New constraints on cosmological parameters and neutrino properties using the expansion rate of the Universe to z~1.75

We have assembled a compilation of observational Hubble parameter measurements estimated with the differential evolution of cosmic chronometers, in the redshift range 0<z<1.75. This sample has been used, in combination with CMB data and with the most recent estimate of the Hubble constant H_0, to derive new constraints on several cosmological parameters. The new Hubble parameter data are very useful to break some of the parameter degeneracies present in CMB-only analysis, and to constrain possible deviations from the standard (minimal) flat \Lambda CDM model. The H(z) data are especially valuable in constraining \Omega_k and \Omega_DE in models that allow a variation of those parameters, yielding constraints that are competitive with those obtained using Supernovae and/or baryon acoustic oscillations. We also find that our H(z) data are important to constrain parameters that do no affect directly the expansion history, by breaking or reducing degeneracies with other parameters. We find that Nrel=3.45\pm0.33 using WMAP 7-years data in combination with South Pole Telescope data and our H(z) determinations (Nrel=3.71\pm0.45 using Atacama Cosmology Telescope data instead of South Pole Telescope). We exclude Nrel>4 at 95% CL (74% CL) using the same datasets combinations. We also put competitive limits on the sum of neutrino masses, \Sigma m_\nu<0.24 eV at 68% confidence level. These results have been proven to be extremely robust to many possible systematic effects, such as the initial choice of stellar population synthesis model adopted to estimate H(z) and the progenitor-bias.Comment: 18 pages, 17 figures, 7 tables, published in JCAP. It is a companion to Moresco et al. (2012a, http://arxiv.org/abs/1201.3609) and Jimenez et al. (2012, http://arxiv.org/abs/1201.3608). The H(z) data can be downloaded at http://www.physics-astronomy.unibo.it/en/research/areas/astrophysics/cosmology-with-cosmic-chronometer

The zCOSMOS survey: the role of the environment in the evolution of the luminosity function of different galaxy types

Aims. An unbiased and detailed characterization of the galaxy luminosity function (LF) is a basic requirement in many astrophysical issues: it is of particular interest in assessing the role of the environment in the evolution of the LF of different galaxy types. Methods. We studied the evolution in the B band LF to redshift z ~ 1 in the zCOSMOS 10k sample, for which both accurate galaxy classifications (spectrophotometric and morphological) and a detailed description of the local density field are available. Results. The global B band LF exhibits a brightening of ~0.7 mag in M^* from z ~ 0.2 to z ~ 0.9. At low redshifts (z -20), while the bright end is populated mainly by spectrophotometric early types. At higher redshift, spectrophotometric late-type galaxies evolve significantly and, at redshift z ~ 1, the contribution from the various types to the bright end of the LF is comparable. The evolution for spectrophotometric early-type galaxies is in both luminosity and normalization: M* brightens by ~0.6 mag but φ^∗ decreases by a factor ~1.7 between the first and the last redshift bin. A similar behaviour is exhibited by spectrophotometric late-type galaxies, but with an opposite trend for the normalization: a brightening of ~0.5 mag is present in M^*, while φ^∗ increases by a factor ~1.8.
Studying the role of the environment, we find that the global LF of galaxies in overdense regions has always a brighter M^* and a flatter slope. In low density environments, the main contribution to the LF is from blue galaxies, while for high density environments there is an important contribution from red galaxies to the bright end.
The differences between the global LF in the two environments are not due to only a difference in the relative numbers of red and blue galaxies, but also to their relative luminosity distributions: the value of M^* for both types in underdense regions is always fainter than in overdense environments. These results indicate that galaxies of the same type in different environments have different properties.
We also detect a differential evolution in blue galaxies in different environments: the evolution in their LF is similar in underdense and overdense regions between z ~ 0.25 and z ~ 0.55, and is mainly in luminosity. In contrast, between z ~ 0.55 and z ~ 0.85 there is little luminosity evolution but there is significant evolution in φ^∗, that is, however, different between the two environments: in overdense regions φ^∗ increases by a factor ~1.6, while in underdense regions this increase reaches a factor ~2.8. Analyzing the blue galaxy population in more detail, we find that this evolution is driven mainly by the bluest types. Conclusions. The “specular” evolution of late- and early-type galaxies is consistent with a scenario where a part of blue galaxies is transformed in red galaxies with increasing cosmic time, without significant changes in the fraction of intermediate-type galaxies. The bulk of this tranformation in overdense regions probably happened before z ~ 1, while it is still ongoing at lower redshifts in underdense environments

Functionalized silica nanoparticles in the detection and treatment of Her2-positive breast cancer

Introduction: Nanobiotechnology can provide the development of nanoparticles for diagnosis/treatment of human cancer. Aim of this work was to validate a silica nanoparticles (SNP)-based system functionalized with anti-Her2 antibody fragment and loaded with radioactive/fluorescent probes for detection of aggressive breast cancer. Methods: SNPs carrying (ETZ-2) or not (ETZ-1, control) the Her2 antibody fragment were used in in vitro binding kinetic in Her2 positive (SKBR-3) and negative (MDA-MB-468) breast cancer cell lines. In parallel, the same SNPs were derivatized with nitril-triacetic acid and reacted with His-Tag, previously labelled with 99mTc-Tricarbonyl complex. Labelled SNPs were used for different experiments: in vitro uptake kinetic in SKBR-3 and MDA-MB-468 cells (20 min, 1 h, 4h and 24h); ex vivo distribution in tumour and peripheral organs in animals implanted with MDA-MB-468 or SKBR-3 cells, at 4h from ETZ-2 injection. SNPs binding in cells was expressed as percentage of the total radioactivity counted; uptake in tumours and tissues were calculated as percentage of injected dose per gram of tissue. Slices of tumour were also fixed with 4% PAF and observed by fluorescence. In parallel, additional animals bearing SKBR-3 or MDA-MB-468 lesions were treated with liposomal doxorubicin (3 mg/kg in 40\ub5l) or vehicle, and tumour uptake of [18F]FDG and [11C]Choline was evaluated ex vivo with double autoradiography. Results: ETZ-2 specifically binds SKBR-3 cells in vitro, reaching a maximum uptake ratio of 2,1 on MDA-MB-468 cells after 4h. The same result was confirmed in tumours, after the biodistribution study and observation in fluorescence. Standard treatment particularly affected SKBR-3 lesions growth, in which we observed a 12,4% decrease of [18F]FDG and a 14.3% increase of [11C]Choline uptake, compared to control. Comparison with NPSs filled with doxorubicin are in progress. Conclusion: Labelled SNPs resulted a useful detection system for Her2 positive breast cancer and could be used for targeted therapy

Functionalized silica nanoparticles in the detection and treatment of Her2-positive breast cancer

Introduction: Nanobiotechnology can provide the development of nanoparticles for diagnosis/treatment of human cancer. Aim of this work was to validate a silica nanoparticles (SNP)-based system functionalized with anti-Her2 antibody fragment and loaded with radioactive/fluorescent probes for detection of aggressive breast cancer. Methods: SNPs carrying (ETZ-2) or not (ETZ-1, control) the Her2 antibody fragment were used in in vitro binding kinetic in Her2 positive (SKBR-3) and negative (MDA-MB-468) breast cancer cell lines. In parallel, the same SNPs were derivatized with nitril-triacetic acid and reacted with His-Tag, previously labelled with 99mTc-Tricarbonyl complex. Labelled SNPs were used for different experiments: in vitro uptake kinetic in SKBR-3 and MDA-MB-468 cells (20 min, 1h, 4h and 24h); ex vivo distribution in tumour and peripheral organs in animals implanted with MDA-MB-468 or SKBR-3 cells, at 4h from ETZ-2 injection. Afterwards, an additional experiment with ex vivo distribution and autoradiography at different time points (4h, 6h and 24h; n=4) were performed after the injection of labelled ETZ-1 and 2 SNPS on animals implanted with SKBR-3 cells. At the same times, in vitro uptake of both SNPs were measured by pre-treating SKBR-3 cells with 1 mg/ml of Trastuzumab. The uptake of labelled SNPs in cells was expressed as percentage of the total radioactivity counted, while in tumours and tissues was calculated as percentage of injected dose per gram of tissue (%ID/g). Tumour sample were also frozen in liquid N2 and sectioned for fluorescence microscopy. We have ongoing the evaluation of doxorubicin filled SNPs in comparison to liposomal doxorubicin (Caelix, 3 mg/kg in 40\ub5l) to assess the efficacy of nanoparticles to targeting chemotherapy. The effect will be assessed by measuring tumoral features as volume and [18F]FDG and [11C]Choline uptake. Results: ETZ-2 specifically binds SKBR-3 cells in vitro, reaching a maximum uptake ratio of 2,1 on MDA-MB-468 cells after 4h. The same result was confirmed in tumours, after the biodistribution study and observation in fluorescence. Caelix treatment particularly affected SKBR-3 lesions growth, in which we observed a 12,4% decrease of [18F]FDG and a 14.3% increase of [11C]Choline uptake, compared to control. Comparison with filled doxorubicin NPSs are in progress. Conclusion: Preliminary results showed that 99mTc-ETZ-2 SNPs could be a useful system for Her2 positive breast cancer detection and treatment

zCOSMOS 20k: Satellite galaxies are the main drivers of environmental effects in the galaxy population at least to z~0.7

We explore the role of environment in the evolution of galaxies over 0.1<z<0.7 using the final zCOSMOS-bright data set. Using the red fraction of galaxies as a proxy for the quenched population, we find that the fraction of red galaxies increases with the environmental overdensity and with the stellar mass, consistent with previous works. As at lower redshift, the red fraction appears to be separable in mass and environment, suggesting the action of two processes: mass and environmental quenching. The parameters describing these appear to be essentially the same at z~0.7 as locally. We explore the relation between red fraction, mass and environment also for the central and satellite galaxies separately, paying close attention to the effects of impurities in the central-satellite classification and using carefully constructed samples matched in stellar mass. There is little evidence for a dependence of the red fraction of centrals on overdensity. Satellites are consistently redder at all overdensities, and the satellite quenching efficiency increases with overdensity at 0.1<z<0.4. This is less marked at higher redshift, but both are nevertheless consistent with the equivalent local measurements. At a given stellar mass, the fraction of galaxies that are satellites also increases with the overdensity. At a given overdensity and mass, the obtained relation between the environmental quenching and the satellite fraction agrees well with the satellite quenching efficiency, demonstrating that the environmental quenching in the overall population is consistent with being entirely produced through the satellite quenching process at least up to z=0.7. However, despite the unprecedented size of our high redshift samples, the associated statistical uncertainties are still significant and our statements should be understood as approximations to physical reality, rather than physically exact formulae.Comment: 22 pages, 19 figures, submitted to MNRA

Start of SPIDER operation towards ITER neutral beams

Heating Neutral Beam (HNB) Injectors will constitute the main plasma heating and current drive tool both in ITER and JT60-SA, which are the next major experimental steps for demonstrating nuclear fusion as viable energy source. In ITER, in order to achieve the required thermonuclear fusion power gain Q=10 for short pulse operation and Q=5 for long pulse operation (up to 3600s), two HNB injectors will be needed [1], each delivering a total power of about 16.5 MW into the magnetically-confined plasma, by means of neutral hydrogen or deuterium particles having a specific energy of about 1 MeV. Since only negatively charged particles can be efficiently neutralized at such energy, the ITER HNB injectors [2] will be based on negative ions, generated by caesium-catalysed surface conversion of atoms in a radio-frequency driven plasma source. A negative deuterium ion current of more than 40 A will be extracted, accelerated and focused in a multi-aperture, multi-stage electrostatic accelerator, having 1280 apertures (~ 14 mm diam.) and 5 acceleration stages (~200 kV each) [3]. After passing through a narrow gas-cell neutralizer, the residual ions will be deflected and discarded, whereas the neutralized particles will continue their trajectory through a duct into the tokamak vessels to deliver the required heating power to the ITER plasma for a pulse duration of about 3600 s. Although the operating principles and the implementation of the most critical parts of the injector have been tested in different experiments, the ITER NBI requirements have never been simultaneously attained. In order to reduce the risks and to optimize the design and operating procedures of the HNB for ITER, a dedicated Neutral Beam Test Facility (NBTF) [4] has been promoted by the ITER Organization with the contribution of the European Union\u2019s Joint Undertaking for ITER and of the Italian Government, with the participation of the Japanese and Indian Domestic Agencies (JADA and INDA) and of several European laboratories, such as IPP-Garching, KIT-Karlsruhe, CCFE-Culham, CEA-Cadarache. The NBTF, nicknamed PRIMA, has been set up at Consorzio RFX in Padova, Italy [5]. The planned experiments will verify continuous HNB operation for one hour, under stringent requirements for beam divergence (< 7 mrad) and aiming (within 2 mrad). To study and optimise HNB performances, the NBTF includes two experiments: MITICA, full-scale NBI prototype with 1 MeV particle energy and SPIDER, with 100 keV particle energy and 40 A current, aiming at testing and optimizing the full-scale ion source. SPIDER will focus on source uniformity, negative ion current density and beam optics. In June 2018 the experimental operation of SPIDER has started

The dependence of Galactic outflows on the properties and orientation of zCOSMOS galaxies at z ~ 1

We present an analysis of cool outflowing gas around galaxies, traced by MgII absorption lines in the co-added spectra of a sample of 486 zCOSMOS galaxies at 1 < z < 1.5. These galaxies span a range of stellar masses (9.45< log[M*/Msun]<10.7) and star formation rates (0.14 < log [SFR/Msun/yr] < 2.35). We identify the cool outflowing component in the MgII absorption and find that the equivalent width of the outflowing component increases with stellar mass. The outflow equivalent width also increases steadily with the increasing star formation rate of the galaxies. At similar stellar masses the blue galaxies exhibit a significantly higher outflow equivalent width as compared to red galaxies. The outflow equivalent width shows strong effect with star formation surface density ({\Sigma}SFR) of the sample. For the disk galaxies, the outflow equivalent width is higher for the face-on systems as compared to the edge-on ones, indicating that for the disk galaxies, the outflowing gas is primarily bipolar in geometry. Galaxies typically exhibit outflow velocities ranging from -200 km/s to -300 km/s and on average the face-on galaxies exhibit higher outflow velocity as compared to the edge-on ones. Galaxies with irregular morphologies exhibit outflow equivalent width as well as outflow velocities comparable to face on disk galaxies. These galaxies exhibit minimum mass outflow rates > 5-7 Msun/yr and a mass loading factor ({\eta} = dMout/dt /SFR) comparable to the star formation rates of the galaxies.Comment: 12 pages, 14 figures, ApJ submitte

Insights into the reionization epoch from cosmic-noon-Civ emitters in the VANDELS survey

Recently, intense emission from nebular CaIII and CIV emission lines have been observed in galaxies in the epoch of reionization (z&gt;6) and have been proposed as the prime way of measuring their redshift and studying their stellar populations. These galaxies might represent the best examples of cosmic reionizers, as suggested by recent low-z observations of Lyman continuum emitting galaxies, but it is hard to directly study the production and escape of ionizing photons at such high redshifts. The ESO spectroscopic public survey VANDELS offers the unique opportunity to find rare examples of such galaxies at cosmic noon (z~3), thanks to the ultra deep observations available. We have selected a sample of 39 galaxies showing CIV emission, whose origin (after a careful comparison to photoionization models) can be ascribed to star formation and not to active galactic nuclei. By using a multiwavelength approach, we determined their physical properties including metallicity and the ionization parameter and compared them to the properties of the parent population to understand what the ingredients are that could characterize the analogs of the cosmic reionizers. We find that CIV emitters are galaxies with high photon production efficiency and there are strong indications that they might also have a large escape fraction: given the visibility of CIV in the epoch of reionization, this could become the best tool to pinpoint the cosmic reioinzers

Insights into the reionization epoch from cosmic-noon-CIV emitters in the VANDELS survey

Recently, intense emission from nebular C III] and C IV emission lines have been observed in galaxies in the epoch of reionization ($z>6$) and have been proposed as the prime way of measuring their redshift and studying their stellar populations. These galaxies might represent the best examples of cosmic reionizers, as suggested by recent low-z observations of Lyman Continuum emitting galaxies, but it is hard to directly study the production and escape of ionizing photons at such high redshifts. The ESO spectroscopic public survey VANDELS offers the unique opportunity to find rare examples of such galaxies at cosmic noon ($z\sim 3$), thanks to the ultra deep observations available. We have selected a sample of 39 galaxies showing C IV emission, whose origin (after a careful comparison to photoionization models) can be ascribed to star formation and not to AGN. By using a multi-wavelength approach, we determine their physical properties including metallicity and ionization parameter and compare them to the properties of the parent population to understand what are the ingredients that could characterize the analogs of the cosmic reionizers. We find that C IV emitters are galaxies with high photons production efficiency and there are strong indications that they might have also large escape fraction: given the visibility of C IV in the epoch of reionization this could become the best tool to pinpoint the cosmic reioinzers.Comment: 15 pages, 10 figures, resubmitted to A&A after addressing the referee comment

Obscured AGN at z~1 from the zCOSMOS-Bright Survey I. Selection and Optical Properties of a [Ne v]-selected sample

A sample of 94 narrow line AGN with 0.65<z<1.20 has been selected from the 20k-Bright zCOSMOS galaxy sample by detection of the high-ionization [NeV]3426 line. Taking advantage of the large amount of data available in the COSMOS field, the properties of the [NeV]-selected Type-2 AGN have been investigated, focusing on their host galaxies, X-ray emission, and optical line flux ratios. Finally, the diagnostic developed by Gilli et al. (2010), based on the X-ray to [NeV] luminosity ratio, has been exploited to search for the more heavily obscured AGN. We found that [Ne v]-selected narrow line AGN have Seyfert 2-like optical spectra, although with emission line ratios diluted by a star-forming component. The ACS morphologies and stellar component in the optical spectra indicate a preference for our Type-2 AGN to be hosted in early-spirals with stellar masses greater than 10^(9.5-10)Msun, on average higher than those of the galaxy parent sample. The fraction of galaxies hosting [NeV]-selected obscured AGN increases with the stellar mass, reaching a maximum of about 3% at 2x10^11 Msun. A comparison with other selection techniques at z~1 shows that the detection of the [Ne v] line is an effective method to select AGN in the optical band, in particular the most heavily obscured ones, but can not provide by itself a complete census of AGN2. Finally, the high fraction of [NeV]-selected Type-2 AGN not detected in medium-deep Chandra observations (67%) is suggestive of the inclusion of Compton-thick sources in our sample. The presence of a population of heavily obscured AGN is corroborated by the X-ray to [NeV] ratio; we estimated, by mean of X-ray stacking technique and simulations, that the Compton-thick fraction in our sample of Type-2 AGN is 43+-4%, in good agreement with standard assumptions by the XRB synthesis models.Comment: 14 pages, 12 figures, accepted for publication in A&