Modeling Architectures and Reference Models: Development and Maintenance Open Source ERP

The adoption Enterprise Resource Planning (ERPs) by small and medium-sized businesses may not possible its cost. At same time, whenever adapt ERP specific needs company, user becomes dependent developers due to the lack access and knowledge respective code. Free and open source software can promote advantages companies, however, for their adoption, it is necessary to develop techniques tools facilitate implementation and maintenance code. This article highlights the importance of defining modeling architectures and reference models for development and maintenance open source ERPs, especially the ERP5 project

Industry/University collaboration in product focussed œnological research in Portugal - the SOGRAPE / UCP ESB partnership 1995 - 1998

A innovative model of collaboration between a wine company and a university research group is presented. A protocol was established as a response to the perceived need to, on the part of the university, (i) focus research on specific scientific bottlenecks which would have a real impact in the producing industry and, on the part of the company, (ii) to have access to the scientific capacity to conduct in-depth studies to approach specific technical challenges. A closely managed programme was jointly established and the major characteristics are presented here together with the main results obtained during the first 2 and a half years of operation

Analysis of Zebrafish contamination with heavy metals using a FF-XRF imaging system based on a MPGD

Funding Information: F.D. Leite is grateful for the grant BII/UI96/9175/2020, R.G. Oliveira is grateful for the grant SFRH/BI/10638/2020, and P.M.S. Carvalho is grateful to FCT for the PhD grant PD/BD/128324/2017. Funding Information: The costs resulting from the FCT (Fundação para a Ciência e a Tecnologia, I.P–Portuguese Foundation for Science and Technology) hiring L.F.N.D. Carramate were funded by national funds (OE) in the scope of the framework contract CEECIND/01369/2017, and S. Pessanha in the scope of the framework contract CEECIND/00278/2018. Funding Information: This work was partially supported by projects PTDC/FIS-AQM/32536/2017, CERN/FIS-INS/0026/2019 and STRONG-2020–824093 through FCT and H2020 programs. It was also developed within the scope of the i3N (UIDB/50025/2020 & UIDP/50025/2020) and CESAM (UIDP/50017/2020 & UIDB/50017/2020 & LA/P/0094/2020), financed by national funds through the FCT/MEC COMPETE , FEDER and POCI programs. Publisher Copyright: © 2022 The AuthorsHeavy metals have been extensively used by humans and are still present in many aspects of modern-day life. Such elements tend to accumulate, degrading the quality of air, soil, and water, negatively affecting the living organisms. As such, it is of paramount importance to understand the environmental risks of heavy metals, including their bioaccumulation capacity in organisms, since they are associated with several harmful health effects, such as neurological damages. The Zebrafish (Danio rerio) has been shown to be an excellent animal model to understand physiological responses in mammals and consequently to perform toxicological studies due to characteristics such as the high genetic and physiological similarity with humans. In this work, a Full-Field Energy Dispersive X-ray Fluorescence (FF-XRF) imaging system, based on the 2D-THCOBRA micropattern gas detector, was used to monitor heavy metal accumulation in Zebrafish during a water borne exposure bioassay. The distributions of Mn, Se, and Pb in Zebrafish, exposed to different concentrations of the heavy metal compounds during different time intervals, were mapped. The results show a preferential accumulation of Mn, Se, and Pb in the Zebrafish's visceral region and highlight the suitability of the FF-XRF imaging system for quick screening of metal accumulation in fish bioassays.publishersversionpublishe

Interventions for the control of Aedes aegypti in Latin America and the Caribbean: systematic review and meta-analysis

Objective: To determine the effectiveness and degree of implementation of interventions for the control of Aedes aegypti in Latin America and the Caribbean (LAC) as reported in scientific literature. Methods: We searched MEDLINE, EMBASE, CENTRAL, SOCINDEX, and LILACS, for experimental and observational studies, economic assessments and qualitative experiences carried out in LAC from 2000 to 2016. We assessed incidence and morbimortality of Aedes aegypti-related diseases and entomological indices: Breteau (containers), House, and Pupae per Person. We used GRADE methodology for assessing quality of evidence. Results: Of 1826 records retrieved, 75 were included and 9 cluster randomised clinical trials could be meta-analysed. We did not identify any intervention supported by a high certainty of evidence. In consistency with qualitative evidence, health education and community engagement probably reduces the entomological indices, as do the use of insecticide-treated materials, indoor residual spraying and the management of containers. There is low certainty of evidence supporting the use of ovitraps or larvitraps, and the integrated epidemiological surveillance strategy to improve indices and reduce the incidence of dengue. The reported degree of implementation of these vector control interventions was variable and most did not extend to whole cities and were not sustained beyond 2 years. Conclusions: We found a general lack of evidence on effectiveness of vector control in the region, despite a few interventions that showed moderate to low certainty of evidence. It is important to engage and educate the community, apart from achieving the implementation of integrated actions between the health and other sectors at national and regional level.Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: García Perdomo, Herney Andrés. Universidad del Valle; ColombiaFil: Alcaraz, Andrea. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Tapia López, Elena. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Ruano Gandara, Ruth Amanda. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Ruvinsky, Silvina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentin

Chemotherapy and diffuse low-grade gliomas: a survey within the European Low-Grade Glioma Network.

Diffuse low-grade gliomas (DLGGs) are rare and incurable tumors. Whereas maximal safe, functional-based surgical resection is the first-line treatment, the timing and choice of further treatments (chemotherapy, radiation therapy, or combined treatments) remain controversial. An online survey on the management of DLGG patients was sent to 28 expert centers from the European Low-Grade Glioma Network (ELGGN) in May 2015. It contained 40 specific questions addressing the modalities of use of chemotherapy in these patients. The survey demonstrated a significant heterogeneity in practice regarding the initial management of DLGG patients and the use of chemotherapy. Interestingly, radiation therapy combined with the procarbazine, CCNU (lomustine), and vincristine regimen has not imposed itself as the gold-standard treatment after surgery, despite the results of the Radiation Therapy Oncology Group 9802 study. Temozolomide is largely used as first-line treatment after surgical resection for high-risk DLGG patients, or at progression. The heterogeneity in the management of patients with DLGG demonstrates that many questions regarding the postoperative strategy and the use of chemotherapy remain unanswered. Our survey reveals a high recruitment potential within the ELGGN for retrospective or prospective studies to generate new data regarding these issues

Nycthemeral and Monthly Occupation of the Fish Assemblage on a Sheltered Beach of Baía Norte, Florianópolis, Santa Catarina State, Brazil

Interpreting fish community records is challenging for several reasons, including the lack of past ichthyofauna data, the cyclical temporal variations in the community, and the methodology employed, which usually underestimates fish assemblages. The objective of this study was to describe short-scale and meso-scale (nycthemeral period and months, respectively) temporal variations in the ichthyofauna composition and structure of a sheltered beach of Baía Norte (Florianópolis, Santa Catarina state, Brazil), using a capéchade net. Samples were collected monthly for a period of 48 hours. During the period from December 2010 to November 2011, a total of 19,302 individuals belonging to 89 species and 39 families were captured. The number of individuals that were sampled during the day and/or night was dependent on the sampling month. On average, the daytime assemblage was more abundant and different in structure and composition than the nighttime assemblage. Of the eight species that had the highest Index of Relative Importance (%IRI), five had higher variations (ANOVA F) between the day and night than between the months. This finding reinforced the need for sampling during both the day and night. The capéchade net effectively captured demersal and pelagic individuals in a broad range of sizes