Atoms in the p-localization of stable homotopy category

We study p-localizations, where p is an odd prime, of the full subcategories Sⁿ of stable homotopy category formed by CW-complexes with cells in n successive dimensions. Using the technique of triangulated categories and matrix problems, we classify the atoms (indecomposable objects) in Spⁿ for n ≤ 4(p − 1) and show that, for n > 4(p − 1), this classification is wild in a sense of the representation theory.Вивчаються p-локалiзацiї (де p — непарне просте число) повних підкатегорій Sⁿ стабільної гомотопічної категорії, що складається з CW-комплексів із клітинами в n послідовних розмірностях. Застосовуючи техніку триангульованих категорій та матричні задачі, ми наводимо класифікацію атомів (нерозкладних об'єктів) у Spⁿ Для n≤4(p−1) i показуємо, що для n>4(p—1) ця класифікація є дикою у сенсі теорії зображень

The leader’s role in the system of managing school education institutions

Дана стаття присвячена вивченню проблеми ефективного керівництва загальноосвітніми закладами. Розроблено методичні рекомендації, щодо особливої ролі в процесі управління шкільною освітою керівника, який є носієм певного образу, іміджу навчального закладу, здатного забезпечити його конкурентоспроможність в системі надання освітніх послуг. Виявлено особливості соціально-психологічних якостей ролі керівника в системі управління закладами шкільної освіти з позиції різних наукових підходів та їх вплив на функціонування середнього навчального закладу. На основі теоретико-методологічного аналізу наукової літератури були розроблені та запропоновані практичні рекомендації, що можуть бути використані керівниками освітніх організацій з метою підвищення ефективності їх функціонування та конкурентоспроможності в системі надання освітніх послуг.This research is devoted to the study of problem of effective managing of school education institutions and is predefined not only by the search of new psychological-pedagogical peculiarities in terms of school education reforming in Ukraine. Methodical recommendations are worked out concerning a special role of a leader in the process of school education management. This leader is a transmitter of certain image, image of educational establishment which is able to provide its competitiveness in the system of educational services. Peculiarities of social-psychological features of a leader are found in the system of school education institutions managing from the prospective of different scientific approaches and their influence on the middle school institution functioning. All this was taken as a basis on creation of psychological model of managing this process. On the basis of theoretical and methodological analysis of scientific literature the practical recommendations were worked out and offered to be applied by the school institutions to advance their effectiveness and competitiveness in the system of educational services. The scientific article clearly outlines the importance of a given research and its purpose

MN Draconis - peculiar, active dwarf nova in the period gap

Context: We present results of an extensive world-wide observing campaign of MN Draconis. Aims: MN Draconis is a poorly known active dwarf nova in the period gap and is one of the only two known cases of period gap SU UMa objects showing the negative superhumps. Photometric behaviour of MN Draconis poses a challenge for existing models of the superhump and superoutburst mechanisms. Therefore, thorough investigation of peculiar systems, such as MN Draconis, is crucial for our understanding of evolution of the close binary stars. Methods: To measure fundamental parameters of the system, we collected photometric data in October 2009, June-September 2013 and June-December 2015. Analysis of the light curves, $O-C$ diagrams and power spectra was carried out. Results: During our three observational seasons we detected four superoutburts and several normal outbursts. Based on the two consecutive superoutbursts detected in 2015, the supercycle length was derived P_sc = 74 +/- 0.5 days and it has been increasing with a rate of P_dot = 3.3 x 10^(-3) during last twelve years. Based on the positive and negative superhumps we calculated the period excess epsilon = 5.6% +/- 0.1%, the period deficit epsilon_ = 2.5% +/- 0.6%, and in result, the orbital period P_orb = 0.0994(1) days (143.126 +/- 0.144 min). We updated the basic light curve parameters of MN Draconis. Conclusions: MN Draconis is the first discovered SU UMa system in the period gap with increasing supercycle length.Comment: 14 pages, 20 figures, 8 tables, accepted for publication in Astronomy and Astrophysic

Naturally occurring highly pathogenic avian influenza virus H5N1 clade 2.3.4.4b infection in three domestic cats in North America during 2023

The Eurasian strain of highly pathogenic avian influenza (HPAI) H5N1 is a devastating pathogen for birds that also has the capacity to infect mammals. This report describes the presentation, clinical case findings (including haemogram and serum biochemistry), gross and microscopic lesions and virus detection in three HPAI H5N1-infected domestic cats from the USA in 2023. All three cats presented with neurological abnormalities and were euthanized due to a poor prognosis within 2 days (two cats) or 10 days (one cat) of known clinical disease onset. Necropsy consistently revealed pulmonary congestion and oedema, and cerebrocortical malacia with haemorrhage was also seen in the cat that survived for 10 days. On histology, all cats had necrotizing encephalitis and interstitial pneumonia with pulmonary congestion, oedema, vasculitis and vascular thrombosis. One cat also had microscopic multifocal necrosis in the liver, pancreas and an adrenal gland. To our knowledge, this report is the first to detail pathological findings in HPAI H5N1 naturally-infected cats during the widespread outbreak in North America beginning in 2021, and that describes a cat surviving for 10 days after onset of HPAI H5N1 encephalitis

Directed differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6.1 factors in IPC progenitors

Additional file 6: Figure S1. Derivation of iPS cells in defined culture conditions

Математическая модель энергетических процессов в промышленной электрической отвертке

An electric screwdriver was designed to work in an automatic cycle on assembly lines. A characteristic feature of the screwdriver is the use of a low power motor in comparison with commonly used devices. The work of tightening the threaded joint takes place at the expense of the kinetic energy of the components of the drive system and the working screwdriver. It has been proved that the ability of the screwdriver to perform the tightening work is determined by the sum of the mass moment of inertia of the working components system and the mass moment of inertia of the motor's rotor, reduced to the axis of the screwdriver bit. The process of tightening is characterized by the number of screwing pulses, screwing torque values at the end of each pulse and the time of screwing process. The limitation of the value of the transmitted tightening torque takes place through the applied overload coupling.  The construction work of the screwdriver was preceded by the development of a mathematical model of the process of screwing and balance of torques acting during each phase of operation was carried out. This allowed the calculation of the value of the kinetic energy of components of the drive and operating system translated into the tightening work. The kinematic conditions to be met by the screwdriver at the end of a single tightening pulse were determined in order to accumulate kinetic energy and start another tightening pulse.Электрическая отвертка была разработана для автоматической работы на сборочных линиях. Характерной особенностью отвертки является использование двигателя малой мощности по сравнению с обычно применяемыми устройствами. Работа по натяжению резьбового соединения происходит за счет кинетической энергии компонентов системы привода и рабочей отвертки. Доказано, что способность отвертки выполнять затяжные работы определяется суммой массового момента инерции системы рабочих компонентов и массового момента инерции ротора двигателя, приведенного к оси наконечника отвертки. Процесс затягивания характеризуется количеством импульсов завинчивания, значениями момента завинчивания в конце каждого импульса и временем процесса завинчивания. Ограничение величины передаваемого момента затяжки происходит через применяемую перегрузочную муфту. Строительным работам по отвертке предшествовала разработка математической модели процесса завинчивания и балансировки крутящих моментов, действующих на каждом этапе работы. Это позволило рассчитать значение кинетической энергии компонентов привода и операционной системы в переводе на затяжные работы. Кинематические условия, которые должны быть выполнены отверткой в конце одного импульса затяжки, были определены для накопления кинетической энергии и запуска другого импульса затяжки

Microbiological changes in meat and minced meat from beavers (Castor fiber L.) during refrigerated and frozen storage

This study aims to evaluate the microbiological status, pH, and water activity of European beaver meat to establish its shelf-life and microbiological safety. In this study, the microbiological profiles of meat and minced meat obtained from the carcasses of beavers were investigated. Microbial evaluation of the chilled meat was performed within 24 h after hunting, on the 7th day and 14th day, and the evaluation of the frozen meat was made during the 11th week of storage. Meat samples were analysed for total viable count (TVC), psychrotrophic bacteria count (PBC), Enterobacteriaceae count (EBC), Escherichia coli count (EC), total staphylococcal count (TSC), lactic acid bacteria count (LABC) and total yeast and mould counts (TYMC). Tests for the presence of pathogenic bacteria from the genus Salmonella and Listeria were also performed. Additionally, the pH and water activity were determined. The initial amount of TVC was 4.94 log CFU/g in meat samples and 4.80 log CFU/g in minced meat. After 14 days of storage, the TVC increased to 8.33 in meat samples and 8.08 log CFU/g in minced meat. Pathogenic bacteria such as Listeria and Salmonella were not found in the beaver meat tested. The microbiological state of meat stored frozen for 11 weeks was comparable to the state found in meat stored refrigerated for seven days regarding the number of microorganisms

Guanfacine treatment improves ADHD phenotypes of impulsivity and hyperactivity in a neurofibromatosis type 1 mouse model

BACKGROUND: Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with a mutation in one copy of the neurofibromin gene (NF1+/-). Even though approximately 40-60% of children with NF1 meet the criteria for attention deficit hyperactivity disorder (ADHD), very few preclinical studies, if any, have investigated alterations in impulsivity and risk-taking behavior. Mice with deletion of a single NF1 gene (Nf1+/-) recapitulate many of the phenotypes of NF1 patients. METHODS: We compared wild-type (WT) and Nf1+/- mouse strains to investigate differences in impulsivity and hyperactivity using the delay discounting task (DDT), cliff avoidance reaction (CAR) test, and open field. We also investigated whether treatment with the clinically effective alpha-2A adrenergic receptor agonist, guanfacine (0.3 mg/kg, i.p.), would reverse deficits observed in behavioral inhibition. RESULTS: Nf1+/- mice chose a higher percentage of smaller rewards when both 10- and 20-s delays were administered compared to WT mice, suggesting Nf1+/- mice are more impulsive. When treated with guanfacine (0.3 mg/kg, i.p.), Nf1+/- mice exhibited decreased impulsive choice by waiting for the larger, delayed reward. Nf1+/- mice also exhibited deficits in behavioral inhibition compared to WT mice in the CAR test by repetitively entering the outer edge of the platform where they risk falling. Treatment with guanfacine ameliorated these deficits. In addition, Nf1+/- mice exhibited hyperactivity as increased distance was traveled compared to WT controls in the open field. This hyperactivity in Nf1+/- mice was reduced with guanfacine pre-treatment. CONCLUSIONS: Overall, our study confirms that Nf1+/- mice exhibit deficits in behavioral inhibition in multiple contexts, a key feature of ADHD, and can be used as a model system to identify alterations in neural circuitry associated with symptoms of ADHD in children with NF1

Optimization of an Alkylpolyglucoside-Based Dishwashing Detergent Formulation.

The aim of this work was to formulate and optimize the washing performance of an alkylpolyglucoside-based dishwashing detergent. The liquid detergent was formulated with five ingredients of commercial origin: anionic (linear sodium alkylbenzenesulfonate and sodium laurylethersulfate), nonionic (C12–C14 alkylpolyglucoside) and zwitterionic (a fatty acid amide derivative with a betaine structure) surfactants, and NaCl for viscosity control. In addition to the plate test, other properties were investigated including ‘‘cloud point’’, viscosity, and emulsion stability. Statistical analysis software was used to generate a central composite experimental design. Then, a second order design and analysis of experiments approach, known as the Response Surface Methodology, was set up to investigate the effects of the five components of the formulation on the studied properties in the region covering plausible component ranges. The method proved to be efficient for locating the domains of concentrations where the desired properties were met

Magnetocaloric effect in nano- and polycrystalline manganite La0.7Ca0.3MnO3La_{0.7}Ca_{0.3}MnO_3

$La_{0.7}Ca_{0.3}MnO_3$ samples were prepared in nano- and polycrystalline forms by sol-gel and solid state reaction methods, respectively, and structurally characterized by synchrotron X-ray diffraction. The magnetic properties determined by ac susceptibility and dc magnetization measurements are discussed. The magnetocaloric effect in this nanocrystalline manganite is spread over a broader temperature interval than in the polycrystalline case. The relative cooling power of the poly- and nanocrystalline manganites is used to evaluate a possible application for magnetic cooling below room temperature.Comment: 6 pages, 5 (double) figures, 1 table, 16 references; submitted to Appl. Phys.