1,041 research outputs found
Statistical mechanics of a colloidal suspension in contact with a fluctuating membrane
Surface effects are generally prevailing in confined colloidal systems. Here
we report on dispersed nanoparticles close to a fluid membrane. Exact results
regarding the static organization are derived for a dilute solution of
non-adhesive colloids. It is shown that thermal fluctuations of the membrane
broaden the density profile, but on average colloids are neither accumulated
nor depleted near the surface. The radial correlation function is also
evaluated, from which we obtain the effective pair-potential between colloids.
This entropically-driven interaction shares many similarities with the familiar
depletion interaction. It is shown to be always attractive with range
controlled by the membrane correlation length. The depth of the potential well
is comparable to the thermal energy, but depends only indirectly upon membrane
rigidity. Consequenses for stability of the suspension are also discussed
Hull Consistency Under Monotonicity
International audienceWe prove that hull consistency for a system of equations or inequalities can be achieved in polynomial time providing that the underlying functions are monotone with respect to each variable. This result holds including when variables have multiple occurrences in the expressions of the functions, which is usually a pitfall for interval-based contractors. For a given constraint, an optimal contractor can thus be enforced quickly under monotonicity and the practical significance of this theoretical result is illustrated on a simple example
Set-up of a population-based familial breast cancer registry in Geneva, Switzerland: validation of first results
Background: This article evaluates the accuracy of family history of breast and ovarian cancer among first-degree relatives of breast cancer patients, retrospectively collected during the setting up of a population-based family breast cancer registry. Patients and methods: Family histories of cancer for all women with breast cancer recorded at the Geneva Cancer Registry from 1990 to 1999 were retrospectively extracted from medical files. The accuracy of these family histories was validated among Swiss women born in Geneva: all 119 with a family history of breast (n = 110) or ovarian (n = 9) cancer and a representative sample of 100 women with no family history of breast or ovarian cancer. We identified the first-degree relatives of these women with information from the Cantonal Population Office. All first-degree relatives, resident in Geneva from 1970 to 1999, were linked to the cancer registry database for breast and ovarian cancer occurrence. Sensitivity, specificity and level of overall agreement (Îș) were calculated. Results: Among 310 first-degree relatives identified, 61 had breast cancer and six had ovarian cancer recorded at the Geneva Cancer Registry. The sensitivity, specificity and Îș of the reported family histories of breast cancer were 98%, 97% and 0.97, respectively. For ovarian cancer, the sensitivity, specificity and Îș were 67%, 99%, and 0.66, respectively. Conclusions: This study indicates that retrospectively obtained family histories are very accurate for breast cancer. For ovarian cancer, family histories are less precise and may need additional verificatio
Truncated Levy Random Walks and Generalized Cauchy Processes
A continuous Markovian model for truncated Levy random walks is proposed. It
generalizes the approach developed previously by Lubashevsky et al. Phys. Rev.
E 79, 011110 (2009); 80, 031148 (2009), Eur. Phys. J. B 78, 207 (2010) allowing
for nonlinear friction in wondering particle motion and saturation of the noise
intensity depending on the particle velocity. Both the effects have own reason
to be considered and individually give rise to truncated Levy random walks as
shown in the paper. The nonlinear Langevin equation governing the particle
motion was solved numerically using an order 1.5 strong stochastic Runge-Kutta
method and the obtained numerical data were employed to calculate the geometric
mean of the particle displacement during a certain time interval and to
construct its distribution function. It is demonstrated that the time
dependence of the geometric mean comprises three fragments following one
another as the time scale increases that can be categorized as the ballistic
regime, the Levy type regime (superballistic, quasiballistic, or superdiffusive
one), and the standard motion of Brownian particles. For the intermediate Levy
type part the distribution of the particle displacement is found to be of the
generalized Cauchy form with cutoff. Besides, the properties of the random
walks at hand are shown to be determined mainly by a certain ratio of the
friction coefficient and the noise intensity rather then their characteristics
individually.Comment: 7 pages, 3 figure
Electrical, morphology and structural properties of biodegradable nanocomposite polyvinyl-acetate/ cellulose nanocrystals
In this work, the dielectric properties and the electrical conductivity of polyvinyl acetate (PVAc) polymer doped with cellulose nanocrystals (CNC), extracted from the date palm rachis, are reported. We investigate the filler effect on the molecular mobility of the PVAc polymer chains and the charge transport properties of this material. PVAc/CNC films structure was characterized by powder X-Ray diffraction (XRD), showing the crystalline behavior of the cellulose filler. The dielectric properties were investigated using impedance spectroscopy, in the frequency range of 102â106âŻHz and temperatures from 200 to 350âŻK. A ÎČ relaxation, assigned to the motions of the -OCOCH3 side groups, and α relaxation, associated with the glass transition of the PVAc matrix, can be detected.publishe
Impact of a positive family history on diagnosis, management, and survival of breast cancer: different effects across socio-economic groups
Background: This study aims to investigate whether increased awareness of breast cancer, due to a positive family history (FH), reduces diagnostic, therapeutic, and survival differences between women of low versus high socio-economic status (SES). Methods: All breast cancer patients registered between 1990 and 2005 at the population-based Geneva Cancer Registry were included. With multivariate logistic and Cox regression analysis, we estimated the impact of SES and FH on method of detection, treatment, and mortality from breast cancer. Results: SES discrepancies in method of detection and suboptimal treatment, as seen among women without a FH, disappeared in the presence of a positive FH. SES differences in stage and survival remained regardless of the presence of a positive FH. Overall, positive FH was associated with better survival. This effect was the strongest in women of high SES (age-adjusted Hazard Ratio [HRageadj] 0.54 [0.3-1.0]) but less pronounced in women of middle (0.77 [0.6-1.0]), and absent in women of low SES (0.80 [0.5-1.2]). Conclusion: A positive FH of breast cancer may reduce SES differences in access to screening and optimal treatment. However, even with better access to early detection and optimal treatment, women of low SES have higher risks of death from their disease than those of high SE
Exhaled nitric oxide decreases after positive food-allergen challenge
Background: Exhaled nitric oxide (FeNO) is a well described marker of airway inflammation in asthma and is also known to increase after chronic exposure to inhaled allergens. It is not known whether monitoring FeNO could be useful during food challenges to detect early or subclinical reactions. Methods: Forty children aged 3 to 16 years undergoing an allergen-food challenge at two centres were prospectively recruited for this study. FeNO was assessed before and repeatedly after the food-challenge. Results: Data were obtained from a total of 53 challenges (16 positive, 37 negative) and were compared between the two groups. Half of the patients with a positive food challenge exhibited clinical upper respiratory symptoms. The FeNO significantly decreased in 7 of 16 patients with a positive challenge test within 60 to 90 minutes after the first symptoms of an allergic reaction. Conclusion: Our results show a significant decrease in FeNO after a positive food challenge suggesting involvement of the lower airways despite absence of clinical and functional changes of lower airways. Prospective blinded studies are needed to confirm these results
Surface critical behavior of driven diffusive systems with open boundaries
Using field theoretic renormalization group methods we study the critical
behavior of a driven diffusive system near a boundary perpendicular to the
driving force. The boundary acts as a particle reservoir which is necessary to
maintain the critical particle density in the bulk. The scaling behavior of
correlation and response functions is governed by a new exponent eta_1 which is
related to the anomalous scaling dimension of the chemical potential of the
boundary. The new exponent and a universal amplitude ratio for the density
profile are calculated at first order in epsilon = 5-d. Some of our results are
checked by computer simulations.Comment: 10 pages ReVTeX, 6 figures include
Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor induced growth arrest and apoptosis through NF-ÎșB activation
Kaposi's sarcoma-associated herpesvirus (KSHV) has been linked to the development of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease (MCD). We have characterized the role of KSHV-encoded viral FLICE inhibitory protein K13 in the modulation of anti-IgM induced growth arrest and apoptosis in B cells. We demonstrate that K13 protects WEHI 231, an immature B cell line, against anti-IgM induced growth arrest and apoptosis. The protective effect of K13 was associated with the activation of the NF-ÎșB pathway and was deficient in its mutant, K13-58AAA, and a structural homolog, vFLIP E8, which lack NF-ÎșB activity. K13 upregulated the expression of NF-ÎșB subunit RelB and blocked the anti-IgM induced decline in c-Myc and rise in p27(Kip1) that have been associated with growth arrest and apoptosis. K13 also upregulated the expression of Mcl-1, an anti-apoptotic member of the Bcl2 family. Finally, K13 protected the mature B cell line Ramos against anti-IgM induced apoptosis through NF-ÎșB activation. Inhibition of anti-IgM induced apoptosis by K13 may contribute to the development of KSHV-associated lymphoproliferative disorders
Implied volatility of basket options at extreme strikes
In the paper, we characterize the asymptotic behavior of the implied
volatility of a basket call option at large and small strikes in a variety of
settings with increasing generality. First, we obtain an asymptotic formula
with an error bound for the left wing of the implied volatility, under the
assumption that the dynamics of asset prices are described by the
multidimensional Black-Scholes model. Next, we find the leading term of
asymptotics of the implied volatility in the case where the asset prices follow
the multidimensional Black-Scholes model with time change by an independent
increasing stochastic process. Finally, we deal with a general situation in
which the dependence between the assets is described by a given copula
function. In this setting, we obtain a model-free tail-wing formula that links
the implied volatility to a special characteristic of the copula called the
weak lower tail dependence function
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