Psychosocial Screening in Disorders/Differences of Sex Development: Psychometric Evaluation of the Psychosocial Assessment Tool

© 2019 S. Karger AG, Basel. Background/Aims: Utilization of a psychosocial screener to identify families affected by a disorder/difference of sex development (DSD) and at risk for adjustment challenges may facilitate efficient use of team resources to optimize care. The Psychosocial Assessment Tool (PAT) has been used in other pediatric conditions. The current study explored the reliability and validity of the PAT (modified for use within the DSD population; PAT-DSD). Methods: Participants were 197 families enrolled in the DSD-Translational Research Network (DSD-TRN) who completed a PAT-DSD during a DSD clinic visit. Psychosocial data were extracted from the DSD-TRN clinical registry. Internal reliability of the PAT-DSD was tested using the Kuder-Richardson-20 coefficient. Validity was examined by exploring the correlation of the PAT-DSD with other measures of caregiver distress and child emotional-behavioral functioning. Results: One-third of families demonstrated psychosocial risk (27.9% Targeted and 6.1% Clinical level of risk). Internal reliability of the PAT-DSD Total score was high (α = 0.86); 4 of 8 subscales met acceptable internal reliability. A priori predicted relationships between the PAT-DSD and other psychosocial measures were supported. The PAT-DSD Total score related to measures of caregiver distress (r = 0.40, p \u3c 0.001) and to both caregiver-reported and patient self-reported behavioral problems (r = 0.61, p \u3c 0.00; r = 0.37, p \u3c 0.05). Conclusions: This study provides evidence for the reliability and validity of the PAT-DSD. Given variability in the internal reliability across subscales, this measure is best used to screen for overall family risk, rather than to assess specific psychosocial concerns

Ubiquitous Molecular Outflows in z > 4 Massive, Dusty Galaxies II. Momentum-Driven Winds Powered by Star Formation in the Early Universe

Galactic outflows of molecular gas are a common occurrence in galaxies and may represent a mechanism by which galaxies self-regulate their growth, redistributing gas that could otherwise have formed stars. We previously presented the first survey of molecular outflows at z > 4 towards a sample of massive, dusty galaxies. Here we characterize the physical properties of the molecular outflows discovered in our survey. Using low-redshift outflows as a training set, we find agreement at the factor-of-two level between several outflow rate estimates. We find molecular outflow rates 150-800Msun/yr and infer mass loading factors just below unity. Among the high-redshift sources, the molecular mass loading factor shows no strong correlations with any other measured quantity. The outflow energetics are consistent with expectations for momentum-driven winds with star formation as the driving source, with no need for energy-conserving phases. There is no evidence for AGN activity in our sample, and while we cannot rule out deeply-buried AGN, their presence is not required to explain the outflow energetics, in contrast to nearby obscured galaxies with fast outflows. The fraction of the outflowing gas that will escape into the circumgalactic medium (CGM), though highly uncertain, may be as high as 50%. This nevertheless constitutes only a small fraction of the total cool CGM mass based on a comparison to z~2-3 quasar absorption line studies, but could represent >~10% of the CGM metal mass. Our survey offers the first statistical characterization of molecular outflow properties in the very early universe.Comment: ApJ accepted. 25 pages, 16 figures. Data and tables from Papers I and II available at https://github.com/spt-smg/publicdat

Ubiquitous Molecular Outflows in z > 4 Massive, Dusty Galaxies I. Sample Overview and Clumpy Structure in Molecular Outflows on 500pc Scales

Massive galaxy-scale outflows of gas are one of the most commonly-invoked mechanisms to regulate the growth and evolution of galaxies throughout the universe. While the gas in outflows spans a large range of temperatures and densities, the cold molecular phase is of particular interest because molecular outflows may be capable of suppressing star formation in galaxies by removing the star-forming gas. We have conducted the first survey of molecular outflows at z > 4, targeting 11 strongly-lensed dusty, star-forming galaxies (DSFGs) with high-resolution Atacama Large Millimeter Array (ALMA) observations of OH 119um absorption as an outflow tracer. In this first paper, we give an overview of the survey, focusing on the detection rate and structure of molecular outflows. We find unambiguous evidence for outflows in 8/11 (73%) galaxies, more than tripling the number known at z > 4. This implies that molecular winds in z > 4 DSFGs must have both a near-unity occurrence rate and large opening angles to be detectable in absorption. Lensing reconstructions reveal that 500pc-scale clumpy structures in the outflows are common. The individual clumps are not directly resolved, but from optical depth arguments we expect that future observations will require 50-200pc spatial resolution to do so. We do not detect high-velocity [CII] wings in any of the sources with clear OH outflows, indicating that [CII] is not a reliable tracer of molecular outflows. Our results represent a first step toward characterizing molecular outflows at z > 4 at the population level, demonstrating that large-scale outflows are ubiquitous among early massive, dusty galaxies.Comment: ApJ accepted. 28 pages, 12 figures + appendix. Data and tables from Papers I and II available at https://github.com/spt-smg/publicdat

Asymmetric magnetization reversal in exchange-biased hysteresis loops

This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.Polarized neutron reflectometry is used to probe the in-plane projection of the net-magnetization vector M of polycrystalline Fe films exchange coupled to twinned (110) MnF2 or FeF2 antiferromagnetic (AF) layers. The magnetization reversal mechanism depends upon the orientation of the cooling field with respect to the twinned microstructure of the AF, and whether the applied field is increased to (or decreased from) a positive saturating field; i.e., the magnetization reversal is asymmetric. The reversal of the sample magnetization from one saturated state to the other occurs via either domain wall motion or magnetization rotation on opposite sides of the same hysteresis loop

A Profile Likelihood Analysis of the Constrained MSSM with Genetic Algorithms

The Constrained Minimal Supersymmetric Standard Model (CMSSM) is one of the simplest and most widely-studied supersymmetric extensions to the standard model of particle physics. Nevertheless, current data do not sufficiently constrain the model parameters in a way completely independent of priors, statistical measures and scanning techniques. We present a new technique for scanning supersymmetric parameter spaces, optimised for frequentist profile likelihood analyses and based on Genetic Algorithms. We apply this technique to the CMSSM, taking into account existing collider and cosmological data in our global fit. We compare our method to the MultiNest algorithm, an efficient Bayesian technique, paying particular attention to the best-fit points and implications for particle masses at the LHC and dark matter searches. Our global best-fit point lies in the focus point region. We find many high-likelihood points in both the stau co-annihilation and focus point regions, including a previously neglected section of the co-annihilation region at large m_0. We show that there are many high-likelihood points in the CMSSM parameter space commonly missed by existing scanning techniques, especially at high masses. This has a significant influence on the derived confidence regions for parameters and observables, and can dramatically change the entire statistical inference of such scans.Comment: 47 pages, 8 figures; Fig. 8, Table 7 and more discussions added to Sec. 3.4.2 in response to referee's comments; accepted for publication in JHE

SUSY Breaking and Moduli Stabilization from Fluxes in Gauged 6D Supergravity

We construct the 4D N=1 supergravity which describes the low-energy limit of 6D supergravity compactified on a sphere with a monopole background a la Salam and Sezgin. This provides a simple setting sharing the main properties of realistic string compactifications such as flat 4D spacetime, chiral fermions and N=1 supersymmetry as well as Fayet-Iliopoulos terms induced by the Green-Schwarz mechanism. The matter content of the resulting theory is a supersymmetric SO(3)xU(1) gauge model with two chiral multiplets, S and T. The expectation value of T is fixed by the classical potential, and S describes a flat direction to all orders in perturbation theory. We consider possible perturbative corrections to the Kahler potential in inverse powers of $Re S$ and $Re T$, and find that under certain circumstances, and when taken together with low-energy gaugino condensation, these can lift the degeneracy of the flat direction for $Re S$. The resulting vacuum breaks supersymmetry at moderately low energies in comparison with the compactification scale, with positive cosmological constant. It is argued that the 6D model might itself be obtained from string compactifications, giving rise to realistic string compactifications on non Ricci flat manifolds. Possible phenomenological and cosmological applications are briefly discussed.Comment: 32 pages, 2 figures. Uses JHEP3.cls. References fixed and updated, some minor typos fixed. Corrected minor error concerning Kaluza-Klein scales. Results remain unchange

Chaotic and Clumpy Galaxy Formation in an Extremely Massive Reionization-era Halo

© 2022. The Author(s). Published by the American Astronomical Society. Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 licence. https://creativecommons.org/licenses/by/4.0/Abstract: The SPT 0311–58 system at z = 6.900 is an extremely massive structure within the reionization epoch and offers a chance to understand the formation of galaxies at an extreme peak in the primordial density field. We present 70 mas Atacama Large Millimeter/submillimeter Array observations of the dust continuum and [C ii] 158 μm emission in the central pair of galaxies and reach physical resolutions of ∼100–350 pc, among the most detailed views of any reionization-era system to date. The observations resolve the source into at least a dozen kiloparsec-size clumps. The global kinematics and high turbulent velocity dispersion within the galaxies present a striking contrast to recent claims of dynamically cold thin-disk kinematics in some dusty galaxies just 800 Myr later at z ∼ 4. We speculate that both gravitational interactions and fragmentation from massive parent disks have likely played a role in the overall dynamics and formation of clumps in the system. Each clump individually is comparable in mass to other 6 < z < 8 galaxies identified in rest-UV/optical deep field surveys, but with star formation rates elevated by a factor of ~3-5. Internally, the clumps themselves bear close resemblance to greatly scaled-up versions of virialized cloud-scale structures identified in low-redshift galaxies. Our observations are qualitatively similar to the chaotic and clumpy assembly within massive halos seen in simulations of high-redshift galaxies.Peer reviewe

Two-stage magnetization reversal in exchange biased bilayers

MnF2/Fe bilayers exhibit asymmetric magnetization reversal that occurs by coherent rotation on one side of the loop and by nucleation and propagation of domain walls on the other side of the loop. Here, we show by polarized neutron reflectometry, magnetization, and magnetotransport measurements that for samples with good crystalline "quality" the rotation is a two-stage process, due to coherent rotation to a stable state perpendicular to the cooling field direction. The result is remarkably asymmetrically shaped hysteresis loops