828 research outputs found
Conductive structures around Las Cañadas caldera, Tenerife (Canary Islands, Spain) : a structural control
External eastern areas of the Las Cañadas caldera (LCC) of Tenerife (Canary Islands, Spain) have been investigated using the audiomagnetotelluric (AMT) method with the aim to characterize the physical rock properties at shallow depth and the thickness of a first resistive layer. Using the results of 50 AMT tensors carried out in the period range of 0.001 s to 0.3 s, this study provides six unpublished AMT profiles distributed in the upper Orotava valley and data from the Pedro Gil caldera (Dorsal Ridge). Showing obvious 1-D behaviour, soundings have been processed through 1-D modeling and gathered to form profiles. Underlying a resistive cover (150-2000 Om), a conductive layer at shallow depth (18-140 Om, 250-1100 m b.g.l.) which is characterized by a "wavy-like" structure, often parallel to the topography, appears in all profiles. This paper points out the ubiquitous existence in Tenerife of such a conductive layer, which is the consequence of two different processes: a) according to geological data, the enhanced conductivity of the flanks is interpreted as a plastic breccia within a clayish matrix generated during huge lateral collapse; and b) along main tectonic structures and inside calderas, this layer is formed by hidrotermal alteration processes. In both areas, the conductive layer is thought to be related to major structural volcanic events (flank or caldera collapse) and can be seen as a temporal marker of the island evolution. Moreover, its slope suggests possible headwall locations of the giant landslides that affected the flanks of Tenerife
Call-by-value non-determinism in a linear logic type discipline
We consider the call-by-value lambda-calculus extended with a may-convergent
non-deterministic choice and a must-convergent parallel composition. Inspired
by recent works on the relational semantics of linear logic and non-idempotent
intersection types, we endow this calculus with a type system based on the
so-called Girard's second translation of intuitionistic logic into linear
logic. We prove that a term is typable if and only if it is converging, and
that its typing tree carries enough information to give a bound on the length
of its lazy call-by-value reduction. Moreover, when the typing tree is minimal,
such a bound becomes the exact length of the reduction
Recommended from our members
A novel heteroditopic terpyridine-pincer ligand as building block for mono- and heterometallic Pd(II) and Ru(II) complexes
A palladium-catalyzed Stille coupling reaction was employed as a versatile method for the synthesis of a novel terpyridine-pincer (3, TPBr) bridging ligand, 4'-{4-BrC6H2(CH2NMe2)(2)-3,5}-2,2':6',2 ''-terpyridine. Mononuclear species [PdX(TP)] (X = Br, Cl), [Ru(TPBr)(tpy)](PF6)(2), and [Ru(TPBr)(2)](PF6)(2), synthesized by selective metalation of the NCNBr-pincer moiety or complexation of the terpyridine of the bifunctional ligand TPBr, were used as building blocks for the preparation of heterodi- and trimetallic complexes [Ru(TPPdCl)(tpy)](PF6)(2) (7) and [Ru(TPPdCl)(2)]-(PF6)(2) (8). The molecular structures in the solid state of [PdBr(TP)] (4a) and [Ru(TPBr)(2)](PF6)(2) (6) have been determined by single-crystal X-ray analysis. Electrochemical behavior and photophysical properties of the mono-and heterometallic complexes are described. All the above di- and trimetallic Ru complexes exhibit absorption bands attributable to (MLCT)-M-1 (Ru -> tpy) transitions. For the heteroleptic complexes, the transitions involving the unsubstituted tpy ligand are at a lower energy than the tpy moiety of the TPBr ligand. The absorption bands observed in the electronic spectra for TPBr and [PdCl(TP)] have been assigned with the aid of TD-DFT calculations. All complexes display weak emission both at room temperature and in a butyronitrile glass at 77 K. The considerable red shift of the emission maxima relative to the signal of the reference compound [Ru(tpy)(2)](2+) indicates stabilization of the luminescent (MLCT)-M-3 state. For the mono- and heterometallic complexes, electrochemical and spectroscopic studies (electronic absorption and emission spectra and luminescence lifetimes recorded at room temperature and 77 K in nitrile solvents), together with the information gained from IR spectroelectrochemical studies of the dimetallic complex [Ru(TPPdSCN)(tpy)](PF6)(2), are indicative of charge redistribution through the bridging ligand TPBr. The results are in line with a weak coupling between the {Ru(tpy)(2)} chromophoric unit and the (non)metalated NCN-pincer moiety
Acetate intolerance is mediated by enhanced synthesis of nitric oxide by endothelial cells.
The clinical picture of acetate intolerance strictly mimics the nitric oxide (NO) effect, including smooth muscle relaxation and extreme vasodilation. Because acetate induces production of cAMP, which is a powerful stimulus of NO synthase (NOS), we evaluated the effect of different dialysate solutions with and without acetate on NOS activity in endothelial cells (EC). NOS activity of EC, evaluated as H3-citrulline produced from H3-arginine, was modulated by the dialysate composition (e.g., 38 mmol/L acetate produced an increase of 3.2 +/- 0.39-fold compared with basal values (P < 0.0005), and the small amount of acetate (4 mmol/L) in 35 mmol/L bicarbonate solution increased the NOS activity by 2 +/- 0.49-fold (P < 0.05). Conversely, the acetate-free solution produced no effect on NOS activity. The mRNA encoding for inducible NOS was highly expressed in EC incubated with acetate buffer and also with acetate in bicarbonate dialysis buffer. The EC proliferative index was depressed by acetate (P < 0.0005), and tumor necrosis factor synthesis was increased (P < 0.0005) compared with acetate-free buffer. This study suggests that dialytic "acetate intolerance" can be induced by the activation, through cAMP and tumor necrosis factor release, of NOS. The small amount of acetate in bicarbonate dialysate, although capable of inducing in vitro NOS activation, is likely to be rapidly metabolized, whereas the large amounts of this anion in acetate fluids overwhelm metabolism by the liver. Acetate-free dialysate is the only solution that provides an acceptable level of biocompatibility both in vivo and in vitro
Hybrid Session Verification through Endpoint API Generation
© Springer-Verlag Berlin Heidelberg 2016.This paper proposes a new hybrid session verification methodology for applying session types directly to mainstream languages, based on generating protocol-specific endpoint APIs from multiparty session types. The API generation promotes static type checking of the behavioural aspect of the source protocol by mapping the state space of an endpoint in the protocol to a family of channel types in the target language. This is supplemented by very light run-time checks in the generated API that enforce a linear usage discipline on instances of the channel types. The resulting hybrid verification guarantees the absence of protocol violation errors during the execution of the session. We implement our methodology for Java as an extension to the Scribble framework, and use it to specify and implement compliant clients and servers for real-world protocols such as HTTP and SMTP
Vitamin e-loaded membrane dialyzers reduce hemodialysis inflammaging
Background Inflammaging is a persistent, low-grade, sterile, nonresolving inflammatory state, associated with the senescence of the immune system. Such condition downregulates both innate and adaptive immune responses during chronic disorders as type II diabetes, cancer and hemodialysis, accounting for their susceptibility to infections, malignancy and resistance to vaccination. Aim of this study was to investigate hemodialysis inflammaging, by evaluating changes of several hemodialysis treatments on indoleamine 2,3-dioxygenase-1 activity and nitric oxide formation. Methods We conducted a randomized controlled observational crossover trial. Eighteen hemodialysis patients were treated with 3 different hemodialysis procedures respectively: 1) Low-flux bicarbonate hemodialysis, 2) Low-flux bicarbonate hemodialysis with vitamin E - loaded dialyzers, and 3) Hemodialfitration. The control group consisted of 14 hospital staff healthy volunteers. Blood samples were collected from all 18 hemodialysis patients just after the long interdialytic interval, at the end of each hemodialysis treatment period. Results Hemodialysis kynurenine and kynurenine/L - tryptophan blood ratio levels were significantly higher, when compared to the control group, indicating an increased indoleamine 2,3-dioxygenase-1 activity in hemodialysis patients. At the end of the low-flux bicarbonate hemodialysis with vitamin E - loaded dialyzers period, L - tryptophan serum levels remained unchanged vs both low-flux bicarbonate hemodialysis and hemodialfitration. Kynurenine levels instead decreased, resulting in a significant reduction of kynurenine/L - tryptophan blood ratio and indoleamine 2,3-dioxygenase-1 activity, when matched to both low-flux bicarbonate hemodialysis and HDF respectively. Serum nitric oxide control group levels, were significantly lower when compared to all hemodialysis patient groups. Interestingly, low-flux bicarbonate hemodialysis with vitamin E - loaded dialyzers nitric oxide serum levels from venous line blood samples taken 60 min after starting the hemodialysis session were significantly lower vs serum taken simultaneously from the arterial blood line. Conclusions The treatment with more biocompatible hemodialysis procedure as low-flux bicarbonate hemodialysis with vitamin E - loaded dialyzers, reduced indoleamine 2,3-dioxygenase-1 activity and nitric oxide formation when compared to both low-flux bicarbonate hemodialysis and hemodialfitration. These data suggest that low-flux bicarbonate hemodialysis with vitamin E - loaded dialyzers lowering hemodialysis inflammaging, could be associated to changes of proinflammatory signalling a regulated molecular level
Automatic Optic Nerve Measurement: A New Tool to Standardize Optic Nerve Assessment in Ultrasound B-Mode Images
Transorbital sonography provides reliable information about the estimation of intra-cranial pressure by measuring the optic nerve sheath diameter (ONSD), whereas the optic nerve (ON) diameter (OND) may reveal ON atrophy in patients with multiple sclerosis. Here, an AUTomatic Optic Nerve MeAsurement (AUTONoMA) system for OND and ONSD assessment in ultrasound B-mode images based on deformable models is presented. The automated measurements were compared with manual ones obtained by two operators, with no significant differences. AUTONoMA correctly segmented the ON and its sheath in 71 out of 75 images. The mean error compared with the expert operator was 0.06 ± 0.52 mm and 0.06 ± 0.35 mm for the ONSD and OND, respectively. The agreement between operators and AUTONoMA was good and a positive correlation was found between the readers and the algorithm with errors comparable with the inter-operator variability. The AUTONoMA system may allow for standardization of OND and ONSD measurements, reducing manual evaluation variability
Intersection types for unbind and rebind
We define a type system with intersection types for an extension of
lambda-calculus with unbind and rebind operators. In this calculus, a term with
free variables, representing open code, can be packed into an "unbound" term,
and passed around as a value. In order to execute inside code, an unbound term
should be explicitly rebound at the point where it is used. Unbinding and
rebinding are hierarchical, that is, the term can contain arbitrarily nested
unbound terms, whose inside code can only be executed after a sequence of
rebinds has been applied. Correspondingly, types are decorated with levels, and
a term has type decorated with k if it needs k rebinds in order to reduce to a
value. With intersection types we model the fact that a term can be used
differently in contexts providing different numbers of unbinds. In particular,
top-level terms, that is, terms not requiring unbinds to reduce to values,
should have a value type, that is, an intersection type where at least one
element has level 0. With the proposed intersection type system we get
soundness under the call-by-value strategy, an issue which was not resolved by
previous type systems.Comment: In Proceedings ITRS 2010, arXiv:1101.410
The Paths to Choreography Extraction
Choreographies are global descriptions of interactions among concurrent
components, most notably used in the settings of verification (e.g., Multiparty
Session Types) and synthesis of correct-by-construction software (Choreographic
Programming). They require a top-down approach: programmers first write
choreographies, and then use them to verify or synthesize their programs.
However, most existing software does not come with choreographies yet, which
prevents their application.
To attack this problem, we propose a novel methodology (called choreography
extraction) that, given a set of programs or protocol specifications,
automatically constructs a choreography that describes their behavior. The key
to our extraction is identifying a set of paths in a graph that represents the
symbolic execution of the programs of interest. Our method improves on previous
work in several directions: we can now deal with programs that are equipped
with a state and internal computation capabilities; time complexity is
dramatically better; we capture programs that are correct but not necessarily
synchronizable, i.e., they work because they exploit asynchronous
communication
- …