20,773 research outputs found
Spirometry reference equations for central European populations from school age to old age.
Spirometry reference values are important for the interpretation of spirometry results. Reference values should be updated regularly, derived from a population as similar to the population for which they are to be used and span across all ages. Such spirometry reference equations are currently lacking for central European populations. To develop spirometry reference equations for central European populations between 8 and 90 years of age. We used data collected between January 1993 and December 2010 from a central European population. The data was modelled using "Generalized Additive Models for Location, Scale and Shape" (GAMLSS). The spirometry reference equations were derived from 118'891 individuals consisting of 60'624 (51%) females and 58'267 (49%) males. Altogether, there were 18'211 (15.3%) children under the age of 18 years. We developed spirometry reference equations for a central European population between 8 and 90 years of age that can be implemented in a wide range of clinical settings
Fitting a 3D Morphable Model to Edges: A Comparison Between Hard and Soft Correspondences
We propose a fully automatic method for fitting a 3D morphable model to
single face images in arbitrary pose and lighting. Our approach relies on
geometric features (edges and landmarks) and, inspired by the iterated closest
point algorithm, is based on computing hard correspondences between model
vertices and edge pixels. We demonstrate that this is superior to previous work
that uses soft correspondences to form an edge-derived cost surface that is
minimised by nonlinear optimisation.Comment: To appear in ACCV 2016 Workshop on Facial Informatic
Supersymmetry Flows, Semi-Symmetric Space Sine-Gordon Models And The Pohlmeyer Reduction
We study the extended supersymmetric integrable hierarchy underlying the
Pohlmeyer reduction of superstring sigma models on semi-symmetric superspaces
F/G. This integrable hierarchy is constructed by coupling two copies of the
homogeneous integrable hierarchy associated to the loop Lie superalgebra
extension f of the Lie superalgebra f of F and this is done by means of the
algebraic dressing technique and a Riemann-Hilbert factorization problem. By
using the Drinfeld-Sokolov procedure we construct explicitly, a set of 2D spin
\pm1/2 conserved supercharges generating supersymmetry flows in the phase space
of the reduced model. We introduce the bi-Hamiltonian structure of the extended
homogeneous hierarchy and show that the two brackets are of the
Kostant-Kirillov type on the co-adjoint orbits defined by the light-cone Lax
operators L_\pm. By using the second symplectic structure, we show that these
supersymmetries are Hamiltonian flows, we compute part of the supercharge
algebra and find the supersymmetric field variations they induce. We also show
that this second Poisson structure coincides with the canonical
Lorentz-Invariant symplectic structure of the WZNW model involved in the
Lagrangian formulation of the extended integrable hierarchy, namely, the
semi-symmetric space sine-Gordon model (SSSSG), which is the Pohlmeyer reduced
action functional for the transverse degrees of freedom of superstring sigma
models on the cosets F/G. We work out in some detail the Pohlmeyer reduction of
the AdS_2xS^2 and the AdS_3xS^3 superstrings and show that the new conserved
supercharges can be related to the supercharges extracted from 2D superspace.
In particular, for the AdS_2xS^2 example, they are formally the same.Comment: V2: Two references added, V3: Modifications in section 2.6, V4:
Published versio
The impact of Stieltjes' work on continued fractions and orthogonal polynomials
Stieltjes' work on continued fractions and the orthogonal polynomials related
to continued fraction expansions is summarized and an attempt is made to
describe the influence of Stieltjes' ideas and work in research done after his
death, with an emphasis on the theory of orthogonal polynomials
The Relativistic Avatars of Giant Magnons and their S-Matrix
The motion of strings on symmetric space target spaces underlies the
integrability of the AdS/CFT correspondence. Although these theories, whose
excitations are giant magnons, are non-relativistic they are classically
equivalent, via the Polhmeyer reduction, to a relativistic integrable field
theory known as a symmetric space sine-Gordon theory. These theories can be
formulated as integrable deformations of gauged WZW models. In this work we
consider the class of symmetric spaces CP^{n+1} and solve the corresponding
generalized sine-Gordon theories at the quantum level by finding the exact
spectrum of topological solitons, or kinks, and their S-matrix. The latter
involves a trignometric solution of the Yang-Baxer equation which exhibits a
quantum group symmetry with a tower of states that is bounded, unlike for
magnons, as a result of the quantum group deformation parameter q being a root
of unity. We test the S-matrix by taking the semi-classical limit and comparing
with the time delays for the scattering of classical solitons. We argue that
the internal CP^{n-1} moduli space of collective coordinates of the solitons in
the classical theory can be interpreted as a q-deformed fuzzy space in the
quantum theory. We analyse the n=1 case separately and provide a further test
of the S-matrix conjecture in this case by calculating the central charge of
the UV CFT using the thermodynamic Bethe Ansatz.Comment: 33 pages, important correction to S-matrix to ensure crossing
symmetr
How Gaussian competition leads to lumpy or uniform species distributions
A central model in theoretical ecology considers the competition of a range
of species for a broad spectrum of resources. Recent studies have shown that
essentially two different outcomes are possible. Either the species surviving
competition are more or less uniformly distributed over the resource spectrum,
or their distribution is 'lumped' (or 'clumped'), consisting of clusters of
species with similar resource use that are separated by gaps in resource space.
Which of these outcomes will occur crucially depends on the competition kernel,
which reflects the shape of the resource utilization pattern of the competing
species. Most models considered in the literature assume a Gaussian competition
kernel. This is unfortunate, since predictions based on such a Gaussian
assumption are not robust. In fact, Gaussian kernels are a border case
scenario, and slight deviations from this function can lead to either uniform
or lumped species distributions. Here we illustrate the non-robustness of the
Gaussian assumption by simulating different implementations of the standard
competition model with constant carrying capacity. In this scenario, lumped
species distributions can come about by secondary ecological or evolutionary
mechanisms or by details of the numerical implementation of the model. We
analyze the origin of this sensitivity and discuss it in the context of recent
applications of the model.Comment: 11 pages, 3 figures, revised versio
Galaxies in N-body simulations: overcoming the overmerging problem
We present analysis of the evolution of dark matter halos in dense
environments of groups and clusters in dissipationless cosmological
simulations. The premature destruction of halos in such environments, known as
the overmerging, reduces the predictive power of N-body simulations and makes
difficult any comparison between models and observations. We analyze the
possible processes that cause the overmerging and assess the extent to which
this problem can be cured with current computer resources and codes. Using both
analytic estimates and high resolution numerical simulations, we argue that the
overmerging is mainly due to the lack of numerical resolution. We find that the
force and mass resolution required for a simulated halo to survive in galaxy
groups and clusters is extremely high and was almost never reached before: ~1-3
kpc and 10^8-10^9 Msun, respectively. We use the high-resolution Adaptive
Refinement Tree (ART) N-body code to run cosmological simulations with the
particle mass of \approx 2x10^8/h Msun} and the spatial resolution of \approx
1-2/h kpc, and show that in these simulations the halos do survive in regions
that would appear overmerged with lower force resolution. Nevertheless, the
halo identification in very dense environments remains a challenge even with
the resolution this high. We present two new halo finding algorithms developed
to identify both isolated and satellite halos that are stable (existed at
previous moments) and gravitationally bound. To illustrate the use of the
satellite halos that survive the overmerging, we present a series of halo
statistics, that can be compared with those of observed galaxies. (Abridged)Comment: Accepted for publication in ApJ, substantional revisions after the
first version, LaTeX 23 pages, 18 figs. (uses emulateapj.sty),
Full-resolution version of Fig.9 is available upon reques
Actuation of Micro-Optomechanical Systems Via Cavity-Enhanced Optical Dipole Forces
We demonstrate a new type of optomechanical system employing a movable,
micron-scale waveguide evanescently-coupled to a high-Q optical microresonator.
Micron-scale displacements of the waveguide are observed for
milliwatt(mW)-level optical input powers. Measurement of the spatial variation
of the force on the waveguide indicates that it arises from a cavity-enhanced
optical dipole force due to the stored optical field of the resonator. This
force is used to realize an all-optical tunable filter operating with sub-mW
control power. A theoretical model of the system shows the maximum achievable
force to be independent of the intrinsic Q of the optical resonator and to
scale inversely with the cavity mode volume, suggesting that such forces may
become even more effective as devices approach the nanoscale.Comment: 4 pages, 5 figures. High resolution version available at
(http://copilot.caltech.edu/publications/CEODF_hires.pdf). For associated
movie, see (http://copilot.caltech.edu/research/optical_forces/index.htm
Enhancement of electroporation facilitated immunogene therapy via T-reg depletion
Regulatory T cells (T-regs) can negatively impact tumor antigen-specific immune responses after infiltration into tumor tissue. However, depletion of T-regs can facilitate enhanced anti-tumor responses, thus augmenting the potential for immunotherapies. Here we focus on treating a highly aggressive form of cancer using a murine melanoma model with a poor prognosis. We utilize a combination of T-reg depletion and immunotherapy plasmid DNA delivered into the B16F10 melanoma tumor model via electroporation. Plasmids encoding murine granulocyte macrophage colony-stimulating factor and human B71 were transfected with electroporation into the tumor and transient elimination of T-regs was achieved with CD25-depleting antibodies (PC61). The combinational treatment effectively depleted T-regs compared to the untreated tumor and significantly reduced lung metastases. The combination treatment was not effective in increasing the survival, but only effective in suppression of metastases. These results indicate the potential for combining T-reg depletion with immunotherapy-based gene electrotransfer to decrease systemic metastasis and potentially enhance survival
Classical and Quantum Solitons in the Symmetric Space Sine-Gordon Theories
We construct the soliton solutions in the symmetric space sine-Gordon
theories. The latter are a series of integrable field theories in
1+1-dimensions which are associated to a symmetric space F/G, and are related
via the Pohlmeyer reduction to theories of strings moving on symmetric spaces.
We show that the solitons are kinks that carry an internal moduli space that
can be identified with a particular co-adjoint orbit of the unbroken subgroup H
of G. Classically the solitons come in a continuous spectrum which encompasses
the perturbative fluctuations of the theory as the kink charge becomes small.
We show that the solitons can be quantized by allowing the collective
coordinates to be time-dependent to yield a form of quantum mechanics on the
co-adjoint orbit. The quantum states correspond to symmetric tensor
representations of the symmetry group H and have the interpretation of a fuzzy
geometric version of the co-adjoint orbit. The quantized finite tower of
soliton states includes the perturbative modes at the base.Comment: 53 pages, additional comments and small errors corrected, final
journal versio
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