Personal health technologies, micropolitics and resistance: A new materialist analysis

Personal health technologies (PHTs) are near-body devices or applications designed for use by a single individual, principally outside healthcare facilities. They enable users to monitor physiological processes or body activity, are frequently communication-enabled, and sometimes also intervene therapeutically. This paper explores a range of PHTs, from blood pressure or blood glucose monitors purchased in pharmacies, fitness monitors such as FitBit and Nike+ Fuelband, through to drug pumps and implantable medical devices. It applies a new materialist analysis, first reverse engineering a range of PHTs to explore their micropolitics, and then forward-engineering PHTs to meet, variously, public health, corporate, patient and resisting-citizen agendas. The paper concludes with a critical discussion of PHTs, and the possibilities of designing devices and apps that might foster a subversive micropolitics and encourage collective and resisting ‘citizen-health’

The sexuality-assemblages of young men: a new materialist analysis

This article presents a new materialist exploration of young men and sexuality that shifts the focus away from bodies and individuals, toward the affective flow within assemblages of bodies, things, ideas and social institutions, and the sexual capacities this flow produces. Using data from two empirical studies, we explore the sexuality assemblages of teen boys and young men, and the micropolitics of these assemblages. We find that the sexuality produced in the bodies of young men is highly territorialised and aggregated by various materialities. However, we also reveal how young men resist these conventional sexualities

Unusual clear cell variant of epithelioid mesothelioma

Clear cell mesothelioma is an extremely rare neoplasm of the pleura, which can easily be mistaken for a metastasis of clear cell carcinoma to the pleura. We report here the histochemical, immunohistochemical, and ultrastructural aspects of a new case of clear cell pleural mesothelioma in a 52-year-old man with no known asbestos exposure. He was admitted to the hospital for recurrent pleural effusion, which was negative for neoplastic cells at the cytologic examination. A partial decortication of the right pleura was performed. The morphologic, immunohistochemical, and ultrastructural features reported for this case are consistent with the diagnosis of clear cell mesothelioma. The differential diagnosis and immunohistochemical features in comparison with other clear cell neoplasms are discussed

Comparação de métodos de melhoramento de feijão (Phaseolus vulgaris L.) para o incremento da fixação simbiótica de nitrogênio.

A produtividade do feijão pode ser melhorada pelo incremento da sua capacidade de fixar nitrogênio através de bactérias do gênero Rhizobium. Este estudo comparou duas metodologias de melhoramento ? linhas derivadas de F2 (LDF 2) e descendência de uma única semente (SSD), ? em um cruzamento entre as cultivares Negro Argel (bom fixador simbiótico de nitrogênio) e Rio Tibagi (baixo potencial simbiótico de nitrogênio), com nitrogênio mineral ou inoculação com Rhizobium. Dezoito famílias foram selecionadas em F4 pelo método LDF2 , com base no N total nos grãos, e sessenta sementes foram avançadas até F5 sem seleção, pelo método SSD. As famílias selecionadas em F4 (LDF2) foram superiores para o potencial de fixação de nitrogênio e produção de grãos, em comparação com famílias conduzidas sem seleção (SSD). As famílias F 4 selecionadas no tratamento com nitrogênio mineral mostraram uma tendência a responder menos à inoculação, do que as famílias selecionadas no tratamento com Rhizobium. Além disso, as famílias selecionadas no tratamento com Rhizobium mostraram melhores respostas no tratamento com nitrogênio mineral. A mesma tendência foi observada para as famílias que responderam a ambas as fontes de nitrogênio. Neste estudo foi observado que a seleção sob o tratamento com Rhizobium proporciona oportunidade para os melhoristas selecionarem genótipos de feijão com potencial para aumentar a fixação de nitrogênio e a produtividade de grãos

DMBT1 expression is down-regulated in breast cancer.

BACKGROUND: We studied the expression of DMBT1 (deleted in malignant brain tumor 1), a putative tumor suppressor gene, in normal, proliferative, and malignant breast epithelium and its possible relation to cell cycle. METHODS: Sections from 17 benign lesions and 55 carcinomas were immunostained with anti DMBT1 antibody (DMBTh12) and sections from 36 samples, were double-stained also with anti MCM5, one of the 6 pre-replicative complex proteins with cell proliferation-licensing functions. DMBT1 gene expression at mRNA level was assessed by RT-PCR in frozen tissues samples from 39 patients. RESULTS: Normal glands and hyperplastic epithelium in benign lesions displayed a luminal polarized DMBTh12 immunoreactivity. Normal and hyperplastic epithelium adjacent to carcinomas showed a loss of polarization, with immunostaining present in basal and perinuclear cytoplasmic compartments. DMBT1 protein expression was down-regulated in the cancerous lesions compared to the normal and/or hyperplastic epithelium adjacent to carcinomas (3/55 positive carcinomas versus 33/42 positive normal/hyperplastic epithelia; p = 0.0001). In 72% of cases RT-PCR confirmed immunohistochemical results. Most of normal and hyperplastic mammary cells positive with DMBTh12 were also MCM5-positive. CONCLUSIONS: The redistribution and up-regulation of DMBT1 in normal and hyperplastic tissues flanking malignant tumours and its down-regulation in carcinomas suggests a potential role in breast cancer. Moreover, the concomitant expression of DMTB1 and MCM5 suggests its possible association with the cell-cycle regulation

Inside the research-assemblage: new materialism and the micropolitics of social inquiry

This paper explores social inquiry in terms of the ‘research-assemblages’ that produce knowledge from events. We use the precepts of new materialism (and specifically DeleuzoGuattarian assemblage ontology) to develop understanding of what happens when social events are researched. From this perspective, research is not at root an enterprise undertaken by human actors, but a machine-like assemblage of things, people, ideas, social collectivities and institutions. During social inquiry, the affect economies of an event-assemblage and a research-assemblage hybridise, generating a third assemblage with its own affective flow. This model of the research-assemblage reveals a micropolitics of social research that suggests a means to interrogate and effectively reverse-engineer different social research methodologies and methods, to analyse what they do, how they work and their micropolitical effects. It also suggests a means to forward-engineer research methods and designs to manipulate the kinds of knowledge produced when events are researched

Mixed methods, materialism and the micropolitics of the research-assemblage

We assess the potential for mixing social research methods, based upon a materialist and micropolitical analysis of the research-assemblage and of what individual research techniques and methods do in practice. Applying a DeleuzoGuattarian toolkit of assemblages, affects and capacities, we document what happens when research methods and techniques interact with the events they wish to study. Micropolitically, many of these techniques and methods have unintended effects of specifying and aggregating events, with the consequently that the knowledge produced by social inquiry is invested with these specifications and aggregations. We argue that rather than abandoning these social research tools, we may use the micropolitical analysis to assess precisely how each method affects knowledge production, and engineer the research designs we use accordingly. This forms the justification for mixing methods that are highly aggregative or specifying with those that are less so, effectively rehabilitating methods that have often been rejected by social researchers, including surveys and experiments

The Limits of Anthropocene Narratives

The rapidly growing transdisciplinary enthusiasm about developing new kinds of Anthropocene stories is based on the shared assumption that the Anthropocene predicament is best made sense of by narrative means. Against this assumption, this article argues that the challenge we are facing today does not merely lie in telling either scientific, socio-political, or entangled Anthropocene narratives to come to terms with our current condition. Instead, the challenge lies in coming to grips with how the stories we can tell in the Anthropocene relate to the radical novelty of the Anthropocene condition about which no stories can be told. What we need to find are meaningful ways to reconcile an inherited commitment to narrativization and the collapse of storytelling as a vehicle of understanding the Anthropocene as our current predicament

Intensive mobilities: figurations of the nomad in contemporary theory

The figure of the nomad, representing the virtues of freedom, mobility, and exploration, is a frequently occurring trope within contemporary continental philosophy and social theory, derived chiefly from the work of Gilles Deleuze and Félix Guattari. This paper will interrogate the concept of nomadism, firstly in the philosophy of these two foundational thinkers, and then subsequently in the feminist and posthumanist theorizations of Rosi Braidotti. Whilst accepting that Braidotti's challenges to sedentarist, essentialist metaphysical accounts of the transcendental subject are still politically relevant, it will be argued that the deployment of the nomadic figure—and more generally, the positing of an ontology of creative desire, or ‘becoming’—risks not only absolutizing the historical contingencies of the digitized, postindustrial society that it seeks to criticize, but actually reinforcing the unsustainable ideology of perpetual production upon which such a society is premised