6,091 research outputs found
A micromechanical model for kink-band formation: Part I - Experimental study and numerical modelling
Counterion density profiles at charged flexible membranes
Counterion distributions at charged soft membranes are studied using
perturbative analytical and simulation methods in both weak coupling
(mean-field or Poisson-Boltzmann) and strong coupling limits. The softer the
membrane, the more smeared out the counterion density profile becomes and
counterions pentrate through the mean-membrane surface location, in agreement
with anomalous scattering results. Membrane-charge repulsion leads to a
short-scale roughening of the membrane.Comment: 4 pages, 4 figure
Lo-fi prototyping to design interactive-tabletop applications for children
Interactive tabletops are an exiting new platform for supporting children's collaboration. With design guidelines and standardized interaction principles still immature, there is a considerable need for iterative prototyping to define the task and interface. Lo-fi prototypes-using cardboard, paper, etc.- are easy to develop, flexible to adjust during design sessions, and intuitive for users to manipulate. Using them can be a valuable step in designing tabletop applications.
In this paper, we detail the design process of two tabletop applications, concentrating on the role of lo-fi prototyping. TransTime is a pattern game for 5-6 year olds to engage how time progresses. OurSpace is a design tool for 7-9 year olds to arrange desks and assign seats for students in their classroom. By comparing the experiences, we arrive at a better understanding of the benefits, challenges, and limits of using lo-fi prototypes to design interactive-tabletop applications for children
Import of community-associated, methicillin-resistant Staphylococcus aureus to Europe through skin and soft-tissue infection in intercontinental travellers, 2011-2016
Objectives: Recently, following import by travel and migration, epidemic community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has caused nosocomial outbreaks in Europe, sometimes with a fatal outcome. We describe clinico-epidemiological characteristics of CA-MRSA detected by the European Network for the Surveillance of imported S. aureus (www.staphtrav.eu) from May 2011 to November 2016. Methods: Sentinel surveillance at 13 travel clinics enrolling patients with travel-associated skin and soft-tissue infection (SSTI) and analysing lesion and nose swabs at one central laboratory. Results: A total of 564 independent case-patients with SSTI were enrolled and had 374 (67%) S. aureus-positive lesions, of which 14% (51/374) were MRSA. The majority of CA-MRSA isolates from SSTI were Panton-Valentine leucocidin (PVL)-positive (43/51, 84%). The risk of methicillin-resistance in imported S. aureus varied by travel region (p Conclusions: Travel-associated CA-MRSA SSTI is a transmissible condition that leads to medical consultations and colonization of the infected host. (c) 2018 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.Peer reviewe
Spin correlations in Ca3Co2O6: A polarised-neutron diffraction and Monte Carlo study
We present polarised-neutron diffraction measurements of the Ising-like
spin-chain compound Ca3Co2O6 above and below the magnetic ordering temperature
TN. Below TN, a clear evolution from a single-phase spin-density wave (SDW)
structure to a mixture of SDW and commensurate antiferromagnet (CAFM)
structures is observed on cooling. For a rapidly-cooled sample, the majority
phase at low temperature is the SDW, while if the cooling is performed
sufficiently slowly, then the SDW and the CAFM structure coexist between 1.5
and 10 K. Above TN, we use Monte Carlo methods to analyse the magnetic diffuse
scattering data. We show that both intra- and inter-chain correlations persist
above TN, but are essentially decoupled. Intra-chain correlations resemble the
ferromagnetic Ising model, while inter-chain correlations resemble the
frustrated triangular-lattice antiferromagnet. Using previously-published bulk
property measurements and our neutron diffraction data, we obtain values of the
ferromagnetic and antiferromagnetic exchange interactions and the single-ion
anisotropy.Comment: 10 pages, 7 figure
Quantum signatures in laser-driven relativistic multiple-scattering
The dynamics of an electronic Dirac wave packet evolving under the influence
of an ultra-intense laser pulse and an ensemble of highly charged ions is
investigated numerically. Special emphasis is placed on the evolution of
quantum signatures from single to multiple scattering events. We quantify the
occurrence of quantum relativistic interference fringes in various situations
and stress their significance in multiple-particle systems, even in the
relativistic range of laser-matter interaction.Comment: 4 pages, 2 figures, LaTeX, revtex
Dose-Related Effects of ACE Inhibition in Man: Quinapril in Patients with Moderate Congestive Heart Failure
Early treatment with ACE inhibitors of even moderate heart failure is clinically beneficial, even though haemodynamic measurements cannot adequately quantitate such improvement. Neurohumoral assessment is, however, supposed to be more accurate In 55 patients with moderate heart failure (ejection fraction ≤ 35%), we investigated the dose-dependent effects of ACE inhibition with quinapril taken orally (2.5, 5 or 10 mg b.i.d.) following a placebo-controlled, parallel design protocol over 12 weeks. Plasma components of the renin angiotensin system, catecholamines and ANF were measured together with haemodymmics both at rest and during exercise. Before ACE inhibitor treatment, median PRA, Ang I and II and catecholamines were normal, while ANF was increased All these parameters including ACE activity, rose during exercise. Chronic inhibition of ACE activity was dose-dependent and the maximal fall in Ang If occurred with quinapril 20 mg.day−1. Humoral changes appeared more assessible than haemodymmic alterations even though many of these changes were reasonably correlated. The effects of chronic ACE inhibition on circulating neurohumoral components in patients with moderate heart failure are small and dose-dependent. Since humoral changes are related to haemodynamics they should account for the clinical benefit. Appropriately high doses of ACE inhibitors should be chosen for treatment of heart failur
Spectral density for a hole in an antiferromagnetic stripe phase
Using variational trial wave function based on the string picture we study
the motion of a single mobile hole in the stripe phase of the doped
antiferromagnet. The holes within the stripes are taken to be static, the
undoped antiferromagnetic domains in between the hole stripes are assumed to
have alternating staggered magnetization, as is suggested by neutron scattering
experiments. The system is described by the t-t'-t''-J model with realistic
parameters and we compute the single particle spectral density.Comment: RevTex-file, 9 PRB pages with 15 .eps and .gif files. To appear in
PRB. Hardcopies of figures (or the entire manuscript) can be obtained by
e-mail request to: [email protected]
Novel tetrameric cell penetrating antimicrobial peptoids effective against mycobacteria and drug-resistant Staphylococcus aureus
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