236 research outputs found
Ecohydrological studies of dune slack vegetation at Kenfig dunes, South Wales, UK
Dune slacks are important coastal sand dune habitats and seasonal changes in water levels within dune aquifers control both their formation and the specific hydrological conditions which then govern the floristic composition of their characteristic plant communities. Kenfig Dunes National Nature Reserve is one of the largest dune sites in South Wales and Southern Britain. It supports an exceptional range of dune slack communities, including most of those recognised in the British National Vegetation Classification scheme. Detailed studies of the vegetation ecology and hydrology of dune slacks reveal the important influence of hydrological variables in controlling the composition of dune slack vegetation and also valuable information on water table profile and the key factors governing the annual hydrological budget of the dune system aquifer
Compatibility of a model for the QCD-Pomeron and chiral-symmetry breaking phenomenologies
The phenomenology of a QCD-Pomeron model based on the exchange of a pair of
non-perturbative gluons, i.e. gluon fields with a finite correlation length in
the vacuum, is studied in comparison with the phenomenology of QCD chiral
symmetry breaking, based on non-perturbative solutions of Schwinger-Dyson
equations for the quark propagator including these non-perturbative gluon
effects. We show that these models are incompatible, and point out some
possibles origins of this problem.Comment: 21 pages, uuencoded latex file, 3 postscript figures, uses epsf.sty
and epsf.tex. To be published in Phys. Lett.
On the structure and evolution of a polar crown prominence/filament system
Polar crown prominences are made of chromospheric plasma partially circling
the Suns poles between 60 and 70 degree latitude. We aim to diagnose the 3D
dynamics of a polar crown prominence using high cadence EUV images from the
Solar Dynamics Observatory (SDO)/AIA at 304 and 171A and the Ahead spacecraft
of the Solar Terrestrial Relations Observatory (STEREO-A)/EUVI at 195A. Using
time series across specific structures we compare flows across the disk in 195A
with the prominence dynamics seen on the limb. The densest prominence material
forms vertical columns which are separated by many tens of Mm and connected by
dynamic bridges of plasma that are clearly visible in 304/171A two-color
images. We also observe intermittent but repetitious flows with velocity 15
km/s in the prominence that appear to be associated with EUV bright points on
the solar disk. The boundary between the prominence and the overlying cavity
appears as a sharp edge. We discuss the structure of the coronal cavity seen
both above and around the prominence. SDO/HMI and GONG magnetograms are used to
infer the underlying magnetic topology. The evolution and structure of the
prominence with respect to the magnetic field seems to agree with the filament
linkage model.Comment: 24 pages, 14 figures, Accepted for publication in Solar Physics
Journal, Movies can be found at http://www2.mps.mpg.de/data/outgoing/panesar
Multiwavelength Studies of Young OB Associations
We discuss how contemporary multiwavelength observations of young
OB-dominated clusters address long-standing astrophysical questions: Do
clusters form rapidly or slowly with an age spread? When do clusters expand and
disperse to constitute the field star population? Do rich clusters form by
amalgamation of smaller subclusters? What is the pattern and duration of
cluster formation in massive star forming regions (MSFRs)? Past observational
difficulties in obtaining good stellar censuses of MSFRs have been alleviated
in recent studies that combine X-ray and infrared surveys to obtain rich,
though still incomplete, censuses of young stars in MSFRs. We describe here one
of these efforts, the MYStIX project, that produced a catalog of 31,784
probable members of 20 MSFRs. We find that age spread within clusters are real
in the sense that the stars in the core formed after the cluster halo. Cluster
expansion is seen in the ensemble of (sub)clusters, and older dispersing
populations are found across MSFRs. Direct evidence for subcluster merging is
still unconvincing. Long-lived, asynchronous star formation is pervasive across
MSFRs.Comment: 22 pages, 9 figures. To appear in "The Origin of Stellar Clusters",
edited by Steven Stahler, Springer, 2017, in pres
Modeling the Subsurface Structure of Sunspots
While sunspots are easily observed at the solar surface, determining their
subsurface structure is not trivial. There are two main hypotheses for the
subsurface structure of sunspots: the monolithic model and the cluster model.
Local helioseismology is the only means by which we can investigate
subphotospheric structure. However, as current linear inversion techniques do
not yet allow helioseismology to probe the internal structure with sufficient
confidence to distinguish between the monolith and cluster models, the
development of physically realistic sunspot models are a priority for
helioseismologists. This is because they are not only important indicators of
the variety of physical effects that may influence helioseismic inferences in
active regions, but they also enable detailed assessments of the validity of
helioseismic interpretations through numerical forward modeling. In this paper,
we provide a critical review of the existing sunspot models and an overview of
numerical methods employed to model wave propagation through model sunspots. We
then carry out an helioseismic analysis of the sunspot in Active Region 9787
and address the serious inconsistencies uncovered by
\citeauthor{gizonetal2009}~(\citeyear{gizonetal2009,gizonetal2009a}). We find
that this sunspot is most probably associated with a shallow, positive
wave-speed perturbation (unlike the traditional two-layer model) and that
travel-time measurements are consistent with a horizontal outflow in the
surrounding moat.Comment: 73 pages, 19 figures, accepted by Solar Physic
Physics of Solar Prominences: II - Magnetic Structure and Dynamics
Observations and models of solar prominences are reviewed. We focus on
non-eruptive prominences, and describe recent progress in four areas of
prominence research: (1) magnetic structure deduced from observations and
models, (2) the dynamics of prominence plasmas (formation and flows), (3)
Magneto-hydrodynamic (MHD) waves in prominences and (4) the formation and
large-scale patterns of the filament channels in which prominences are located.
Finally, several outstanding issues in prominence research are discussed, along
with observations and models required to resolve them.Comment: 75 pages, 31 pictures, review pape
Nanoparticles Targeted to Fibroblast Activation Protein Outperform PSMA for MRI Delineation of Primary Prostate Tumors
OnlinePublAccurate delineation of gross tumor volumes remains a barrier to radiotherapy dose escalation and boost dosing in the treatment of solid tumors, such as prostate cancer. Magnetic resonance imaging (MRI) of tumor targets has the power to enable focal dose boosting, particularly when combined with technological advances such as MRI-linear accelerator. Fibroblast activation protein (FAP) is overexpressed in stromal components of >90% of epithelial carcinomas. Herein, the authors compare targeted MRI of prostate specific membrane antigen (PSMA) with FAP in the delineation of orthotopic prostate tumors. Control, FAP, and PSMA-targeting iron oxide nanoparticles were prepared with modification of a lymphotropic MRI agent (FerroTrace, Ferronova). Mice with orthotopic LNCaP tumors underwent MRI 24 h after intravenous injection of nanoparticles. FAP and PSMA nanoparticles produced contrast enhancement on MRI when compared to control nanoparticles. FAP-targeted MRI increased the proportion of tumor contrast-enhancing black pixels by 13%, compared to PSMA. Analysis of changes in R2 values between healthy prostates and LNCaP tumors indicated an increase in contrast-enhancing pixels in the tumor border of 15% when targeting FAP, compared to PSMA. This study demonstrates the preclinical feasibility of PSMA and FAP-targeted MRI which can enable targeted image-guided focal therapy of localized prostate cancer.Nicole Dmochowska, Valentina Milanova, Ramesh Mukkamala, Kwok Keung Chow, Nguyen T. H. Pham, Madduri Srinivasarao, Lisa M. Ebert, Timothy Stait-Gardner, Hien Le, Anil Shetty, Melanie Nelson, Philip S. Low, and Benjamin Thierr
Radiosynthesis and preclinical evaluation of [68Ga]Ga-NOTA-folate for PET imaging of folate receptor β-positive macrophages
Folate receptor β (FR-β), a marker expressed on macrophages, is a promising target for imaging of inflammation. Here, we report the radiosynthesis and preclinical evaluation of [68Ga]Ga-NOTA-folate (68Ga-FOL). After determining the affinity of 68Ga-FOL using cells expressing FR-β, we studied atherosclerotic mice with 68Ga-FOL and 18F-FDG PET/CT. In addition, we studied tracer distribution and co-localization with macrophages in aorta cryosections using autoradiography, histology, and immunostaining. The specificity of 68Ga-FOL was assessed in a blocking study with folate glucosamine. As a final step, human radiation doses were extrapolated from rat PET data. We were able to produce 68Ga-FOL with high radiochemical purity and moderate molar activity. Cell binding studies revealed that 68Ga-FOL had 5.1 nM affinity for FR-β. Myocardial uptake of 68Ga-FOL was 20-fold lower than that of 18F-FDG. Autoradiography and immunohistochemistry of the aorta revealed that 68Ga-FOL radioactivity co-localized with Mac-3–positive macrophage-rich atherosclerotic plaques. The plaque-to-healthy vessel wall ratio of 68Ga-FOL was significantly higher than that of 18F-FDG. Blocking studies verified that 68Ga-FOL was specific for FR. Based on estimations from rat data, the human effective dose was 0.0105 mSv/MBq. Together, these findings show that 68Ga-FOL represents a promising new FR-β–targeted tracer for imaging macrophage-associated inflammation.</p
Cluster Density and the IMF
Observed variations in the IMF are reviewed with an emphasis on environmental
density. The remote field IMF studied in the LMC by several authors is clearly
steeper than most cluster IMFs, which have slopes close to the Salpeter value.
Local field regions of star formation, like Taurus, may have relatively steep
IMFs too. Very dense and massive clusters, like super star clusters, could have
flatter IMFs, or inner-truncated IMFs. We propose that these variations are the
result of three distinct processes during star formation that affect the mass
function in different ways depending on mass range. At solar to intermediate
stellar masses, gas processes involving thermal pressure and supersonic
turbulence determine the basic scale for stellar mass, starting with the
observed pre-stellar condensations, and they define the mass function from
several tenths to several solar masses. Brown dwarfs require extraordinarily
high pressures for fragmentation from the gas, and presumably form inside the
pre-stellar condensations during mutual collisions, secondary fragmentations,
or in disks. High mass stars form in excess of the numbers expected from pure
turbulent fragmentation as pre-stellar condensations coalesce and accrete with
an enhanced gravitational cross section. Variations in the interaction rate,
interaction strength, and accretion rate among the primary fragments formed by
turbulence lead to variations in the relative proportions of brown dwarfs,
solar to intermediate mass stars, and high mass stars.Comment: 14 pages, 3 figures, to be published in ``IMF@50: A Fest-Colloquium
in honor of Edwin E. Salpeter,'' held at Abbazia di Spineto, Siena, Italy,
May 16-20, 2004. Kluwer Academic Publishers; edited by E. Corbelli, F. Palla,
and H. Zinnecke
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