596 research outputs found
Theory of collective opinion shifts: from smooth trends to abrupt swings
We unveil collective effects induced by imitation and social pressure by
analyzing data from three different sources: birth rates, sales of cell phones
and the drop of applause in concert halls. We interpret our results within the
framework of the Random Field Ising Model, which is a threshold model for
collective decisions accounting both for agent heterogeneity and social
imitation. Changes of opinion can occur either abruptly or continuously,
depending on the importance of herding effects. The main prediction of the
model is a scaling relation between the height h of the speed of variation peak
and its width of the form h ~ w^{-kappa}, with kappa = 2/3 for well
connected populations. Our three sets of data are compatible with such a
prediction, with kappa ~ 0.62 for birth rates, kappa ~ 0.71 for cell phones and
kappa ~ 0.64 for clapping. In this last case, we in fact observe that some
clapping samples end discontinuously (w=0), as predicted by the model for
strong enough imitation.Comment: 11 pages, 8 figure
Differential regulation of the attachment of KSHV infected human B cells to ECM by KSHV encoded gB and cellular alpha-V integrins
KaposiĂąâŹâąs sarcoma-associated herpesvirus (KSHV) has two modes replication: latent and lytic replication. Reactivation from latency is dictated, in part, by the cell cycle. Herein, we have attempted to delineate the importance of cell cycle in KSHV pathogenesis by exploring the expression pattern of cell surface receptors during different phases of the cell cycle. ñV integrin expression is augmented
during S phase in fibroblasts, epithelial, and KSHV infected cells. Using a Matrigel system, we pioneer the concept that KSHV infected primary effusion lymphoma (PEL) cells can attach to extracellular matrix proteins. This attachment is mediated primarily via ñV integrins or virally encoded gB, and occurs preferentially in cells from S phase or cells from S phase actively supporting a lytic infection, respectively. Such an ability of infected B cells to attach to endothelial cells may
also aid in the dissemination of infection. The keystone of this work is that for the first time, we describe the ability of KSHV infected B cells to preferentially use cellular (ñV) or viral (gB) receptors to specifically bind cells, depending upon the stage of the cell cycle and infection. Originally published Cellular Microbiology, Vol. 10, No. 7, July 200
Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor induced growth arrest and apoptosis through NF-ÎșB activation
Kaposi's sarcoma-associated herpesvirus (KSHV) has been linked to the development of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease (MCD). We have characterized the role of KSHV-encoded viral FLICE inhibitory protein K13 in the modulation of anti-IgM induced growth arrest and apoptosis in B cells. We demonstrate that K13 protects WEHI 231, an immature B cell line, against anti-IgM induced growth arrest and apoptosis. The protective effect of K13 was associated with the activation of the NF-ÎșB pathway and was deficient in its mutant, K13-58AAA, and a structural homolog, vFLIP E8, which lack NF-ÎșB activity. K13 upregulated the expression of NF-ÎșB subunit RelB and blocked the anti-IgM induced decline in c-Myc and rise in p27(Kip1) that have been associated with growth arrest and apoptosis. K13 also upregulated the expression of Mcl-1, an anti-apoptotic member of the Bcl2 family. Finally, K13 protected the mature B cell line Ramos against anti-IgM induced apoptosis through NF-ÎșB activation. Inhibition of anti-IgM induced apoptosis by K13 may contribute to the development of KSHV-associated lymphoproliferative disorders
Tip of the clade on the top of the Worldâthe first fossil Lophopidae (Hemiptera: Fulgoromorpha) from the Palaeocene of Tibet
Limits of conservative surgery for early-stage breast cancer and place of shared-making decision
Granular superconductivity and charge/orbital order in YBa 2 Cu 3 O 7 /manganite trilayers
We studied how the electronic, superconducting, and magnetic properties of YBa2Cu3O7/Nd1âx(Ca1âySry )xMnO3 multilayers depend on the tolerance factor and the hole doping of the manganite. In particular, we investigated the granular superconducting state and the related magnetic-field-driven insulator-to- superconductor transition that was previously discovered in corresponding multilayers with Pr0.5La0.2Ca0.3MnO3 [B. P. P. Mallett et al., Phys. Rev. B 94, 180503(R) (2016)]. We found that this granular uperconducting state occurs only when the manganite layer is in a charge/orbital ordered and CE-type antiferromagnetic state (Mn-CO/OO). The coupling mechanism underlying this intriguing proximity effect seems to involve the domain boundaries of the Mn-CO/OO and/or the charge disordered regions of the manganite layer that become more numerous as the hole doping is reduced below x = 0.5
Hepatitis C virus cell-cell transmission and resistance to direct-acting antiviral agents
Hepatitis C virus (HCV) is transmitted between hepatocytes via classical cell entry but also uses direct cell-cell transfer to infect neighboring hepatocytes. Viral cell-cell transmission has been shown to play an important role in viral persistence allowing evasion from neutralizing antibodies. In contrast, the role of HCV cell-cell transmission for antiviral resistance is unknown. Aiming to address this question we investigated the phenotype of HCV strains exhibiting resistance to direct-acting antivirals (DAAs) in state-of-the-art model systems for cell-cell transmission and spread. Using HCV genotype 2 as a model virus, we show that cell-cell transmission is the main route of viral spread of DAA-resistant HCV. Cell-cell transmission of DAA-resistant viruses results in viral persistence and thus hampers viral eradication. We also show that blocking cell-cell transmission using host-targeting entry inhibitors (HTEIs) was highly effective in inhibiting viral dissemination of resistant genotype 2 viruses. Combining HTEIs with DAAs prevented antiviral resistance and led to rapid elimination of the virus in cell culture model. In conclusion, our work provides evidence that cell-cell transmission plays an important role in dissemination and maintenance of resistant variants in cell culture models. Blocking virus cell-cell transmission prevents emergence of drug resistance in persistent viral infection including resistance to HCV DAAs
The 5âČHS4 insulator element is an efficient tool to analyse the transient expression of an EÎŒ-GFP vector in a transgenic mouse model
Letter to the Edito
Cancers associated with Kaposi's sarcoma (KS) in AIDS: a link between KS herpesvirus and immunoblastic lymphoma
Kaposi's sarcoma (KS), common among persons with acquired immunodeficiency syndrome (AIDS), is caused by KS herpesvirus (KSHV) but whether KSHV causes other malignancies is uncertain. Using linked United States AIDS and cancer registries, we measured the incidence of specific malignancies in persons with AIDS (4â27 months after AIDS onset). We identified associations with KSHV by calculating a relative risk: cancer incidence in persons with KS (all were KSHV-infected) divided by incidence in persons without KS. Using Poisson regression, relative risks were adjusted for human immunodeficiency virus risk group, gender, age, race, and calendar year. We included 189 159 subjects (26â972 with KS). Immunoblastic lymphoma was significantly associated with KS (506 cases; relative risks: unadjusted 2.44, 95%CI 2.00â2.96, adjusted 1.58, 95%CI 1.29â1.93). Only one immunoblastic lymphoma had pleura as primary site. None of 37 other specified malignancies (other non-Hodgkin lymphomas, haematological malignancies, solid tumours) was significantly associated with KS. In summary, the association of immunoblastic lymphoma with KS was specific among examined malignancies and remained significant after statistical adjustment. Our findings, and the previously demonstrated presence of KSHV in the histologically related primary effusion lymphoma, suggest that KSHV is involved in the pathogenesis of some immunoblastic lymphomas. © 2001 Cancer Research Campaig
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