484 research outputs found
Louse (Insecta : Phthiraptera) mitochondrial 12S rRNA secondary structure is highly variable
Lice are ectoparasitic insects hosted by birds and mammals. Mitochondrial 12S rRNA sequences obtained from lice show considerable length variation and are very difficult to align. We show that the louse 12S rRNA domain III secondary structure displays considerable variation compared to other insects, in both the shape and number of stems and loops. Phylogenetic trees constructed from tree edit distances between louse 12S rRNA structures do not closely resemble trees constructed from sequence data, suggesting that at least some of this structural variation has arisen independently in different louse lineages. Taken together with previous work on mitochondrial gene order and elevated rates of substitution in louse mitochondrial sequences, the structural variation in louse 12S rRNA confirms the highly distinctive nature of molecular evolution in these insects
The Magnificent Seven: Magnetic fields and surface temperature distributions
Presently seven nearby radio-quiet isolated neutron stars discovered in ROSAT
data and characterized by thermal X-ray spectra are known. They exhibit very
similar properties and despite intensive searches their number remained
constant since 2001 which led to their name ``The Magnificent Seven''. Five of
the stars exhibit pulsations in their X-ray flux with periods in the range of
3.4 s to 11.4 s. XMM-Newton observations revealed broad absorption lines in the
X-ray spectra which are interpreted as cyclotron resonance absorption lines by
protons or heavy ions and / or atomic transitions shifted to X-ray energies by
strong magnetic fields of the order of 10^13 G. New XMM-Newton observations
indicate more complex X-ray spectra with multiple absorption lines. Pulse-phase
spectroscopy of the best studied pulsars RX J0720.4-3125 and RBS 1223 reveals
variations in derived emission temperature and absorption line depth with pulse
phase. Moreover, RX J0720.4-3125 shows long-term spectral changes which are
interpreted as due to free precession of the neutron star. Modeling of the
pulse profiles of RX J0720.4-3125 and RBS 1223 provides information about the
surface temperature distribution of the neutron stars indicating hot polar caps
which have different temperatures, different sizes and are probably not located
in antipodal positions.Comment: 10 pages, 8 figures, to appear in Astrophysics and Space Science, in
the proceedings of "Isolated Neutron Stars: from the Interior to the
Surface", edited by D. Page, R. Turolla and S. Zan
Responsible agriculture must adapt to the wetland character of mid‐latitude peatlands
Drained, lowland agricultural peatlands are greenhouse gas (GHG) emission hotspots and a large but vulnerable store of irrecoverable carbon. They exhibit soil loss rates of ~2.0 cm yr−1 and are estimated to account for 32% of global cropland emissions while producing only 1.1% of crop kilocalories. Carbon dioxide emissions account for >80% of their terrestrial GHG emissions and are largely controlled by water table depth. Reducing drainage depths is, therefore, essential for responsible peatland management. Peatland restoration can substantially reduce emissions. However, this may conflict with societal needs to maintain productive use, to protect food security and livelihoods. Wetland agriculture strategies will, therefore, be required to adapt agriculture to the wetland character of peatlands, and balance GHG mitigation against productivity, where halting emissions is not immediately possible. Paludiculture may substantially reduce GHG emissions but will not always be viable in the current economic landscape. Reduced drainage intensity systems may deliver partial reductions in the rate of emissions, with smaller modifications to existing systems. These compromise systems may face fewer hurdles to adoption and minimize environmental harm until societal conditions favour strategies that can halt emissions. Wetland agriculture will face agronomic, socio-economic and water management challenges, and careful implementation will be required. Diversity of values and priorities among stakeholders creates the potential for conflict. Successful implementation will require participatory research approaches and co-creation of workable solutions. Policymakers, private sector funders and researchers have key roles to play but adoption risks would fall predominantly on land managers. Development of a robust wetland agriculture paradigm is essential to deliver resilient production systems and wider environmental benefits. The challenge of responsible use presents an opportunity to rethink peatland management and create thriving, innovative and green wetland landscapes for everyone's future benefit, while making a vital contribution to global climate change mitigation
Case Report: Precision Medicine Target Revealed by In Vitro Modeling of Relapsed, Refractory Acute Lymphoblastic Leukemia From a Child With Neurofibromatosis
Children with neurofibromatosis have a higher risk of developing juvenile myelomonocytic leukemia and acute myeloid leukemia, but rarely develop B-cell acute lymphoblastic leukemia (B-ALL). Through in-vitro modeling, a novel NF1 p.L2467 frameshift (fs) mutation identified in a relapsed/refractory Ph-like B-ALL patient with neurofibromatosis demonstrated cytokine independence and increased RAS signaling, indicative of leukemic transformation. Furthermore, these cells were sensitive to the MEK inhibitors trametinib and mirdametinib. Bi-allelic NF1 loss of function may be a contributing factor to relapse and with sensitivity to MEK inhibitors, suggests a novel precision medicine target in the setting of neurofibromatosis patients with B-ALL.Susan L. Heatley, Elyse C. Page, Laura N. Eadie, Barbara J. McClure, Jacqueline Rehn, David T. Yeung, Michael Osborn, Tamas Revesz, Maria Kirby, and Deborah L. Whit
Exotic Meson Production in the System observed in the Reaction at 18 GeV/c
This letter reports results from the partial wave analysis of the
final state in collisions at 18GeV/c.
Strong evidence is observed for production of two mesons with exotic quantum
numbers of spin, parity and charge conjugation, in the decay
channel . The mass MeV/c^2 and
width MeV/c^2 of the first state are consistent
with the parameters of the previously observed . The second
resonance with mass MeV/c^2 and width MeV/c^2 agrees very well with predictions from theoretical
models. In addition, the presence of is confirmed with mass MeV/c^2 and width MeV/c^2
and a new state, , is observed with mass
MeV/c^2 and width MeV/c^2. The decay properties of
these last two states are consistent with flux tube model predictions for
hybrid mesons with non-exotic quantum numbers
Evidence for a narrow dip structure at 1.9 GeV/c in diffractive photoproduction
A narrow dip structure has been observed at 1.9 GeV/c in a study of
diffractive photoproduction of the final state performed by the
Fermilab experiment E687.Comment: The data of Figure 6 can be obtained by downloading the raw data file
e687_6pi.txt. v5 (2nov2018): added Fig. 7, the 6 pion energy distribution as
requested by a reade
Exact Hypersurface-Homogeneous Solutions in Cosmology and Astrophysics
A framework is introduced which explains the existence and similarities of
most exact solutions of the Einstein equations with a wide range of sources for
the class of hypersurface-homogeneous spacetimes which admit a Hamiltonian
formulation. This class includes the spatially homogeneous cosmological models
and the astrophysically interesting static spherically symmetric models as well
as the stationary cylindrically symmetric models. The framework involves
methods for finding and exploiting hidden symmetries and invariant submanifolds
of the Hamiltonian formulation of the field equations. It unifies, simplifies
and extends most known work on hypersurface-homogeneous exact solutions. It is
shown that the same framework is also relevant to gravitational theories with a
similar structure, like Brans-Dicke or higher-dimensional theories.Comment: 41 pages, REVTEX/LaTeX 2.09 file (don't use LaTeX2e !!!) Accepted for
publication in Phys. Rev.
The complex physics of dusty star-forming galaxies at high redshifts as revealed by Herschel and Spitzer
We combine far-infrared photometry from Herschel (PEP/HerMES) with deep mid-infrared spectroscopy from
Spitzer to investigate the nature and the mass assembly history of a sample of 31 luminous and ultraluminous
infrared galaxies ((U)LIRGs) at z ∼ 1 and 2 selected in GOODS-S with 24μm fluxes between 0.2 and 0.5 mJy.We
model the data with a self-consistent physical model (GRASIL) which includes a state-of-the-art treatment of dust
extinction and reprocessing. We find that all of our galaxies appear to require massive populations of old (>1 Gyr)
stars and, at the same time, to host a moderate ongoing activity of star formation (SFR 100M yr−1). The bulk of
the stars appear to have been formed a few Gyr before the observation in essentially all cases. Only five galaxies of
the sample require a recent starburst superimposed on a quiescent star formation history.We also find discrepancies
between our results and those based on optical-only spectral energy distribution (SED) fitting for the same objects;
by fitting their observed SEDs with our physical model we find higher extinctions (by ΔAV ∼ 0.81 and 1.14)
and higher stellar masses (by Δlog(M ) ∼ 0.16 and 0.36 dex) for z ∼ 1 and z ∼ 2 (U)LIRGs, respectively. The
stellar mass difference is larger for the most dust-obscured objects. We also find lower SFRs than those computed
from LIR using the Kennicutt relation due to the significant contribution to the dust heating by intermediate-age
stellar populations through “cirrus” emission (∼73% and ∼66% of the total LIR for z ∼ 1 and z ∼ 2 (U)LIRGs,
respectively).Department of HE and Training approved lis
Observers and Locality in Everett Quantum Field Theory
A model for measurement in collapse-free nonrelativistic fermionic quantum
field theory is presented. In addition to local propagation and
effectively-local interactions, the model incorporates explicit representations
of localized observers, thus extending an earlier model of entanglement
generation in Everett quantum field theory [M. A. Rubin, Found. Phys. 32,
1495-1523 (2002)]. Transformations of the field operators from the Heisenberg
picture to the Deutsch-Hayden picture, involving fictitious auxiliary fields,
establish the locality of the model. The model is applied to manifestly-local
calculations of the results of measurements, using a type of sudden
approximation and in the limit of massive systems in narrow-wavepacket states.
Detection of the presence of a spin-1/2 system in a given spin state by a
freely-moving two-state observer illustrates the features of the model and the
nonperturbative computational methodology. With the help of perturbation theory
the model is applied to a calculation of the quintessential "nonlocal" quantum
phenomenon, spin correlations in the Einstein-Podolsky-Rosen-Bohm experiment.Comment: Some changes to introduction and discussion sections, typos
corrected, conclusions unchanged. To appear in Foundations of Physic
Therapeutic options for mucinous ovarian carcinoma
OBJECTIVE: Mucinous ovarian carcinoma (MOC) is an uncommon ovarian cancer histotype that responds poorly to conventional chemotherapy regimens. Although long overall survival outcomes can occur with early detection and optimal surgical resection, recurrent and advanced disease are associated with extremely poor survival. There are no current guidelines specifically for the systemic management of recurrent MOC. We analyzed data from a large cohort of women with MOC to evaluate the potential for clinical utility from a range of systemic agents. METHODS: We analyzed gene copy number (n = 191) and DNA sequencing data (n = 184) from primary MOC to evaluate signatures of mismatch repair deficiency and homologous recombination deficiency, and other genetic events. Immunohistochemistry data were collated for ER, CK7, CK20, CDX2, HER2, PAX8 and p16 (n = 117-166). RESULTS: Molecular aberrations noted in MOC that suggest a match with current targeted therapies include amplification of ERBB2 (26.7%) and BRAF mutation (9%). Observed genetic events that suggest potential efficacy for agents currently in clinical trials include: KRAS/NRAS mutations (66%), TP53 missense mutation (49%), RNF43 mutation (11%), ARID1A mutation (10%), and PIK3CA/PTEN mutation (9%). Therapies exploiting homologous recombination deficiency (HRD) may not be effective in MOC, as only 1/191 had a high HRD score. Mismatch repair deficiency was similarly rare (1/184). CONCLUSIONS: Although genetically diverse, MOC has several potential therapeutic targets. Importantly, the lack of response to platinum-based therapy observed clinically corresponds to the lack of a genomic signature associated with HRD, and MOC are thus also unlikely to respond to PARP inhibition
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