83 research outputs found

    Near-field interactions between a subwavelength tip and a small-volume photonic-crystal nanocavity

    Get PDF
    International audienceThe fundamentals of the near-field interaction between a subwavelength metallic tip and a photonic-crystal nanocavity are investigated experimentally and theoretically. It is shown experimentally that the cavity resonance is tuned without any degradation by the presence of the tip and that the reported near-field interaction is strongly related to the field distribution within the nanostructure. Then, in light of a perturbation theory, we show that this interaction is selectively related to the electric field or magnetic field distribution within the cavity, depending on the tip properties

    In vivo stem cell tracking using scintigraphy in a canine model of DMD

    Get PDF
    One of the main challenges in cell therapy for muscle diseases is to efficiently target the muscle. To address this issue and achieve better understanding of in vivo cell fate, we evaluated the relevance of a non-invasive cell tracking method in the Golden Retriever Muscular Dystrophy (GRMD) model, a well-recognised model of Duchenne Muscular Dystrophy (DMD). Mesoangioblasts were directly labelled with 111In-oxine, and injected through one of the femoral arteries. The scintigraphy images obtained provided the first quantitative mapping of the immediate biodistribution of mesoangioblasts in a large animal model of DMD. The results revealed that cells were trapped by the first capillary filters: the injected limb and the lung. During the days following injection, radioactivity was redistributed to the liver. In vitro studies, performed with the same cells prepared for injecting the animal, revealed prominent cell death and 111In release. In vivo, cell death resulted in 111In release into the vasculature that was taken up by the liver, resulting in a non-specific and non-cell-bound radioactive signal. Indirect labelling methods would be an attractive alternative to track cells on the mid- and long-term

    Towards a codification of practical knowledge

    Get PDF
    International audienceAs practical knowledge seems to have a central place in organisational issues, we focus on possibilities to study and formalize it. From an unusual theoretical perspective, we view practical knowledge as embodied knowing which only is only manifest through action in a particular situation. Although this knowledge is largely implicit, we try to make what is 'articulable' explicit. After highlighting the stakes involved in the codification of practices, we review the ontological and epistemological assumptions underlying the method developed. It is founded on participant observation, a video recording of a situated subjective perspective and an ex post interview using this perspective to aid an actor to make part of his/her practical knowledge explicit. We present its implementation within research on polar expeditions in order to understand how an experienced actor deals with risks. In conclusion, we point out (1) the importance of this kind of data in knowledge management, (2) some lines of further research

    Electrodynamics in complex systems: Application to near-field probing of optical microresonators

    Full text link
    This paper discusses recent theoretical efforts to develop a general and flexible method for the calculation of the field distributions around and inside complex optical systems involving both dielectric and metallic materials. Starting from the usual light-matter coupling Hamiltonian, we derive a self-consistent equation for the optical field in arbitrary optical systems composed of N different subdomains. We show that an appropriate solving procedure based on the real-space discretization of each subdomain raises the present approach to the rank of an accurate predictive numerical scheme. In order to illustrate its applicability, we use this formalism to address challenging problems related to nonradiative energy transfers in near-field optics. In particular, we investigate in detail the detuning of a microresonator probed by a near-field optical probe.</p
    corecore