A screening for serum markers of arbovirus infections in healthy blood donors from the Volgograd Region

Volgograd region is considered to be endemic West Nile fever (WNF) area due to the established circulation of the West Nile virus (WNV) therein. Some previous independent studies examining samples collected on the territory of the Volgograd region revealed markers related to the California serogroup (CSG), Sindbis and Ukuniemi viruses. WNF, CSG, Sindbis and Ukuniemi fever mainly being asymptomatic posing thereby a threat of virus spread due to transfusiological manipulations along with vector-borne transmission are manifested by diverse clinical signs. The study was aimed at detection of antibodies specific to West Nile, tick-borne encephalitis, California serogroup (Tyaginya, Inko), Sidbis, and Ukuniemi viruses in blood donors from the Volgograd region. For this, 404 blood sera samples collected from blood donors residing in the Volgograd as well as the Volgograd region were examined by ELISA. It was found that percentage of blood serum samples positive for arbovirus-specific antibodies was 18.32%. Among the, 67 out of 404 (16.58%) samples contained anti-WNV antibodies, 3 out of 279 (1.08%) samples — to tick-borne encephalitis virus, 1 out of 92 (1.09%) — to California serogroup fever and Ukuniemi viruses, and 2 out of 92 (2.17%) — to Sindbis fever virus. Importantly, the peak number of IgG and IgM WNV-positive samples was found among residents of Volgograd (29 out of 110, 26%) and Oktyabrsky district (7 out of 25, 28%). In addition, anti-Sindbis, Ukuniemi and CSG virus antibodies were detected in blood serum samples from blood donors residing in the Kalachevsky region and the city of Volgograd. Analyzing age-related distribution and percentage of seropositive subjects in each age group showed as follows: the lowest percentage (14.5%) was positive for anti-WNV, Sindbis, Ukuniemi and CSG virus antibodies in blood donors aged 32–41 years, whereas the peak percentage (25%) — in the subjects aged 52–61 years. Thus, virus specific antibodies detected in healthy individuals in the aforementioned region evidence about potential recovery after asymptomatic infections. In this regard, further research is required to determine a role of the such arboviruses in the structure of regional infectious diseases. The data obtained suggest a need to continue serological arbovirus monitoring in the Volgograd region

History of Spinal Neurosurgery and Spine Societies

info:eu-repo/semantics/publishedVersio

Endocrinologic, neurologic, and visual morbidity after treatment for craniopharyngioma

Craniopharyngiomas are locally aggressive tumors which typically are focused in the sellar and suprasellar region near a number of critical neural and vascular structures mediating endocrinologic, behavioral, and visual functions. The present study aims to summarize and compare the published literature regarding morbidity resulting from treatment of craniopharyngioma. We performed a comprehensive search of the published English language literature to identify studies publishing outcome data of patients undergoing surgery for craniopharyngioma. Comparisons of the rates of endocrine, vascular, neurological, and visual complications were performed using Pearson’s chi-squared test, and covariates of interest were fitted into a multivariate logistic regression model. In our data set, 540 patients underwent surgical resection of their tumor. 138 patients received biopsy alone followed by some form of radiotherapy. Mean overall follow-up for all patients in these studies was 54 ± 1.8 months. The overall rate of new endocrinopathy for all patients undergoing surgical resection of their mass was 37% (95% CI = 33–41). Patients receiving GTR had over 2.5 times the rate of developing at least one endocrinopathy compared to patients receiving STR alone or STR + XRT (52 vs. 19 vs. 20%, χ2P < 0.00001). On multivariate analysis, GTR conferred a significant increase in the risk of endocrinopathy compared to STR + XRT (OR = 3.45, 95% CI = 2.05–5.81, P < 0.00001), after controlling for study size and the presence of significant hypothalamic involvement. There was a statistical trend towards worse visual outcomes in patients receiving XRT after STR compared to GTR or STR alone (GTR = 3.5% vs. STR 2.1% vs. STR + XRT 6.4%, P = 0.11). Given the difficulty in obtaining class 1 data regarding the treatment of this tumor, this study can serve as an estimate of expected outcomes for these patients, and guide decision making until these data are available

Случай ветряной оспы с множественными бактериальными осложнениями, потребовавшими хирургического лечения

Chickenpox is a controlled infection, even a single vaccination effectively prevents the development of severe forms (up to 98%).Purpose — to demonstrate a case of severe chicken pox in a child aged 3.8 years with secondary infection of the skin of the right subscapular region and subcutaneous fat (phlegmon of the trunk) of streptococcal etiology.The diagnosis of varicella was confirmed by the detection of Varicella-Zoster virus DNA by PCR from the skin. Surgical treatment was performed — opening and drainage of phlegmon, purulent-serous discharge was obtained, sowing was performed, Streptococcus pyogenes was isolated.The child received antibiotic therapy — cefepime sulbactam, amikacin, acyclovir, infusion therapy, local treatment.Conclusions. The given clinical case demonstrates the development of a severe bacterial complication of chicken pox, which required surgical treatment and substantiates the need for vaccination against chicken pox and its possible complications.Ветряная оспа является управляемой инфекцией, даже однократная вакцинация эффективно предотвращает развитие тяжелых форм (до 98%).Цель — демонстрация случая тяжелой ветряной оспы у ребенка в возрасте 3,8 лет с вторичным инфицированием кожных покровов правой подлопаточной области и подкожно-жировой клетчатки (флегмоны туловища) стрептококковой этиологии.Диагноз ветряной оспы подтвержден обнаружением ДНК Varicella-Zoster virus методом ПЦР с кожи. Проведено хирургическое лечение — вскрытие и дренирование флегмоны, получено гнойно-серозное отделяемое, выполнен посев, выделен Streptococcus pyogenes.Ребенок получал антибактериальную терапию — цефепим сульбактам, амикацин, ацикловир, инфузионную терапию, местное лечение.Выводы. Приведенный клинический случай демонстрирует развитие тяжелого бактериального осложнения ветряной оспы, потребовавшего хирургического лечения и обосновывает необходимость вакцинации против ветряной оспы и ее возможных осложнений

ICAR: endoscopic skull‐base surgery

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NUCLEAR FUEL CYCLE OBJECTIVES

The nuclear fuel cycle objectives are drawn from many sources, including the conclusions of major international conferences on different stages and aspects of nuclear fuel cycles, many of which are held in cooperation with the IAEA. Experts from various Member States provided advice to the IAEA through a number of consultants meetings and Technical Working Groups (TWGs), such as the TWGs on Nuclear Fuel Performance and Technology, on Nuclear Fuel Cycle Options and Spent Fuel Management, and on Research Reactors, and through the OECD/NEA–IAEA Uranium Group. The IAEA’s International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) is another important source of guidance.JRC.E-Institute for Transuranium Elements (Karlsruhe