8 research outputs found
VIII Encuentro de Docentes e Investigadores en Historia del Diseño, la Arquitectura y la Ciudad
Acta de congresoLa conmemoración de los cien años de la Reforma Universitaria de 1918 se presentó como una ocasión propicia para debatir el rol de la historia, la teoría y la crítica en la formación y en la práctica profesional de diseñadores, arquitectos y urbanistas.
En ese marco el VIII Encuentro de Docentes e Investigadores en Historia del Diseño, la Arquitectura y la Ciudad constituyó un espacio de intercambio y reflexión cuya realización ha sido posible gracias a la colaboración entre Facultades de Arquitectura, Urbanismo y Diseño de la Universidad Nacional y la Facultad de Arquitectura de la Universidad Católica de Córdoba, contando además con la activa participación de mayoría de las Facultades, Centros e Institutos de Historia de la Arquitectura del país y la región.
Orientado en su convocatoria tanto a docentes como a estudiantes de Arquitectura y Diseño Industrial de todos los niveles de la FAUD-UNC promovió el debate de ideas a partir de experiencias concretas en instancias tales como mesas temáticas de carácter interdisciplinario, que adoptaron la modalidad de presentación de ponencias, entre otras actividades.
En el ámbito de VIII Encuentro, desarrollado en la sede Ciudad Universitaria de Córdoba, se desplegaron numerosas posiciones sobre la enseñanza, la investigación y la formación en historia, teoría y crítica del diseño, la arquitectura y la ciudad; sumándose el aporte realizado a través de sus respectivas conferencias de Ana Clarisa Agüero, Bibiana Cicutti, Fernando Aliata y Alberto Petrina. El conjunto de ponencias que se publican en este Repositorio de la UNC son el resultado de dos intensas jornadas de exposiciones, cuyos contenidos han posibilitado actualizar viejos dilemas y promover nuevos debates.
El evento recibió el apoyo de las autoridades de la FAUD-UNC, en especial de la Secretaría de Investigación y de la Biblioteca de nuestra casa, como así también de la Facultad de Arquitectura de la UCC; va para todos ellos un especial agradecimiento
Anacardic acid derivatives as inhibitors of glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi
Chagas` disease, a parasitic infection caused by the flagellate protozoan Trypanosoma cruzi, is a major public health problem affecting millions of individuals in Latin America. On the basis of the essential role in the life cycle of T. cruzi, the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been considered an attractive target for the development of novel antitrypanosomatid agents. In the present work, we describe the inhibitory effects of a small library of natural and synthetic anacardic acid derivatives against the target enzyme. The most potent inhibitors, 6-n-pentadecyl-(1) and 6-n-dodecylsalicilic acids (10e), have IC(50) values of 28 and 55 mu M, respectively. The inhibition was not reversed or prevented by the addition of Triton X-100, indicating that aggregate-based inhibition did not occur. In addition, detailed mechanistic characterization of the effects of these compounds on the T. cruzi GAPDH-catalyzed reaction showed clear noncompetitive inhibition with respect to both substrate and cofactor. (C) 2008 Elsevier Ltd. All rights reserved.FAPESPFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)CAPESConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)CNP
Changes in Psychological and Cognitive Outcomes after Green versus Suburban Walking: A Pilot Crossover Study
Interplay of Degradation, Dissolution and Stabilization of Clarithromycin and Its Amorphous Solid Dispersions
Clarithromycin (CLA) is an aminomacrolide
antibiotic whose physical
properties are fascinating and challenging. It has very poor solubility
at neutral intestinal pH, but much better solubility under acidic
conditions due to amine protonation. The improved solubility in an
acid environment is confounded by the poor chemical stability of clarithromycin
that is quite labile toward acid-catalyzed degradation. This creates
a complex system under gastrointestinal (GI) conditions: dissolution
in the stomach, degradation, potential for precipitation in the small
intestine, and interplay with the formulation components. We report
herein a study of amorphous solid dispersion (ASD) of CLA with carboxyl-containing
cellulose derivatives, which have recently been shown to be excellent
ASD matrices for maximizing oral bioavailability. This approach was
intended to improve CLA solubility in neutral media while minimizing
release in an acid environment, and thereby increase its uptake from
the small intestine. Amorphous polymer/CLA nanoparticles were also
prepared by high-shear mixing in a multi-inlet vortex mixer (MIVM).
Different extents of release were observed at low pH from the various
formulations. Thus the solubility increase from nanosizing was deleterious
to the concentration of intact CLA obtained upon reaching small intestine
conditions; the high extent of release at gastric pH led to complete
degradation of CLA. Using pH-switch experiments, it was possible to
separate the effects of loss of CLA from solution by crystallization
vs. that from chemical degradation. It was found that the hydrophobic
cellulose derivative cellulose acetate adipate propionate (CAAdP)
was effective at protecting CLA from dissolution in the stomach, and
preventing CLA decomposition at low pH; 54% of CLA in CAADP ASD was
released intact, vs. 0% and 6% from HPMCAS and CMCAB ASDs, respectively.
We conclude that protection against degradation is central to enhancing
overall release of <i>intact</i> CLA from ASD formulations;
the formulations studied herein have great promise for simultaneous
CLA solubility enhancement and protection from loss to chemical degradation,
thereby reducing dose requirements and potentially decreasing colonic
exposure to CLA (reduced colonic exposure is expected to minimize
killing of beneficial colonic bacteria by CLA)