142 research outputs found
Is a wearable sensor-based characterisation of gait robust enough to overcome differences between measurement protocols? A multi-centric pragmatic study in patients with multiple sclerosis
Inertial measurement units (IMUs) allow accurate quantification of gait impairment of people with multiple sclerosis (pwMS). Nonetheless, it is not clear how IMU-based metrics might be influenced by pragmatic aspects associated with clinical translation of this approach, such as data collection settings and gait protocols. In this study, we hypothesised that these aspects do not significantly alter those characteristics of gait that are more related to quality and energetic efficiency and are quantifiable via acceleration related metrics, such as intensity, smoothness, stability, symmetry, and regularity. To test this hypothesis, we compared 33 IMU-based metrics extracted from data, retrospectively collected by two independent centres on two matched cohorts of pwMS. As a worst-case scenario, a walking test was performed in the two centres at a different speed along corridors of different lengths, using different IMU systems, which were also positioned differently. The results showed that the majority of the temporal metrics (9 out of 12) exhibited significant between-centre differences. Conversely, the between-centre differences in the gait quality metrics were small and comparable to those associated with a test-retest analysis under equivalent conditions. Therefore, the gait quality metrics are promising candidates for reliable multi-centric studies aiming at assessing rehabilitation interventions within a routine clinical context
WIMP-nucleon cross-section results from the second science run of ZEPLIN-III
We report experimental upper limits on WIMP-nucleon elastic scattering cross
sections from the second science run of ZEPLIN-III at the Boulby Underground
Laboratory. A raw fiducial exposure of 1,344 kg.days was accrued over 319 days
of continuous operation between June 2010 and May 2011. A total of eight events
was observed in the signal acceptance region in the nuclear recoil energy range
7-29 keV, which is compatible with background expectations. This allows the
exclusion of the scalar cross-section above 4.8E-8 pb near 50 GeV/c^2 WIMP mass
with 90% confidence. Combined with data from the first run, this result
improves to 3.9E-8 pb. The corresponding WIMP-neutron spin-dependent
cross-section limit is 8.0E-3 pb. The ZEPLIN programme reaches thus its
conclusion at Boulby, having deployed and exploited successfully three liquid
xenon experiments of increasing reach
The ZEPLIN-III dark matter detector: instrument design, manufacture and commissioning
We present details of the technical design and manufacture of the ZEPLIN-III
dark matter experiment. ZEPLIN-III is a two-phase xenon detector which measures
both the scintillation light and the ionisation charge generated in the liquid
by interacting particles and radiation. The instrument design is driven by both
the physics requirements and by the technology requirements surrounding the use
of liquid xenon. These include considerations of key performance parameters,
such as the efficiency of scintillation light collection, restrictions placed
on the use of materials to control the inherent radioactivity levels,
attainment of high vacuum levels and chemical contamination control. The
successful solution has involved a number of novel design and manufacturing
features which will be of specific use to future generations of direct dark
matter search experiments as they struggle with similar and progressively more
demanding requirements.Comment: 25 pages, 19 figures. Submitted to Astropart. Phys. Some figures down
sampled to reduce siz
Quenching Factor for Low Energy Nuclear Recoils in a Plastic Scintillator
Plastic scintillators are widely used in industry, medicine and scientific
research, including nuclear and particle physics. Although one of their most
common applications is in neutron detection, experimental data on their
response to low-energy nuclear recoils are scarce. Here, the relative
scintillation efficiency for neutron-induced nuclear recoils in a
polystyrene-based plastic scintillator (UPS-923A) is presented, exploring
recoil energies between 125 keV and 850 keV. Monte Carlo simulations,
incorporating light collection efficiency and energy resolution effects, are
used to generate neutron scattering spectra which are matched to observed
distributions of scintillation signals to parameterise the energy-dependent
quenching factor. At energies above 300 keV the dependence is reasonably
described using the semi-empirical formulation of Birks and a kB factor of
(0.014+/-0.002) g/MeVcm^2 has been determined. Below that energy the measured
quenching factor falls more steeply than predicted by the Birks formalism.Comment: 8 pages, 9 figure
The ZEPLIN II dark matter detector: data acquisition system and data reduction
ZEPLIN-II is a two-phase (liquid/gas) xenon dark matter detector searching
for WIMP-nucleon interactions. In this paper we describe the data acquisition
system used to record the data from ZEPLIN-II and the reduction procedures
which parameterise the data for subsequent analysis.Comment: 11 pages, 10 figure
The ZEPLIN II dark matter detector: data acquisition system and data reduction
ZEPLIN-II is a two-phase (liquid/gas) xenon dark matter detector searching
for WIMP-nucleon interactions. In this paper we describe the data acquisition
system used to record the data from ZEPLIN-II and the reduction procedures
which parameterise the data for subsequent analysis.Comment: 11 pages, 10 figure
Single electron emission in two-phase xenon with application to the detection of coherent neutrino-nucleus scattering
We present an experimental study of single electron emission in ZEPLIN-III, a
two-phase xenon experiment built to search for dark matter WIMPs, and discuss
applications enabled by the excellent signal-to-noise ratio achieved in
detecting this signature. Firstly, we demonstrate a practical method for
precise measurement of the free electron lifetime in liquid xenon during normal
operation of these detectors. Then, using a realistic detector response model
and backgrounds, we assess the feasibility of deploying such an instrument for
measuring coherent neutrino-nucleus elastic scattering using the ionisation
channel in the few-electron regime. We conclude that it should be possible to
measure this elusive neutrino signature above an ionisation threshold of
3 electrons both at a stopped pion source and at a nuclear reactor.
Detectable signal rates are larger in the reactor case, but the triggered
measurement and harder recoil energy spectrum afforded by the accelerator
source enable lower overall background and fiducialisation of the active
volume
Limits on spin-dependent WIMP-nucleon cross-sections from the first ZEPLIN-II data
The first underground data run of the ZEPLIN-II experiment has set a limit on
the nuclear recoil rate in the two-phase xenon detector for direct dark matter
searches. In this paper the results from this run are converted into the limits
on spin-dependent WIMP-proton and WIMP-neutron cross-sections. The minimum of
the curve for WIMP-neutron cross-section corresponds to 0.07 pb at a WIMP mass
of around 65 GeV.Comment: 12 pages, 2 figures, to be published in Physics Letters
The LAGUNA design study- towards giant liquid based underground detectors for neutrino physics and astrophysics and proton decay searches
The feasibility of a next generation neutrino observatory in Europe is being
considered within the LAGUNA design study. To accommodate giant neutrino
detectors and shield them from cosmic rays, a new very large underground
infrastructure is required. Seven potential candidate sites in different parts
of Europe and at several distances from CERN are being studied: Boulby (UK),
Canfranc (Spain), Fr\'ejus (France/Italy), Pyh\"asalmi (Finland),
Polkowice-Sieroszowice (Poland), Slanic (Romania) and Umbria (Italy). The
design study aims at the comprehensive and coordinated technical assessment of
each site, at a coherent cost estimation, and at a prioritization of the sites
within the summer 2010.Comment: 5 pages, contribution to the Workshop "European Strategy for Future
Neutrino Physics", CERN, Oct. 200
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