3 at K551 in vivo, without affecting Sp3 protein levels. Expression profiling revealed that spermatocyte-specific genes, such as Dmc1 and Dnahc8, and neuronal genes, including Paqr6, Rims3, and Robo3, are de-repressed in non-testicular and extra-neuronal mouse tissues and in mouse embryonic fibroblasts expressing the SUMOylation-deficient Sp3E553D mutant protein. Chromatin immunoprecipitation experiments show that transcriptional de-repression of these genes is accompanied by the loss of repressive heterochromatic marks such as H3K9 and H4K20 tri-methylation and impaired recruitment of repressive chromatin-modifying enzymes. Finally, analysis of the DNA methylation state of the Dmc1, Paqr6, and Rims3 promoters by bisulfite sequencing revealed that these genes are highly methylated in Sp3wt MEFs but are unmethylated in Sp3E553D MEFs linking SUMOylation of Sp3 to tissue-specific CpG methylation. Our results establish SUMO conjugation to Sp3 as a molecular beacon for the assembly of repression machineries to maintain tissue-specific transcriptional gene silencing
Entrainment of the Mammalian Cell Cycle by the Circadian Clock: Modeling Two Coupled Cellular Rhythms
The cell division cycle and the circadian clock represent two major cellular rhythms. These two periodic processes are coupled in multiple ways, given that several molecular components of the cell cycle network are controlled in a circadian manner. For example, in the network of cyclin-dependent kinases (Cdks) that governs progression along the successive phases of the cell cycle, the synthesis of the kinase Wee1, which inhibits the G2/M transition, is enhanced by the complex CLOCK-BMAL1 that plays a central role in the circadian clock network. Another component of the latter network, REV-ERBα, inhibits the synthesis of the Cdk inhibitor p21. Moreover, the synthesis of the oncogene c-Myc, which promotes G1 cyclin synthesis, is repressed by CLOCK-BMAL1. Using detailed computational models for the two networks we investigate the conditions in which the mammalian cell cycle can be entrained by the circadian clock. We show that the cell cycle can be brought to oscillate at a period of 24 h or 48 h when its autonomous period prior to coupling is in an appropriate range. The model indicates that the combination of multiple modes of coupling does not necessarily facilitate entrainment of the cell cycle by the circadian clock. Entrainment can also occur as a result of circadian variations in the level of a growth factor controlling entry into G1. Outside the range of entrainment, the coupling to the circadian clock may lead to disconnected oscillations in the cell cycle and the circadian system, or to complex oscillatory dynamics of the cell cycle in the form of endoreplication, complex periodic oscillations or chaos. The model predicts that the transition from entrainment to 24 h or 48 h might occur when the strength of coupling to the circadian clock or the level of growth factor decrease below critical values
Evidence for an excess of B -> D(*) Tau Nu decays
Based on the full BaBar data sample, we report improved measurements of the
ratios R(D(*)) = B(B -> D(*) Tau Nu)/B(B -> D(*) l Nu), where l is either e or
mu. These ratios are sensitive to new physics contributions in the form of a
charged Higgs boson. We measure R(D) = 0.440 +- 0.058 +- 0.042 and R(D*) =
0.332 +- 0.024 +- 0.018, which exceed the Standard Model expectations by 2.0
sigma and 2.7 sigma, respectively. Taken together, our results disagree with
these expectations at the 3.4 sigma level. This excess cannot be explained by a
charged Higgs boson in the type II two-Higgs-doublet model. We also report the
observation of the decay B -> D Tau Nu, with a significance of 6.8 sigma.Comment: Expanded section on systematics, text corrections, improved the
format of Figure 2 and included the effect of the change of the Tau
polarization due to the charged Higg
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