Proposal of Communication Mix in the Selected Company

Předmětem této bakalářské práce je návrh komunikačního mixu pro mnou vybraný podnik NOVAline, s. r. o., který provozuje kamennou prodejnu i e-shop, a který se hlavně zaměřuje na prodej dekorací a nábytku. Obsahuje podrobnou analýza současného stavu, stanovení možných nedostatků a sestavení návrhu nového komunikačního mixu. Nový komunikační mix by měl vylepšit postavení na trhu a přilákat nové zákazníky. Teoretická část je zaměřená na základní pojmy marketingového prostředí, marketingového mixu a komunikace.The subject and scope of my thesis is proposal of a communication mix for the shop and e-shop, which mainly operates is the current state analysis of a company in order to discover its core problems, which could be remedied by otimizing the current or drawing up a new marketing communication mix. The theoretical part of the thesis deals with basic marketing terminology.

Preparation on the setting of the ISO 9001 standard in the new production hall PLASTYMAT CZ LTD

96 s., 1 s. příl. :obr., tab., grafy +CD ROMDiplomová práce se zabývá problematikou zavádění systému řízení jakosti dle normy ČSN EN ISO 9001:2009 v nové výrobní hale PLASTYMAT CZ s.r.o. Úvodní část práce popisuje význam pojmu kvalita, vývoj systému řízení kvality a druhy koncepcí managementu kvality. Dále zahrnuje podrobnou charakteristiku norem řady ISO 9000 a to především normy ČSN EN ISO 9001:2009. Druhá část práce je zaměřena na postup zavádění systému managementu jakosti ve vybraném podniku, s cílem odhalit možné nedostatky, které musí být odstraněny před certifikací. Vyústěním analýzy současného stavu systému řízení jakosti ve společnosti je odhalení zásadních neshod a představení návrhu na jejich řešení. Tento návrh je zaměřen především na proces hodnocení dodavatele a řízení neshodného výrobku. V závěrečné části práce jsou uvedeny náklady a přínosy související s certifikací systému managementu jakosti podle normy ISO 9001 v daném podniku

Evaluation of the CNB's Monetary Policy in the Years 1997-2014

Import 02/11/2016Předmětem diplomové práce je hodnocení měnové politiky ČNB v letech 1997 - 2014. Cílem této diplomové práce je vyhodnocení plnění primárního cíle ČNB v letech 1997 - 2014. Hlavní místo v měnové politice zaujímá centrální banka. Cenová stabilita je posláním většiny centrálních bank na světě. Měnová politika ČNB se provádí prostřednictvím měnově-politického režimu cílování inflace. Při plnění svého cíle ČNB využívá měnově-politické nástroje, jimiž jsou operace na volném trhu, automatické facility, mimořádné facility, povinné minimální rezervy a devizové intervence. Vyhodnocení plnění primárního cíle ČNB v letech 1997 – 2014 je zhodnoceno na základě plnění inflačních cílů a prognózy ČNB ve stanoveném období.The subject of this thesis is to evaluate the CNB's monetary policy in the years 1997 - 2014. The aim of this thesis is to evaluate the performance of the primary goals of the CNB in 1997 - 2014. Central bank occupies main place in monetary policy. Price stability is the mission of most central banks in the world. CNB's monetary policy is conducted through monetary policy of inflation targeting. In fulfilling its goal of CNB uses monetary policy instruments, namely open market operations, automatic facilities, extraordinary facilities, reserve requirements, foreign exchange interventions. Evaluation of the performance of the primary goals of the CNB in the years 1997 - 2014 is evaluated on the basis of the fulfillment of inflation targets and CNB prognosis a specified period.120 - Katedra evropské integracedobř

Effect of selected catechins on doxorubicin antiproliferative efficacy and hepatotoxicity in vitro

Catechins may influence both desirable and undesirable effects of many drugs. In this study, the in vitro effect of (+)-catechin, (–)-epicatechin, (–)-epigallocatechin, (–)-epicatechingallate, and (–)-epigallocatechingallate (EGCG)on the efficacy of anticancer drug doxorubicin (DOX) was studiedin HCT-8 cancer cells.Rat hepatocytes were used to study the influence of EGCG on DOX hepatotoxicity. Cell proliferation and viability were studied by 3-4,5-dimethylthiazol-2-yl-2,5-diphenyl tetrazolium bromide and neutral red uptake assays. Formation of reactive oxigen species was determined using the dichlorofluorescein assay. All of the studied catechins(1–25 µmol L–1) had no effect on the proliferation of intestinal cancer cells and did not affect the antiproliferative effect of DOX (1–8 µmol L–1) in these cells. Moreover, EGCG at 25 µmol L–1 increased the viability of isolated hepatocytes and significantly protected these cells against DOX-induced toxicity and ROS production. Consumption of EGCG during DOX therapy seems to be safe and beneficial, since EGCG does not decrease DOX anticancer efficacy and could ameliorate DOX hepatotoxicity

Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo

Green tea is a favorite beverage and its extracts are popular components of dietary supplements. The aim of the present in vivo study was to obtain detailed information about the effect of a standard green tea extract (Polyphenon, P), at different doses, on antioxidant enzymes and oxidative stress markers in murine blood, liver, small and large intestine. In all doses, P improved the oxidative stress status via an increased content of plasmatic SH-groups (by 21–67 %). Regarding antioxidant enzymes in tissues, the low dose of P had the best effect as it elevated the activity of NADPH/quinone reductase in liver and small intestine, thioredoxin reductase in small intestine and hepatic superoxide dismutase. Based on these facts, consumation of green tea seems to be safe and beneficial, while consumption of dietary supplements containing high doses of catechins may disturb oxidative balance by lowering the activity of thioredoxin reductase, glutathione S-transferase, glutathione reductase and superoxide dismutase

Induction of xenobiotic-metabolizing enzymes in hepatocytes by beta-naphthoflavone: Time-dependent changes in activities, protein and mRNA levels

In the present study, time-dependency of the induction effect of a selective inducer on the activity, protein and mRNA levels of cytochromes P450 1A1/2 (CYP1A1/2), NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione S-transferases (GSTA), in primary culture of rat hepatocytes was tested and evaluated. To show the differences in responses of tested enzymes, the common aryl hydrocarbon receptor (AhR) ligand agonist, beta-naphthoflavone (BNF), was used. Induction of CYP1A1/2 by BNF was detected at all time intervals and at all levels (i.e., mRNA, protein, enzyme activity). Different responses of NQO1 and GSTA upon BNF treatment were observed. Our results demonstrate that the responses of different xenobiotic-metabolizing enzymes to the inducer vary in time and depend on the measured parameter. For these reasons, an induction study featuring only one-time interval treatment and/or one parameter testing could produce misleading information

Atmospheric pressure plasma polymerized oxazoline-based thin films: antibacterial properties and cytocompatibility performance

Polyoxazolines are a new promising class of polymers for biomedical applications. Antibiofouling polyoxazoline coatings can suppress bacterial colonization of medical devices, which can cause infections to patients. However, the creation of oxazoline-based films using conventional methods is difficult. This study presents a new way to produce plasma polymerized oxazoline-based films with antibiofouling properties and good biocompatibility. The films were created via plasma deposition from 2-methyl-2-oxazoline vapors in nitrogen atmospheric pressure dielectric barrier discharge. Diverse film properties were achieved by increasing the substrate temperature at the deposition. The physical and chemical properties of plasma polymerized polyoxazoline films were studied by SEM, EDX, FTIR, AFM, depth-sensing indentation technique, and surface energy measurement. After tuning of the deposition parameters, films with a capacity to resist bacterial biofilm formation were achieved. Deposited films also promote cell viability.Ministry of Education, Youth and Sports of the Czech RepublicMinistry of Education, Youth & Sports - Czech Republic [LO1411]; Czech Science FoundationGrant Agency of the Czech Republic [GACR 19-15240S]; Ministry of Defence of the Czech Republi

UDP-glycosyltransferase family in Haemonchus contortus: Phylogenetic analysis, constitutive expression, sex-differences and resistance-related differences

UDP-glycosyltransferases (UGT), catalysing conjugation of UDP-activated sugar donors to small lipophilic chemicals, are widespread in living organisms from bacteria to fungi, plant, or animals. The progress of genome sequencing has enabled an assessment of the UGT multigene family in Haemonchus contortus (family Trichostrongylidae, Nematoda), a hematophagous gastrointestinal parasite of small ruminants. Here we report 32 putative UGT genes divided into 15 UGT families. Phylogenetic analysis in comparison with UGTs from Caenorhabditis elegans, a free-living model nematode, revealed several single member homologues, a lack of the dramatic gene expansion seen in C. elegans, but also several families (UGT365, UGT366, UGT368) expanded in H. contortus only. The assessment of constitutive UGT mRNA expression in H. contortus adults identified significant differences between females and males. In addition, we compared the expression of selected UGTs in the drug-sensitive ISE strain to two benzimidazole-resistant strains, IRE and WR, with different genetic backgrounds. Constitutive expression of UGT368B2 was significantly higher in both resistant strains than in the sensitive strain. As resistant strains were able to deactivate benzimidazole anthelmintics via glycosylation more effectively then the sensitive strain, UGT368B2 enhanced constitutive expression might contribute to drug resistance in H. contortus