Anticipation is the key to understanding music and the effects of music on emotion

There is certainly a need for a framework to guide the study of the physiological mechanisms underlying the experience of music and the emotions that music evokes. However, this framework should be organised hierarchically, with musical anticipation as its fundamental mechanism

Current iodine status and progress over the last decade towards elimination of iodine deficiency in Rajkot District, Gujarat

Objective: To find out prevalence of goitre in primary school children; to compare prevalence with previous survey; to determine median urinary iodine concentration; to assess level of iodine in salt samples at household and retail shop level; and to study profile of salt sold at retail shops. Design & Settings: 30 cluster survey study in primary schools of Rajkot district. Subjects: Children studying in 1st to 7th standard. Methods: Total 70 students including five boys and five girls from 1st to 7th standard present in class on the day of visit were selected randomly for Goitre examination, so, total 2100 students were examined in schools. Urine sample was collected from one boy & one girl from each standard in each cluster. From community, 28 students including two boys and two girls from each standard in same age group were examined and also salt samples were tested from their households. From each village, one retail shop was visited and salts were purchased and tested for iodine on the spot with spot kit. Results: Goitre prevalence was found 8.8% among primary school children compare to 5.6% in 1999. As the age increases the Goitre prevalence also increases except in age group of 12 years. Median urinary iodine excretion level was found 110 µg/L. Iodine level >15 ppm was found in 81% salts samples tested at household level. Conclusion: Present study showed mild Goitre prevalence in primary school children in Rajkot district of Gujarat but still iodine content of salt found inadequate at household level

Cosmology in a brane-universe

This contribution presents the cosmological models with extra dimensions that have been recently elaborated, which assume that ordinary matter is confined on a surface, called brane, embedded in a higher dimensional spacetime.Comment: 12 pages; Invited review talk at the JENAM 2002 workshop on "The cosmology of extra dimensions and varying fundamental constants", Porto, Portugal, September 200

Dirichlet boundary conditions in a noncommutative theory

We study the problem of imposing Dirichlet-like boundary conditions along a static spatial curve, in a planar Noncommutative Quantum Field Theory model. After constructing interaction terms that impose the boundary conditions, we discuss their implementation at the level of an interacting theory, with a focus on their physical consequences, and the symmetries they preserve. We also derive the effect they have on certain observables, like the Casimir energies.Comment: 19 pages, 1 figure, pdflate

Phase-change computing

PosterThis is the final version. Available from E\PCOS via the URL in this record.Phase-change materials and devices are currently generating much interest for their potential to provide practicable alternatives to traditional von-Neumann computing (i.e. alternatives to computing in which memory and processing functions are carried out at physically separated locations). Indeed, many years after Ovshinsky and colleagues first showed the remarkable computing capabilities of phase-change devices (see for example [1-3]), other researchers have recently experimentally demonstrated the potential of phase-change devices to perform not only arithmetic computing [4], but also to provide hardware mimics of both synapses [5, 6] and neurons [4] (so opening the way to so-called bio-inspired or neuromorphic computing). We ourselves recently demonstrated reliable execution of the four basic arithmetic operations of addition, subtraction, multiplication and division using phase-change materials and micrometrescale optical excitation with (groups of) femtosecond pulses [4]. In this paper however we demonstrate that this arithmetic capability is also accessible via the electrical domain and on the nanoscale. [...

Isolation, biology and chemistry of the disorazoles: New anti-cancer macrodiolides

The disorazoles comprise a family of 29 closely related macrocyclic polyketides isolated in 1994 from the fermentation broth of the gliding myxobacterium Sorangium cellulosum. Disorazoles A1, E and C 1 have shown exceptional biological activities toward inhibiting the proliferation of human cancer cell lines in picomolar and nanomolar concentrations through the disruption of microtubule polymerization. This review gives a brief introduction describing the biosynthesis and the significance of the disorazoles as a new class of microtubulin disruptors. Another portion of the review focuses on the biology of the disorazoles, specifically disorazole A1 and C1, and their antiproliferative efficacy against animal and human tumor cell lines, as well as the available SAR data. The majority of the discussion addresses synthetic efforts, including partial syntheses of various disorazoles and a summary of the total synthesis of disorazole C1. © 2009 The Royal Society of Chemistry

What can polysemy tell us about theories of explanation?

Philosophical accounts of scientific explanation are broadly divided into ontic and epistemic views. This paper explores the idea that the lexical ambiguity of the verb to explain and its nominalisation supports an ontic conception of explanation. I analyse one argument which challenges this strategy by criticising the claim that explanatory talk is lexically ambiguous, 375–394, 2012). I propose that the linguistic mechanism of transfer of meaning, 109–132, 1995) provides a better account of the lexical alternations that figure in the systematic polysemy of explanatory talk, and evaluate the implications of this proposal for the debate between ontic and epistemic conceptions of scientific explanation

Crassula invasion levels and success of recent eradication attempts at the Thompson Common pingo ponds

Crassula helmsii (New Zealand Pigmyweed) is an invasive aquatic plant in the UK which has caused considerable damage to native aquatic plant communities in ponds and lakes (Leach & Dawson, 1999). It is notoriously difficult to eradicate this species and much evidence suggests that success (which is rare) requires very early detection at the point of colonisation (Dawson, 1996; Willby, 2007)

Quantifying process-level uncertainty contributions to TCRE and carbon budgets for meeting Paris Agreement climate targets

This is the final version. Available on open access from IOP Publishing via the DOI in this recordTo achieve the goals of the Paris Agreement requires deep and rapid reductions in anthropogenic CO2 emissions, but uncertainty surrounds the magnitude and depth of reductions. Earth system models provide a means to quantify the link from emissions to global climate change. Using the concept of TCRE - the transient climate response to cumulative carbon emissions - we can estimate the remaining carbon budget to achieve 1.5 or 2 °C. But the uncertainty is large, and this hinders the usefulness of the concept. Uncertainty in carbon budgets associated with a given global temperature rise is determined by the physical Earth system, and therefore Earth system modelling has a clear and high priority remit to address and reduce this uncertainty. Here we explore multi-model carbon cycle simulations across three generations of Earth system models to quantitatively assess the sources of uncertainty which propagate through to TCRE. Our analysis brings new insights which will allow us to determine how we can better direct our research priorities in order to reduce this uncertainty. We emphasise that uses of carbon budget estimates must bear in mind the uncertainty stemming from the biogeophysical Earth system, and we recommend specific areas where the carbon cycle research community needs to re-focus activity in order to try to reduce this uncertainty. We conclude that we should revise focus from the climate feedback on the carbon cycle to place more emphasis on CO2 as the main driver of carbon sinks and their long-term behaviour. Our proposed framework will enable multiple constraints on components of the carbon cycle to propagate to constraints on remaining carbon budgets.Joint UK BEIS/Defra Met Office Hadley Centre Climate ProgrammeEuropean Union Horizon 202