639 research outputs found
Photoinduced Electron Paramagnetic Resonance Study Of Electron Traps In Tio2 Crystals: Oxygen Vacancies And Ti3+ Ions
SOD1 Function and Its Implications for Amyotrophic Lateral Sclerosis Pathology: New and Renascent Themes
The canonical role of superoxide dismutase 1 (SOD1) is as an antioxidant enzyme protecting the cell from reactive oxygen species toxicity. SOD1 was also the first gene in which mutations were found to be causative for the neurodegenerative disease amyotrophic lateral sclerosis (ALS), more than 20 years ago. ALS is a relentless and incurable mid-life onset disease, which starts with a progressive paralysis and usually leads to death within 3 to 5 years of diagnosis; in the majority of cases, the intellect appears to remain intact while the motor system degenerates. It rapidly became clear that when mutated SOD1 takes on a toxic gain of function in ALS. However, this novel function remains unknown and many cellular systems have been implicated in disease. Now it seems that SOD1 may play a rather larger role in the cell than originally realized, including as a key modulator of glucose signaling (at least so far in yeast) and in RNA binding. Here, we consider some of the new findings for SOD1 in health and disease, which may shed light on how single amino acid changes at sites throughout this protein can cause devastating neurodegeneration in the mammalian motor system
Time's up. descriptive epidemiology of multi-morbidity and time spent on health related activity by older Australians: a time use survey.
This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.Most Western health systems remain single illness orientated despite the growing prevalence of multi-morbidity. Identifying how much time people with multiple chronic conditions spend managing their health will help policy makers and health service providers make decisions about areas of patient need for support. This article presents findings from an Australian study concerning the time spent on health related activity by older adults (aged 50 years and over), most of whom had multiple chronic conditions. A recall questionnaire was developed, piloted, and adjusted. Sampling was undertaken through three bodies; the Lung Foundation Australia (COPD sub-sample), National Diabetes Services Scheme (Diabetes sub-sample) and National Seniors Australia (Seniors sub-sample). Questionnaires were mailed out during 2011 to 10,600 older adults living in Australia. 2540 survey responses were received and analysed. Descriptive analyses were completed to obtain median values for the hours spent on each activity per month. The mean number of chronic conditions was 3.7 in the COPD sub-sample, 3.4 in the Diabetes sub-sample and 2.0 in the NSA sub-sample. The study identified a clear trend of increased time use associated with increased number of chronic conditions. Median monthly time use was 5-16 hours per month overall for our three sub-samples. For respondents in the top decile with five or more chronic conditions the median time use was equivalent to two to three hours per day, and if exercise is included in the calculations, respondents spent from between five and eight hours per day: an amount similar to full-time work. Multi-morbidity imposes considerable time burdens on patients. Ageing is associated with increasing rates of multi-morbidity. Many older adults are facing high demands on their time to manage their health in the face of decreasing energy and mobility. Their time use must be considered in health service delivery and health system reform.National Health and Medical Research Counci
The UTMOST: A hybrid digital signal processor transforms the MOST
The Molonglo Observatory Synthesis Telescope (MOST) is an 18,000 square meter
radio telescope situated some 40 km from the city of Canberra, Australia. Its
operating band (820-850 MHz) is now partly allocated to mobile phone
communications, making radio astronomy challenging. We describe how the
deployment of new digital receivers (RX boxes), Field Programmable Gate Array
(FPGA) based filterbanks and server-class computers equipped with 43 GPUs
(Graphics Processing Units) has transformed MOST into a versatile new
instrument (the UTMOST) for studying the dynamic radio sky on millisecond
timescales, ideal for work on pulsars and Fast Radio Bursts (FRBs). The
filterbanks, servers and their high-speed, low-latency network form part of a
hybrid solution to the observatory's signal processing requirements. The
emphasis on software and commodity off-the-shelf hardware has enabled rapid
deployment through the re-use of proven 'software backends' for its signal
processing. The new receivers have ten times the bandwidth of the original MOST
and double the sampling of the line feed, which doubles the field of view. The
UTMOST can simultaneously excise interference, make maps, coherently dedisperse
pulsars, and perform real-time searches of coherent fan beams for dispersed
single pulses. Although system performance is still sub-optimal, a pulsar
timing and FRB search programme has commenced and the first UTMOST maps have
been made. The telescope operates as a robotic facility, deciding how to
efficiently target pulsars and how long to stay on source, via feedback from
real-time pulsar folding. The regular timing of over 300 pulsars has resulted
in the discovery of 7 pulsar glitches and 3 FRBs. The UTMOST demonstrates that
if sufficient signal processing can be applied to the voltage streams it is
possible to perform innovative radio science in hostile radio frequency
environments.Comment: 12 pages, 6 figure
Some Like it Hot: The X-Ray Emission of The Giant Star YY Mensae
(Abridged abstract) We present an analysis of the X-ray emission of the
rapidly rotating giant star YY Mensae observed by Chandra HETGS and XMM-Newton.
Although no obvious flare was detected, the X-ray luminosity changed by a
factor of two between the XMM-Newton and Chandra observations taken 4 months
apart. The coronal abundances and the emission measure distribution have been
derived from three different methods using optically thin collisional
ionization equilibrium models. The abundances show an inverse first ionization
potential (FIP) effect. We further find a high N abundance which we interpret
as a signature of material processed in the CNO cycle. The corona is dominated
by a very high temperature (20-40 MK) plasma, which places YY Men among the
magnetically active stars with the hottest coronae. Lower temperature plasma
also coexists, albeit with much lower emission measure. Line broadening is
reported, which we interpret as Doppler thermal broadening, although rotational
broadening due to X-ray emitting material high above the surface could be
present as well. We use two different formalisms to discuss the shape of the
emission measure distribution. The first one infers the properties of coronal
loops, whereas the second formalism uses flares as a statistical ensemble. We
find that most of the loops in the corona of YY Men have their maximum
temperature equal to or slightly larger than about 30 MK. We also find that
small flares could contribute significantly to the coronal heating in YY Men.
Although there is no evidence of flare variability in the X-ray light curves,
we argue that YY Men's distance and X-ray brightness does not allow us to
detect flares with peak luminosities Lx <= 10^{31} erg/s with current
detectors.Comment: Accepted paper to appear in Astrophysical Journal, issue Nov 10, 2004
(v615). This a revised version. Small typos are corrected. Figure 7 and its
caption and some related text in Sct 7.2 are changed, without incidence for
the conclusion
The Commensal Real-time ASKAP Fast Transients (CRAFT) survey
We are developing a purely commensal survey experiment for fast (<5s)
transient radio sources. Short-timescale transients are associated with the
most energetic and brightest single events in the Universe. Our objective is to
cover the enormous volume of transients parameter space made available by
ASKAP, with an unprecedented combination of sensitivity and field of view. Fast
timescale transients open new vistas on the physics of high brightness
temperature emission, extreme states of matter and the physics of strong
gravitational fields. In addition, the detection of extragalactic objects
affords us an entirely new and extremely sensitive probe on the huge reservoir
of baryons present in the IGM. We outline here our approach to the considerable
challenge involved in detecting fast transients, particularly the development
of hardware fast enough to dedisperse and search the ASKAP data stream at or
near real-time rates. Through CRAFT, ASKAP will provide the testbed of many of
the key technologies and survey modes proposed for high time resolution science
with the SKA.Comment: accepted for publication in PAS
Reconstruction by fluorescence imaging of the spatio-temporal evolution of the viscosity field in Hele-Shaw flows
The extraordinary linear polarisation structure of the southern Centaurus A lobe revealed by ASKAP
We present observations of linear polarisation in the southern radio lobe of
Centaurus A, conducted during commissioning of the Australian Square Kilometre
Array Pathfinder (ASKAP) telescope. We used 16 antennas to observe a 30 square
degree region in a single 12 hour pointing over a 240 MHz band centred on 913
MHz. Our observations achieve an angular resolution of arcseconds
(480 parsecs), a maximum recoverable angular scale of 30 arcminutes, and a
full-band sensitivity of 85 \muupJy beam. The resulting maps of
polarisation and Faraday rotation are amongst the most detailed ever made for
radio lobes, with of order 10 resolution elements covering the source. We
describe several as-yet unreported observational features of the lobe,
including its detailed peak Faraday depth structure, and intricate networks of
depolarised filaments. These results demonstrate the exciting capabilities of
ASKAP for widefield radio polarimetry.Comment: 10 pages, 6 figures. Accepted in "The Power of Faraday Tomography"
special issue of Galaxie
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