The Microsoft vs. Netscape browser’s war: A game theory based analysis

During 1996 the world’s attention was captured by the litigation posed by the United States’ government against Microsoft, blaming the latter of abusive use of its monopoly power in order to win what was known as the “browser’s war”. This paper presents the previous scenario to the web browser’s battle carried out by Microsoft and Netscape, analyzing both firm’s strategies in a short and also in a long term horizon game. The study provided is based on game theory tools and attempts to give a model that explains the firms’ behavior. Although the presented model is quite simple, it accurately explains the strategic interaction between the firms and its predictions fits with the actual results.Eje: V - Workshop de agentes y sistemas inteligentesRed de Universidades con Carreras en Informática (RedUNCI

Valoración de la Biopsia cutánea en el tratamiento con condroitin sulfato frente a placebo en pacientes afectos de gonartrosis y psoriasis en placas

Tesis doctoral inédita leida en la Universidad Autónoma de Madrid. Facultad de Medicina. Dpto de Anatomía Patológica. Fecha de lectura: 2 de Diciembre de 200

The Microsoft vs. Netscape browser’s war: A game theory based analysis

During 1996 the world’s attention was captured by the litigation posed by the United States’ government against Microsoft, blaming the latter of abusive use of its monopoly power in order to win what was known as the “browser’s war”. This paper presents the previous scenario to the web browser’s battle carried out by Microsoft and Netscape, analyzing both firm’s strategies in a short and also in a long term horizon game. The study provided is based on game theory tools and attempts to give a model that explains the firms’ behavior. Although the presented model is quite simple, it accurately explains the strategic interaction between the firms and its predictions fits with the actual results.Eje: V - Workshop de agentes y sistemas inteligentesRed de Universidades con Carreras en Informática (RedUNCI

Note: Vectorial-magneto optical Kerr effect technique combined with variable temperature and full angular range all in a single setup

Here, we report on a versatile full angular resolved/broad temperature range/vectorial magneto optical Kerr effect (MOKE) magnetometer, named TRISTAN. Its versatility relies on its capacity to probe temperature and angular dependencies of magnetization reversal processes without the need to do any intervention on the apparatus during measurements. The setup is a combination of a vectorial MOKE bench and a cryostat with optical access. The cryostat has a motorized rotatable sample holder with azimuthal correction. It allows for simultaneous and quantitative acquisition of the two in-plane magnetization components during the hysteresis loop at different temperatures from 4 K up to 500 K and in the whole angular range, without neither changing magnet orientation nor opening the cryostat. Measurements performed in a model system with competing collinear biaxial and uniaxial contributions are presented to illustrate its capabilitiesP.P. acknowledges financial support from MINECO through Contract No. JCI-2011- 09602. F.J.T. acknowledges financial support from Ramon y Cajal program (RYC-2011-09617). This work has been supported by MINECO through Project Nos. MAT2011-25598 and MAT2012-39308, by the Comunidad de Madrid through Project No. S2013/MIT-2850 NANOFRONTMAG-CM and by EU-FP7 through NANOPYME Project (No. 310516

Magnetization reversal signatures in the magnetoresistance of magnetic multilayers

The simultaneous determination of magnetoresistance and vectorial-resolved magnetization hysteresis curves in a spin valve structure reveals distinct magnetoresistive features for different magnetic field orientations, which are directly related to the magnetization reversal processes. Measurements performed in the whole angular range demonstrate that the magnetoresistive response originates from the intrinsic anisotropic angular dependence of the magnetization orientation between the two ferromagnetic layers. This also provides direct proof that the spin-dependent scattering in the bulk of the magnetic layers is at the origin of the magnetoresistive signal

The Globall Football Glossary® Application: Timeless product and legacy of the 2014 FIFA World Cup™

This paper aims to analyse the development process of the Globall Football Glossary®. The Globall Football Glossary® is a mobile application developed by the Olympic Studies Research Group (GPEO) of the Pontifical University Catholic of Rio Grande do Sul (PUCRS) for the FIFA World Cup Brazil 2014, aiming to broaden the cultural exchange among supporters and professionals during the megaevent. The application has more than 300 football terms and makes them available in four languages: Spanish, English, Portuguese and Russian. In the first development stage of the application it was used the different methodological steps of the Terminology’s Communication Theory for the definition of its database. As a result, it was created the Football Multilingual Lexicon containing eight semantical fields related to football: arbitration, areas of the field, equipment, act/action, positions, tactics, people e terms of the game. In the second development stage, the use of the terminotics and the concept Learning by Doing resulted in the creation and update of the application. A hybrid application was the choice of the authors made through an online platform for the development of applications called Thunkable. In this sense, the Globall Football Glossary® is characterized as a product that contributed with the academic-scientific legacy of the FIFA World Cup Brazil 2014 as well as timeless since it is updated every edition of the megaevent

Emergence of the Stoner-Wohlfarth astroid in thin films at dynamic regime

The Stoner-Wohlfarth (SW) model is the simplest model that describes adequately the magnetization reversal of nanoscale systems that are small enough to contain single magnetic domains. However for larger sizes where multi-domain effects are present, e.g., in thin films, this simple macrospin approximation fails and the experimental critical curve, referred as SW astroid, is far from its predictions. Here we show that this discrepancy could vanish also in extended system. We present a detailed angular-dependent study of magnetization reversal dynamics of a thin film with well-defined uniaxial magnetic anisotropy, performed over 9 decades of applied field sweep rate (dH/dt). The angular-dependent properties display a gradual transition from domain wall pinning and motion-like behaviour to a nucleative single-particle one, as dH/dt increases. Remarkably, in the high dynamic regime, where nucleation of reversed domains is the dominant mechanism of the magnetization reversal (nucleative regime), the magnetic properties including the astroid become closer to the ones predicted by SW model. The results also show why the SW model can successfully describe other extended systems that present nucleative regime, even in quasi-static conditionsThis work has been supported by MINECO (Ministerio de Economía y Competitividad) through Projects No. MAT2012-39308, FIS2015-67287-P, and FIS2016-78591-C3-1-R, by the Comunidad de Madrid through Project S2013/MIT-2850 NANOFRONTMAG-CM, and by MINECO through the FLAGERA Programme of Graphene Flagship: SOgraph project (No. PCIN-2015-216); and M-era.Net Programme: NEXMAG project (PCIN- 2015-126). IMDEA-Nanociencia acknowledges support from the ‘Severo Ochoa’ Program for Centres of Excellence in R&D (MINECO, Grant SEV-2016-0686). P.P. acknowledges support through the Marie Curie AMAROUT EU Programme and JCI-2011-09602. A.B. acknowledges MINECO through the ENMA-National project (MAT2014-56955-R)

The role of CCR5/CXCR3 expressing CD8+ cells in liver damage and viral control during persistent hepatitis C virus infection

20 p.Background/Aims:CXCR3 and CCR5 play a major role in recruiting cytotoxic T cells (Tc) and secreting secondary type 1 cytokines (Tc1) in the liver. HCV could impair their expression as a survival mechanism. The role of these chemokine receptors on CD8+ cells in chronic hepatitis C is analysed. Methods:Serum, chemokines, peripheral blood and intrahepatic lymphocytes from chronic hepatitis C patients were studied. CXCR3 / CCR5 expressing CD8+ cells were quantified by flow-cytometry. Serum chemokines concentration (CXCL10/CCL3) was measured by ELISA. Basal data were correlated with liver inflammation. Longitudinal data were obtained during treatment and correlated with virologic response. Results:CCR5/CXCR3 expressing CD8+ cells were enriched in the liver and correlated with inflammation. Chronic HCV patients presented the same frequency of CCR5high/CXCR3high expressing CD8+ cells in peripheral blood as in healthy controls but higher serum concentration of CXCL10/CCL3. Treatment with PEG-interferon a-2b plus ribavirin increased CCR5high/CXCR3high expressing CD8+ cells frequency in peripheral blood and decreased CXCL10/CCL3 serum concentration. Increase in CXCR3high expressing CD8+ cells after 24 weeks of treatment was correlated with SVR. Conclusions:In chronic hepatitis C, anti-viral treatment induces an increase in CD8+ cells expressing chemokine receptors associated with Tc1 response and a reduction in their ligands. Achievement of viral control is associated with an increase in CXCR3high expressing CD8+ cells during treatmentSchering-Plough-SpainJunta de Comunidades de Castilla-La Manch

Prediction and Monitoring of Partial Remission in Pediatric Type 1 Diabetes

[EN] The partial remission (PR) phase, a period experienced by most patients with type 1 diabetes (T1D) soon after diagnosis, is characterized by low insulin requirements and improved glycemic control. Given the great potential of this phase as a therapeutic window for immunotherapies because of its association with immunoregulatory mechanisms and beta-cell protection, our objective was to find peripheral immunological biomarkers for its better characterization, monitoring, and prediction. The longitudinal follow-up of 17 pediatric patients with new-onset T1D over one year revealed that, during the PR phase, remitter patients show increased percentages of effector memory (EM) T lymphocytes, terminally differentiated EM T lymphocytes, and neutrophils in comparison to non-remitter patients. On the contrary, remitter patients showed lower percentages of naive T lymphocytes, regulatory T cells (T-REG), and dendritic cells (DCs). After a year of follow-up, these patients also presented increased levels of regulatory B cells and transitional T1 B lymphocytes. On the other hand, although none of the analyzed cytokines (IL-2, IL-6, TGF-beta 1, IL-17A, and IL-10) could distinguish or predict remission, IL-17A was increased at T1D diagnosis in comparison to control subjects, and remitter patients tended to maintain lower levels of this cytokine than non-remitters. Therefore, these potential monitoring immunological biomarkers of PR support that this stage is governed by both metabolic and immunological factors and suggest immunoregulatory attempts during this phase. Furthermore, since the percentage of T-REG, monocytes, and DCs, and the total daily insulin dose at diagnosis were found to be predictors of the PR phase, we next created an index-based predictive model comprising those immune cell percentages that could potentially predict remission at T1D onset. Although our preliminary study needs further validation, these candidate biomarkers could be useful for the immunological characterization of the PR phase, the stratification of patients with better disease prognosis, and a more personalized therapeutic management.Funding for this study was provided by the Spanish Government (FIS PI18/00436) co-financed with the European Regional Development funds (FEDER), and by DiabetesCero Foundation. LGM is supported by the Generalitat de Catalunya (PERIS PIF-Salut Grant No. SLT017/20/000049). This work has been supported by positive discussion through Consolidated Research Group #2017 SGR 103, AGAUR, Generalitat de Catalunya

Performance of risk scores in predicting mortality at 3, 6, and 12 months in patients diagnosed with community-acquired pneumonia

Background: Risk scores (RS) evaluate the likelihood of short-term mortality in patients diagnosed with community-acquired pneumonia (CAP). However, there is a scarcity of evidence to determine the risk of long-term mortality. This article aims to compare the effectiveness of 16 scores in predicting mortality at three, six, and twelve months in adult patients with CAP. Methods: A retrospective cohort study on individuals diagnosed with CAP was conducted across two hospitals in Colombia. Receiver Operating Characteristic (ROC) curves were constructed at 3, 6, and 12 months to assess the predictive ability of death for the following scoring systems: CURB-65, CRB-65, SCAP, CORB, ADROP, NEWS, Pneumonia Shock, REA-ICU, PSI, SMART-COP, SMRT-CO, SOAR, qSOFA, SIRS, CAPSI, and Charlson Comorbidity Index (CCI). Results: A total of 3688 patients were included in the final analysis. Mortality at 3, 6, and 12 months was 5.2%, 8.3%, and 16.3% respectively. At 3 months, PSI, CCI, and CRB-65 scores showed ROC curves of 0.74 (95% CI: 0.71–0.77), 0.71 (95% CI: 0.67–0.74), and 0.70 (95% CI: 0.66–0.74). At 6 months, PSI and CCI scores showed performances of 0.74 (95% CI: 0.72–0.77) and 0.72 (95% CI: 0.69–0.74), respectively. Finally at 12 months, all evaluated scores showed poor discriminatory capacity, including PSI, which decreased from acceptable to poor with an ROC curve of 0.64 (95% CI: 0.61–0.66). Conclusion: When predicting mortality in patients with CAP, at 3 months, PSI, CCI, and CRB-65 showed acceptable predictive performances. At 6 months, only PSI and CCI maintained acceptable levels of accuracy. For the 12-month period, all evaluated scores exhibited very limited discriminatory ability, ranging from poor to almost negligible